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The map label for this gene is phoP [H]

Identifier: 57650564

GI number: 57650564

Start: 1774360

End: 1775064

Strand: Reverse

Name: phoP [H]

Synonym: SACOL1740

Alternate gene names: 57650564

Gene position: 1775064-1774360 (Counterclockwise)

Preceding gene: 57650565

Following gene: 57650563

Centisome position: 63.18

GC content: 33.9

Gene sequence:

>705_bases
ATGTCGCAAAAAGTGTTGGTAGTAGATGACGAACATTCAATCGTAACATTACTTAAATATAACTTAGAAACAGCTGGTTA
TGAAGTTGTTGTCGCATTTGATGGTGATGAGGCTTTAGAAAAGGTAGAAAGTGAACAGCCAGATTTAATTATTTTAGATG
TTATGCTACCTAAAAAAGATGGCATTGACGTATGTAAGACTGTAAGAACAAATAAAAATTTAGTCCCTATATTAATGTTA
ACGGCGAAAAATGATGAATTTGATCGGGTATTAGGTTTAGAATTAGGTGCCGATGACTATATGACTAAGCCTTTTTCACC
TAGAGAAGTTGTTGCCCGTGTGAAAGCCATTTTAAGACGTTCTCAATTTGTAAAAGAAGTAGAAGAGATTGACGATGATA
TTACCATCGGATCGATACGTATTAGACCCGATTATTTTGAAGTATATAAGCATAATGAGTTATTGGAGCTAACACCGAAA
GAATTTGAACTCTTGCTTTATTTGATAGAAAGACAAGGCAGAGTCATTACGAGAGAGCATATGTTAAATACGGTATGGAA
TTATGAATTTGCAGGAGACTCAAGAATTGTTGATGTACATATCAGTCATTTAAGAGATAAATTAGAAGATAATCCTAAGA
AGCCACAACTTATTAAAACTGTGCGTGGCTTAGGCTATAAATTGGAAAGACCTAAAGAACAATGA

Upstream 100 bases:

>100_bases
AAAGTAATGTAAAAAATGTGTAAAGATAATGTGTAGGATGTTATTTTTATAAATAGTTCGGTTATAATGTAAATATAATT
ATAAGTTAGGGAGGCATACC

Downstream 100 bases:

>100_bases
TGAAGTTTCACCACCGCTTAATGTTATTGATAAGCAGTATATTAATTATCAGTTTTGTTACATTAGGCATTATTATTCAC
GCTTCCATCACATATGTTTT

Product: alkaline phosphatase synthesis transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MSQKVLVVDDEHSIVTLLKYNLETAGYEVVVAFDGDEALEKVESEQPDLIILDVMLPKKDGIDVCKTVRTNKNLVPILML
TAKNDEFDRVLGLELGADDYMTKPFSPREVVARVKAILRRSQFVKEVEEIDDDITIGSIRIRPDYFEVYKHNELLELTPK
EFELLLYLIERQGRVITREHMLNTVWNYEFAGDSRIVDVHISHLRDKLEDNPKKPQLIKTVRGLGYKLERPKEQ

Sequences:

>Translated_234_residues
MSQKVLVVDDEHSIVTLLKYNLETAGYEVVVAFDGDEALEKVESEQPDLIILDVMLPKKDGIDVCKTVRTNKNLVPILML
TAKNDEFDRVLGLELGADDYMTKPFSPREVVARVKAILRRSQFVKEVEEIDDDITIGSIRIRPDYFEVYKHNELLELTPK
EFELLLYLIERQGRVITREHMLNTVWNYEFAGDSRIVDVHISHLRDKLEDNPKKPQLIKTVRGLGYKLERPKEQ
>Mature_233_residues
SQKVLVVDDEHSIVTLLKYNLETAGYEVVVAFDGDEALEKVESEQPDLIILDVMLPKKDGIDVCKTVRTNKNLVPILMLT
AKNDEFDRVLGLELGADDYMTKPFSPREVVARVKAILRRSQFVKEVEEIDDDITIGSIRIRPDYFEVYKHNELLELTPKE
FELLLYLIERQGRVITREHMLNTVWNYEFAGDSRIVDVHISHLRDKLEDNPKKPQLIKTVRGLGYKLERPKEQ

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=41.9213973799127, Blast_Score=170, Evalue=6e-44,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=41.7391304347826, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=43.8053097345133, Blast_Score=168, Evalue=3e-43,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=36.4444444444444, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=40.7894736842105, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1786784, Length=231, Percent_Identity=38.5281385281385, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=37.3333333333333, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=34.6491228070175, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=34.2222222222222, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=33.4745762711864, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=34.2222222222222, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=34.4978165938865, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=33.7719298245614, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=32.0512820512821, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1790299, Length=118, Percent_Identity=33.8983050847458, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788550, Length=132, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790437, Length=101, Percent_Identity=37.6237623762376, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787487, Length=133, Percent_Identity=31.5789473684211, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27123; Mature: 26991

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKVLVVDDEHSIVTLLKYNLETAGYEVVVAFDGDEALEKVESEQPDLIILDVMLPKKD
CCCCEEEEECCCCEEEEEEECCCCCCEEEEEEECCHHHHHHHHCCCCCEEEEEEEECCCC
GIDVCKTVRTNKNLVPILMLTAKNDEFDRVLGLELGADDYMTKPFSPREVVARVKAILRR
CHHHHHHHHCCCCEEEEEEEEECCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
SQFVKEVEEIDDDITIGSIRIRPDYFEVYKHNELLELTPKEFELLLYLIERQGRVITREH
HHHHHHHHHCCCCEEEEEEEECCHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCEEEHHH
MLNTVWNYEFAGDSRIVDVHISHLRDKLEDNPKKPQLIKTVRGLGYKLERPKEQ
HHHHHHCEEECCCCEEEEEEHHHHHHHHHCCCCCCHHHHHHHHCCEECCCCCCC
>Mature Secondary Structure 
SQKVLVVDDEHSIVTLLKYNLETAGYEVVVAFDGDEALEKVESEQPDLIILDVMLPKKD
CCCEEEEECCCCEEEEEEECCCCCCEEEEEEECCHHHHHHHHCCCCCEEEEEEEECCCC
GIDVCKTVRTNKNLVPILMLTAKNDEFDRVLGLELGADDYMTKPFSPREVVARVKAILRR
CHHHHHHHHCCCCEEEEEEEEECCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
SQFVKEVEEIDDDITIGSIRIRPDYFEVYKHNELLELTPKEFELLLYLIERQGRVITREH
HHHHHHHHHCCCCEEEEEEEECCHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCEEEHHH
MLNTVWNYEFAGDSRIVDVHISHLRDKLEDNPKKPQLIKTVRGLGYKLERPKEQ
HHHHHHCEEECCCCEEEEEEHHHHHHHHHCCCCCCHHHHHHHHCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]