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The map label for this gene is hemC [H]

Identifier: 57650542

GI number: 57650542

Start: 1747722

End: 1748648

Strand: Reverse

Name: hemC [H]

Synonym: SACOL1717

Alternate gene names: 57650542

Gene position: 1748648-1747722 (Counterclockwise)

Preceding gene: 57650543

Following gene: 57650541

Centisome position: 62.24

GC content: 34.52

Gene sequence:

>927_bases
ATGCGTAAATTAGTCGTTGGCTCCAGAAGAAGTAAATTAGCTTTAACACAAAGCCAGCAATTTATTGATAAATTAAAAGC
TGTCGAGCCAAATCTAGAAATTGAAATTAAAGAAATTGTCACGAAAGGCGATCGTATAGTAGATAAACAATTGTCTAAAG
TCGGAGGCAAAGGCTTATTTGTTAAAGAAATACAACATGAACTTTTTGAAAAAAATATCGATATGGCAATACACTCGCTT
AAAGACGTACCAAGTGTAATTCCGGAAGGTTTAACATTAGGTTGTATCCCTGATAGAGAATTACCTTTTGATGCGTATAT
TTCTAAAACACATACACCACTATCCCAATTGCCAGAAGGCAGTATTATTGGTACTAGTTCATTACGTCGTGGTGCACAAA
TATTATCTAAGTATCCTAATTTAGAGATTAAATGGATTAGAGGTAATATAGATACACGATTAGAAAAGTTACAAACTGAA
GATTATGATGCGATTATTTTAGCTGCAGCTGGTTTAAGAAGAATGGGCTGGTCAGATGATATTGTAACATCTTATCTTGA
TAGAGATACATTGTTACCTGCAATCGGACAAGGTGCTTTAGGGATAGAATGTCGTAGTGACGATGAAGAACTATTAACAT
TATTAAGCAAAGTACATAATGATGAGGTTGCAAAATGTGTGACTGCTGAACGAACGTTTTTAGCAGAAATGGATGGTAGT
TGTCAGGTGCCAATTGCAGGATATGCTACAATCTCAGATCAAAACGAAATCGAATTTACAGGTTTAATTATGACCCCAGA
TGGTAAAGAACGATTTGAATATACAATGAACGGAACAGATCCGGTTGAGTTAGGCAAAACAGTGAGTAACAAATTAAAAG
AGCAAGGTGCTTATGAAATTATAAAACGCTTAAATGAACAACATTAA

Upstream 100 bases:

>100_bases
TTATTTTATTTTGCTTAAATATGATTAATTTATTTTTTGCAACACATTTTGTGAATTGAGAAAATAATCTAGAGCAATCC
GTTCCTAGGAGGAATTGAAC

Downstream 100 bases:

>100_bases
ATAATGGAGTGACGTTTAAATATGAAGCCAGTTGTAGTTATGACACAAACAAATGACATGCAAAGTGATTTAGTATCAAT
TATTCACAAACCCTTTATTG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MRKLVVGSRRSKLALTQSQQFIDKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLFVKEIQHELFEKNIDMAIHSL
KDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTE
DYDAIILAAAGLRRMGWSDDIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGS
CQVPIAGYATISDQNEIEFTGLIMTPDGKERFEYTMNGTDPVELGKTVSNKLKEQGAYEIIKRLNEQH

Sequences:

>Translated_308_residues
MRKLVVGSRRSKLALTQSQQFIDKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLFVKEIQHELFEKNIDMAIHSL
KDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTE
DYDAIILAAAGLRRMGWSDDIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGS
CQVPIAGYATISDQNEIEFTGLIMTPDGKERFEYTMNGTDPVELGKTVSNKLKEQGAYEIIKRLNEQH
>Mature_308_residues
MRKLVVGSRRSKLALTQSQQFIDKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLFVKEIQHELFEKNIDMAIHSL
KDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTE
DYDAIILAAAGLRRMGWSDDIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGS
CQVPIAGYATISDQNEIEFTGLIMTPDGKERFEYTMNGTDPVELGKTVSNKLKEQGAYEIIKRLNEQH

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=286, Percent_Identity=43.7062937062937, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI66933009, Length=286, Percent_Identity=43.7062937062937, Blast_Score=239, Evalue=3e-63,
Organism=Escherichia coli, GI48994974, Length=300, Percent_Identity=46.3333333333333, Blast_Score=251, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6319996, Length=318, Percent_Identity=34.9056603773585, Blast_Score=189, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20130425, Length=277, Percent_Identity=40.4332129963899, Blast_Score=204, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34355; Mature: 34355

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLVVGSRRSKLALTQSQQFIDKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLF
CCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCHHHHHHHHHHHCCCCCH
VKEIQHELFEKNIDMAIHSLKDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHCCCCCHHHCCCC
SIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTEDYDAIILAAAGLRRMGWSDD
CEECHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCCEEEEEHHHHHHCCCCHH
IVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGS
HHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
CQVPIAGYATISDQNEIEFTGLIMTPDGKERFEYTMNGTDPVELGKTVSNKLKEQGAYEI
CCCCCCEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHH
IKRLNEQH
HHHHHCCC
>Mature Secondary Structure
MRKLVVGSRRSKLALTQSQQFIDKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLF
CCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCHHHHHHHHHHHCCCCCH
VKEIQHELFEKNIDMAIHSLKDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHCCCCCHHHCCCC
SIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTEDYDAIILAAAGLRRMGWSDD
CEECHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCCEEEEEHHHHHHCCCCHH
IVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGS
HHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
CQVPIAGYATISDQNEIEFTGLIMTPDGKERFEYTMNGTDPVELGKTVSNKLKEQGAYEI
CCCCCCEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHH
IKRLNEQH
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA