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The map label for this gene is hemD [H]

Identifier: 57650541

GI number: 57650541

Start: 1747032

End: 1747700

Strand: Reverse

Name: hemD [H]

Synonym: SACOL1716

Alternate gene names: 57650541

Gene position: 1747700-1747032 (Counterclockwise)

Preceding gene: 57650542

Following gene: 57650540

Centisome position: 62.21

GC content: 30.49

Gene sequence:

>669_bases
ATGAAGCCAGTTGTAGTTATGACACAAACAAATGACATGCAAAGTGATTTAGTATCAATTATTCACAAACCCTTTATTGA
TATAAAGCCACTAAATTTTGATATTCATTTGTTAAATCAACGCTATGACTGGCTTATTTTTTCATCTAAAAATGCTGTGA
AATTCTTTTATAAATATCTAAAAGGAATTAATGTTGATAACATTGCTGTGATAGGAAGTAAGACAGCGCAATATTGTGAA
TCACTTGGCATTCGAGTTGATTTTATGCCAAACGACTTTTCTCAAGAAGGATTTTTAAAATCATTTAATCAAACTAACCA
AAAAATACTTTTGCCTTCGAGTGAATTGGCGAGACCATTGTTATTAGCAGCGTTATCTAAAGATAATGAAGTTGTTAAAA
TAGATTTATATACTTCAGTGCCTAACAAACAAAATATACAAGATGTTAAAGAAATGATAGAACATCAACAAATCGATGCA
TTAACATTTTCAAGTTCGTCGGCAGTACGTTATTATTTTAATGAAGGATTTGTACCAAAATTCAAGTCGTATTTTGCTAT
TGGAGAACAAACAGCACGGACCATTAAATCATATCAACAACCAGTAACAATTGCAGAAATTCAAACACTCGAATCACTAA
TTGAAAAGATTTTAGAAAGTAGGGGCTAA

Upstream 100 bases:

>100_bases
GTTAGGCAAAACAGTGAGTAACAAATTAAAAGAGCAAGGTGCTTATGAAATTATAAAACGCTTAAATGAACAACATTAAA
TAATGGAGTGACGTTTAAAT

Downstream 100 bases:

>100_bases
AAATGAAATTTGATAGACATAGAAGATTGAGATCATCAGCGACAATGAGAGATATGGTTAGAGAGAATCATGTAAGAAAA
GAAGATTTAATATATCCAAT

Product: uroporphyrinogen III synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKPVVVMTQTNDMQSDLVSIIHKPFIDIKPLNFDIHLLNQRYDWLIFSSKNAVKFFYKYLKGINVDNIAVIGSKTAQYCE
SLGIRVDFMPNDFSQEGFLKSFNQTNQKILLPSSELARPLLLAALSKDNEVVKIDLYTSVPNKQNIQDVKEMIEHQQIDA
LTFSSSSAVRYYFNEGFVPKFKSYFAIGEQTARTIKSYQQPVTIAEIQTLESLIEKILESRG

Sequences:

>Translated_222_residues
MKPVVVMTQTNDMQSDLVSIIHKPFIDIKPLNFDIHLLNQRYDWLIFSSKNAVKFFYKYLKGINVDNIAVIGSKTAQYCE
SLGIRVDFMPNDFSQEGFLKSFNQTNQKILLPSSELARPLLLAALSKDNEVVKIDLYTSVPNKQNIQDVKEMIEHQQIDA
LTFSSSSAVRYYFNEGFVPKFKSYFAIGEQTARTIKSYQQPVTIAEIQTLESLIEKILESRG
>Mature_222_residues
MKPVVVMTQTNDMQSDLVSIIHKPFIDIKPLNFDIHLLNQRYDWLIFSSKNAVKFFYKYLKGINVDNIAVIGSKTAQYCE
SLGIRVDFMPNDFSQEGFLKSFNQTNQKILLPSSELARPLLLAALSKDNEVVKIDLYTSVPNKQNIQDVKEMIEHQQIDA
LTFSSSSAVRYYFNEGFVPKFKSYFAIGEQTARTIKSYQQPVTIAEIQTLESLIEKILESRG

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 25419; Mature: 25419

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVVVMTQTNDMQSDLVSIIHKPFIDIKPLNFDIHLLNQRYDWLIFSSKNAVKFFYKYL
CCCEEEEEECCCHHHHHHHHHHCCCCEEECCCEEEEEECCCCEEEEEECCCHHHHHHHHH
KGINVDNIAVIGSKTAQYCESLGIRVDFMPNDFSQEGFLKSFNQTNQKILLPSSELARPL
HCCCCCCEEEECCHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCEEECCCHHHHHHH
LLAALSKDNEVVKIDLYTSVPNKQNIQDVKEMIEHQQIDALTFSSSSAVRYYFNEGFVPK
HHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCEEEECCCCEEEEEECCCCCHH
FKSYFAIGEQTARTIKSYQQPVTIAEIQTLESLIEKILESRG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPVVVMTQTNDMQSDLVSIIHKPFIDIKPLNFDIHLLNQRYDWLIFSSKNAVKFFYKYL
CCCEEEEEECCCHHHHHHHHHHCCCCEEECCCEEEEEECCCCEEEEEECCCHHHHHHHHH
KGINVDNIAVIGSKTAQYCESLGIRVDFMPNDFSQEGFLKSFNQTNQKILLPSSELARPL
HCCCCCCEEEECCHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCEEECCCHHHHHHH
LLAALSKDNEVVKIDLYTSVPNKQNIQDVKEMIEHQQIDALTFSSSSAVRYYFNEGFVPK
HHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCEEEECCCCEEEEEECCCCCHH
FKSYFAIGEQTARTIKSYQQPVTIAEIQTLESLIEKILESRG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]