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The map label for this gene is relA2 [H]

Identifier: 57650515

GI number: 57650515

Start: 1718109

End: 1720298

Strand: Reverse

Name: relA2 [H]

Synonym: SACOL1689

Alternate gene names: 57650515

Gene position: 1720298-1718109 (Counterclockwise)

Preceding gene: 57650516

Following gene: 57650514

Centisome position: 61.23

GC content: 34.57

Gene sequence:

>2190_bases
ATGAACAACGAATATCCATATAGTGCAGACGAAGTTCTTCACAAAGCAAAATCATATTTGTCAGCAGATGAATATGAGTA
TGTTTTAAAAAGCTATCATATTGCTTATGAAGCACATAAAGGTCAGTTCCGAAAAAACGGATTACCATACATTATGCATC
CTATACAAGTTGCAGGTATTTTAACAGAAATGCGATTAGACGGACCGACGATTGTCGCAGGTTTTTTGCATGATGTAATT
GAAGATACACCGTATACATTTGAAGATGTAAAAGAAATGTTCAATGAAGAAGTTGCTCGAATTGTTGATGGTGTGACGAA
GCTTAAAAAAGTAAAATACCGCTCAAAAGAAGAACAACAAGCTGAAAATCATCGCAAGTTATTTATTGCGATTGCCAAAG
ATGTACGCGTAATTTTGGTGAAATTAGCAGACAGATTACATAATATGCGTACCTTGAAAGCCATGCCGCGCGAAAAACAA
ATTAGAATTTCTCGAGAAACATTAGAAATTTATGCACCATTAGCACATCGTCTTGGTATTAATACAATCAAATGGGAACT
AGAAGATACGGCTCTTCGTTATATTGATAATGTGCAATATTTTAGAATAGTCAATTTAATGAAGAAGAAACGTAGTGAAC
GTGAAGCGTATATCGAAACGGCTATTGATAGAATACGTACTGAAATGGACCGAATGAATATCGAAGGCGATATAAATGGT
AGACCTAAACATATTTACAGTATTTATCGGAAAATGATGAAGCAGAAAAAACAATTTGATCAAATTTTTGATTTGTTGGC
GATACGTGTTATTGTCAATTCTATTAATGATTGTTATGCGATACTTGGGTTGGTGCATACGTTATGGAAACCGATGCCAG
GACGTTTTAAAGATTATATTGCAATGCCTAAACAAAATTTGTATCAGTCATTGCATACTACAGTAGTAGGCCCAAATGGA
GACCCGCTCGAAATCCAAATACGAACGTTTGATATGCACGAAATTGCTGAGCATGGTGTTGCAGCACACTGGGCTTACAA
AGAAGGTAAAAAAGTAAGTGAAAAAGATCAAACTTATCAAAATAAGTTAAATTGGTTAAAAGAATTAGCTGAAGCGGATC
ATACATCGTCTGACGCTCAAGAATTTATGGAAACCTTAAAATATGACTTACAGAGTGACAAAGTATACGCATTTACCCCA
GCGAGTGATGTTATTGAGTTGCCATATGGTGCTGTGCCGATTGATTTTGCTTATGCGATTCACAGTGAAGTAGGTAATAA
GATGATTGGTGCCAAGGTGAATGGCAAAATTGTACCAATTGACTATATTTTACAAACAGGCGATATTGTTGAAATACGTA
CTAGTAAACATTCATATGGACCAAGTCGTGATTGGTTGAAAATTGTTAAATCGTCTAGTGCCAAAGGTAAAATTAAAAGT
TTCTTCAAAAAACAAGATCGTTCATCTAATATTGAAAAAGGCCGAATGATGGTTGAAGCTGAAATAAAAGAGCAAGGATT
TAGAGTCGAAGATATTTTGACAGAGAAAAATATTCAGGTTGTTAATGAAAAATATAACTTTGCAAATGAAGATGATTTAT
TCGCAGCTGTAGGATTTGGCGGCGTGACATCCTTACAGATTGTTAATAAATTAACTGAAAGACAACGTATTTTAGATAAA
CAACGTGCTTTAAATGAAGCACAAGAAGTTACGAAATCATTGCCTATTAAAGACAACATCATTACTGATAGTGGTGTCTA
TGTAGAAGGTTTAGAAAATGTACTTATCAAGTTGTCAAAATGTTGTAATCCTATACCAGGTGATGATATTGTAGGTTATA
TCACCAAAGGTCACGGTATTAAAGTACATCGCACTGATTGCCCAAATATTAAGAACGAAACTGAACGACTAATTAATGTT
GAATGGGTAAAATCAAAAGACGCAACTCAAAAATATCAGGTTGATTTAGAGGTAACTGCGTATGACCGAAATGGCTTGTT
GAATGAAGTACTACAAGCTGTTAGCTCGACAGCCGGCAATTTAATTAAAGTTTCAGGACGTTCAGATATTGATAAAAATG
CAATAATAAATATTAGTGTCATGGTGAAAAACGTGAATGATGTTTATCGTGTGGTAGAAAAGATCAAACAACTTGGTGAT
GTTTATACAGTAACAAGAGTTTGGAACTAG

Upstream 100 bases:

>100_bases
CGACGGACGTATGATTGGTGTGGGACAAATACTATTCAACAAGAGTACCTAAATCATTGTTTAAGGCGAAGTAATAAATA
TGAATGGGGTGTATCATATA

Downstream 100 bases:

>100_bases
AGGTGCAAAATATGAAAGTAGTTGTACAAAGAGTTAAAGAAGCATCGGTGACGAATGATACATTAAATAATCAAATCAAA
AAAGGATATTGTTTATTAGT

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 729; Mature: 729

Protein sequence:

>729_residues
MNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVAGFLHDVI
EDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQAENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQ
IRISRETLEIYAPLAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDING
RPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNG
DPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQNKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTP
ASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSSAKGKIKS
FFKKQDRSSNIEKGRMMVEAEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDK
QRALNEAQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINV
EWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGD
VYTVTRVWN

Sequences:

>Translated_729_residues
MNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVAGFLHDVI
EDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQAENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQ
IRISRETLEIYAPLAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDING
RPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNG
DPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQNKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTP
ASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSSAKGKIKS
FFKKQDRSSNIEKGRMMVEAEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDK
QRALNEAQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINV
EWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGD
VYTVTRVWN
>Mature_729_residues
MNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVAGFLHDVI
EDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQAENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQ
IRISRETLEIYAPLAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDING
RPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNG
DPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQNKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTP
ASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSSAKGKIKS
FFKKQDRSSNIEKGRMMVEAEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDK
QRALNEAQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINV
EWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGD
VYTVTRVWN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=143, Percent_Identity=35.6643356643357, Blast_Score=67, Evalue=8e-11,
Organism=Escherichia coli, GI1790082, Length=716, Percent_Identity=39.5251396648045, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1789147, Length=713, Percent_Identity=37.5876577840112, Blast_Score=499, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI25143118, Length=133, Percent_Identity=38.3458646616541, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24650996, Length=119, Percent_Identity=36.9747899159664, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83695; Mature: 83695

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGI
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHEECCCCCHHHCCCCEEEHHHHHHHH
LTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQ
HHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIRISRETLEIYAPLAHRLGI
HHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHCCC
NTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDING
CEEEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQ
HCCHHHHHHHHHHEEECCCCCEEEEEEEECCHHHHHHCCCEEEEEHHCCCCCCHHHHHHH
NKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTPASDVIELPYGAVPIDFAYAI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCCHHHHHHH
HSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSSAKGKIKS
HHHHCCCEECEECCCEEEEHHHEECCCCEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHH
FFKKQDRSSNIEKGRMMVEAEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFG
HHHHHCCCCCCCCCCEEEEEEHHHCCCCHHHHHHCCCHHEEEHHCCCCCCCCCEEEECCC
GVTSLQIVNKLTERQRILDKQRALNEAQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHH
CCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINVEWVKSKDATQKYQVDLEVTA
HCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHEEEEEECCCCCCCEEEEEEEEEE
YDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGD
ECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHCC
VYTVTRVWN
EEEEEEECC
>Mature Secondary Structure
MNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGI
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHEECCCCCHHHCCCCEEEHHHHHHHH
LTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQ
HHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIRISRETLEIYAPLAHRLGI
HHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHCCC
NTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDING
CEEEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQ
HCCHHHHHHHHHHEEECCCCCEEEEEEEECCHHHHHHCCCEEEEEHHCCCCCCHHHHHHH
NKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTPASDVIELPYGAVPIDFAYAI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCCHHHHHHH
HSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSSAKGKIKS
HHHHCCCEECEECCCEEEEHHHEECCCCEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHH
FFKKQDRSSNIEKGRMMVEAEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFG
HHHHHCCCCCCCCCCEEEEEEHHHCCCCHHHHHHCCCHHEEEHHCCCCCCCCCEEEECCC
GVTSLQIVNKLTERQRILDKQRALNEAQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHH
CCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINVEWVKSKDATQKYQVDLEVTA
HCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHEEEEEECCCCCCCEEEEEEEEEE
YDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGD
ECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHCC
VYTVTRVWN
EEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]