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The map label for this gene is proC

Identifier: 57650459

GI number: 57650459

Start: 1582014

End: 1582829

Strand: Direct

Name: proC

Synonym: SACOL1546

Alternate gene names: 57650459

Gene position: 1582014-1582829 (Clockwise)

Preceding gene: 57650456

Following gene: 57650461

Centisome position: 56.31

GC content: 33.33

Gene sequence:

>816_bases
ATGAAACTCGTATTTTATGGAGCTGGTAATATGGCACAAGCTATATTTACAGGAATTATTAACTCAAGCAACTTAGATGC
CAATGATATATATTTAACAAATAAATCTAATGAACAAGCTTTAAAAGCATTCGCTGAAAAACTAGGTGTTAACTATAGTT
ATGATGATGCGACATTATTAAAAGATGCAGATTATGTATTTTTAGGTACCAAACCACATGATTTTGATGCTCTAGCAACA
CGCATCAAACCACATATTACAAAAGACAATTGCTTCATTTCAATTATGGCAGGTATTCCGATTGATTATATTAAACAACA
ATTAGAATGCCAAAATCCAGTTGCTAGAATTATGCCAAACACAAATGCGCAAGTTGGACACTCTGTTACTGGCATTAGTT
TTTCAAACAACTTTGACCCTAAATCTAAAGATGAAATTAACGATTTAGTTAAAGCATTTGGTTCTGTAATTGAAGTATCA
GAAGATCATTTACATCAAGTAACAGCTATCACCGGAAGCGGCCCAGCATTTTTATATCATGTATTCGAGCAATATGTTAA
AGCTGGTACGAAACTTGGTCTAGAAAAAGAACAAGTTGAAGAATCTATACGCAACCTTATTATAGGTACAAGTAAGATGA
TTGAACGTTCAGATTTGAGCATGGCTCAATTAAGAAAAAATATTACCTCTAAAGGTGGTACGACACAAGCTGGCCTTGAT
ACATTGTCACAATATGATTTAGTATCTATTTTCGAAGATTGTCTAAACGCTGCCGTCGACCGTAGTATTGAACTTTCTAA
TATAGAAGACCAATAA

Upstream 100 bases:

>100_bases
AACTTTACATAATTGAGACAAGTTGATTATCTTTCCTAATATATATACAATAATAAGAAAATATAACATACAAATCAAAA
ACTAAAGGGATGTGACGTTA

Downstream 100 bases:

>100_bases
AAACAAACCCGCCAACACATGTATGCATCATCGCAAGCACTGTGTTTGACGGGTTATTTTTATAATTTATTGTTATTTGG
CAAGCATTGTTTATTACTTT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLLKDADYVFLGTKPHDFDALAT
RIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPNTNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVS
EDHLHQVTAITGSGPAFLYHVFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLD
TLSQYDLVSIFEDCLNAAVDRSIELSNIEDQ

Sequences:

>Translated_271_residues
MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLLKDADYVFLGTKPHDFDALAT
RIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPNTNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVS
EDHLHQVTAITGSGPAFLYHVFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLD
TLSQYDLVSIFEDCLNAAVDRSIELSNIEDQ
>Mature_271_residues
MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLLKDADYVFLGTKPHDFDALAT
RIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPNTNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVS
EDHLHQVTAITGSGPAFLYHVFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLD
TLSQYDLVSIFEDCLNAAVDRSIELSNIEDQ

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family

Homologues:

Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=27.4436090225564, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI24797095, Length=274, Percent_Identity=26.6423357664234, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI24797097, Length=274, Percent_Identity=26.6423357664234, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI21361454, Length=274, Percent_Identity=26.6423357664234, Blast_Score=108, Evalue=4e-24,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=24.4360902255639, Blast_Score=114, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=30.1526717557252, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17540664, Length=284, Percent_Identity=22.887323943662, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320861, Length=260, Percent_Identity=28.0769230769231, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21358587, Length=262, Percent_Identity=26.3358778625954, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24647700, Length=165, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): P5CR_STAAC (Q5HFR9)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186388.1
- ProteinModelPortal:   Q5HFR9
- SMR:   Q5HFR9
- STRING:   Q5HFR9
- EnsemblBacteria:   EBSTAT00000009641
- GeneID:   3237752
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1546
- TIGR:   SACOL1546
- eggNOG:   COG0345
- GeneTree:   EBGT00050000024862
- HOGENOM:   HBG726602
- OMA:   AMKPKDV
- ProtClustDB:   CLSK885395
- BioCyc:   SAUR93062:SACOL1546-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11645
- PIRSF:   PIRSF000193
- TIGRFAMs:   TIGR00112

Pfam domain/function: PF03807 F420_oxidored; SSF48179 6DGDH_C_like

EC number: =1.5.1.2

Molecular weight: Translated: 29840; Mature: 29840

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLL
CEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHE
KDADYVFLGTKPHDFDALATRIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPN
ECCCEEEECCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHCCC
TNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVSEDHLHQVTAITGSGPAFLYH
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHEEEEECCCCHHHHHH
VFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHH
TLSQYDLVSIFEDCLNAAVDRSIELSNIEDQ
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure
MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLL
CEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHE
KDADYVFLGTKPHDFDALATRIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPN
ECCCEEEECCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHCCC
TNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVSEDHLHQVTAITGSGPAFLYH
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHEEEEECCCCHHHHHH
VFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHH
TLSQYDLVSIFEDCLNAAVDRSIELSNIEDQ
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA