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The map label for this gene is srrB

Identifier: 57650447

GI number: 57650447

Start: 1572353

End: 1574104

Strand: Reverse

Name: srrB

Synonym: SACOL1534

Alternate gene names: 57650447

Gene position: 1574104-1572353 (Counterclockwise)

Preceding gene: 57650448

Following gene: 57650446

Centisome position: 56.03

GC content: 33.11

Gene sequence:

>1752_bases
ATGATGAGCCGGCTAAATAGTGTCGTAATTAAACTGTGGTTAACTATTATTTTAATAGTGACGACAGTTTTAATTTTATT
AAGTATTGCTTTAATTACCTTTATGCAATACTATTTCACACAAGAAACCGAAAATGCCATAAGAGAAGATGCTAGACGTA
TAAGTTCACTGGTCGAACAATCACATAATAAAGAAGAAGCAATAAAATATAGTCAAACATTAATTGAAAATCCTGGTGGG
TTGATGATTATAAATAATAAACATCGTCAATCAACGGCTTCACTTTCTAATATTAAAAAGCAAATGTTGAATGAAGTAGT
CAACAACGACCATTTTGACGATGTGTTTGATAAAGGTAAATCTGTTACTCGAAATGTAACGATTAAAGAAAAGGGCTCAT
CTCAAACATATATTTTGTTAGGCTATCCAACAAAAGCACAGAAGAATAGTCATAGCAAATATAGTGGAGTCTTTATATAT
AAAGACTTGAAATCAATCGAAGATACAAATAATGCTATTACGATTATCACCATAATTACGGCTGTTATTTTCTTAACAAT
TACAACAGTCTTTGCGTTTTTCTTATCGTCAAGAATTACAAAACCTTTAAGACGTTTAAGAGACCAAGCTACACGTGTAT
CTGAAGGGGATTACTCTTATAAACCTTCTGTCACAACGAAAGATGAAATTGGTCAATTATCGCAGGCATTTAATCAGATG
AGTACAGAAATCGAAGAGCATGTCGACGCATTATCCACATCTAAAAATATTAGAGACAGCTTAATTAACTCTATGGTAGA
AGGTGTCCTAGGTATTAATGAGAGTCGACAAATTATCTTATCTAATAAGATGGCGAATGATATTATGGACAATATTGATG
AAGATGCTAAAGCTTTCTTATTAAGACAAATAGAAGATACTTTTAAATCAAAACAAACTGAAATGCGCGATTTAGAAATG
AATGCACGATTCTTTGTTGTGACCACAAGCTATATCGACAAGATTGAACAGGGAGGTAAAAGTGGTGTTGTTGTGACAGT
TCGTGATATGACTAATGAGCACAATCTAGATCAAATGAAGAAAGATTTCATTGCTAATGTATCACATGAATTACGTACAC
CGATATCATTACTTCAAGGTTATACTGAATCAATTGTAGATGGTATTGTTACAGAACCGGATGAAATAAAAGAATCGCTT
GCCATTGTCCTTGATGAATCGAAACGTTTAAATCGTTTAGTTAATGAATTGTTAAATGTCGCACGCATGGATGCTGAAGG
GTTATCCGTAAATAAAGAAGTTCAGCCTATTGCAGCGTTACTAGATAAGATGAAAATTAAGTATCGCCAACAAGCTGATG
ATTTAGGTCTAAATATGACTTTTAATTATTGTAAGAAGCGTGTTTGGAGTTATGATATGGATCGCATGGACCAAGTACTA
ACGAACTTAATTGATAATGCATCACGTTATACGAAACCTGGAGATGAAATTGCAATTACTTGTGATGAAAATGAAAGCGA
AGATATTTTATACATTAAAGATACAGGTACAGGCATTGCACCAGAACATTTACAACAAGTATTTGATCGTTTTTATAAAG
TTGATGCAGCGAGAACGCGAGGTAAACAAGGTACCGGTTTAGGTTTGTTCATTTGTAAAATGATTATCGAAGAGCATGGT
GGTTCCATAGATGTTAAAAGCGAATTAGGGAAAGGCACAACATTTATTATTAAACTACCAAAACCAGAATAA

Upstream 100 bases:

>100_bases
GTTAAACGACTTAGAGAAAAGTTAAATCGTGTGTCTAGTGAAGCTGCGCATATGATTCAAACAGTCTGGGGCGTTGGGTA
TAAATTTGAGGTTAAATCTA

Downstream 100 bases:

>100_bases
AATTGAATATAGTTATTTCAGAACGCATGTTATTGATTAGAGACTCTAATTTATAGCATGCGTTTTTTGATTGATGTGGG
GAATTTTGTATGTGGATTAG

Product: sensor histidine kinase SrrB

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGG
LMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIY
KDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQM
STEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLEM
NARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESL
AIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVL
TNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHG
GSIDVKSELGKGTTFIIKLPKPE

Sequences:

>Translated_583_residues
MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGG
LMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIY
KDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQM
STEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLEM
NARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESL
AIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVL
TNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHG
GSIDVKSELGKGTTFIIKLPKPE
>Mature_583_residues
MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGG
LMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIY
KDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQM
STEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLEM
NARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESL
AIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVL
TNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHG
GSIDVKSELGKGTTFIIKLPKPE

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1786600, Length=336, Percent_Identity=28.2738095238095, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788393, Length=223, Percent_Identity=32.2869955156951, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1786783, Length=221, Percent_Identity=34.3891402714932, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=29.3859649122807, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI48994928, Length=465, Percent_Identity=24.0860215053763, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=29.7071129707113, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=30.5309734513274, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=30.6034482758621, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790346, Length=268, Percent_Identity=27.2388059701493, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=28.82096069869, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788549, Length=423, Percent_Identity=23.8770685579196, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=31.0810810810811, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=27.4261603375527, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788279, Length=229, Percent_Identity=32.7510917030568, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787374, Length=200, Percent_Identity=23.5, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1789403, Length=220, Percent_Identity=27.7272727272727, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=24.1545893719807, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790300, Length=240, Percent_Identity=25.4166666666667, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790567, Length=353, Percent_Identity=25.2124645892351, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=245, Percent_Identity=24.8979591836735, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRRB_STAA8 (Q2FY80)

Other databases:

- EMBL:   AY197750
- EMBL:   CP000253
- RefSeq:   YP_500100.1
- ProteinModelPortal:   Q2FY80
- SMR:   Q2FY80
- STRING:   Q2FY80
- EnsemblBacteria:   EBSTAT00000029881
- GeneID:   3920001
- GenomeReviews:   CP000253_GR
- KEGG:   sao:SAOUHSC_01585
- eggNOG:   COG0642
- GeneTree:   EBGT00050000023863
- HOGENOM:   HBG334875
- OMA:   TTIFAFF
- ProtClustDB:   CLSK885386
- BioCyc:   SAUR93061:SAOUHSC_01585-MONOMER
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 66077; Mature: 66077

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd2e020c)-; HASH(0xe2dddd0)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHNKEEAIKYSQTLIENPGGLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGK
CCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
SVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITIITIIT
CCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCCHHHHHHH
AVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
STEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHHHHHHH
LRQIEDTFKSKQTEMRDLEMNARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMK
HHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
KDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVL
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHH
TNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTR
HHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
GKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE
CCCCCCHHHHHHHHHHHHCCCCEEEHHHCCCCCEEEEECCCCH
>Mature Secondary Structure
MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHNKEEAIKYSQTLIENPGGLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGK
CCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
SVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITIITIIT
CCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCCHHHHHHH
AVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
STEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHHHHHHH
LRQIEDTFKSKQTEMRDLEMNARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMK
HHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
KDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVL
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHH
TNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTR
HHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
GKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE
CCCCCCHHHHHHHHHHHHCCCCEEEHHHCCCCCEEEEECCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA