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The map label for this gene is srrA

Identifier: 57650448

GI number: 57650448

Start: 1574085

End: 1574810

Strand: Reverse

Name: srrA

Synonym: SACOL1535

Alternate gene names: 57650448

Gene position: 1574810-1574085 (Counterclockwise)

Preceding gene: 57650449

Following gene: 57650447

Centisome position: 56.05

GC content: 34.44

Gene sequence:

>726_bases
ATGTCGAACGAAATACTTATCGTAGATGATGAGGATAGAATCAGAAGATTACTTAAAATGTATTTAGAAAGAGAATCTTT
TGAAATCCATGAAGCAAGTAATGGCCAAGAGGCTTATGAACTTGCAATGGAGAATAATTATGCTTGCATACTACTAGATT
TAATGTTGCCTGAAATGGATGGTATCCAGGTGGCAACTAAATTGCGTGAACATAAACAAACACCGATTATTATGTTGACT
GCTAAAGGTGAAGAAACAAACCGTGTTGAAGGTTTTGAATCTGGTGCAGATGATTATATCGTCAAACCATTTTCACCAAG
AGAAGTAGTCTTAAGAGTTAAAGCACTTCTAAGAAGAACGCAATCTACAACTGTAGAACAAAGCGAACCTCACGCACGTG
ATGTGATTGAATTTAAACATTTAGAAATAGATAATGATGCACATCGCGTACTTGCTGATAATCAAGAAGTTAATTTGACT
CCTAAAGAGTACGAATTATTAATATATTTAGCTAAAACACCAAATAAAGTATTTGACCGTGAACAATTATTAAAAGAAGT
TTGGCATTATGAATTCTATGGTGATTTAAGAACAGTTGATACTCATGTTAAACGACTTAGAGAAAAGTTAAATCGTGTGT
CTAGTGAAGCTGCGCATATGATTCAAACAGTCTGGGGCGTTGGGTATAAATTTGAGGTTAAATCTAATGATGAGCCGGCT
AAATAG

Upstream 100 bases:

>100_bases
AGAATTTTTTCACAAAATTTTAGGTTTTTAATAACTGTATGCGCTTTCCTGTGATATAATACTTTTGTAAAGAAAAGCAT
GTGTGGGAGGTATGACCTGT

Downstream 100 bases:

>100_bases
TGTCGTAATTAAACTGTGGTTAACTATTATTTTAATAGTGACGACAGTTTTAATTTTATTAAGTATTGCTTTAATTACCT
TTATGCAATACTATTTCACA

Product: DNA-binding response regulator SrrA

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSNEILIVDDEDRIRRLLKMYLERESFEIHEASNGQEAYELAMENNYACILLDLMLPEMDGIQVATKLREHKQTPIIMLT
AKGEETNRVEGFESGADDYIVKPFSPREVVLRVKALLRRTQSTTVEQSEPHARDVIEFKHLEIDNDAHRVLADNQEVNLT
PKEYELLIYLAKTPNKVFDREQLLKEVWHYEFYGDLRTVDTHVKRLREKLNRVSSEAAHMIQTVWGVGYKFEVKSNDEPA
K

Sequences:

>Translated_241_residues
MSNEILIVDDEDRIRRLLKMYLERESFEIHEASNGQEAYELAMENNYACILLDLMLPEMDGIQVATKLREHKQTPIIMLT
AKGEETNRVEGFESGADDYIVKPFSPREVVLRVKALLRRTQSTTVEQSEPHARDVIEFKHLEIDNDAHRVLADNQEVNLT
PKEYELLIYLAKTPNKVFDREQLLKEVWHYEFYGDLRTVDTHVKRLREKLNRVSSEAAHMIQTVWGVGYKFEVKSNDEPA
K
>Mature_240_residues
SNEILIVDDEDRIRRLLKMYLERESFEIHEASNGQEAYELAMENNYACILLDLMLPEMDGIQVATKLREHKQTPIIMLTA
KGEETNRVEGFESGADDYIVKPFSPREVVLRVKALLRRTQSTTVEQSEPHARDVIEFKHLEIDNDAHRVLADNQEVNLTP
KEYELLIYLAKTPNKVFDREQLLKEVWHYEFYGDLRTVDTHVKRLREKLNRVSSEAAHMIQTVWGVGYKFEVKSNDEPAK

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1786599, Length=237, Percent_Identity=41.7721518987342, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=37.9912663755458, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1788394, Length=235, Percent_Identity=40.8510638297872, Blast_Score=157, Evalue=4e-40,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=36.3636363636364, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1786784, Length=231, Percent_Identity=36.7965367965368, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.5789473684211, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=35.0877192982456, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=36.5638766519824, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786911, Length=231, Percent_Identity=34.1991341991342, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=30.1310043668122, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=30.8695652173913, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.9012875536481, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=28.1385281385281, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=41.8803418803419, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790299, Length=127, Percent_Identity=30.7086614173228, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788191, Length=106, Percent_Identity=29.2452830188679, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRRA_STAA8 (Q2FY79)

Other databases:

- EMBL:   AY197750
- EMBL:   CP000253
- RefSeq:   YP_500101.1
- ProteinModelPortal:   Q2FY79
- SMR:   Q2FY79
- STRING:   Q2FY79
- EnsemblBacteria:   EBSTAT00000028752
- GeneID:   3920002
- GenomeReviews:   CP000253_GR
- KEGG:   sao:SAOUHSC_01586
- eggNOG:   COG0745
- GeneTree:   EBGT00050000024053
- HOGENOM:   HBG753323
- OMA:   VWHYEFF
- ProtClustDB:   CLSK873069
- BioCyc:   SAUR93061:SAOUHSC_01586-MONOMER
- GO:   GO:0005737
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 28161; Mature: 28030

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEILIVDDEDRIRRLLKMYLERESFEIHEASNGQEAYELAMENNYACILLDLMLPEMD
CCCCEEEECCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCC
GIQVATKLREHKQTPIIMLTAKGEETNRVEGFESGADDYIVKPFSPREVVLRVKALLRRT
CHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHH
QSTTVEQSEPHARDVIEFKHLEIDNDAHRVLADNQEVNLTPKEYELLIYLAKTPNKVFDR
HCCCCCCCCCCHHHHHHHHEEEECCCHHHHEECCCCCCCCCCCEEEEEEEECCCCHHHHH
EQLLKEVWHYEFYGDLRTVDTHVKRLREKLNRVSSEAAHMIQTVWGVGYKFEVKSNDEPA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
K
C
>Mature Secondary Structure 
SNEILIVDDEDRIRRLLKMYLERESFEIHEASNGQEAYELAMENNYACILLDLMLPEMD
CCCEEEECCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCC
GIQVATKLREHKQTPIIMLTAKGEETNRVEGFESGADDYIVKPFSPREVVLRVKALLRRT
CHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHH
QSTTVEQSEPHARDVIEFKHLEIDNDAHRVLADNQEVNLTPKEYELLIYLAKTPNKVFDR
HCCCCCCCCCCHHHHHHHHEEEECCCHHHHEECCCCCCCCCCCEEEEEEEECCCCHHHHH
EQLLKEVWHYEFYGDLRTVDTHVKRLREKLNRVSSEAAHMIQTVWGVGYKFEVKSNDEPA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA