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The map label for this gene is trpC [H]

Identifier: 57650374

GI number: 57650374

Start: 1417185

End: 1417967

Strand: Direct

Name: trpC [H]

Synonym: SACOL1406

Alternate gene names: 57650374

Gene position: 1417185-1417967 (Clockwise)

Preceding gene: 57650373

Following gene: 57650375

Centisome position: 50.44

GC content: 31.55

Gene sequence:

>783_bases
ATGACGATTTTATCAGAAATTGTTAAATATAAACAGTCACTTTTACAAAATGGCTATTATCAAGACAAACTTAATACCTT
GAAAAGTGTGAAGATTCAGAATAAAAAATCTTTTATAAACGCAATTGAGAAAGAACCAAAGCTAGCAATTATTGCAGAAA
TTAAATCGAAGAGTCCTACAGTTAATGACTTACCTGAACGAGATTTATCGCAACAAATCTCAGATTATGACCAATATGGT
GCAAATGCCGTGTCCATTTTAACTGATGAAAAGTACTTTAGTGGTAGTTTTGAAAGATTACAAGCATTGACGACAAAAAC
AACATTACCCGTATTATGCAAAGACTTTATTATAGACCCGCTTCAAATTGATGTTGCTAAACAAGCTGGTGCATCTATGA
TTTTATTGATCGTTAACATCTTATCTGATAAACAATTGAAAGATTTATATAACTACGCTATATCGCAAAATCTAGAAGTG
TTAGTTGAAGTACATGATCGCCATGAATTAGAACGTGCCTATAAGGTTAATGCTAAATTGATTGGTGTAAATAACAGGGA
CTTAAAACGATTTGTTACAAATGTGGAACATACAAATACTATTTTAGAAAATAAAAAAACAAATCATTATTATATTTCTG
AAAGTGGTATTCACGATGCATCTGATGTAAGAAAAATCTTGCATAGTGGTATCGATGGCTTACTAATAGGTGAGGCGCTT
ATGCGTTGTGACAATCTATCTGAATTTTTACCACAACTGAAAATGCAAAAGGTGAAGTCATGA

Upstream 100 bases:

>100_bases
GAGAAAGTGGATACCATCGCAGAAGGCATAGAACTTGCAACTACATTGATTGATAATGGTGAAGCATTGGAAAAATACCA
TCAAATGAGAGGTGAATAAT

Downstream 100 bases:

>100_bases
TGAAATTGAAATTTTGTGGCTTTACATCAATAAAGGATGTTACAGCGGCCAGTCAATTACCTATTGATGCGATAGGTTTC
ATCCATTATGAAAAAAGTAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTILSEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPKLAIIAEIKSKSPTVNDLPERDLSQQISDYDQYG
ANAVSILTDEKYFSGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEV
LVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIGEAL
MRCDNLSEFLPQLKMQKVKS

Sequences:

>Translated_260_residues
MTILSEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPKLAIIAEIKSKSPTVNDLPERDLSQQISDYDQYG
ANAVSILTDEKYFSGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEV
LVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIGEAL
MRCDNLSEFLPQLKMQKVKS
>Mature_259_residues
TILSEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPKLAIIAEIKSKSPTVNDLPERDLSQQISDYDQYGA
NAVSILTDEKYFSGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVL
VEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIGEALM
RCDNLSEFLPQLKMQKVKS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=245, Percent_Identity=35.9183673469388, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322638, Length=216, Percent_Identity=36.1111111111111, Blast_Score=132, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29557; Mature: 29426

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILSEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPKLAIIAEIKSKSPT
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
VNDLPERDLSQQISDYDQYGANAVSILTDEKYFSGSFERLQALTTKTTLPVLCKDFIIDP
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
LQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVLVEVHDRHELERAYKVNAKL
HHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEE
IGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIGEAL
EECCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHH
MRCDNLSEFLPQLKMQKVKS
HHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TILSEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPKLAIIAEIKSKSPT
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
VNDLPERDLSQQISDYDQYGANAVSILTDEKYFSGSFERLQALTTKTTLPVLCKDFIIDP
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
LQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVLVEVHDRHELERAYKVNAKL
HHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEE
IGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIGEAL
EECCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHH
MRCDNLSEFLPQLKMQKVKS
HHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA