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The map label for this gene is gyaR [H]

Identifier: 41410292

GI number: 41410292

Start: 4663810

End: 4664793

Strand: Reverse

Name: gyaR [H]

Synonym: MAP4194c

Alternate gene names: 41410292

Gene position: 4664793-4663810 (Counterclockwise)

Preceding gene: 41410295

Following gene: 41410291

Centisome position: 96.58

GC content: 72.97

Gene sequence:

>984_bases
GTGACGTCCAAACCGCGCGCCTTGGTGACCGCCCCGCTGCGCGGGCCGGGCCTGGACAAACTGCGGGTGCTGGCCGAGGT
GGTCTACGACCCCTGGATCGAGCAGCGGCCGTTGCGCATCTACAGCGCCGAGCAGCTGGCCGAGCGGATCGCGGCCGAGG
AAGCCGAAATCGTGGTGGTGGTGGAAAGCGATTCGGTGCGCGGCCCGGTGTTCGAGCTCGGTGTGCGCGCGATCGCCGCG
ACGCGCGGCGACCCCAACAACGTCGACATCGACGGCGCCACCGCGGCGGGCATCCCGGTGCTGAACACCCCGGGCCGCAA
CGCCGACGCCGTCGCCGAGATGACCGTGGCGCTGCTGCTGGCCGCCACCCGTCACCTGCTTCCCGCCGACGCGGATGTGC
GCGGCGGCAACATCTTTCGCGACGGCAGCATCCCGTATCAGCGGTTCCGCGGCGGCGAGATCGCGGGCCTGACCGCGGGG
CTGGTGGGCCTGGGCGCGGTCGGCCGCGCCACCCGGTGGCGGCTGAGCGGGCTGGGTCTGCGCGTCATCGCGCACGACCC
CTACCACCCCGAGGCCCGGCACGGTCTGGACGAGCTGTTGGCCGAGTCCGACGTGGTGTCGCTGCACGCCCCGGTCACCG
ACGAGACCACCGGCATGATCGGCGCCGAGCAGTTCGCGGCCATGCGCGACGGCGTGGTCTTCCTCAACACCGCCCGCGCC
CAGCTGCACGACACCGACGCGCTGGTCGAGGCGCTGCGCGCCGGCAAGGTGGCCGCCGCCGGGCTGGACCACTTCGTCGG
TGAGTGGCTGCCGACCGATCACCCGCTGGTCGGCATGCCGAACGTGGTGCTGACGCCGCACATCGGCGGGGCCACGTGGA
ACACTGAGGCCCGGCAGGCGCAGCTGGTGGCCGACGACCTGGAAGCGCTGCTGGCCGGCGCGACGCCCGCCCACATCGTC
AACCCGGAGGTGTTGGCCCGATGA

Upstream 100 bases:

>100_bases
CGTCGGCGGCTAACGCCTTGACCGCGGTGCTGCCGACGTCGATGCCGATTGTGACGTCCTTGCGTGACACGGGCGTCACC
GTACGCCAGCATTGGCAGGC

Downstream 100 bases:

>100_bases
AGTTCGTCGACGACCCGGAACAGGCGGTGCTGGACGCCGCCAAGGACATGCTGCGCCGCGGCCTGGTGGAGGGCACCGCC
GGCAACATCTCGGCGCGCCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTSKPRALVTAPLRGPGLDKLRVLAEVVYDPWIEQRPLRIYSAEQLAERIAAEEAEIVVVVESDSVRGPVFELGVRAIAA
TRGDPNNVDIDGATAAGIPVLNTPGRNADAVAEMTVALLLAATRHLLPADADVRGGNIFRDGSIPYQRFRGGEIAGLTAG
LVGLGAVGRATRWRLSGLGLRVIAHDPYHPEARHGLDELLAESDVVSLHAPVTDETTGMIGAEQFAAMRDGVVFLNTARA
QLHDTDALVEALRAGKVAAAGLDHFVGEWLPTDHPLVGMPNVVLTPHIGGATWNTEARQAQLVADDLEALLAGATPAHIV
NPEVLAR

Sequences:

>Translated_327_residues
MTSKPRALVTAPLRGPGLDKLRVLAEVVYDPWIEQRPLRIYSAEQLAERIAAEEAEIVVVVESDSVRGPVFELGVRAIAA
TRGDPNNVDIDGATAAGIPVLNTPGRNADAVAEMTVALLLAATRHLLPADADVRGGNIFRDGSIPYQRFRGGEIAGLTAG
LVGLGAVGRATRWRLSGLGLRVIAHDPYHPEARHGLDELLAESDVVSLHAPVTDETTGMIGAEQFAAMRDGVVFLNTARA
QLHDTDALVEALRAGKVAAAGLDHFVGEWLPTDHPLVGMPNVVLTPHIGGATWNTEARQAQLVADDLEALLAGATPAHIV
NPEVLAR
>Mature_326_residues
TSKPRALVTAPLRGPGLDKLRVLAEVVYDPWIEQRPLRIYSAEQLAERIAAEEAEIVVVVESDSVRGPVFELGVRAIAAT
RGDPNNVDIDGATAAGIPVLNTPGRNADAVAEMTVALLLAATRHLLPADADVRGGNIFRDGSIPYQRFRGGEIAGLTAGL
VGLGAVGRATRWRLSGLGLRVIAHDPYHPEARHGLDELLAESDVVSLHAPVTDETTGMIGAEQFAAMRDGVVFLNTARAQ
LHDTDALVEALRAGKVAAAGLDHFVGEWLPTDHPLVGMPNVVLTPHIGGATWNTEARQAQLVADDLEALLAGATPAHIVN
PEVLAR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=248, Percent_Identity=33.4677419354839, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI6912396, Length=239, Percent_Identity=33.0543933054393, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI145580578, Length=263, Percent_Identity=27.7566539923954, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4557499, Length=263, Percent_Identity=27.7566539923954, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI145580575, Length=263, Percent_Identity=27.7566539923954, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI61743967, Length=250, Percent_Identity=29.2, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4557497, Length=250, Percent_Identity=29.2, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI87082289, Length=259, Percent_Identity=36.2934362934363, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1787645, Length=269, Percent_Identity=32.3420074349442, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789279, Length=253, Percent_Identity=33.596837944664, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17532191, Length=230, Percent_Identity=33.0434782608696, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=265, Percent_Identity=31.3207547169811, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=258, Percent_Identity=34.1085271317829, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=258, Percent_Identity=32.9457364341085, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=32.1138211382114, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=267, Percent_Identity=25.4681647940075, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=122, Percent_Identity=30.327868852459, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=261, Percent_Identity=32.183908045977, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574286, Length=257, Percent_Identity=31.9066147859922, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646446, Length=301, Percent_Identity=29.2358803986711, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646448, Length=301, Percent_Identity=29.2358803986711, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646452, Length=301, Percent_Identity=29.2358803986711, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646450, Length=301, Percent_Identity=29.2358803986711, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585516, Length=241, Percent_Identity=31.1203319502075, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI62472511, Length=301, Percent_Identity=29.2358803986711, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45552429, Length=257, Percent_Identity=30.7392996108949, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28571528, Length=326, Percent_Identity=31.2883435582822, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI45551003, Length=257, Percent_Identity=30.7392996108949, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24585514, Length=257, Percent_Identity=30.7392996108949, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28574282, Length=257, Percent_Identity=30.7392996108949, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28574284, Length=257, Percent_Identity=30.7392996108949, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34593; Mature: 34462

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKPRALVTAPLRGPGLDKLRVLAEVVYDPWIEQRPLRIYSAEQLAERIAAEEAEIVVV
CCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHCCCCCEEEE
VESDSVRGPVFELGVRAIAATRGDPNNVDIDGATAAGIPVLNTPGRNADAVAEMTVALLL
ECCCCCCCHHHHHHHHHHEECCCCCCCEECCCCCCCCCCEECCCCCCHHHHHHHHHHHHH
AATRHLLPADADVRGGNIFRDGSIPYQRFRGGEIAGLTAGLVGLGAVGRATRWRLSGLGL
HHHHHHCCCCCCCCCCCEEECCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCEE
RVIAHDPYHPEARHGLDELLAESDVVSLHAPVTDETTGMIGAEQFAAMRDGVVFLNTARA
EEEECCCCCCHHHHCHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHCCEEEEECCHH
QLHDTDALVEALRAGKVAAAGLDHFVGEWLPTDHPLVGMPNVVLTPHIGGATWNTEARQA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHH
QLVADDLEALLAGATPAHIVNPEVLAR
HHHHHHHHHHHHCCCCCCCCCHHHHCC
>Mature Secondary Structure 
TSKPRALVTAPLRGPGLDKLRVLAEVVYDPWIEQRPLRIYSAEQLAERIAAEEAEIVVV
CCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHCCCCCEEEE
VESDSVRGPVFELGVRAIAATRGDPNNVDIDGATAAGIPVLNTPGRNADAVAEMTVALLL
ECCCCCCCHHHHHHHHHHEECCCCCCCEECCCCCCCCCCEECCCCCCHHHHHHHHHHHHH
AATRHLLPADADVRGGNIFRDGSIPYQRFRGGEIAGLTAGLVGLGAVGRATRWRLSGLGL
HHHHHHCCCCCCCCCCCEEECCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCEE
RVIAHDPYHPEARHGLDELLAESDVVSLHAPVTDETTGMIGAEQFAAMRDGVVFLNTARA
EEEECCCCCCHHHHCHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHCCEEEEECCHH
QLHDTDALVEALRAGKVAAAGLDHFVGEWLPTDHPLVGMPNVVLTPHIGGATWNTEARQA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHH
QLVADDLEALLAGATPAHIVNPEVLAR
HHHHHHHHHHHHCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA