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The map label for this gene is fadR [C]

Identifier: 41410179

GI number: 41410179

Start: 4550963

End: 4551673

Strand: Direct

Name: fadR [C]

Synonym: MAP4081

Alternate gene names: 41410179

Gene position: 4550963-4551673 (Clockwise)

Preceding gene: 41410177

Following gene: 41410180

Centisome position: 94.23

GC content: 69.9

Gene sequence:

>711_bases
ATGGCGCTGCAGCCGGTGATTCGCCGATCGGTGCCCGAAGCGGTTTTCGACCAGATCGCCACCGACGTGCTCAGCGGTGA
GCTGCCAGCGGGTTCGGCGTTGCCCAGCGAGCGCCGGCTGGCGGAGGTCTTCGGGGTGTCGCGCCCCGCCGTCCGCGAGG
CGCTCAAGCGGCTGTCGGCAGCCAGCCTCGTCGAGGTGCGCCAGGGCGGCGTCACGACGGTGCGCGACTTCCGGCGGCAC
GCCGGTCTTGACCTGTTGCCGCAGTTGGTGTTTCGCGACGGCGAACTCGACGCGGGGGTGTTTCGCAGCATTCTGGAGAC
CCGGCTGCGGATCGGTCCGAAGGTCGCGGAACTGGCCGCCGAACAGCACGGCCCGGAACTGGCTGCGCTGCTCGACGATT
CGCTGCGCCGGCTGGAGGCCTCGCGCAGCGCGGTCGAGTGGCATCGCGGCACTCTCGAGTTCTGGGATCACATGGTCGAC
AGCTCCGGCTCGATCGTATTCCGGCTGATGTACAACCCTTTCCGCGCGGCCTATGAGCGAGCTGTGGGTGTGCTGGCCGC
CGCGATTCCCGCCGAGATCAACCGCACCGACGCGTATCGTGCACTGGCCCAGGCGATCTGCGCCGGCGATGCGGACGAGG
CGGGCCGCGGCGCCCGCGAGGTCCTCGAACTCGCCAACGCCACCATGATCGGCGCGCTGGAGCGGCGATGA

Upstream 100 bases:

>100_bases
TATCGCGCGCTTGCCGGCGGGTTGGGTGAGTCGCGGAAAGATGCGCGACACGCCGGTGGTCTGACCACCTGACTGGCCGT
CGGCCCGCCACACTGGCCGC

Downstream 100 bases:

>100_bases
GCAGCCAAGCCGTGATCGCGAACTACCTGCGGGGCCAGATTCAGCCCGGGATAGACGCGGTCGGCGGCTTCTTCAGGACG
TGCGTGCTGACCGGCAAGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MALQPVIRRSVPEAVFDQIATDVLSGELPAGSALPSERRLAEVFGVSRPAVREALKRLSAASLVEVRQGGVTTVRDFRRH
AGLDLLPQLVFRDGELDAGVFRSILETRLRIGPKVAELAAEQHGPELAALLDDSLRRLEASRSAVEWHRGTLEFWDHMVD
SSGSIVFRLMYNPFRAAYERAVGVLAAAIPAEINRTDAYRALAQAICAGDADEAGRGAREVLELANATMIGALERR

Sequences:

>Translated_236_residues
MALQPVIRRSVPEAVFDQIATDVLSGELPAGSALPSERRLAEVFGVSRPAVREALKRLSAASLVEVRQGGVTTVRDFRRH
AGLDLLPQLVFRDGELDAGVFRSILETRLRIGPKVAELAAEQHGPELAALLDDSLRRLEASRSAVEWHRGTLEFWDHMVD
SSGSIVFRLMYNPFRAAYERAVGVLAAAIPAEINRTDAYRALAQAICAGDADEAGRGAREVLELANATMIGALERR
>Mature_235_residues
ALQPVIRRSVPEAVFDQIATDVLSGELPAGSALPSERRLAEVFGVSRPAVREALKRLSAASLVEVRQGGVTTVRDFRRHA
GLDLLPQLVFRDGELDAGVFRSILETRLRIGPKVAELAAEQHGPELAALLDDSLRRLEASRSAVEWHRGTLEFWDHMVDS
SGSIVFRLMYNPFRAAYERAVGVLAAAIPAEINRTDAYRALAQAICAGDADEAGRGAREVLELANATMIGALERR

Specific function: Multifunctional Regulator Of Fatty Acid Metabolism. Represses Transcription Of At Least Eight Genes Required For Fatty Acid Transport And Beta-Oxidation Among Which Fada, Fadb, Fadd, Fadl And Fade. Activates Transcription Of At Least Three Genes Required

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787436, Length=181, Percent_Identity=25.9668508287293, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 25721; Mature: 25589

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQPVIRRSVPEAVFDQIATDVLSGELPAGSALPSERRLAEVFGVSRPAVREALKRLSA
CCCCHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
ASLVEVRQGGVTTVRDFRRHAGLDLLPQLVFRDGELDAGVFRSILETRLRIGPKVAELAA
HHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
EQHGPELAALLDDSLRRLEASRSAVEWHRGTLEFWDHMVDSSGSIVFRLMYNPFRAAYER
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
AVGVLAAAIPAEINRTDAYRALAQAICAGDADEAGRGAREVLELANATMIGALERR
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALQPVIRRSVPEAVFDQIATDVLSGELPAGSALPSERRLAEVFGVSRPAVREALKRLSA
CCCHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
ASLVEVRQGGVTTVRDFRRHAGLDLLPQLVFRDGELDAGVFRSILETRLRIGPKVAELAA
HHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
EQHGPELAALLDDSLRRLEASRSAVEWHRGTLEFWDHMVDSSGSIVFRLMYNPFRAAYER
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
AVGVLAAAIPAEINRTDAYRALAQAICAGDADEAGRGAREVLELANATMIGALERR
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]