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The map label for this gene is fadD8

Identifier: 41410146

GI number: 41410146

Start: 4507216

End: 4508817

Strand: Reverse

Name: fadD8

Synonym: MAP4048c

Alternate gene names: 41410146

Gene position: 4508817-4507216 (Counterclockwise)

Preceding gene: 41410154

Following gene: 41410144

Centisome position: 93.35

GC content: 68.54

Gene sequence:

>1602_bases
ATGGGTGACGAGCTGCTGCGCCATCCCATTCATTCCGGACACCTGACCGTCGGTGCGCTCAAGCGCAACAAAGACAAGCC
GGTGCTGCATCTCGGCGACACCACGCTGACCGGGGGTCAGCTCGCCGAGCGGATCAGCCAGTACATCCAGGCGTTCGAGG
CGCTCGGCGCGGGCACCGGCGCCACCGTCGGGTTGCTGTCGCTGAACCGGCCCGAGGTGCTGATGATCATCGGCGCCGGC
CAGACCCAGGGGTATCGGCGCGTGGCGCTGCACCCGCTGGGCTCGCTGGACGACCACGCCTACGTGCTGGACGACGCCGG
CGTGACGTCGCTGATCATTGACCCGACCCCGGCGTTCGTCGAGCGGGCGCTGGGCCTGCTGGAGAAGGTGCCCGGCCTCA
AGCAGATCCTCACCATCGGCCCGGTGCCCGAGGCGTTGAGCGGTTCCGCGGTGGACCTGGTGGCCGAGGCCGCCAAGTAT
GCGCCGAAACCGTTGGTGGCGGCCGATCTTCCGCCCGATCACATCGGCGGGATGGCCTACACCGGCGGCACCACCGGCAA
GCCCAAGGGTGTGCTGGGCACCGCGCAGTCGATCACCACGATGACCACGATCCAGCTCGCCGAATGGGAGTGGCCAGAGA
ACCCGCGCTTTTTGATGTGCACCCCGCTGTCGCATGCCGGGGCCGCGTTCTTCGTGCCGACCATCATCAAGGGCGGCGAG
CTGGTGGTGCTGACCAAGTTCGACCCGGCCGAGGTGTTGCGGGTGATCGAGGAGCAGAAGATCACCGCGACCATGCTGGT
GCCGTCGATGATCTACGCGCTGATGGATCACCCCGATTCGCACACCCGCGACCTGTCCTCGCTGGAGACGGTCTACTACG
GCGCCTCGGCGATGAACCCGGTGCGGCTGGCCGAGGCCATCCGCCGCTTCGGGCCGATCTTCGCCCAGTACTACGGGCAG
TCCGAGGCGCCGATGGTGATCTCATACCTGGCCAAGAAGGACCACGACGAGAAGCGGCTCACCTCCTGCGGGCGGCCCAC
CCTGTTCGCCCGCACCGCGCTGCTGGACGCCGACGGCAACCCGGTGCCGCAGGGCGAAGTCGGCGAGATCTGCGTGTCCG
GGCCGCTTTTGAGCGGCGGGTACTGGAACCTGCCGGAGGAGACGGCCAAGACGTTCAAGGACGGCTGGCTGCACACCGGC
GACATGGCCCGCGAGGACGAGGACGGCTTCTGGTTCATCGTCGACCGGGTCAAGGACATGATCGTCACCGGCGGCTTCAA
CGTGTTCCCGCGCGAGGTCGAGGACGTCGTCGCCGAGCACCCGGCCGTCGCGCAGGTCTGCGTGATCGGCACGCCGGACG
AGAAGTGGGGCGAGGCCGTCACCGCCGTGATCGTGCTGCGGCCCGACCATCCCTCCGACGAGGAGTCGGTGGCGAAGGTG
ACGGCCGAGATCCAGGCGGCGGTCAAGAAGCGCAAGGGTTCGGTGCAATCGCCCAAGCAGGTGATCGTCGTCGACTCCGT
GCCGGTGACCGCGCTGGGCAAGCCCGACAAGAAGGCCGTGCGCGCGCGGTTCTGGGAGGGCGCCGGCCGCGCCGTCGGCT
AG

Upstream 100 bases:

>100_bases
TCCGAGGGTGCGGCTGACCGGAATTGCAACACGTTCTAGTCTGGCCCCATGAGTCGCGCCGGCGACGATGCAGAGCCAAG
CGATGAGGAGGAGCCACGCC

Downstream 100 bases:

>100_bases
GTGAGCGTGTGGCGTGTGGGCTCGCCCGGGCTATCGCCCGGCGCCCGGCCGGCCCCTACCGCCGAGCGTGAAGTTAACTT
CACGCTCGCGTGCGAACGTG

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MGDELLRHPIHSGHLTVGALKRNKDKPVLHLGDTTLTGGQLAERISQYIQAFEALGAGTGATVGLLSLNRPEVLMIIGAG
QTQGYRRVALHPLGSLDDHAYVLDDAGVTSLIIDPTPAFVERALGLLEKVPGLKQILTIGPVPEALSGSAVDLVAEAAKY
APKPLVAADLPPDHIGGMAYTGGTTGKPKGVLGTAQSITTMTTIQLAEWEWPENPRFLMCTPLSHAGAAFFVPTIIKGGE
LVVLTKFDPAEVLRVIEEQKITATMLVPSMIYALMDHPDSHTRDLSSLETVYYGASAMNPVRLAEAIRRFGPIFAQYYGQ
SEAPMVISYLAKKDHDEKRLTSCGRPTLFARTALLDADGNPVPQGEVGEICVSGPLLSGGYWNLPEETAKTFKDGWLHTG
DMAREDEDGFWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVIGTPDEKWGEAVTAVIVLRPDHPSDEESVAKV
TAEIQAAVKKRKGSVQSPKQVIVVDSVPVTALGKPDKKAVRARFWEGAGRAVG

Sequences:

>Translated_533_residues
MGDELLRHPIHSGHLTVGALKRNKDKPVLHLGDTTLTGGQLAERISQYIQAFEALGAGTGATVGLLSLNRPEVLMIIGAG
QTQGYRRVALHPLGSLDDHAYVLDDAGVTSLIIDPTPAFVERALGLLEKVPGLKQILTIGPVPEALSGSAVDLVAEAAKY
APKPLVAADLPPDHIGGMAYTGGTTGKPKGVLGTAQSITTMTTIQLAEWEWPENPRFLMCTPLSHAGAAFFVPTIIKGGE
LVVLTKFDPAEVLRVIEEQKITATMLVPSMIYALMDHPDSHTRDLSSLETVYYGASAMNPVRLAEAIRRFGPIFAQYYGQ
SEAPMVISYLAKKDHDEKRLTSCGRPTLFARTALLDADGNPVPQGEVGEICVSGPLLSGGYWNLPEETAKTFKDGWLHTG
DMAREDEDGFWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVIGTPDEKWGEAVTAVIVLRPDHPSDEESVAKV
TAEIQAAVKKRKGSVQSPKQVIVVDSVPVTALGKPDKKAVRARFWEGAGRAVG
>Mature_532_residues
GDELLRHPIHSGHLTVGALKRNKDKPVLHLGDTTLTGGQLAERISQYIQAFEALGAGTGATVGLLSLNRPEVLMIIGAGQ
TQGYRRVALHPLGSLDDHAYVLDDAGVTSLIIDPTPAFVERALGLLEKVPGLKQILTIGPVPEALSGSAVDLVAEAAKYA
PKPLVAADLPPDHIGGMAYTGGTTGKPKGVLGTAQSITTMTTIQLAEWEWPENPRFLMCTPLSHAGAAFFVPTIIKGGEL
VVLTKFDPAEVLRVIEEQKITATMLVPSMIYALMDHPDSHTRDLSSLETVYYGASAMNPVRLAEAIRRFGPIFAQYYGQS
EAPMVISYLAKKDHDEKRLTSCGRPTLFARTALLDADGNPVPQGEVGEICVSGPLLSGGYWNLPEETAKTFKDGWLHTGD
MAREDEDGFWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVIGTPDEKWGEAVTAVIVLRPDHPSDEESVAKVT
AEIQAAVKKRKGSVQSPKQVIVVDSVPVTALGKPDKKAVRARFWEGAGRAVG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=535, Percent_Identity=26.9158878504673, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI187761345, Length=385, Percent_Identity=29.0909090909091, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI187761343, Length=385, Percent_Identity=29.0909090909091, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI42544132, Length=394, Percent_Identity=26.6497461928934, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI38505220, Length=358, Percent_Identity=28.4916201117318, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI122937307, Length=269, Percent_Identity=30.4832713754647, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI157311624, Length=298, Percent_Identity=28.1879194630872, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI157311622, Length=298, Percent_Identity=28.1879194630872, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI58082049, Length=298, Percent_Identity=28.5234899328859, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI115511026, Length=286, Percent_Identity=30.4195804195804, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI27477105, Length=514, Percent_Identity=25.0972762645914, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI28416953, Length=364, Percent_Identity=24.7252747252747, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI13375727, Length=540, Percent_Identity=24.4444444444444, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI8923896, Length=372, Percent_Identity=23.1182795698925, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI253970489, Length=372, Percent_Identity=23.1182795698925, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1788107, Length=540, Percent_Identity=28.1481481481481, Blast_Score=175, Evalue=8e-45,
Organism=Escherichia coli, GI145693145, Length=356, Percent_Identity=30.3370786516854, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI221142682, Length=496, Percent_Identity=25.8064516129032, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1786810, Length=391, Percent_Identity=27.8772378516624, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790505, Length=369, Percent_Identity=26.2872628726287, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786529, Length=534, Percent_Identity=25.8426966292135, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788595, Length=329, Percent_Identity=27.0516717325228, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786801, Length=373, Percent_Identity=25.4691689008043, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559526, Length=424, Percent_Identity=29.7169811320755, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994703, Length=367, Percent_Identity=29.9727520435967, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71994690, Length=367, Percent_Identity=30.5177111716621, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71994694, Length=367, Percent_Identity=29.9727520435967, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17558820, Length=502, Percent_Identity=25.2988047808765, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17560308, Length=516, Percent_Identity=26.7441860465116, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32563687, Length=505, Percent_Identity=24.7524752475248, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17531443, Length=551, Percent_Identity=25.9528130671506, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17557194, Length=414, Percent_Identity=29.7101449275362, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17560140, Length=376, Percent_Identity=27.3936170212766, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17538037, Length=421, Percent_Identity=28.5035629453682, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71996755, Length=392, Percent_Identity=27.5510204081633, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI25141359, Length=509, Percent_Identity=24.5579567779961, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17556552, Length=554, Percent_Identity=23.1046931407942, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=359, Percent_Identity=24.7910863509749, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17564090, Length=348, Percent_Identity=23.8505747126437, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=360, Percent_Identity=25.5555555555556, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319264, Length=555, Percent_Identity=22.8828828828829, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323182, Length=569, Percent_Identity=23.1985940246046, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581924, Length=497, Percent_Identity=28.5714285714286, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21355181, Length=481, Percent_Identity=28.8981288981289, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI18859661, Length=363, Percent_Identity=30.3030303030303, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24648255, Length=514, Percent_Identity=27.2373540856031, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24648253, Length=515, Percent_Identity=26.7961165048544, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21358303, Length=364, Percent_Identity=27.1978021978022, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21356441, Length=359, Percent_Identity=28.6908077994429, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281365686, Length=362, Percent_Identity=27.6243093922652, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24653035, Length=539, Percent_Identity=25.974025974026, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI21356947, Length=374, Percent_Identity=27.5401069518717, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24648257, Length=369, Percent_Identity=28.7262872628726, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161076582, Length=553, Percent_Identity=25.497287522604, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20130357, Length=355, Percent_Identity=25.3521126760563, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI19922652, Length=531, Percent_Identity=25.8003766478343, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656500, Length=535, Percent_Identity=24.1121495327103, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648260, Length=528, Percent_Identity=23.8636363636364, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648676, Length=421, Percent_Identity=26.603325415677, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI19921316, Length=488, Percent_Identity=24.1803278688525, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI62472339, Length=378, Percent_Identity=25.1322751322751, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667959, Length=368, Percent_Identity=25.5434782608696, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667955, Length=368, Percent_Identity=25.5434782608696, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355225, Length=367, Percent_Identity=23.9782016348774, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 57222; Mature: 57091

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDELLRHPIHSGHLTVGALKRNKDKPVLHLGDTTLTGGQLAERISQYIQAFEALGAGTG
CCCHHHHCCCCCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
ATVGLLSLNRPEVLMIIGAGQTQGYRRVALHPLGSLDDHAYVLDDAGVTSLIIDPTPAFV
CEEEEEECCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCEEEEECCCHHHH
ERALGLLEKVPGLKQILTIGPVPEALSGSAVDLVAEAAKYAPKPLVAADLPPDHIGGMAY
HHHHHHHHHCCCHHHHHCCCCCCHHHCCCHHHHHHHHHHHCCCCEEECCCCHHHCCCEEE
TGGTTGKPKGVLGTAQSITTMTTIQLAEWEWPENPRFLMCTPLSHAGAAFFVPTIIKGGE
ECCCCCCCCCCEECCHHHEEEEEEEEEECCCCCCCCEEEECCCCCCCCCEEHHHHCCCCC
LVVLTKFDPAEVLRVIEEQKITATMLVPSMIYALMDHPDSHTRDLSSLETVYYGASAMNP
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCH
VRLAEAIRRFGPIFAQYYGQSEAPMVISYLAKKDHDEKRLTSCGRPTLFARTALLDADGN
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEEECCCC
PVPQGEVGEICVSGPLLSGGYWNLPEETAKTFKDGWLHTGDMAREDEDGFWFIVDRVKDM
CCCCCCCCCEEECCCEECCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCEEEEHHHHHHH
IVTGGFNVFPREVEDVVAEHPAVAQVCVIGTPDEKWGEAVTAVIVLRPDHPSDEESVAKV
EEECCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHCCEEEEEEEECCCCCCCHHHHHHH
TAEIQAAVKKRKGSVQSPKQVIVVDSVPVTALGKPDKKAVRARFWEGAGRAVG
HHHHHHHHHHHCCCCCCCCEEEEECCCCEEECCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GDELLRHPIHSGHLTVGALKRNKDKPVLHLGDTTLTGGQLAERISQYIQAFEALGAGTG
CCHHHHCCCCCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
ATVGLLSLNRPEVLMIIGAGQTQGYRRVALHPLGSLDDHAYVLDDAGVTSLIIDPTPAFV
CEEEEEECCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCEEEEECCCHHHH
ERALGLLEKVPGLKQILTIGPVPEALSGSAVDLVAEAAKYAPKPLVAADLPPDHIGGMAY
HHHHHHHHHCCCHHHHHCCCCCCHHHCCCHHHHHHHHHHHCCCCEEECCCCHHHCCCEEE
TGGTTGKPKGVLGTAQSITTMTTIQLAEWEWPENPRFLMCTPLSHAGAAFFVPTIIKGGE
ECCCCCCCCCCEECCHHHEEEEEEEEEECCCCCCCCEEEECCCCCCCCCEEHHHHCCCCC
LVVLTKFDPAEVLRVIEEQKITATMLVPSMIYALMDHPDSHTRDLSSLETVYYGASAMNP
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCH
VRLAEAIRRFGPIFAQYYGQSEAPMVISYLAKKDHDEKRLTSCGRPTLFARTALLDADGN
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEEECCCC
PVPQGEVGEICVSGPLLSGGYWNLPEETAKTFKDGWLHTGDMAREDEDGFWFIVDRVKDM
CCCCCCCCCEEECCCEECCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCEEEEHHHHHHH
IVTGGFNVFPREVEDVVAEHPAVAQVCVIGTPDEKWGEAVTAVIVLRPDHPSDEESVAKV
EEECCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHCCEEEEEEEECCCCCCCHHHHHHH
TAEIQAAVKKRKGSVQSPKQVIVVDSVPVTALGKPDKKAVRARFWEGAGRAVG
HHHHHHHHHHHCCCCCCCCEEEEECCCCEEECCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]