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The map label for this gene is menE [H]

Identifier: 41408498

GI number: 41408498

Start: 2695203

End: 2696660

Strand: Direct

Name: menE [H]

Synonym: MAP2400

Alternate gene names: 41408498

Gene position: 2695203-2696660 (Clockwise)

Preceding gene: 41408497

Following gene: 41408499

Centisome position: 55.8

GC content: 72.98

Gene sequence:

>1458_bases
ATGCCGCGTCATCCCCTCGTCCAGCGCATCGCCGACGTGCTCGACCTCGACCCGCACGGCCGCGCCATCGAGTATGGCGG
CCAATGGTTTTCCTGGGCACAGCTGGGCGCGACGGCGCGACAGGTGGCCGCTCGCACCACCGGCACCGAGGTGGGGATGC
TGCTACGCAACCGGCCCTGGCAGGTGGCGGCGTTCCTGGGCGTGCTGCTGGGCGGCGGAACCGTCGTGGTGGTCAACCCG
TCCCGCGGCGACGAGCGCACCAGGGCCGACCTGGCGCGGCTGCGGCTGCCCCTGATCATCGGCGAGCCCGACGATCTGGC
CGCCCTGGTGACCGACGACACCCCGACGATGCCGATCTCGCGCCTCGCCGACCCGCCGGGGCCGGCCGCCCCGCCCGCCG
CCGCGCCGCGCAGTGTGGCGGTGCGCATGTTGACCAGCGGCACCACCGGCCCACCGAAGCGAATCGACCTGGGCTACGAC
ATGCTGGCGCGCAGCGTGCTGGGCGTCGAGCCGGGCACCGCACCGGCGCCCACCGAACCGCGGCGCGACGTCGCCATCGT
GAACTCTCCGCTGGTGCACATCGGCGGGGTGTTCCGCGTGCTGCAATGCGTCGCCGAGGCAAGGCCATTCGTGTTGCTGG
AACGCTTCGAGCTGAACGCCTGGACCGCCGCCGTGCGCAGGCACCGGCCCCGCGCGGTGTCGCTGGTGCCCGCCGCGCTG
CGCACGGTGCTGCACTCCGACCTGCCGCGCGCCGATCTGGAAAGCATCCAGGTCGTCACCTGCGGCACCGCGCCGCTGTC
GGCCGACGACGCCGACGCGTTCACCGAGAAGTACGGCATCCCGGTGCTGACCTCTTATGCGGCAACGGAATTCGGTGGCG
GCGTGGCGGGCTGGACCCTCGCCGATCACCGGCGGTACTGGCGGGTCAAACGGGGCAGTGTCGGCCGGGCCAACCCGGGC
GCGGCGCTGCGGGTGGTCGCCGAGGACGGAACACCGCTGGGGCCGGACGAAATCGGGCTGCTGGAGGTCAAGCCCGGGCA
GCTGGGGCCCGACGCGGGCTGGCTGCGCACCACCGACATGGCGCGCATCGACGCCGACGGGTTTGTCTGGATCGTCGGGC
GCGCCGACCAAGCGATCATTCGCGGCGGGTTCAAGGTGATGCCCGACGACGTGCGCGCCGCGCTGGAAAGCCACCCCGCG
GTCGCCGGTGCGGCCGTCGTCGCCCGGCCCGACCCACGACTGGGAGAGACGCCGGTGGCCATGGTCGAACTCCGCGCGCC
GTCGACGACCGACGCACTGGTCCAGCATCTCCGAGAGCGCTTGGCGCGCTACGAGATTCCCACCGAGATCGCGATCGTCG
ACGCCCTGCCCCGAACCCCGTCCGGCAAGGCCGACCTGGCCGCGGTCCGCGGCTACTTCGCCGAGCGGCCGACGGTACTG
CGCAACCATGCCCGGTGA

Upstream 100 bases:

>100_bases
TCATCTACACCCGGCTGGGCAATCCGCTGGGCACCGCCGAGCTGGCCGCCGGCCGGGACGCCGGTGCACGCGGCGCGGCA
CGCACACCGAAGATCCGCTG

Downstream 100 bases:

>100_bases
TTTCGCGACGGTCGGCGCGACGTTGCGGCACCAGGCGCGGCGGCGCGGCGACCACCCGCTGCTGATCTGCGACGCCGAAC
GGATCAGCTACGCCGAGGCC

Product: hypothetical protein

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MPRHPLVQRIADVLDLDPHGRAIEYGGQWFSWAQLGATARQVAARTTGTEVGMLLRNRPWQVAAFLGVLLGGGTVVVVNP
SRGDERTRADLARLRLPLIIGEPDDLAALVTDDTPTMPISRLADPPGPAAPPAAAPRSVAVRMLTSGTTGPPKRIDLGYD
MLARSVLGVEPGTAPAPTEPRRDVAIVNSPLVHIGGVFRVLQCVAEARPFVLLERFELNAWTAAVRRHRPRAVSLVPAAL
RTVLHSDLPRADLESIQVVTCGTAPLSADDADAFTEKYGIPVLTSYAATEFGGGVAGWTLADHRRYWRVKRGSVGRANPG
AALRVVAEDGTPLGPDEIGLLEVKPGQLGPDAGWLRTTDMARIDADGFVWIVGRADQAIIRGGFKVMPDDVRAALESHPA
VAGAAVVARPDPRLGETPVAMVELRAPSTTDALVQHLRERLARYEIPTEIAIVDALPRTPSGKADLAAVRGYFAERPTVL
RNHAR

Sequences:

>Translated_485_residues
MPRHPLVQRIADVLDLDPHGRAIEYGGQWFSWAQLGATARQVAARTTGTEVGMLLRNRPWQVAAFLGVLLGGGTVVVVNP
SRGDERTRADLARLRLPLIIGEPDDLAALVTDDTPTMPISRLADPPGPAAPPAAAPRSVAVRMLTSGTTGPPKRIDLGYD
MLARSVLGVEPGTAPAPTEPRRDVAIVNSPLVHIGGVFRVLQCVAEARPFVLLERFELNAWTAAVRRHRPRAVSLVPAAL
RTVLHSDLPRADLESIQVVTCGTAPLSADDADAFTEKYGIPVLTSYAATEFGGGVAGWTLADHRRYWRVKRGSVGRANPG
AALRVVAEDGTPLGPDEIGLLEVKPGQLGPDAGWLRTTDMARIDADGFVWIVGRADQAIIRGGFKVMPDDVRAALESHPA
VAGAAVVARPDPRLGETPVAMVELRAPSTTDALVQHLRERLARYEIPTEIAIVDALPRTPSGKADLAAVRGYFAERPTVL
RNHAR
>Mature_484_residues
PRHPLVQRIADVLDLDPHGRAIEYGGQWFSWAQLGATARQVAARTTGTEVGMLLRNRPWQVAAFLGVLLGGGTVVVVNPS
RGDERTRADLARLRLPLIIGEPDDLAALVTDDTPTMPISRLADPPGPAAPPAAAPRSVAVRMLTSGTTGPPKRIDLGYDM
LARSVLGVEPGTAPAPTEPRRDVAIVNSPLVHIGGVFRVLQCVAEARPFVLLERFELNAWTAAVRRHRPRAVSLVPAALR
TVLHSDLPRADLESIQVVTCGTAPLSADDADAFTEKYGIPVLTSYAATEFGGGVAGWTLADHRRYWRVKRGSVGRANPGA
ALRVVAEDGTPLGPDEIGLLEVKPGQLGPDAGWLRTTDMARIDADGFVWIVGRADQAIIRGGFKVMPDDVRAALESHPAV
AGAAVVARPDPRLGETPVAMVELRAPSTTDALVQHLRERLARYEIPTEIAIVDALPRTPSGKADLAAVRGYFAERPTVLR
NHAR

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=264, Percent_Identity=28.7878787878788, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI42544132, Length=367, Percent_Identity=25.3405994550409, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI122937307, Length=362, Percent_Identity=25.414364640884, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI115511026, Length=262, Percent_Identity=25.5725190839695, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI187761345, Length=417, Percent_Identity=26.6187050359712, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI187761343, Length=417, Percent_Identity=26.6187050359712, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI58082049, Length=360, Percent_Identity=26.9444444444444, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI157311624, Length=359, Percent_Identity=26.1838440111421, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI157311622, Length=359, Percent_Identity=26.1838440111421, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI156151445, Length=351, Percent_Identity=25.6410256410256, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI253970489, Length=116, Percent_Identity=36.2068965517241, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI8923896, Length=116, Percent_Identity=36.2068965517241, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI221142682, Length=465, Percent_Identity=25.5913978494624, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI145693145, Length=396, Percent_Identity=26.5151515151515, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788107, Length=353, Percent_Identity=25.4957507082153, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786810, Length=272, Percent_Identity=26.8382352941176, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786529, Length=366, Percent_Identity=25.9562841530055, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790505, Length=362, Percent_Identity=25.9668508287293, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788595, Length=403, Percent_Identity=26.7990074441687, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17531443, Length=399, Percent_Identity=27.8195488721804, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17558820, Length=484, Percent_Identity=27.2727272727273, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=428, Percent_Identity=24.0654205607477, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=347, Percent_Identity=27.3775216138329, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17560140, Length=338, Percent_Identity=26.6272189349112, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25141359, Length=449, Percent_Identity=21.1581291759465, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17557194, Length=373, Percent_Identity=23.0563002680965, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71985884, Length=344, Percent_Identity=23.8372093023256, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=126, Percent_Identity=30.952380952381, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560308, Length=374, Percent_Identity=25.9358288770053, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=405, Percent_Identity=24.6913580246914, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319264, Length=285, Percent_Identity=27.719298245614, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355181, Length=377, Percent_Identity=26.790450928382, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18859661, Length=357, Percent_Identity=26.890756302521, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648253, Length=419, Percent_Identity=23.1503579952267, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356441, Length=412, Percent_Identity=23.5436893203883, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648255, Length=419, Percent_Identity=23.1503579952267, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24581924, Length=133, Percent_Identity=35.3383458646617, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922652, Length=363, Percent_Identity=23.9669421487603, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24653035, Length=367, Percent_Identity=22.6158038147139, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356947, Length=492, Percent_Identity=20.9349593495935, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161076582, Length=365, Percent_Identity=22.1917808219178, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI62472339, Length=116, Percent_Identity=36.2068965517241, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667955, Length=116, Percent_Identity=36.2068965517241, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667959, Length=116, Percent_Identity=36.2068965517241, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 51897; Mature: 51766

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRHPLVQRIADVLDLDPHGRAIEYGGQWFSWAQLGATARQVAARTTGTEVGMLLRNRPW
CCCCHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCH
QVAAFLGVLLGGGTVVVVNPSRGDERTRADLARLRLPLIIGEPDDLAALVTDDTPTMPIS
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHEEEEEEECCCCEEEEEECCCCCCCHH
RLADPPGPAAPPAAAPRSVAVRMLTSGTTGPPKRIDLGYDMLARSVLGVEPGTAPAPTEP
HHCCCCCCCCCCCCCCHHHEEEEEECCCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCCC
RRDVAIVNSPLVHIGGVFRVLQCVAEARPFVLLERFELNAWTAAVRRHRPRAVSLVPAAL
CCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCEEHHHHHHH
RTVLHSDLPRADLESIQVVTCGTAPLSADDADAFTEKYGIPVLTSYAATEFGGGVAGWTL
HHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCEEEHHHHHHCCCCEEECEE
ADHRRYWRVKRGSVGRANPGAALRVVAEDGTPLGPDEIGLLEVKPGQLGPDAGWLRTTDM
HHCHHHEEEECCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCEEECCC
ARIDADGFVWIVGRADQAIIRGGFKVMPDDVRAALESHPAVAGAAVVARPDPRLGETPVA
EEECCCCEEEEEECCCHHHHHCCCEECCHHHHHHHHCCCCHHCEEEEECCCCCCCCCCEE
MVELRAPSTTDALVQHLRERLARYEIPTEIAIVDALPRTPSGKADLAAVRGYFAERPTVL
EEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHH
RNHAR
HCCCC
>Mature Secondary Structure 
PRHPLVQRIADVLDLDPHGRAIEYGGQWFSWAQLGATARQVAARTTGTEVGMLLRNRPW
CCCHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCH
QVAAFLGVLLGGGTVVVVNPSRGDERTRADLARLRLPLIIGEPDDLAALVTDDTPTMPIS
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHEEEEEEECCCCEEEEEECCCCCCCHH
RLADPPGPAAPPAAAPRSVAVRMLTSGTTGPPKRIDLGYDMLARSVLGVEPGTAPAPTEP
HHCCCCCCCCCCCCCCHHHEEEEEECCCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCCC
RRDVAIVNSPLVHIGGVFRVLQCVAEARPFVLLERFELNAWTAAVRRHRPRAVSLVPAAL
CCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCEEHHHHHHH
RTVLHSDLPRADLESIQVVTCGTAPLSADDADAFTEKYGIPVLTSYAATEFGGGVAGWTL
HHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCEEEHHHHHHCCCCEEECEE
ADHRRYWRVKRGSVGRANPGAALRVVAEDGTPLGPDEIGLLEVKPGQLGPDAGWLRTTDM
HHCHHHEEEECCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCEEECCC
ARIDADGFVWIVGRADQAIIRGGFKVMPDDVRAALESHPAVAGAAVVARPDPRLGETPVA
EEECCCCEEEEEECCCHHHHHCCCEECCHHHHHHHHCCCCHHCEEEEECCCCCCCCCCEE
MVELRAPSTTDALVQHLRERLARYEIPTEIAIVDALPRTPSGKADLAAVRGYFAERPTVL
EEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHH
RNHAR
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA