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The map label for this gene is echA16_1

Identifier: 41408497

GI number: 41408497

Start: 2694391

End: 2695203

Strand: Direct

Name: echA16_1

Synonym: MAP2399

Alternate gene names: 41408497

Gene position: 2694391-2695203 (Clockwise)

Preceding gene: 41408496

Following gene: 41408498

Centisome position: 55.79

GC content: 68.02

Gene sequence:

>813_bases
TTGGCAATGCCGATGAGCGCACAGTTCGACACCATCCTGCTCGAGGTGGACGCCACCGACCACGTCGCCACCATCACGCT
CAATCGGCCCGAGCAGCTCAACGCGTTCAACCGCGCCATGTGTGCCGAGATGGCTCAGGCGTGGCGCCTGGTCAAGCTCG
ACGACGCGGTGCACGCGGTGGTGTTGCGGGCCGCCGGCGACCGGGCGTTCAGCGCCGGGCTGGACATCAAGACGCCGTAC
GGTCAGCCCGAAAACATCTGGAACCACGAGGATCCCGGCGAAGCCCTGAGCCCGAAGTGGCAGAAGATGTGGAAGCCGGT
GGTGTGCGCGGTCCAGGGCATGTGTACCGCGGGCGCGTTCTACTTCGTCAACGAGTCCGACGTGGTCATCTGCTCGCAGG
ACGCCACCTTTTTCGATTCGCATGTGTCGGCTGGCCTGGTCTGTGCCCTGGAACCGGTCGGCCTGATGCGTCGCATCGGG
CTCGGCGAGACGTTGCGGATCGCACTGATGGGCAACGACGAACGGGTCGGGGCGGACACCGCGCTGCGGATCGGCCTGGT
GACGGAAGTGGTTCCCGCCGAACGGCTCTGGGACCGGGCCCACGAGATCGCGGCGACCATCGCCGCCAAGCCCCCGACCG
CGACCGCGGGCACGGTGAAGGCGATCTGGGAATCACTGGACAAGCCGTATCGCGCGGCGATGGAGCAGGGCCTCATCTAC
ACCCGGCTGGGCAATCCGCTGGGCACCGCCGAGCTGGCCGCCGGCCGGGACGCCGGTGCACGCGGCGCGGCACGCACACC
GAAGATCCGCTGA

Upstream 100 bases:

>100_bases
ACGAGGCGGAGATCCTCGCCGAGACCTTCCGCGAGCGGGTGTTGCGAACCGAGGACGCGGCCGAAGGACCGAGGGCCTTC
GTGGAAAAGCGCCAACCGAA

Downstream 100 bases:

>100_bases
TGCCGCGTCATCCCCTCGTCCAGCGCATCGCCGACGTGCTCGACCTCGACCCGCACGGCCGCGCCATCGAGTATGGCGGC
CAATGGTTTTCCTGGGCACA

Product: EchA16_1

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MAMPMSAQFDTILLEVDATDHVATITLNRPEQLNAFNRAMCAEMAQAWRLVKLDDAVHAVVLRAAGDRAFSAGLDIKTPY
GQPENIWNHEDPGEALSPKWQKMWKPVVCAVQGMCTAGAFYFVNESDVVICSQDATFFDSHVSAGLVCALEPVGLMRRIG
LGETLRIALMGNDERVGADTALRIGLVTEVVPAERLWDRAHEIAATIAAKPPTATAGTVKAIWESLDKPYRAAMEQGLIY
TRLGNPLGTAELAAGRDAGARGAARTPKIR

Sequences:

>Translated_270_residues
MAMPMSAQFDTILLEVDATDHVATITLNRPEQLNAFNRAMCAEMAQAWRLVKLDDAVHAVVLRAAGDRAFSAGLDIKTPY
GQPENIWNHEDPGEALSPKWQKMWKPVVCAVQGMCTAGAFYFVNESDVVICSQDATFFDSHVSAGLVCALEPVGLMRRIG
LGETLRIALMGNDERVGADTALRIGLVTEVVPAERLWDRAHEIAATIAAKPPTATAGTVKAIWESLDKPYRAAMEQGLIY
TRLGNPLGTAELAAGRDAGARGAARTPKIR
>Mature_269_residues
AMPMSAQFDTILLEVDATDHVATITLNRPEQLNAFNRAMCAEMAQAWRLVKLDDAVHAVVLRAAGDRAFSAGLDIKTPYG
QPENIWNHEDPGEALSPKWQKMWKPVVCAVQGMCTAGAFYFVNESDVVICSQDATFFDSHVSAGLVCALEPVGLMRRIGL
GETLRIALMGNDERVGADTALRIGLVTEVVPAERLWDRAHEIAATIAAKPPTATAGTVKAIWESLDKPYRAAMEQGLIYT
RLGNPLGTAELAAGRDAGARGAARTPKIR

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=247, Percent_Identity=27.5303643724696, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI70995211, Length=227, Percent_Identity=29.9559471365639, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787660, Length=205, Percent_Identity=33.1707317073171, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082183, Length=213, Percent_Identity=28.169014084507, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI221142681, Length=231, Percent_Identity=26.8398268398268, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788597, Length=190, Percent_Identity=30, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787659, Length=224, Percent_Identity=24.5535714285714, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25145438, Length=222, Percent_Identity=30.6306306306306, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17554946, Length=232, Percent_Identity=28.448275862069, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI20129971, Length=225, Percent_Identity=28, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24653477, Length=225, Percent_Identity=28, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357171, Length=238, Percent_Identity=26.0504201680672, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 29171; Mature: 29040

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMPMSAQFDTILLEVDATDHVATITLNRPEQLNAFNRAMCAEMAQAWRLVKLDDAVHAV
CCCCCCCCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEEEEHHHHHHH
VLRAAGDRAFSAGLDIKTPYGQPENIWNHEDPGEALSPKWQKMWKPVVCAVQGMCTAGAF
HHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEE
YFVNESDVVICSQDATFFDSHVSAGLVCALEPVGLMRRIGLGETLRIALMGNDERVGADT
EEECCCCEEEECCCCHHHHHHCCCCEEEEECHHHHHHHCCCCCEEEEEEECCCCCCCCCH
ALRIGLVTEVVPAERLWDRAHEIAATIAAKPPTATAGTVKAIWESLDKPYRAAMEQGLIY
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHCCEEE
TRLGNPLGTAELAAGRDAGARGAARTPKIR
EECCCCCCCHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AMPMSAQFDTILLEVDATDHVATITLNRPEQLNAFNRAMCAEMAQAWRLVKLDDAVHAV
CCCCCCCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEEEEHHHHHHH
VLRAAGDRAFSAGLDIKTPYGQPENIWNHEDPGEALSPKWQKMWKPVVCAVQGMCTAGAF
HHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEE
YFVNESDVVICSQDATFFDSHVSAGLVCALEPVGLMRRIGLGETLRIALMGNDERVGADT
EEECCCCEEEECCCCHHHHHHCCCCEEEEECHHHHHHHCCCCCEEEEEEECCCCCCCCCH
ALRIGLVTEVVPAERLWDRAHEIAATIAAKPPTATAGTVKAIWESLDKPYRAAMEQGLIY
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHCCEEE
TRLGNPLGTAELAAGRDAGARGAARTPKIR
EECCCCCCCHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]