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The map label for this gene is mmuM

Identifier: 41408377

GI number: 41408377

Start: 2548945

End: 2549865

Strand: Direct

Name: mmuM

Synonym: MAP2279

Alternate gene names: 41408377

Gene position: 2548945-2549865 (Clockwise)

Preceding gene: 41408372

Following gene: 41408381

Centisome position: 52.78

GC content: 70.47

Gene sequence:

>921_bases
GTGGGTTCAGCCCGGGGCTTCACCTGGCCCAGCGATCCCGTGCTGCTCGACGGCGGCCTGGCCACCGAGCTGGAAGCGCG
CGGTCACGACCTCTCCGACCCGTTGTGGTCGGCGCGGCTGCTGGCCGACGCCCCGCAGGAGATCGTCGCGGTGCACGCCG
CCTACTTCCGCGCCGGGGCGATGATCGCGACGACGGCCAGCTACCAGGCGTCCTTCGAGGGCTTCGCGGCCCGCGGAATC
AGCCGTTCCGACACCGCCGGATTGCTTCGGCGCAGTGTCGAACTCGCCAAGGCCGCGCGGGATGAGGCAGGTGTTGCGGG
CCACGTGGCCGCGTCGGTCGGCCCGTACGGCGCCGCACTTGCGGACGGCTCCGAATACCGCGGCCGCTACGGGATCAGCG
TGAGGCAGCTGGAGGACTGGCACCGGCCGCGGCTGGAGGTGTTGGCCGGCGCCGACGCGGACGTCTTGGCAGTGGAAACC
ATCCCCGACGTCGACGAGGCCGAGGCGCTGGTGAATCTGGTGCGCTCGCTCGGTGTGCCGGCGTGGCTGAGCTACACCAT
TGACGGCGCCCACACCCGGGCGGGTCAGCCGCTAGCCGACGCTTTCGCGGTGGCGGCAGGGGTGCCCGAGATTGTCGCTG
TCGGCGTCAATTGCTGCGCGCCGGACGACGTGTTGCCCACGATCGAGATCGCCGCGGCGATCGGCAAGCCGGTGATCGTC
TACCCGAACAGCGGAGAGCACTGGAATGCCTTGCGGCACAACTGGACCGGGCCGTCGCGTTTTTCGGCGCCGCTGGCCGC
GCGGTGGATCTCGGCGGGAGCACGTATCGTCGGCGGATGCTGCCAGGTGCGGCCCACCGACATCGCGGCCGTTCGCCGTG
CGTGCAGTGACGGCGAAAATTCCGCCAAAAAATCGCCCTGA

Upstream 100 bases:

>100_bases
CTTTGCGTGTCTTTGGCGTGTCGCGGTCGTGATGCGACCGAGGCTGGCGGCCGGCTCGAGGCGTGGGCGAACCCCCACGA
AATCACCCTACAGTGGCCAG

Downstream 100 bases:

>100_bases
GTGCACGTTCGGCGCAGCGAGTTAGGCCGTCTGCGCCGACAGCTTGCGGTACTCCAGCACGGTGTCGATGATCCCGTAGT
CCTTGGCCTCTTCGGCGGTC

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MGSARGFTWPSDPVLLDGGLATELEARGHDLSDPLWSARLLADAPQEIVAVHAAYFRAGAMIATTASYQASFEGFAARGI
SRSDTAGLLRRSVELAKAARDEAGVAGHVAASVGPYGAALADGSEYRGRYGISVRQLEDWHRPRLEVLAGADADVLAVET
IPDVDEAEALVNLVRSLGVPAWLSYTIDGAHTRAGQPLADAFAVAAGVPEIVAVGVNCCAPDDVLPTIEIAAAIGKPVIV
YPNSGEHWNALRHNWTGPSRFSAPLAARWISAGARIVGGCCQVRPTDIAAVRRACSDGENSAKKSP

Sequences:

>Translated_306_residues
MGSARGFTWPSDPVLLDGGLATELEARGHDLSDPLWSARLLADAPQEIVAVHAAYFRAGAMIATTASYQASFEGFAARGI
SRSDTAGLLRRSVELAKAARDEAGVAGHVAASVGPYGAALADGSEYRGRYGISVRQLEDWHRPRLEVLAGADADVLAVET
IPDVDEAEALVNLVRSLGVPAWLSYTIDGAHTRAGQPLADAFAVAAGVPEIVAVGVNCCAPDDVLPTIEIAAAIGKPVIV
YPNSGEHWNALRHNWTGPSRFSAPLAARWISAGARIVGGCCQVRPTDIAAVRRACSDGENSAKKSP
>Mature_305_residues
GSARGFTWPSDPVLLDGGLATELEARGHDLSDPLWSARLLADAPQEIVAVHAAYFRAGAMIATTASYQASFEGFAARGIS
RSDTAGLLRRSVELAKAARDEAGVAGHVAASVGPYGAALADGSEYRGRYGISVRQLEDWHRPRLEVLAGADADVLAVETI
PDVDEAEALVNLVRSLGVPAWLSYTIDGAHTRAGQPLADAFAVAAGVPEIVAVGVNCCAPDDVLPTIEIAAAIGKPVIVY
PNSGEHWNALRHNWTGPSRFSAPLAARWISAGARIVGGCCQVRPTDIAAVRRACSDGENSAKKSP

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=321, Percent_Identity=25.8566978193146, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786456, Length=300, Percent_Identity=47.3333333333333, Blast_Score=254, Evalue=5e-69,
Organism=Escherichia coli, GI1790450, Length=320, Percent_Identity=28.4375, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322966, Length=309, Percent_Identity=28.4789644012945, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324982, Length=313, Percent_Identity=27.7955271565495, Blast_Score=115, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24585077, Length=330, Percent_Identity=34.2424242424242, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI20129603, Length=326, Percent_Identity=33.1288343558282, Blast_Score=152, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 31969; Mature: 31838

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSARGFTWPSDPVLLDGGLATELEARGHDLSDPLWSARLLADAPQEIVAVHAAYFRAGA
CCCCCCCCCCCCCEEECCCCCCHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
MIATTASYQASFEGFAARGISRSDTAGLLRRSVELAKAARDEAGVAGHVAASVGPYGAAL
CEEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCC
ADGSEYRGRYGISVRQLEDWHRPRLEVLAGADADVLAVETIPDVDEAEALVNLVRSLGVP
CCCHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCC
AWLSYTIDGAHTRAGQPLADAFAVAAGVPEIVAVGVNCCAPDDVLPTIEIAAAIGKPVIV
EEEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEE
YPNSGEHWNALRHNWTGPSRFSAPLAARWISAGARIVGGCCQVRPTDIAAVRRACSDGEN
ECCCCCCHHHHHCCCCCCCHHCCHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHCCCCC
SAKKSP
CCCCCC
>Mature Secondary Structure 
GSARGFTWPSDPVLLDGGLATELEARGHDLSDPLWSARLLADAPQEIVAVHAAYFRAGA
CCCCCCCCCCCCEEECCCCCCHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
MIATTASYQASFEGFAARGISRSDTAGLLRRSVELAKAARDEAGVAGHVAASVGPYGAAL
CEEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCC
ADGSEYRGRYGISVRQLEDWHRPRLEVLAGADADVLAVETIPDVDEAEALVNLVRSLGVP
CCCHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCC
AWLSYTIDGAHTRAGQPLADAFAVAAGVPEIVAVGVNCCAPDDVLPTIEIAAAIGKPVIV
EEEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEE
YPNSGEHWNALRHNWTGPSRFSAPLAARWISAGARIVGGCCQVRPTDIAAVRRACSDGEN
ECCCCCCHHHHHCCCCCCCHHCCHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHCCCCC
SAKKSP
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]