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The map label for this gene is lipP

Identifier: 41408381

GI number: 41408381

Start: 2553030

End: 2554220

Strand: Direct

Name: lipP

Synonym: MAP2283

Alternate gene names: 41408381

Gene position: 2553030-2554220 (Clockwise)

Preceding gene: 41408377

Following gene: 41408385

Centisome position: 52.86

GC content: 69.44

Gene sequence:

>1191_bases
ATGAGCGACCTGAAGACGGACGCGCCGATTCATGGCTCATGTGCGCCGGACTTCGTCGGGGTACGCGACGCCTTCGAGCG
CAATTTCACCCACGGCGGTGAGGTCGGCGCGGCCGTCGCCGTCTGGGTGGACGGGTCGCTGGTCGTCAATCTGTGGGGCG
GCTGGGCCGACGCCGCGCGCACCCGCCCCTGGCAGCAGAACACCCTGACCACGGTGCTGTCCGGCACCAAGGGCCTGTCC
GCCACCTGTGTGCACCAACTGGCCGACCGCGGGCAGCTGGACCTGCAGGCGCCGGTGGCCCGCTACTGGCCCGAGTTCGC
CCAGGCGGGCAAACAAGACATCACCCTGGCGATGGTGATGAGCCACCGATCCGGGGTGATCGGGCCGCGCACCCGGATGC
GCTGGGAACAGGTCGCCGACTGGGACTACGTCTGCGAACAGCTGGCCGCCGCCGAGCCGTGGTGGGAGCCGGGCACCGCC
CAGGGCTACCACATGACCACCTTCGGTTTCATCATGGGCGAGGTGTTCCGCCGGGTCACCGGCCGAACCATCGGCCACTA
CCTGCGCACCGAGATCGCCGGACCGTTCGGCGCCGACGTCCACATCGGGTTGCCGCTGGCCGAACAACACCGCTGCGCCG
AGCGGGTCAACAAGCCGCACGCCCGCGACCTGCTGGCCGACGCCAACGCCCCCACCGACCCGAGGAGCCTTGCCGAGCAC
CCCAAGGCCGGGCTGTCCATCTCGATGGGTTTCGCCCCCGACGACGAGCTGGGCTCGCACGATCTGAACCTGTGGCGCGA
ACTGGAGTTCCCGGGCACCAACGGGCAGGTGTCGGCGCTCGGCTTGGCGACCTTCTATAACGCGCTGGCCCAGGAGAAGT
TGCTCAGCCGCGAGCACATGGACCGGGTGCGGGTGTGCCAGGGCGGGCTGGACACCGACCTGGTGCTGGGACCGCGGGTC
GCCGACCACGGCTGGGGCCTGGGGTACATGCTCAACCAGCGGTGCGTCAACGGACCCAACCCGCGGATCTTCGGCCACGG
CGGGCTGGGCGGCTCGTTCGGATTCGTCGACCTGGAACACCGGATCGGCTACGCGTACGTGATGAATCGCTTCGACGCCA
CCAAGGCCAACGCCGATCCGCGCAGCCTGGCGCTGTCCAACGAGGTCTACTCCGTGCTGGGCGTCCGCTAA

Upstream 100 bases:

>100_bases
GGCGTAGCTCAATGGTAGAGCCCTAGTCTTCCAAACTAGCTACGCGGGTTCGATTCCCGTCGCCCGCTCGGGCTAACTAT
CTTCTCGCTAGAGAGGCGCC

Downstream 100 bases:

>100_bases
CTGCGACGCGAACGCGCCCCGCCGGGATCGGCGGGGCGCGTTCGGGTTACGTGGACGCGCGCGGCGTCAGGGGTGCCAGC
CGTGCGGCGGCGGCGGTCCG

Product: LipP

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: Esterase; Carboxylesterase; Beta-Lactamase Class C; Esterase A; Esterase/Lipase LipP; Lactone Hydrolase; Lipase LipE; Esterase/Lipase/Beta-Lactamase; Beta-Lactamase Protein; Esterase LipL; Lipase LipD; Lipase/Esterase/Beta-Lactamase; Beta-Lactamase Family Protein; Hydrolase; Esterase/Lipase; Carboxylesterase EstC; Serine Hydrolase; Beta-Lactamase Family; Fusion Of Enoyl-CoA Hydratase; Beta-Lactamase-Like Protein

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSDLKTDAPIHGSCAPDFVGVRDAFERNFTHGGEVGAAVAVWVDGSLVVNLWGGWADAARTRPWQQNTLTTVLSGTKGLS
ATCVHQLADRGQLDLQAPVARYWPEFAQAGKQDITLAMVMSHRSGVIGPRTRMRWEQVADWDYVCEQLAAAEPWWEPGTA
QGYHMTTFGFIMGEVFRRVTGRTIGHYLRTEIAGPFGADVHIGLPLAEQHRCAERVNKPHARDLLADANAPTDPRSLAEH
PKAGLSISMGFAPDDELGSHDLNLWRELEFPGTNGQVSALGLATFYNALAQEKLLSREHMDRVRVCQGGLDTDLVLGPRV
ADHGWGLGYMLNQRCVNGPNPRIFGHGGLGGSFGFVDLEHRIGYAYVMNRFDATKANADPRSLALSNEVYSVLGVR

Sequences:

>Translated_396_residues
MSDLKTDAPIHGSCAPDFVGVRDAFERNFTHGGEVGAAVAVWVDGSLVVNLWGGWADAARTRPWQQNTLTTVLSGTKGLS
ATCVHQLADRGQLDLQAPVARYWPEFAQAGKQDITLAMVMSHRSGVIGPRTRMRWEQVADWDYVCEQLAAAEPWWEPGTA
QGYHMTTFGFIMGEVFRRVTGRTIGHYLRTEIAGPFGADVHIGLPLAEQHRCAERVNKPHARDLLADANAPTDPRSLAEH
PKAGLSISMGFAPDDELGSHDLNLWRELEFPGTNGQVSALGLATFYNALAQEKLLSREHMDRVRVCQGGLDTDLVLGPRV
ADHGWGLGYMLNQRCVNGPNPRIFGHGGLGGSFGFVDLEHRIGYAYVMNRFDATKANADPRSLALSNEVYSVLGVR
>Mature_395_residues
SDLKTDAPIHGSCAPDFVGVRDAFERNFTHGGEVGAAVAVWVDGSLVVNLWGGWADAARTRPWQQNTLTTVLSGTKGLSA
TCVHQLADRGQLDLQAPVARYWPEFAQAGKQDITLAMVMSHRSGVIGPRTRMRWEQVADWDYVCEQLAAAEPWWEPGTAQ
GYHMTTFGFIMGEVFRRVTGRTIGHYLRTEIAGPFGADVHIGLPLAEQHRCAERVNKPHARDLLADANAPTDPRSLAEHP
KAGLSISMGFAPDDELGSHDLNLWRELEFPGTNGQVSALGLATFYNALAQEKLLSREHMDRVRVCQGGLDTDLVLGPRVA
DHGWGLGYMLNQRCVNGPNPRIFGHGGLGGSFGFVDLEHRIGYAYVMNRFDATKANADPRSLALSNEVYSVLGVR

Specific function: This Protein Is A Serine Beta-Lactamase With A Substrate Specificity For Cephalosporins. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Caenorhabditis elegans, GI71983659, Length=386, Percent_Identity=33.6787564766839, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17538001, Length=374, Percent_Identity=34.7593582887701, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI71983666, Length=316, Percent_Identity=35.126582278481, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535191, Length=403, Percent_Identity=31.0173697270471, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17535177, Length=377, Percent_Identity=30.5039787798408, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17538474, Length=403, Percent_Identity=29.7766749379653, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71990590, Length=402, Percent_Identity=26.1194029850746, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 43341; Mature: 43210

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLKTDAPIHGSCAPDFVGVRDAFERNFTHGGEVGAAVAVWVDGSLVVNLWGGWADAAR
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEEECCCHHHHHH
TRPWQQNTLTTVLSGTKGLSATCVHQLADRGQLDLQAPVARYWPEFAQAGKQDITLAMVM
CCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHCHHHHHCCCCCEEEEEEE
SHRSGVIGPRTRMRWEQVADWDYVCEQLAAAEPWWEPGTAQGYHMTTFGFIMGEVFRRVT
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GRTIGHYLRTEIAGPFGADVHIGLPLAEQHRCAERVNKPHARDLLADANAPTDPRSLAEH
HHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHC
PKAGLSISMGFAPDDELGSHDLNLWRELEFPGTNGQVSALGLATFYNALAQEKLLSREHM
CCCCCEEEECCCCCCCCCCCCCCHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DRVRVCQGGLDTDLVLGPRVADHGWGLGYMLNQRCVNGPNPRIFGHGGLGGSFGFVDLEH
HHHHHHCCCCCCCEEECCEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEHHH
RIGYAYVMNRFDATKANADPRSLALSNEVYSVLGVR
HCCHHHHHHHHHCCCCCCCHHHEEHHHHHHHHHCCC
>Mature Secondary Structure 
SDLKTDAPIHGSCAPDFVGVRDAFERNFTHGGEVGAAVAVWVDGSLVVNLWGGWADAAR
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEEECCCHHHHHH
TRPWQQNTLTTVLSGTKGLSATCVHQLADRGQLDLQAPVARYWPEFAQAGKQDITLAMVM
CCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHCHHHHHCCCCCEEEEEEE
SHRSGVIGPRTRMRWEQVADWDYVCEQLAAAEPWWEPGTAQGYHMTTFGFIMGEVFRRVT
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GRTIGHYLRTEIAGPFGADVHIGLPLAEQHRCAERVNKPHARDLLADANAPTDPRSLAEH
HHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHC
PKAGLSISMGFAPDDELGSHDLNLWRELEFPGTNGQVSALGLATFYNALAQEKLLSREHM
CCCCCEEEECCCCCCCCCCCCCCHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DRVRVCQGGLDTDLVLGPRVADHGWGLGYMLNQRCVNGPNPRIFGHGGLGGSFGFVDLEH
HHHHHHCCCCCCCEEECCEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEHHH
RIGYAYVMNRFDATKANADPRSLALSNEVYSVLGVR
HCCHHHHHHHHHCCCCCCCHHHEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA