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The map label for this gene is leuD [H]

Identifier: 41408354

GI number: 41408354

Start: 2520729

End: 2521280

Strand: Direct

Name: leuD [H]

Synonym: MAP2256

Alternate gene names: 41408354

Gene position: 2520729-2521280 (Clockwise)

Preceding gene: 41408353

Following gene: 41408355

Centisome position: 52.19

GC content: 69.2

Gene sequence:

>552_bases
ATGTTCCGCGGCAAGGTCTGGGTGTTCGGCGACAACCTGAACACCGACGCCATGTACCCGGCGTTCGCGATGAAGATGCA
GCCCGCCGAAGCCGCCAAACACGTGTTCTACCAGGTGCGGCCGGGCTGGACCGACGAGGTGTCGCCGGGCGATATCGTGC
TGGCCGGCAAGAACTTCGGGCTGGGTTCGTCGCGACCAGTGGCGGCGTTGTTCGTCGAACTCGGCGTCGCGGGGCTGGTC
GCCGAGGAATTCAACTCGCTGTTCTTCCGCAACGCCGTCAACTCCGGGCTGCCGGCCATCACCGTCCCCGACGCCACCGC
GGTGTTCCGCGACGGCGACACCGGCACCTTCGACCTCGCCGAGGGCAGCTGGCGCAACGACACCACCGGCGCCTCGGGCA
CCGTCCCGAAACTTCCCGACCTGATCCTCGACATCATCGACAGCGGCGGTGTGCTGCCCCGGCTTGCCCGGCAGGGATAC
CTGCCCGGCGAGCTGGCCGACCTGCTGCGCTCGCCCACGGTGGCGATGCGCGGCGCGGGCAGCGGCGCATGA

Upstream 100 bases:

>100_bases
CCGAAATCTTCATGGCCTCGCCGGCCACCGTCGCGGCGTCCGCGGTCGCCGGCTACATCACCGACCCGAGGAGTGTGACC
GCATGACGCTGCGCTCGCTA

Downstream 100 bases:

>100_bases
GCGCTCGACGCCGCCGTTGCCGACACCGCGCGCAACCCCGCTGACCTGCGGTTGGCAGTGTTTGGCAGCGTAGCGCGTCG
ATCTGGCAGTGGTGGGCGAG

Product: hypothetical protein

Products: NA

Alternate protein names: Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MFRGKVWVFGDNLNTDAMYPAFAMKMQPAEAAKHVFYQVRPGWTDEVSPGDIVLAGKNFGLGSSRPVAALFVELGVAGLV
AEEFNSLFFRNAVNSGLPAITVPDATAVFRDGDTGTFDLAEGSWRNDTTGASGTVPKLPDLILDIIDSGGVLPRLARQGY
LPGELADLLRSPTVAMRGAGSGA

Sequences:

>Translated_183_residues
MFRGKVWVFGDNLNTDAMYPAFAMKMQPAEAAKHVFYQVRPGWTDEVSPGDIVLAGKNFGLGSSRPVAALFVELGVAGLV
AEEFNSLFFRNAVNSGLPAITVPDATAVFRDGDTGTFDLAEGSWRNDTTGASGTVPKLPDLILDIIDSGGVLPRLARQGY
LPGELADLLRSPTVAMRGAGSGA
>Mature_183_residues
MFRGKVWVFGDNLNTDAMYPAFAMKMQPAEAAKHVFYQVRPGWTDEVSPGDIVLAGKNFGLGSSRPVAALFVELGVAGLV
AEEFNSLFFRNAVNSGLPAITVPDATAVFRDGDTGTFDLAEGSWRNDTTGASGTVPKLPDLILDIIDSGGVLPRLARQGY
LPGELADLLRSPTVAMRGAGSGA

Specific function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate [H]

COG id: COG0066

COG function: function code E; 3-isopropylmalate dehydratase small subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the leuD family. LeuD type 2 subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012305
- InterPro:   IPR015937
- InterPro:   IPR015928
- InterPro:   IPR000573
- InterPro:   IPR011827 [H]

Pfam domain/function: PF00694 Aconitase_C [H]

EC number: =4.2.1.33 [H]

Molecular weight: Translated: 19319; Mature: 19319

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRGKVWVFGDNLNTDAMYPAFAMKMQPAEAAKHVFYQVRPGWTDEVSPGDIVLAGKNFG
CCCCEEEEECCCCCCCCCCCHHHEEECHHHHHHHEEEEECCCCCCCCCCCCEEEECCCCC
LGSSRPVAALFVELGVAGLVAEEFNSLFFRNAVNSGLPAITVPDATAVFRDGDTGTFDLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCEEECC
EGSWRNDTTGASGTVPKLPDLILDIIDSGGVLPRLARQGYLPGELADLLRSPTVAMRGAG
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHCCCCEEECCCC
SGA
CCC
>Mature Secondary Structure
MFRGKVWVFGDNLNTDAMYPAFAMKMQPAEAAKHVFYQVRPGWTDEVSPGDIVLAGKNFG
CCCCEEEEECCCCCCCCCCCHHHEEECHHHHHHHEEEEECCCCCCCCCCCCEEEECCCCC
LGSSRPVAALFVELGVAGLVAEEFNSLFFRNAVNSGLPAITVPDATAVFRDGDTGTFDLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCEEECC
EGSWRNDTTGASGTVPKLPDLILDIIDSGGVLPRLARQGYLPGELADLLRSPTVAMRGAG
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHCCCCEEECCCC
SGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA