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The map label for this gene is ilvG [H]

Identifier: 41407630

GI number: 41407630

Start: 1682950

End: 1683588

Strand: Direct

Name: ilvG [H]

Synonym: MAP1532

Alternate gene names: 41407630

Gene position: 1682950-1683588 (Clockwise)

Preceding gene: 41407628

Following gene: 41407631

Centisome position: 34.85

GC content: 75.27

Gene sequence:

>639_bases
ATGACCAGTGACGCCACCCCCGCACCGACCCTGCACGCCGGCCGGCTGGTCGCGCGCCGGCTGCGGGCCGGCGGTGTCGA
CACCGTCTTCACGCTGTCCGGCGGCCACCTGTTCTCCATCTACGACGGCTGCCGCGACGAAGGCATTCGGCTGATCGACA
CCCGGCACGAACAGACCGCGACGTTCGCCGCCGAGGGCTGGTCGAAGGTGACCCGGCTGCCCGGGGTGGCCGCGCTGACC
GCCGGACCCGGCGTCACCAACGGGATGAGCGCGATGGCCGCCGCGCAACAGAACTCCTCGCCGCTGGTGGTGCTGGGGGG
CCGGGCGCCGGCGCAGCGGTGGGGCATGGGTTCGCTGCAGGAGATCGACCACGTGCCGTTCGTGGCGCCGCTGGCCCGTT
TCGCCGCCACCGCGCAATCGGCCGCCGACGCCGGCCGGCTGGTCGACGACGCCTTGCGCGCGGCCGTCGGTGCCCCGTCC
GGCGTGGGCTTCGTGGACTTCCCGATGGACCACGTGTTCTCCATGGCCGCGGACGACGGCCGCCCCGGGGCGCTCATCGA
CCTGCCGCGCGAACCCGAACCCGACGGCGCCGCGCTGGGCCGGGCCGCCGGCCTGCTGTCCGGCGCGAAGCGGCGGTGA

Upstream 100 bases:

>100_bases
CACCCATCGTCGGCGTCTCCTTACGGTCGAGGTGGTCGGACTCTCCTCAACTTGAAATCCTTCGGCGAAGGTACCGGACG
GATCTGGATAGGCTGCGGTG

Downstream 100 bases:

>100_bases
TCATGGCGGGCACCAACGTCTGGTGGGGGCATGGGGAAGCGGCTCTGCTGCGGCTGGCCGAGGAACTGGCCATCCCGGTG
CTGATGAACGGGATGGCGCG

Product: hypothetical protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MTSDATPAPTLHAGRLVARRLRAGGVDTVFTLSGGHLFSIYDGCRDEGIRLIDTRHEQTATFAAEGWSKVTRLPGVAALT
AGPGVTNGMSAMAAAQQNSSPLVVLGGRAPAQRWGMGSLQEIDHVPFVAPLARFAATAQSAADAGRLVDDALRAAVGAPS
GVGFVDFPMDHVFSMAADDGRPGALIDLPREPEPDGAALGRAAGLLSGAKRR

Sequences:

>Translated_212_residues
MTSDATPAPTLHAGRLVARRLRAGGVDTVFTLSGGHLFSIYDGCRDEGIRLIDTRHEQTATFAAEGWSKVTRLPGVAALT
AGPGVTNGMSAMAAAQQNSSPLVVLGGRAPAQRWGMGSLQEIDHVPFVAPLARFAATAQSAADAGRLVDDALRAAVGAPS
GVGFVDFPMDHVFSMAADDGRPGALIDLPREPEPDGAALGRAAGLLSGAKRR
>Mature_211_residues
TSDATPAPTLHAGRLVARRLRAGGVDTVFTLSGGHLFSIYDGCRDEGIRLIDTRHEQTATFAAEGWSKVTRLPGVAALTA
GPGVTNGMSAMAAAQQNSSPLVVLGGRAPAQRWGMGSLQEIDHVPFVAPLARFAATAQSAADAGRLVDDALRAAVGAPSG
VGFVDFPMDHVFSMAADDGRPGALIDLPREPEPDGAALGRAAGLLSGAKRR

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=162, Percent_Identity=40.1234567901235, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI93004078, Length=158, Percent_Identity=29.746835443038, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI87081685, Length=161, Percent_Identity=33.5403726708075, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1790104, Length=157, Percent_Identity=29.9363057324841, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788716, Length=206, Percent_Identity=28.1553398058252, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786717, Length=194, Percent_Identity=28.3505154639175, Blast_Score=67, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17542570, Length=162, Percent_Identity=41.358024691358, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323755, Length=161, Percent_Identity=29.8136645962733, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320816, Length=208, Percent_Identity=25.4807692307692, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922626, Length=203, Percent_Identity=33.0049261083744, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 21807; Mature: 21676

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDATPAPTLHAGRLVARRLRAGGVDTVFTLSGGHLFSIYDGCRDEGIRLIDTRHEQTA
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCCCCEEEEECCCHHHH
TFAAEGWSKVTRLPGVAALTAGPGVTNGMSAMAAAQQNSSPLVVLGGRAPAQRWGMGSLQ
HHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHCCCCCHH
EIDHVPFVAPLARFAATAQSAADAGRLVDDALRAAVGAPSGVGFVDFPMDHVFSMAADDG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCC
RPGALIDLPREPEPDGAALGRAAGLLSGAKRR
CCCCEEECCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSDATPAPTLHAGRLVARRLRAGGVDTVFTLSGGHLFSIYDGCRDEGIRLIDTRHEQTA
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCCCCEEEEECCCHHHH
TFAAEGWSKVTRLPGVAALTAGPGVTNGMSAMAAAQQNSSPLVVLGGRAPAQRWGMGSLQ
HHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHCCCCCHH
EIDHVPFVAPLARFAATAQSAADAGRLVDDALRAAVGAPSGVGFVDFPMDHVFSMAADDG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCC
RPGALIDLPREPEPDGAALGRAAGLLSGAKRR
CCCCEEECCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]