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The map label for this gene is pyrG

Identifier: 41407504

GI number: 41407504

Start: 1519109

End: 1520860

Strand: Direct

Name: pyrG

Synonym: MAP1406

Alternate gene names: 41407504

Gene position: 1519109-1520860 (Clockwise)

Preceding gene: 41407503

Following gene: 41407505

Centisome position: 31.45

GC content: 67.41

Gene sequence:

>1752_bases
GTGCGAAAGCACCCGCAAACCGCCACCAAGCACCTCTTCGTCAGCGGGGGCGTCGCATCCTCGTTGGGCAAGGGATTGAC
CGCCAGCAGCCTCGGTCAGCTACTGACGGCGCGCGGGTTGTACGTGACGATGCAAAAGCTCGATCCGTACCTCAACGTCG
ACCCCGGCACCATGAACCCGTTCCAGCACGGCGAGGTCTTCGTCACCGAGGACGGCGCCGAAACCGACCTCGACGTCGGC
CATTACGAGCGGTTCCTGGATCGCGATCTGTCCGGTTCGGCGAATGTCACTACGGGACAGGTGTATTCGACCGTCATCGC
CAAGGAACGGCGCGGTGAATACCTGGGCGACACCGTCCAGGTGATCCCGCACATCACCGACGAGATCAAGGGCCGCATCC
TGGCGATGGCCCAGCCGGACGCGCAGGGCAACCGCCCCGACGTCGTCATCACCGAAATCGGCGGCACCGTCGGCGACATC
GAGTCGCAGCCCTTCCTGGAGGCGGCCCGGCAGGTGCGCCACGACCTGGGCCGGGAAAACGTCTTCTTCCTGCACGTGTC
GCTGGTGCCCTACCTGGCACCGTCCGGTGAGCTCAAGACCAAACCCACCCAGCACTCGGTCGCCGCGCTGCGCAGCATCG
GTATCACCCCCGACGCGCTGATCCTGCGCTGCGACCGCGACGTGCCCGAGGCGCTGAAGAACAAGATCGCGCTGATGTGC
GACGTGGACATCGACGGCGTCATCTCCACCCCGGACGCGCCGTCCATCTACGACATTCCCAAGGTGCTGCACCGCGAGGA
GCTCGACGCCTACGTGGTGCGCCGGCTCAACCTGCCGTTCCGCGATGTCGACTGGACCGAATGGGACGACCTGCTGCGCC
GGGTGCACGAACCGCACGAGACGGTGCGAATCGCCTTGGTGGGCAAGTACGTTGAGCTTTCCGACGCCTACCTGTCGGTC
ACCGAGGCATTGCGTGCCGGCGGGTTCTTCCACCACGCCAAGGTCGAGATGGTGTGGGTGGCCTCCGACGACTGCGAGAG
CGCGTCCGGTGCCGCGGCGGCGCTGGGGGAGGTGCACGGCGTGCTGATCCCCGGCGGGTTCGGCATCCGCGGCATCGAGG
GCAAGATCGGGGCCATCCACTACGCCCGCACCCGCGGGCTGCCGGTGCTGGGGCTGTGCCTGGGCCTGCAATGCATTGTG
ATCGAGGCCGCCCGCGCGGCCGGCCTGGCCGGCGCCAACTCGGCCGAATTCGACCCGGACACACCGGATCCCGTCATCTC
CACGATGGCCGACCAGGTGGACATCGTCGCCGGCGCGGCCGACCTGGGCGGCACCATGCGACTGGGCGCCTATCCCGCTG
TGCTGGAAGAGGATTCGATCGTGGCCCGGGCCTACGGGACGACGCAGGTGTCGGAGCGGCACCGGCACCGCTACGAGGTC
AACAACGCCTACCGCGACAAGATCGCCGAAAGCGGCCTGAGGTTCTCCGGAACATCGCCCGACGGCCATCTGGTGGAGTT
CGTCGAATACCCGCCCGACGTGCACCCGTTCATCGTGGGCACCCAGGCCCACCCGGAGCTGAAGAGCCGGCCCACCCGTC
CGCACCCGTTGTTCGTCGCATTCGTCGGGGCGGCCATGGATTACAAAGCGGGAGAACTGCTTCCGGTGGAAATCCCCGAG
CAGTCCTCCAACGGCATCCAGCATCGGGACAGCGCTGCGCGGCCCATACCTGAGCCCGCGGCCCGTGGCTGA

Upstream 100 bases:

>100_bases
GCGCCGTGGATGTTAGGGTGGGTTTCCGTGGGTCGGCAGGCCCAGCTAGTGATTCGCTAGAACAATTTTGACGCCCTGCC
CGTCTTCACGGAGGTCGCCT

Downstream 100 bases:

>100_bases
ACACGTCTTCGAGACGGCGTCATCCGAAACGCTGTACACCGGAAAGATTTTCGCGCTACGCCGCGACCAGGTCCGGATGC
CGGGCGGCAAGGTCGTCACC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLYVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVG
HYERFLDRDLSGSANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITDEIKGRILAMAQPDAQGNRPDVVITEIGGTVGDI
ESQPFLEAARQVRHDLGRENVFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMC
DVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTEWDDLLRRVHEPHETVRIALVGKYVELSDAYLSV
TEALRAGGFFHHAKVEMVWVASDDCESASGAAAALGEVHGVLIPGGFGIRGIEGKIGAIHYARTRGLPVLGLCLGLQCIV
IEAARAAGLAGANSAEFDPDTPDPVISTMADQVDIVAGAADLGGTMRLGAYPAVLEEDSIVARAYGTTQVSERHRHRYEV
NNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDVHPFIVGTQAHPELKSRPTRPHPLFVAFVGAAMDYKAGELLPVEIPE
QSSNGIQHRDSAARPIPEPAARG

Sequences:

>Translated_583_residues
MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLYVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVG
HYERFLDRDLSGSANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITDEIKGRILAMAQPDAQGNRPDVVITEIGGTVGDI
ESQPFLEAARQVRHDLGRENVFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMC
DVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTEWDDLLRRVHEPHETVRIALVGKYVELSDAYLSV
TEALRAGGFFHHAKVEMVWVASDDCESASGAAAALGEVHGVLIPGGFGIRGIEGKIGAIHYARTRGLPVLGLCLGLQCIV
IEAARAAGLAGANSAEFDPDTPDPVISTMADQVDIVAGAADLGGTMRLGAYPAVLEEDSIVARAYGTTQVSERHRHRYEV
NNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDVHPFIVGTQAHPELKSRPTRPHPLFVAFVGAAMDYKAGELLPVEIPE
QSSNGIQHRDSAARPIPEPAARG
>Mature_583_residues
MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLYVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVG
HYERFLDRDLSGSANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITDEIKGRILAMAQPDAQGNRPDVVITEIGGTVGDI
ESQPFLEAARQVRHDLGRENVFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMC
DVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTEWDDLLRRVHEPHETVRIALVGKYVELSDAYLSV
TEALRAGGFFHHAKVEMVWVASDDCESASGAAAALGEVHGVLIPGGFGIRGIEGKIGAIHYARTRGLPVLGLCLGLQCIV
IEAARAAGLAGANSAEFDPDTPDPVISTMADQVDIVAGAADLGGTMRLGAYPAVLEEDSIVARAYGTTQVSERHRHRYEV
NNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDVHPFIVGTQAHPELKSRPTRPHPLFVAFVGAAMDYKAGELLPVEIPE
QSSNGIQHRDSAARPIPEPAARG

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=554, Percent_Identity=44.4043321299639, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI28559085, Length=553, Percent_Identity=43.3996383363472, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI28559083, Length=553, Percent_Identity=43.3996383363472, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI221316689, Length=553, Percent_Identity=43.3996383363472, Blast_Score=455, Evalue=1e-128,
Organism=Escherichia coli, GI1789142, Length=549, Percent_Identity=51.183970856102, Blast_Score=528, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI25148299, Length=608, Percent_Identity=37.0065789473684, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6322563, Length=565, Percent_Identity=42.8318584070797, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319432, Length=565, Percent_Identity=41.9469026548673, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24664469, Length=555, Percent_Identity=44.8648648648649, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI21357815, Length=500, Percent_Identity=43.8, Blast_Score=389, Evalue=1e-108,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 63143; Mature: 63143

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLYVTMQKLDPYLNVDPGTMNP
CCCCCCCHHHEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCEECCCCCCCC
FQHGEVFVTEDGAETDLDVGHYERFLDRDLSGSANVTTGQVYSTVIAKERRGEYLGDTVQ
CCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHH
VIPHITDEIKGRILAMAQPDAQGNRPDVVITEIGGTVGDIESQPFLEAARQVRHDLGREN
HHHHHHHHHCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCC
VFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMC
EEEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHCCEEEEE
DVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTEWDDLLRRVHEPHE
ECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCC
TVRIALVGKYVELSDAYLSVTEALRAGGFFHHAKVEMVWVASDDCESASGAAAALGEVHG
EEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCCCHHHHHHCCCE
VLIPGGFGIRGIEGKIGAIHYARTRGLPVLGLCLGLQCIVIEAARAAGLAGANSAEFDPD
EEECCCCCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHEEEHHHHHHCCCCCCCCCCCCC
TPDPVISTMADQVDIVAGAADLGGTMRLGAYPAVLEEDSIVARAYGTTQVSERHRHRYEV
CCCHHHHHHHHHHHEEECCHHCCCEEEECCCCCEECCCCEEEEECCCHHHHHHHHHHHHC
NNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDVHPFIVGTQAHPELKSRPTRPHPLFVA
CHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCCCCEEEECCCCCHHHCCCCCCCCEEEE
FVGAAMDYKAGELLPVEIPEQSSNGIQHRDSAARPIPEPAARG
EEHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLYVTMQKLDPYLNVDPGTMNP
CCCCCCCHHHEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCEECCCCCCCC
FQHGEVFVTEDGAETDLDVGHYERFLDRDLSGSANVTTGQVYSTVIAKERRGEYLGDTVQ
CCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHH
VIPHITDEIKGRILAMAQPDAQGNRPDVVITEIGGTVGDIESQPFLEAARQVRHDLGREN
HHHHHHHHHCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCC
VFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMC
EEEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHCCEEEEE
DVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTEWDDLLRRVHEPHE
ECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCC
TVRIALVGKYVELSDAYLSVTEALRAGGFFHHAKVEMVWVASDDCESASGAAAALGEVHG
EEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCCCHHHHHHCCCE
VLIPGGFGIRGIEGKIGAIHYARTRGLPVLGLCLGLQCIVIEAARAAGLAGANSAEFDPD
EEECCCCCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHEEEHHHHHHCCCCCCCCCCCCC
TPDPVISTMADQVDIVAGAADLGGTMRLGAYPAVLEEDSIVARAYGTTQVSERHRHRYEV
CCCHHHHHHHHHHHEEECCHHCCCEEEECCCCCEECCCCEEEEECCCHHHHHHHHHHHHC
NNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDVHPFIVGTQAHPELKSRPTRPHPLFVA
CHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCCCCEEEECCCCCHHHCCCCCCCCEEEE
FVGAAMDYKAGELLPVEIPEQSSNGIQHRDSAARPIPEPAARG
EEHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9415801; 12788972 [H]