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The map label for this gene is trpB

Identifier: 41407404

GI number: 41407404

Start: 1393571

End: 1394836

Strand: Direct

Name: trpB

Synonym: MAP1306

Alternate gene names: 41407404

Gene position: 1393571-1394836 (Clockwise)

Preceding gene: 41407403

Following gene: 41407405

Centisome position: 28.85

GC content: 68.01

Gene sequence:

>1266_bases
GTGGACATCTCCCCCCGGACCCGTCCGGACCTTCCGCTTCCGAGCGCAGCGATCGCCGAACCCACCCGTCATGAACCCGA
CGCCGGTGGGCATTTCGGCGTGTACGGCGGCCGTTACGTCGCGGAGGCGCTGATGGCCGTCATCGAAGAGGTCACCACCG
CCTACGAGAAGGAGCGCGTCAACCAGGATTTCCTGGACACGCTGGACTATCTGCAGGCGAACTACGCCGGGCGGCCGTCG
CCGTTGTACGAGGCCCCGCGGCTGTCCGAGCAGGCCGGCGCGCGGATCTTCCTCAAGCGAGAAGACTTGAACCACACCGG
TTCTCACAAGATCAACAACGTGCTCGGTCAGGCGTTGCTGGCCCAGCGGATGGGCAAGAAGCGGGTGATCGCCGAGACCG
GGGCCGGCCAGCACGGCGTGGCCACCGCCACGGCCTGCGCCCTGCTGGGCCTGGAATGCGTGATCTACATGGGTGCGGTG
GACACCGAGCGCCAGGCGCTCAACGTGGCGCGGATGCGCCTGCTGGGTGCGACGGTCGTCTCGGTGCAGAGCGGTTCGAA
AACGCTCAAGGACGCCATCAACGAAGCCTTCCGGGACTGGGTCACCAACGCCGACAACACCTTCTACTGCTTCGGCACCG
CGGCCGGGCCGCACCCCTTCCCGGCCATGGTCCGCGATTTCCAGCGCATCGTCGGGCTGGAGGCCCGCGCCCAGATCCAG
GCGCAGGCGGGCCGGCTGCCCGACGCGGTGGTGGCCTGCATCGGCGGCGGCTCCAACGCCATCGGGATCTTCCATCCGTT
CATCGACGACCCCGGCGTGCGGCTGGTGGGATTCGAGGCGGCCGGTGACGGCGTCGAAACCGGAAGGCACGCCGCGACTT
TCAGCGGCGGCTCGCCCGGGGCGTTCCAGGGGTCGTTCTCCTACCTGCTGCAGGACGAAGACGGGCAGACCATCGAATCC
CATTCCATCTCAGCGGGTCTCGACTATCCCGGAGTCGGTCCAGAACATGCGTATCTGCGCGAGACCGGCCGTGCCGAATA
CCGTCCGATCACCGACGCCGAGGCGATGGAAGCGTTTCGGGTGCTGTGCCGCACCGAGGGGATCATCCCGGCCATCGAGT
CCGCGCACGCCGTGGCGGGTGCGCTGAAGTTGGGGCCCGAGCTAGGTCGCGGCGCGATCATCGTGGTGAACCTGTCCGGG
CGCGGGGACAAGGACGTCGAGACGGCGGCAAAGTGGTTCGGGCTGTTGGGGTCCAGCGACCGATGA

Upstream 100 bases:

>100_bases
CCTGTCCGAAACCGGCTCGCTAACCGCTCACGTCAGTGAAGAGCCGCCCCGCCGAAACGTTGAACCCGATGAGCCATCCC
CGCGTAGAGCCCTGGTGACG

Downstream 100 bases:

>100_bases
CCGTCAAGCAGAGCCAGGCGAGCCGGCTGTCGCCGATCTTCGAGCCGTGCCGCGACGACGATCGGGCGGCGCTGATCGGT
TACCTGCCCACCGGCTACCC

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDISPRTRPDLPLPSAAIAEPTRHEPDAGGHFGVYGGRYVAEALMAVIEEVTTAYEKERVNQDFLDTLDYLQANYAGRPS
PLYEAPRLSEQAGARIFLKREDLNHTGSHKINNVLGQALLAQRMGKKRVIAETGAGQHGVATATACALLGLECVIYMGAV
DTERQALNVARMRLLGATVVSVQSGSKTLKDAINEAFRDWVTNADNTFYCFGTAAGPHPFPAMVRDFQRIVGLEARAQIQ
AQAGRLPDAVVACIGGGSNAIGIFHPFIDDPGVRLVGFEAAGDGVETGRHAATFSGGSPGAFQGSFSYLLQDEDGQTIES
HSISAGLDYPGVGPEHAYLRETGRAEYRPITDAEAMEAFRVLCRTEGIIPAIESAHAVAGALKLGPELGRGAIIVVNLSG
RGDKDVETAAKWFGLLGSSDR

Sequences:

>Translated_421_residues
MDISPRTRPDLPLPSAAIAEPTRHEPDAGGHFGVYGGRYVAEALMAVIEEVTTAYEKERVNQDFLDTLDYLQANYAGRPS
PLYEAPRLSEQAGARIFLKREDLNHTGSHKINNVLGQALLAQRMGKKRVIAETGAGQHGVATATACALLGLECVIYMGAV
DTERQALNVARMRLLGATVVSVQSGSKTLKDAINEAFRDWVTNADNTFYCFGTAAGPHPFPAMVRDFQRIVGLEARAQIQ
AQAGRLPDAVVACIGGGSNAIGIFHPFIDDPGVRLVGFEAAGDGVETGRHAATFSGGSPGAFQGSFSYLLQDEDGQTIES
HSISAGLDYPGVGPEHAYLRETGRAEYRPITDAEAMEAFRVLCRTEGIIPAIESAHAVAGALKLGPELGRGAIIVVNLSG
RGDKDVETAAKWFGLLGSSDR
>Mature_421_residues
MDISPRTRPDLPLPSAAIAEPTRHEPDAGGHFGVYGGRYVAEALMAVIEEVTTAYEKERVNQDFLDTLDYLQANYAGRPS
PLYEAPRLSEQAGARIFLKREDLNHTGSHKINNVLGQALLAQRMGKKRVIAETGAGQHGVATATACALLGLECVIYMGAV
DTERQALNVARMRLLGATVVSVQSGSKTLKDAINEAFRDWVTNADNTFYCFGTAAGPHPFPAMVRDFQRIVGLEARAQIQ
AQAGRLPDAVVACIGGGSNAIGIFHPFIDDPGVRLVGFEAAGDGVETGRHAATFSGGSPGAFQGSFSYLLQDEDGQTIES
HSISAGLDYPGVGPEHAYLRETGRAEYRPITDAEAMEAFRVLCRTEGIIPAIESAHAVAGALKLGPELGRGAIIVVNLSG
RGDKDVETAAKWFGLLGSSDR

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine [H]

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family [H]

Homologues:

Organism=Escherichia coli, GI1787515, Length=379, Percent_Identity=55.9366754617414, Blast_Score=426, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6321412, Length=388, Percent_Identity=56.4432989690722, Blast_Score=449, Evalue=1e-127,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 44805; Mature: 44805

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISPRTRPDLPLPSAAIAEPTRHEPDAGGHFGVYGGRYVAEALMAVIEEVTTAYEKERV
CCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NQDFLDTLDYLQANYAGRPSPLYEAPRLSEQAGARIFLKREDLNHTGSHKINNVLGQALL
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCEEEEEECCCCCCCCHHHHHHHHHHHH
AQRMGKKRVIAETGAGQHGVATATACALLGLECVIYMGAVDTERQALNVARMRLLGATVV
HHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHE
SVQSGSKTLKDAINEAFRDWVTNADNTFYCFGTAAGPHPFPAMVRDFQRIVGLEARAQIQ
EECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHH
AQAGRLPDAVVACIGGGSNAIGIFHPFIDDPGVRLVGFEAAGDGVETGRHAATFSGGSPG
HHHCCCCHHHEEEECCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCC
AFQGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAYLRETGRAEYRPITDAEAMEAFR
CCCCCEEEEEECCCCCEEHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHH
VLCRTEGIIPAIESAHAVAGALKLGPELGRGAIIVVNLSGRGDKDVETAAKWFGLLGSSD
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCC
R
C
>Mature Secondary Structure
MDISPRTRPDLPLPSAAIAEPTRHEPDAGGHFGVYGGRYVAEALMAVIEEVTTAYEKERV
CCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NQDFLDTLDYLQANYAGRPSPLYEAPRLSEQAGARIFLKREDLNHTGSHKINNVLGQALL
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCEEEEEECCCCCCCCHHHHHHHHHHHH
AQRMGKKRVIAETGAGQHGVATATACALLGLECVIYMGAVDTERQALNVARMRLLGATVV
HHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHE
SVQSGSKTLKDAINEAFRDWVTNADNTFYCFGTAAGPHPFPAMVRDFQRIVGLEARAQIQ
EECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHH
AQAGRLPDAVVACIGGGSNAIGIFHPFIDDPGVRLVGFEAAGDGVETGRHAATFSGGSPG
HHHCCCCHHHEEEECCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCC
AFQGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAYLRETGRAEYRPITDAEAMEAFR
CCCCCEEEEEECCCCCEEHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHH
VLCRTEGIIPAIESAHAVAGALKLGPELGRGAIIVVNLSGRGDKDVETAAKWFGLLGSSD
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA