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The map label for this gene is trpC

Identifier: 41407403

GI number: 41407403

Start: 1392675

End: 1393493

Strand: Direct

Name: trpC

Synonym: MAP1305

Alternate gene names: 41407403

Gene position: 1392675-1393493 (Clockwise)

Preceding gene: 41407402

Following gene: 41407404

Centisome position: 28.84

GC content: 70.21

Gene sequence:

>819_bases
ATGAGTCCGGCTACCGTGCTTGACTCCATCCTCGAAGGAGTCCGGGCCGACGTTGCCGCGCGCGAAGCCCTGATCAGCCT
GTCGGAGATCAAAGCCGCCGCGGCCGCCGCGCCACCGCCACTCGACGTGATGGCCGCGTTGCGCGAGCCCGGAATCGGCG
TCATCGCCGAAGTCAAGCGCGCCAGCCCGTCGGCGGGTTCCCTGGCGACCATTGCCGATCCGGCCAAACTGGCACGCGCC
TACGAAGACGGCGGCGCCCGCATCATCAGCGTGTTGACCGAGGAGCGACGCTTCCACGGCTCGCTCGACGACCTCGACGC
GGTCCGGGCCGCGGTCTCCATCCCGGTGCTGCGCAAAGACTTTGTGGTGCAGCCGTATCAGATCCACGAGGCGCGTGCGC
ACGGCGCCGACATGCTGCTGCTCATCGTGGCCGCGCTGGAGCAGTCGGCGCTGGTGTCGATGCTGGACCGCACCGAATCG
CTGGGCATGACCGCGCTCGTCGAGGTGCACACCGAGGAAGAAGCCGACCGGGCGCTGCGGGCTGGCGCCAAGGTGATCGG
CGTCAACGCCCGCGATCTGGCGACGCTGGAGGTGGACCGGGATTGCTTCGCCCGCATCGCTCCAGGCCTGCCCAGCAACG
TGATCCGGATCGCCGAGTCCGGCGTGCGCGGCACCGGTGACCTGCTGGCGTATGCCGGCGCGGGCGCCGACGCCGTCCTG
GTGGGCGAGGGCCTGGTGAAAAGCGGTGACCCGCGCGCCGCGGTCGCCGACCTGGTTACCGCGGGCACCCATCCGTCCTG
TCCGAAACCGGCTCGCTAA

Upstream 100 bases:

>100_bases
GCGGGCCGCTACCCTTCATTGACGTCGTCGCAATCGGCTGGGGAACAACGAAGTGGCCGTGGGATGACGGCGGGCGACAG
GGCGAAGGGAAACGACAGGC

Downstream 100 bases:

>100_bases
CCGCTCACGTCAGTGAAGAGCCGCCCCGCCGAAACGTTGAACCCGATGAGCCATCCCCGCGTAGAGCCCTGGTGACGGTG
GACATCTCCCCCCGGACCCG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSPATVLDSILEGVRADVAAREALISLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGSLATIADPAKLARA
YEDGGARIISVLTEERRFHGSLDDLDAVRAAVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSALVSMLDRTES
LGMTALVEVHTEEEADRALRAGAKVIGVNARDLATLEVDRDCFARIAPGLPSNVIRIAESGVRGTGDLLAYAGAGADAVL
VGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR

Sequences:

>Translated_272_residues
MSPATVLDSILEGVRADVAAREALISLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGSLATIADPAKLARA
YEDGGARIISVLTEERRFHGSLDDLDAVRAAVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSALVSMLDRTES
LGMTALVEVHTEEEADRALRAGAKVIGVNARDLATLEVDRDCFARIAPGLPSNVIRIAESGVRGTGDLLAYAGAGADAVL
VGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR
>Mature_271_residues
SPATVLDSILEGVRADVAAREALISLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGSLATIADPAKLARAY
EDGGARIISVLTEERRFHGSLDDLDAVRAAVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSALVSMLDRTESL
GMTALVEVHTEEEADRALRAGAKVIGVNARDLATLEVDRDCFARIAPGLPSNVIRIAESGVRGTGDLLAYAGAGADAVLV
GEGLVKSGDPRAAVADLVTAGTHPSCPKPAR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=218, Percent_Identity=38.0733944954128, Blast_Score=131, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6322638, Length=272, Percent_Identity=38.9705882352941, Blast_Score=162, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_MYCA1 (A0QHH0)

Other databases:

- EMBL:   CP000479
- RefSeq:   YP_882358.1
- ProteinModelPortal:   A0QHH0
- SMR:   A0QHH0
- STRING:   A0QHH0
- EnsemblBacteria:   EBMYCT00000009630
- GeneID:   4527075
- GenomeReviews:   CP000479_GR
- KEGG:   mav:MAV_3175
- TIGR:   MAV_3175
- eggNOG:   COG0134
- GeneTree:   EBGT00050000017090
- HOGENOM:   HBG540956
- OMA:   VICEVKR
- ProtClustDB:   PRK00278
- BioCyc:   MAVI243243:MAV_3175-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28126; Mature: 27994

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPATVLDSILEGVRADVAAREALISLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHH
ASPSAGSLATIADPAKLARAYEDGGARIISVLTEERRFHGSLDDLDAVRAAVSIPVLRKD
CCCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHH
FVVQPYQIHEARAHGADMLLLIVAALEQSALVSMLDRTESLGMTALVEVHTEEEADRALR
HCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHH
AGAKVIGVNARDLATLEVDRDCFARIAPGLPSNVIRIAESGVRGTGDLLAYAGAGADAVL
CCCEEEECCCCCEEEEEECHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHEECCCCCCEEE
VGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR
ECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SPATVLDSILEGVRADVAAREALISLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHH
ASPSAGSLATIADPAKLARAYEDGGARIISVLTEERRFHGSLDDLDAVRAAVSIPVLRKD
CCCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHH
FVVQPYQIHEARAHGADMLLLIVAALEQSALVSMLDRTESLGMTALVEVHTEEEADRALR
HCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHH
AGAKVIGVNARDLATLEVDRDCFARIAPGLPSNVIRIAESGVRGTGDLLAYAGAGADAVL
CCCEEEECCCCCEEEEEECHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHEECCCCCCEEE
VGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR
ECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA