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The map label for this gene is impA

Identifier: 41407396

GI number: 41407396

Start: 1386766

End: 1387566

Strand: Direct

Name: impA

Synonym: MAP1298

Alternate gene names: 41407396

Gene position: 1386766-1387566 (Clockwise)

Preceding gene: 41407395

Following gene: 41407397

Centisome position: 28.71

GC content: 72.53

Gene sequence:

>801_bases
ATGGACCTGGACGCGTTGGTGGCGCGGGCGTCGGCGATCCTCGACGACGCCTCGAAGCCCTTCCTCGCCGGTCACCGCGC
CGACTCCGCGGTCCGCAAGAAGGGCAACGACTTTGCCACGGACGTCGACCTCGCCATCGAGCGGCAGGTGGTCGCCGCGC
TGGTGGAGGCCACCGGGATCGGCGTGCACGGCGAGGAGTTCGGCGGTTCGGCCGTCGACTCGGAATGGGTGTGGGTGCTC
GACCCGGTGGACGGCACGTTCAACTACGCGGCCGGGTCCCCGATGGCCGGGATCCTGCTGGCCCTGCTGCACCACGGCGA
CCCGGTGGCCGGGCTGACCTGGTTGCCGTTCCTCGACCAGCGCTACACCGCGGTGACCGGCGGCCCGCTGCGCAAGAACG
AAATCCCGCGGCCGCCACTGACTTCCATCGACCTGGCCGACGCCCTGGTCGGGGCCGGATCGTTCAGCGCGGACGCCCGC
GGCCGGTTCCCGGGGCGCTACCGGATGGCGGTGCTGGAAAACCTCAGCCGGGTCTCGTCCCGGTTGCGCATGCACGGCTC
CACCGGCCTGGATCTGGCCTATGTCGCCGACGGGATATTGGGCGCGGCGGTCAGTTTCGGCGGGCACGTGTGGGACCACG
CCGCCGGGGTGGCGCTGGTGCGGGCCGCCGGCGGCGTGGTGACCGACCTGGCCGGGCGGCCGTGGACCCCGGCCTCGGAT
TCGGCGCTGGCCGCCGGACCCGGCGCGCACGCCGAGATCCTGGACATCCTGCGCAATATCGGCCGACCGGAGGACTACTG
A

Upstream 100 bases:

>100_bases
CACCGGCCGCGGGGTCGAGGGCGCCATCGTCGGCAAGGCCCTCTACGCCGGGCGATTCACCCTGCCCCAGGCGCTGGCCG
CGGTCGCGGAGTAACGCCGC

Downstream 100 bases:

>100_bases
GATGAGCCCGAACTCCACCGGCCTGGCGGTACGCGTGATCCCCTGCCTGGACGTCGACGACGGGCGGGTGGTCAAGGGCG
TCAACTTCGAAAACCTTAGG

Product: ImpA

Products: NA

Alternate protein names: I-1-Pase; IMPase; Inositol-1-phosphatase [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MDLDALVARASAILDDASKPFLAGHRADSAVRKKGNDFATDVDLAIERQVVAALVEATGIGVHGEEFGGSAVDSEWVWVL
DPVDGTFNYAAGSPMAGILLALLHHGDPVAGLTWLPFLDQRYTAVTGGPLRKNEIPRPPLTSIDLADALVGAGSFSADAR
GRFPGRYRMAVLENLSRVSSRLRMHGSTGLDLAYVADGILGAAVSFGGHVWDHAAGVALVRAAGGVVTDLAGRPWTPASD
SALAAGPGAHAEILDILRNIGRPEDY

Sequences:

>Translated_266_residues
MDLDALVARASAILDDASKPFLAGHRADSAVRKKGNDFATDVDLAIERQVVAALVEATGIGVHGEEFGGSAVDSEWVWVL
DPVDGTFNYAAGSPMAGILLALLHHGDPVAGLTWLPFLDQRYTAVTGGPLRKNEIPRPPLTSIDLADALVGAGSFSADAR
GRFPGRYRMAVLENLSRVSSRLRMHGSTGLDLAYVADGILGAAVSFGGHVWDHAAGVALVRAAGGVVTDLAGRPWTPASD
SALAAGPGAHAEILDILRNIGRPEDY
>Mature_266_residues
MDLDALVARASAILDDASKPFLAGHRADSAVRKKGNDFATDVDLAIERQVVAALVEATGIGVHGEEFGGSAVDSEWVWVL
DPVDGTFNYAAGSPMAGILLALLHHGDPVAGLTWLPFLDQRYTAVTGGPLRKNEIPRPPLTSIDLADALVGAGSFSADAR
GRFPGRYRMAVLENLSRVSSRLRMHGSTGLDLAYVADGILGAAVSFGGHVWDHAAGVALVRAAGGVVTDLAGRPWTPASD
SALAAGPGAHAEILDILRNIGRPEDY

Specific function: Catalyzes the dephosphorylation of inositol-1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788882, Length=208, Percent_Identity=31.7307692307692, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193202570, Length=224, Percent_Identity=30.3571428571429, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193202572, Length=223, Percent_Identity=29.5964125560538, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320493, Length=208, Percent_Identity=28.3653846153846, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357303, Length=259, Percent_Identity=30.1158301158301, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21357329, Length=272, Percent_Identity=29.7794117647059, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.25 [H]

Molecular weight: Translated: 27736; Mature: 27736

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLDALVARASAILDDASKPFLAGHRADSAVRKKGNDFATDVDLAIERQVVAALVEATGI
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
GVHGEEFGGSAVDSEWVWVLDPVDGTFNYAAGSPMAGILLALLHHGDPVAGLTWLPFLDQ
CCCCHHCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEHHHHHCC
RYTAVTGGPLRKNEIPRPPLTSIDLADALVGAGSFSADARGRFPGRYRMAVLENLSRVSS
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RLRMHGSTGLDLAYVADGILGAAVSFGGHVWDHAAGVALVRAAGGVVTDLAGRPWTPASD
HHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
SALAAGPGAHAEILDILRNIGRPEDY
CCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDLDALVARASAILDDASKPFLAGHRADSAVRKKGNDFATDVDLAIERQVVAALVEATGI
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
GVHGEEFGGSAVDSEWVWVLDPVDGTFNYAAGSPMAGILLALLHHGDPVAGLTWLPFLDQ
CCCCHHCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEHHHHHCC
RYTAVTGGPLRKNEIPRPPLTSIDLADALVGAGSFSADARGRFPGRYRMAVLENLSRVSS
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RLRMHGSTGLDLAYVADGILGAAVSFGGHVWDHAAGVALVRAAGGVVTDLAGRPWTPASD
HHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
SALAAGPGAHAEILDILRNIGRPEDY
CCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]