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The map label for this gene is hisA

Identifier: 41407395

GI number: 41407395

Start: 1386028

End: 1386759

Strand: Direct

Name: hisA

Synonym: MAP1297

Alternate gene names: 41407395

Gene position: 1386028-1386759 (Clockwise)

Preceding gene: 41407394

Following gene: 41407396

Centisome position: 28.7

GC content: 72.4

Gene sequence:

>732_bases
GTGTTGATCTTGTTGCCCGCGGTCGACGTGGTCGACGGCCGCGCCGTGCGTTTGGTGCAGGGCAAGGCGGGGAGTGAAAC
CGAATACGGCTCGGCGCTGGACGCCGCGCTGGGCTGGCAGCGCGACGGCGCGGAATGGATCCATCTGGTGGACCTGGACG
CGGCGTTCGGACGCGGGTCCAACCGCGAGCTGCTCGCCGAGGTGGTCGGCAAGCTGGACGTGCGGGTGGAGCTGTCCGGC
GGGATTCGCGACGACGATTCGCTGGCCGCGGCGCTGGCCACCGGCTGCGCCCGGGTGAACCTGGGCACCGCGGCGCTGGA
GAACCCGCAGTGGTGCGCCCGGGCGATCGGCGAGCACGGCGACAAGGTCGCCGTCGGGCTGGACGTCCAGATCATCGACG
GGCAGCACCGGCTGCGCGGCCGCGGCTGGGAAACCGATGGGGGCGACCTGTGGGAGGTGCTGGAACGCCTTGAGCGGCAA
GGCTGTTCGCGGTACGTGGTTACCGACGTCACCAAGGACGGCACGCTGGGCGGCCCGAACCTGGACCTGCTGGGCGCGGT
GGCCGACCGAACCGACGCCCCGGTGATCGCCTCCGGCGGGGTGTCCAGCCTGGACGACCTGCGTGCCATCGCCACGCTCA
CCGGCCGCGGGGTCGAGGGCGCCATCGTCGGCAAGGCCCTCTACGCCGGGCGATTCACCCTGCCCCAGGCGCTGGCCGCG
GTCGCGGAGTAA

Upstream 100 bases:

>100_bases
TGTCGGCCACGCAGTTTCACCCGGAGAAGAGCGGGGATGCCGGCGCGGCCGTGCTGCGCAATTGGATTGAGCGCCTGTGA
AAAGCAGCTCAGGAGGGAAT

Downstream 100 bases:

>100_bases
CGCCGCATGGACCTGGACGCGTTGGTGGCGCGGGCGTCGGCGATCCTCGACGACGCCTCGAAGCCCTTCCTCGCCGGTCA
CCGCGCCGACTCCGCGGTCC

Product: phosphoribosyl isomerase A

Products: NA

Alternate protein names: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; N-(5'-phosphoribosyl)anthranilate isomerase; PRAI; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLILLPAVDVVDGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGSNRELLAEVVGKLDVRVELSG
GIRDDDSLAAALATGCARVNLGTAALENPQWCARAIGEHGDKVAVGLDVQIIDGQHRLRGRGWETDGGDLWEVLERLERQ
GCSRYVVTDVTKDGTLGGPNLDLLGAVADRTDAPVIASGGVSSLDDLRAIATLTGRGVEGAIVGKALYAGRFTLPQALAA
VAE

Sequences:

>Translated_243_residues
MLILLPAVDVVDGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGSNRELLAEVVGKLDVRVELSG
GIRDDDSLAAALATGCARVNLGTAALENPQWCARAIGEHGDKVAVGLDVQIIDGQHRLRGRGWETDGGDLWEVLERLERQ
GCSRYVVTDVTKDGTLGGPNLDLLGAVADRTDAPVIASGGVSSLDDLRAIATLTGRGVEGAIVGKALYAGRFTLPQALAA
VAE
>Mature_243_residues
MLILLPAVDVVDGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGSNRELLAEVVGKLDVRVELSG
GIRDDDSLAAALATGCARVNLGTAALENPQWCARAIGEHGDKVAVGLDVQIIDGQHRLRGRGWETDGGDLWEVLERLERQ
GCSRYVVTDVTKDGTLGGPNLDLLGAVADRTDAPVIASGGVSSLDDLRAIATLTGRGVEGAIVGKALYAGRFTLPQALAA
VAE

Specific function: Involved in both the histidine and tryptophan biosynthetic pathways [H]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=245, Percent_Identity=35.1020408163265, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1788336, Length=239, Percent_Identity=23.0125523012552, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR010188
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16; =5.3.1.24 [H]

Molecular weight: Translated: 25402; Mature: 25402

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLILLPAVDVVDGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGS
CEEEEECCEECCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEECHHHCCCC
NRELLAEVVGKLDVRVELSGGIRDDDSLAAALATGCARVNLGTAALENPQWCARAIGEHG
CHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHEECCHHHCCCHHHHHHHHHCCC
DKVAVGLDVQIIDGQHRLRGRGWETDGGDLWEVLERLERQGCSRYVVTDVTKDGTLGGPN
CEEEEEEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
LDLLGAVADRTDAPVIASGGVSSLDDLRAIATLTGRGVEGAIVGKALYAGRFTLPQALAA
HHHEEHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEHHHHHCCCCCHHHHHHH
VAE
HCC
>Mature Secondary Structure
MLILLPAVDVVDGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGS
CEEEEECCEECCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEECHHHCCCC
NRELLAEVVGKLDVRVELSGGIRDDDSLAAALATGCARVNLGTAALENPQWCARAIGEHG
CHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHEECCHHHCCCHHHHHHHHHCCC
DKVAVGLDVQIIDGQHRLRGRGWETDGGDLWEVLERLERQGCSRYVVTDVTKDGTLGGPN
CEEEEEEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
LDLLGAVADRTDAPVIASGGVSSLDDLRAIATLTGRGVEGAIVGKALYAGRFTLPQALAA
HHHEEHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEHHHHHCCCCCHHHHHHH
VAE
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA