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The map label for this gene is hisB

Identifier: 41407393

GI number: 41407393

Start: 1384767

End: 1385390

Strand: Direct

Name: hisB

Synonym: MAP1295

Alternate gene names: 41407393

Gene position: 1384767-1385390 (Clockwise)

Preceding gene: 41407392

Following gene: 41407394

Centisome position: 28.67

GC content: 69.23

Gene sequence:

>624_bases
ATGACCGCCGTGCAAGCTGCCCGTCGCGCGCGAATCGAGCGCCGCACCAAGGAATCCGACATCGTCATCGAACTCGACTT
GGACGGCACCGGCCGGGTCGACGTGGAGACCGGTGTGCCGTTCTACGACCACATGCTCACCGCACTGGGCAGCCACGCCA
GCTTCGACCTGACCGTGCGCACCACGGGCGACGTCGAGATCGAGGCACACCACACCATCGAGGACACCGCCATCGCGCTG
GGCGCCGCGCTGGGCCAGGCGCTCGGCGACAAGCGGGGCATCCGCCGGTTCGGTGACGCCTTCATCCCGATGGACGAGAC
GCTGGCCCACGCCGCCGTCGACGTGTCCGGCCGGCCCTACTGCGTGCACAGCGGCGAGCCGGATCACCTGCAGCACAGCA
CGATCGCCGGCAGCTCGGTGCCCTACCACACCGTCATCAACCGGCACGTGTTCGAGTCGCTGGCGATGAACGCCCGCATC
GCGCTGCACGTGCGGGTGCTCTACGGGCGCGACCCGCACCACATCACCGAAGCGCAGTACAAGGCGGTGGCCCGTGCGCT
GCGTCAGGCCGTCGAGCCCGACCCGCGGGTGTCGGACGTGCCGTCCACCAAAGGTGTTCTGTGA

Upstream 100 bases:

>100_bases
CCCAACTCGCCGCCACCGAGCTGGCCCCCGTCAACGTAGGAGCGATCGCAAACGCAGCCGAGCCGCGCGCAGCGGGTCGC
GACCGTGTGTTAGGAGCCCC

Downstream 100 bases:

>100_bases
CAAGTAAATCGGTTGTTGTCCTCGACTACGGCTCGGGCAACCTGCGGTCGGCGCAGCGCGCGCTGGAGCGGGTCGGCGCC
TCGGTGCAGGTGACCGCCGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MTAVQAARRARIERRTKESDIVIELDLDGTGRVDVETGVPFYDHMLTALGSHASFDLTVRTTGDVEIEAHHTIEDTAIAL
GAALGQALGDKRGIRRFGDAFIPMDETLAHAAVDVSGRPYCVHSGEPDHLQHSTIAGSSVPYHTVINRHVFESLAMNARI
ALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSDVPSTKGVL

Sequences:

>Translated_207_residues
MTAVQAARRARIERRTKESDIVIELDLDGTGRVDVETGVPFYDHMLTALGSHASFDLTVRTTGDVEIEAHHTIEDTAIAL
GAALGQALGDKRGIRRFGDAFIPMDETLAHAAVDVSGRPYCVHSGEPDHLQHSTIAGSSVPYHTVINRHVFESLAMNARI
ALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSDVPSTKGVL
>Mature_206_residues
TAVQAARRARIERRTKESDIVIELDLDGTGRVDVETGVPFYDHMLTALGSHASFDLTVRTTGDVEIEAHHTIEDTAIALG
AALGQALGDKRGIRRFGDAFIPMDETLAHAAVDVSGRPYCVHSGEPDHLQHSTIAGSSVPYHTVINRHVFESLAMNARIA
LHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSDVPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=210, Percent_Identity=40.4761904761905, Blast_Score=148, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324776, Length=224, Percent_Identity=37.9464285714286, Blast_Score=148, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22584; Mature: 22453

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVQAARRARIERRTKESDIVIELDLDGTGRVDVETGVPFYDHMLTALGSHASFDLTVR
CCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEEE
TTGDVEIEAHHTIEDTAIALGAALGQALGDKRGIRRFGDAFIPMDETLAHAAVDVSGRPY
ECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCE
CVHSGEPDHLQHSTIAGSSVPYHTVINRHVFESLAMNARIALHVRVLYGRDPHHITEAQY
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHH
KAVARALRQAVEPDPRVSDVPSTKGVL
HHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAVQAARRARIERRTKESDIVIELDLDGTGRVDVETGVPFYDHMLTALGSHASFDLTVR
CHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEEE
TTGDVEIEAHHTIEDTAIALGAALGQALGDKRGIRRFGDAFIPMDETLAHAAVDVSGRPY
ECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCE
CVHSGEPDHLQHSTIAGSSVPYHTVINRHVFESLAMNARIALHVRVLYGRDPHHITEAQY
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHH
KAVARALRQAVEPDPRVSDVPSTKGVL
HHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]