Click here to switch to the map view.

The map label for this gene is mprA [H]

Identifier: 41407319

GI number: 41407319

Start: 1279052

End: 1279711

Strand: Direct

Name: mprA [H]

Synonym: MAP1221

Alternate gene names: 41407319

Gene position: 1279052-1279711 (Clockwise)

Preceding gene: 41407313

Following gene: 41407320

Centisome position: 26.48

GC content: 71.67

Gene sequence:

>660_bases
GTGCTGGTCGTCGAGGACTCCGAGACCATCCGCGAGATGGTCAGCGAGGCGCTCACCGAGGTCGGCTACCACACCGAGGC
CCGCCGCGACGGCGAGCGACTCGAAGAGCTGCTCGACGGCATCCGGCCCGACCTGGTGGTGCTCGACGTGATGCTGCCCG
GACGCGACGGGTTCGCGCTGATCGACGTGATCCGCGACTGGGGCGACATCGGCATCGTGCTGATCACCGCCCGCGACGGC
CTGCCGGACCGGCTGCGCGGCCTGGACGGCGGCGCCGACGACTACGTCATCAAGCCCTTCGAGCTGGCCGAGCTGGTGTC
GCGGGTGGGCGCGGTGCTGCGCCGGCGGGGACGGCTGCCGCAGGTGATCCAGGTCGGCGACGTCACGCTGGACCCCGGCG
CCGGAGTCGCCGCGCGCGGCGGTCACCGGCTGGACCTGACCGCCACCGAGCTGCGCGTGCTGACATTTCTGGTGGAGCAG
CGCGGCCGGATCGTCAGCGCCGGCCAGATCCTCAACGGGGTGTGGGGTTACGACGCCTACGACCCCAACCTGGTGCAGGT
TCACGTCAGCGGGCTGCGGCGCAAGCTCGAGGCACACGGCCCGCGGATCCTGCACACCGTCCGCGGCATCGGCTACCGCC
TACAACCCGAGCGGTCATGA

Upstream 100 bases:

>100_bases
CGACGCCTTCAGGTTGGTTTCAGCACCGGCGCCGACAATGGTGGCCATGACGGATTGTCTCCGCGGGGCGGCCGGCCAAT
TCACCGTCGGCACCCCGCGG

Downstream 100 bases:

>100_bases
CGCCGACGCCGTCGCTGCAACGCCGGGTGACGCTGGTGGTGCTGGCGCTGTTGACCGTGCTGCTGGTGGTGCTCGGCGTC
ACCATCGACGTCACGATGGG

Product: hypothetical protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MLVVEDSETIREMVSEALTEVGYHTEARRDGERLEELLDGIRPDLVVLDVMLPGRDGFALIDVIRDWGDIGIVLITARDG
LPDRLRGLDGGADDYVIKPFELAELVSRVGAVLRRRGRLPQVIQVGDVTLDPGAGVAARGGHRLDLTATELRVLTFLVEQ
RGRIVSAGQILNGVWGYDAYDPNLVQVHVSGLRRKLEAHGPRILHTVRGIGYRLQPERS

Sequences:

>Translated_219_residues
MLVVEDSETIREMVSEALTEVGYHTEARRDGERLEELLDGIRPDLVVLDVMLPGRDGFALIDVIRDWGDIGIVLITARDG
LPDRLRGLDGGADDYVIKPFELAELVSRVGAVLRRRGRLPQVIQVGDVTLDPGAGVAARGGHRLDLTATELRVLTFLVEQ
RGRIVSAGQILNGVWGYDAYDPNLVQVHVSGLRRKLEAHGPRILHTVRGIGYRLQPERS
>Mature_219_residues
MLVVEDSETIREMVSEALTEVGYHTEARRDGERLEELLDGIRPDLVVLDVMLPGRDGFALIDVIRDWGDIGIVLITARDG
LPDRLRGLDGGADDYVIKPFELAELVSRVGAVLRRRGRLPQVIQVGDVTLDPGAGVAARGGHRLDLTATELRVLTFLVEQ
RGRIVSAGQILNGVWGYDAYDPNLVQVHVSGLRRKLEAHGPRILHTVRGIGYRLQPERS

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=39.6396396396396, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=34.2465753424658, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=36.8181818181818, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=35.4260089686099, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=35.2941176470588, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=33.9366515837104, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=35.6223175965665, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1790552, Length=217, Percent_Identity=35.0230414746544, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=30.1369863013699, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=35.2678571428571, Blast_Score=100, Evalue=5e-23,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=32.5892857142857, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=34.2222222222222, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=27.7533039647577, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=27.8969957081545, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=33.9622641509434, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=31.3725490196078, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24181; Mature: 24181

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVVEDSETIREMVSEALTEVGYHTEARRDGERLEELLDGIRPDLVVLDVMLPGRDGFAL
CEEECCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHH
IDVIRDWGDIGIVLITARDGLPDRLRGLDGGADDYVIKPFELAELVSRVGAVLRRRGRLP
HHHHHCCCCEEEEEEEECCCCHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCC
QVIQVGDVTLDPGAGVAARGGHRLDLTATELRVLTFLVEQRGRIVSAGQILNGVWGYDAY
CEEEECCEEECCCCCEECCCCCEEECHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCC
DPNLVQVHVSGLRRKLEAHGPRILHTVRGIGYRLQPERS
CCCEEEEEHHHHHHHHHHCCCHHHHHHHCCCEEECCCCC
>Mature Secondary Structure
MLVVEDSETIREMVSEALTEVGYHTEARRDGERLEELLDGIRPDLVVLDVMLPGRDGFAL
CEEECCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHH
IDVIRDWGDIGIVLITARDGLPDRLRGLDGGADDYVIKPFELAELVSRVGAVLRRRGRLP
HHHHHCCCCEEEEEEEECCCCHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCC
QVIQVGDVTLDPGAGVAARGGHRLDLTATELRVLTFLVEQRGRIVSAGQILNGVWGYDAY
CEEEECCEEECCCCCEECCCCCEEECHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCC
DPNLVQVHVSGLRRKLEAHGPRILHTVRGIGYRLQPERS
CCCEEEEEHHHHHHHHHHCCCHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA