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The map label for this gene is hemH

Identifier: 41407309

GI number: 41407309

Start: 1272041

End: 1273051

Strand: Direct

Name: hemH

Synonym: MAP1211

Alternate gene names: 41407309

Gene position: 1272041-1273051 (Clockwise)

Preceding gene: 41407308

Following gene: 41407311

Centisome position: 26.34

GC content: 71.41

Gene sequence:

>1011_bases
ATGGATTTCGACGCCGTCCTGCTGCTGTCCTTCGGCGGGCCGGAAGGGCCCGAGCAGGTGCGGCCGTTCTTGGAGAACGT
CACCCGGGGCCGCGGCGTGCCGCCGGAACGTCTCGACCACGTCGCCGAGCACTACCTGCATTTCGGCGGGGTGTCACCGA
TCAACGGCATCAACCGCGCGCTGATCGAGCAGCTGCGGGCCGCCCAGGACCTGCCCGTCTACTTCGGCAACCGCAACTGG
GAGCCCTACGTCGAAGACACGGTGAAGGTCATGCGCGACAACGGGATTCGGCGTGCCGCGGTGTTCACCACCTCCGCCTG
GAGCGGCTACTCCAGCTGCACGCAGTACGTCGAGGACATCGCCCGGGCGCGCACCGCGGCCGGGACGGGCGCGCCCGAAC
TGGTCAAGCTGCGACCGTATTTCGACCATCCGCTGTTCGTGGAGATGTTCGCCGGCGCGATCGCCGACGCGGCGGCGAAG
GTACCCGCGGGGGCGCGTCTGGTGTTCACCGCGCATTCGGTCCCGGTGGCCGCGGACGAGCGCCTGGGGCCGCGACTGTA
CAGCCGCCAAGTCGCATATGCCGCAAGGCTTGTGGCGGCCGCCGCCGGGTACGCCGAGCACGACCTGGTGTGGCAGTCGC
GTTCCGGGCCACCCCAGGTCCGCTGGCTCGAACCCGACGTCGCCGACCATCTGCGCGCCCTGGCCGAATCCGGCACCCGG
GCCGTCATCGTCTGCCCGATCGGGTTCGTGGCCGACCACATCGAGGTGGTGTGGGACCTCGACGAGGAGCTGCGCGCGCA
GGCCGAGTCGGCGGGGATGCTGATGGCGCGCGCGTCGACGCCCAACGCCCAGCCGCGTTTCGCGCGGTTGGCGGCCGACC
TGATCGACGAATTGCGTTGCGGCCGAACGCCCGCCCGGGTGACCGGCCCCGACCCGGTGCCCGGTTGTCTGGCCAGCGTC
AACGGCGCGCCGTGCCGGCCGCCGCACTGCGCGGCCCAAGCTACCGGCTAG

Upstream 100 bases:

>100_bases
AAGACGGTGTGCGCGCTGCTGTCCGACTGGCTGCCGGCCACCACCGGCACCATCATCTACGCCGACGGCGGCGCCAGCAC
CCAATTGCTGTAGACGGGCA

Downstream 100 bases:

>100_bases
GACCTAATCGCCCCAGGCGGAATGCAGGATCGCGGTGACCGCCGCCATCCGCGCCGAACGCACCACCGCGGTGAGCGGCC
GCAGCGCATCGCCGGCGATG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MDFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPPERLDHVAEHYLHFGGVSPINGINRALIEQLRAAQDLPVYFGNRNW
EPYVEDTVKVMRDNGIRRAAVFTTSAWSGYSSCTQYVEDIARARTAAGTGAPELVKLRPYFDHPLFVEMFAGAIADAAAK
VPAGARLVFTAHSVPVAADERLGPRLYSRQVAYAARLVAAAAGYAEHDLVWQSRSGPPQVRWLEPDVADHLRALAESGTR
AVIVCPIGFVADHIEVVWDLDEELRAQAESAGMLMARASTPNAQPRFARLAADLIDELRCGRTPARVTGPDPVPGCLASV
NGAPCRPPHCAAQATG

Sequences:

>Translated_336_residues
MDFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPPERLDHVAEHYLHFGGVSPINGINRALIEQLRAAQDLPVYFGNRNW
EPYVEDTVKVMRDNGIRRAAVFTTSAWSGYSSCTQYVEDIARARTAAGTGAPELVKLRPYFDHPLFVEMFAGAIADAAAK
VPAGARLVFTAHSVPVAADERLGPRLYSRQVAYAARLVAAAAGYAEHDLVWQSRSGPPQVRWLEPDVADHLRALAESGTR
AVIVCPIGFVADHIEVVWDLDEELRAQAESAGMLMARASTPNAQPRFARLAADLIDELRCGRTPARVTGPDPVPGCLASV
NGAPCRPPHCAAQATG
>Mature_336_residues
MDFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPPERLDHVAEHYLHFGGVSPINGINRALIEQLRAAQDLPVYFGNRNW
EPYVEDTVKVMRDNGIRRAAVFTTSAWSGYSSCTQYVEDIARARTAAGTGAPELVKLRPYFDHPLFVEMFAGAIADAAAK
VPAGARLVFTAHSVPVAADERLGPRLYSRQVAYAARLVAAAAGYAEHDLVWQSRSGPPQVRWLEPDVADHLRALAESGTR
AVIVCPIGFVADHIEVVWDLDEELRAQAESAGMLMARASTPNAQPRFARLAADLIDELRCGRTPARVTGPDPVPGCLASV
NGAPCRPPHCAAQATG

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=275, Percent_Identity=28, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI60499025, Length=275, Percent_Identity=28, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17864156, Length=325, Percent_Identity=26.7692307692308, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45552018, Length=165, Percent_Identity=32.7272727272727, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36321; Mature: 36321

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPPERLDHVAEHYLHFGGVSPINGINRA
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
LIEQLRAAQDLPVYFGNRNWEPYVEDTVKVMRDNGIRRAAVFTTSAWSGYSSCTQYVEDI
HHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHH
ARARTAAGTGAPELVKLRPYFDHPLFVEMFAGAIADAAAKVPAGARLVFTAHSVPVAADE
HHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCH
RLGPRLYSRQVAYAARLVAAAAGYAEHDLVWQSRSGPPQVRWLEPDVADHLRALAESGTR
HCCHHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCCCCCEEEECCCHHHHHHHHHHCCCC
AVIVCPIGFVADHIEVVWDLDEELRAQAESAGMLMARASTPNAQPRFARLAADLIDELRC
EEEEECCHHHHHHHHHHCCCCHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHC
GRTPARVTGPDPVPGCLASVNGAPCRPPHCAAQATG
CCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPPERLDHVAEHYLHFGGVSPINGINRA
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
LIEQLRAAQDLPVYFGNRNWEPYVEDTVKVMRDNGIRRAAVFTTSAWSGYSSCTQYVEDI
HHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHH
ARARTAAGTGAPELVKLRPYFDHPLFVEMFAGAIADAAAKVPAGARLVFTAHSVPVAADE
HHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCH
RLGPRLYSRQVAYAARLVAAAAGYAEHDLVWQSRSGPPQVRWLEPDVADHLRALAESGTR
HCCHHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCCCCCEEEECCCHHHHHHHHHHCCCC
AVIVCPIGFVADHIEVVWDLDEELRAQAESAGMLMARASTPNAQPRFARLAADLIDELRC
EEEEECCHHHHHHHHHHCCCCHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHC
GRTPARVTGPDPVPGCLASVNGAPCRPPHCAAQATG
CCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA