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The map label for this gene is eno

Identifier: 41407088

GI number: 41407088

Start: 1031237

End: 1032526

Strand: Direct

Name: eno

Synonym: MAP0990

Alternate gene names: 41407088

Gene position: 1031237-1032526 (Clockwise)

Preceding gene: 41407087

Following gene: 41407089

Centisome position: 21.35

GC content: 69.84

Gene sequence:

>1290_bases
GTGCCGATTATCGAGCAGGTCGGGGCCCGCGAGATCCTCGACTCCCGCGGTAACCCGACAGTCGAGGTCGAGATCGCCCT
GACCGACGGAACGTTCGCCCGCGCGGCGGTGCCGTCCGGGGCGTCGACCGGTGAGCACGAGGCCGTCGAACTGCGCGACG
GCGGGGAGCGGTACGGCGGCAAGGGCGTGCAGAAGGCGGTGCAGGCCGTGCTGGACGAGATCGGCCCGGCGGTGATCGGG
CTGAACGCCGACGACCAGCGCCTGGTGGACCAGGCGCTGGTCGACCTGGACGGCACCCCGGACAAGTCGAGGCTGGGCGG
CAACGCGATCCTGGGCGTGTCGCTGGCCGTGGCCAAGGCGGCCGCCGATTCCGCGGAGTTGCCGCTGTTCCGCTACCTGG
GCGGGCCCAACGCGCACATCCTGCCGGTGCCGATGATGAACATCCTCAACGGCGGCGCGCACGCCGACACCGCCGTCGAC
ATCCAGGAGTTCATGGTCGCCCCGATCGGCGCGCCGAGTTTCGCCGAGGCGTTGCGCTGGGGTGCGGAGGTGTATCACTC
GCTGAAGTCGGTGCTGAAGAAGGAGGGCCTGAGCACCGGCCTGGGCGACGAGGGCGGCTTCGCCCCCGACGTGGCGGGCA
CCACCGCGGCGCTGGACCTGATCGGCCGGGCCATCGAATCGGCCGGCTTCAAACTCGGCACCGACGTGGCGCTGGCCCTC
GACGCGGCGGCCACCGAGTTCTACAGCGACGGCACCGGCTACAAGTTCGAGGGCAGCACCCGCACCGCCGAGCAGATGGC
CGAGTTCTACGCCGGGCTGCTCGGCGCGTATCCGTTGGTGTCCATCGAAGACCCGCTGTCCGAAGATGATTGGGACGGCT
GGGCGGCGCTGACCGCGTCGATCGGCGACCGGGTGCAGCTCGTCGGCGACGACGTCTTCGTCACCAATCCCGAACGCCTG
GAAGAGGGTATCGAGAAGGGCGTCGCAAATGCGTTGCTGGTCAAGGTGAATCAGATCGGCACGCTGACCGAGACGCTGGA
CGCCGTCGCGCTGGCCCACCACAGCGGCTACCGCACGATGATGAGCCACCGCAGCGGTGAAACCGAGGACACCACGATCG
CCGACCTGGCGGTGGCCGTCGGCAGTGGGCAGATCAAGACCGGAGCGCCGGCCCGCAGCGAGCGGGTGGCCAAGTACAAC
CAGCTGCTGCGGATCGAGGAGGCGCTCGGCGACGCCGCGCGTTACGCCGGCGACCTGGCCTTCCCGCGGTTCGCGTTGGA
GACCAGATAG

Upstream 100 bases:

>100_bases
GCGCGATTGGGCGACCGCTTACGCCAAAGGTCACCCGCTGTAGCAGGATGTATCGCTGACGACGAGTGCACGCACCGGCT
ACGGATACAAGGAGAACTCA

Downstream 100 bases:

>100_bases
CTTGCCCGCCAAGCCCGATCCGAAGCGCCGCTCCCCGGCATCGCGGCCGGGGAAAGCCGGCGATTCGGTTCGGCGCCGTC
GCGCGGCCAAGCCGTCGCAG

Product: phosphopyruvate hydratase

Products: NA

Alternate protein names: 2-phospho-D-glycerate hydro-lyase; 2-phosphoglycerate dehydratase

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MPIIEQVGAREILDSRGNPTVEVEIALTDGTFARAAVPSGASTGEHEAVELRDGGERYGGKGVQKAVQAVLDEIGPAVIG
LNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKAAADSAELPLFRYLGGPNAHILPVPMMNILNGGAHADTAVD
IQEFMVAPIGAPSFAEALRWGAEVYHSLKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLIGRAIESAGFKLGTDVALAL
DAAATEFYSDGTGYKFEGSTRTAEQMAEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTASIGDRVQLVGDDVFVTNPERL
EEGIEKGVANALLVKVNQIGTLTETLDAVALAHHSGYRTMMSHRSGETEDTTIADLAVAVGSGQIKTGAPARSERVAKYN
QLLRIEEALGDAARYAGDLAFPRFALETR

Sequences:

>Translated_429_residues
MPIIEQVGAREILDSRGNPTVEVEIALTDGTFARAAVPSGASTGEHEAVELRDGGERYGGKGVQKAVQAVLDEIGPAVIG
LNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKAAADSAELPLFRYLGGPNAHILPVPMMNILNGGAHADTAVD
IQEFMVAPIGAPSFAEALRWGAEVYHSLKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLIGRAIESAGFKLGTDVALAL
DAAATEFYSDGTGYKFEGSTRTAEQMAEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTASIGDRVQLVGDDVFVTNPERL
EEGIEKGVANALLVKVNQIGTLTETLDAVALAHHSGYRTMMSHRSGETEDTTIADLAVAVGSGQIKTGAPARSERVAKYN
QLLRIEEALGDAARYAGDLAFPRFALETR
>Mature_428_residues
PIIEQVGAREILDSRGNPTVEVEIALTDGTFARAAVPSGASTGEHEAVELRDGGERYGGKGVQKAVQAVLDEIGPAVIGL
NADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKAAADSAELPLFRYLGGPNAHILPVPMMNILNGGAHADTAVDI
QEFMVAPIGAPSFAEALRWGAEVYHSLKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLIGRAIESAGFKLGTDVALALD
AAATEFYSDGTGYKFEGSTRTAEQMAEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTASIGDRVQLVGDDVFVTNPERLE
EGIEKGVANALLVKVNQIGTLTETLDAVALAHHSGYRTMMSHRSGETEDTTIADLAVAVGSGQIKTGAPARSERVAKYNQ
LLRIEEALGDAARYAGDLAFPRFALETR

Specific function: Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis

COG id: COG0148

COG function: function code G; Enolase

Gene ontology:

Cell location: Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the bacterial ce

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enolase family

Homologues:

Organism=Homo sapiens, GI5803011, Length=428, Percent_Identity=53.9719626168224, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI301897477, Length=430, Percent_Identity=52.3255813953488, Blast_Score=427, Evalue=1e-120,
Organism=Homo sapiens, GI301897469, Length=430, Percent_Identity=52.3255813953488, Blast_Score=427, Evalue=1e-120,
Organism=Homo sapiens, GI4503571, Length=430, Percent_Identity=51.1627906976744, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI301897479, Length=428, Percent_Identity=48.1308411214953, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI169201331, Length=335, Percent_Identity=24.4776119402985, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI169201757, Length=335, Percent_Identity=24.4776119402985, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI239744207, Length=335, Percent_Identity=24.4776119402985, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI1789141, Length=425, Percent_Identity=55.7647058823529, Blast_Score=455, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17536383, Length=432, Percent_Identity=51.8518518518518, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71995829, Length=432, Percent_Identity=51.8518518518518, Blast_Score=413, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI32563855, Length=189, Percent_Identity=51.3227513227513, Blast_Score=197, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6321693, Length=432, Percent_Identity=52.7777777777778, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6323985, Length=431, Percent_Identity=51.0440835266821, Blast_Score=398, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6324974, Length=431, Percent_Identity=51.0440835266821, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6324969, Length=431, Percent_Identity=51.0440835266821, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321968, Length=432, Percent_Identity=51.8518518518518, Blast_Score=383, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24580918, Length=429, Percent_Identity=51.5151515151515, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24580916, Length=429, Percent_Identity=51.5151515151515, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24580920, Length=429, Percent_Identity=51.5151515151515, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24580914, Length=429, Percent_Identity=51.5151515151515, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI281360527, Length=429, Percent_Identity=51.5151515151515, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI17137654, Length=429, Percent_Identity=51.5151515151515, Blast_Score=403, Evalue=1e-112,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase,

Swissprot (AC and ID): ENO_MYCA1 (A0QBX4)

Other databases:

- EMBL:   CP000479
- RefSeq:   YP_880412.1
- ProteinModelPortal:   A0QBX4
- SMR:   A0QBX4
- STRING:   A0QBX4
- EnsemblBacteria:   EBMYCT00000009315
- GeneID:   4529347
- GenomeReviews:   CP000479_GR
- KEGG:   mav:MAV_1164
- TIGR:   MAV_1164
- eggNOG:   COG0148
- GeneTree:   EBGT00050000016239
- HOGENOM:   HBG726599
- OMA:   GSHADSN
- PhylomeDB:   A0QBX4
- ProtClustDB:   PRK00077
- BioCyc:   MAVI243243:MAV_1164-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_00318
- InterPro:   IPR000941
- InterPro:   IPR020810
- InterPro:   IPR020809
- InterPro:   IPR020811
- PIRSF:   PIRSF001400
- PRINTS:   PR00148
- TIGRFAMs:   TIGR01060

Pfam domain/function: PF00113 Enolase_C; PF03952 Enolase_N

EC number: =4.2.1.11

Molecular weight: Translated: 44874; Mature: 44743

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: PS00164 ENOLASE

Important sites: ACT_SITE 204-204 ACT_SITE 335-335 BINDING 154-154 BINDING 163-163 BINDING 283-283 BINDING 310-310 BINDING 335-335 BINDING 386-386

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIIEQVGAREILDSRGNPTVEVEIALTDGTFARAAVPSGASTGEHEAVELRDGGERYGG
CCCHHHCCHHHHHHCCCCCEEEEEEEEECCCCHHHCCCCCCCCCCCCEEEECCCCCCCCC
KGVQKAVQAVLDEIGPAVIGLNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKA
HHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHCCCCEEEHHHHHHHHH
AADSAELPLFRYLGGPNAHILPVPMMNILNGGAHADTAVDIQEFMVAPIGAPSFAEALRW
HCCCCCCCHHHHCCCCCCEEECCCHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
GAEVYHSLKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLIGRAIESAGFKLGTDVALAL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
DAAATEFYSDGTGYKFEGSTRTAEQMAEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTAS
HHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHH
IGDRVQLVGDDVFVTNPERLEEGIEKGVANALLVKVNQIGTLTETLDAVALAHHSGYRTM
CCCEEEEECCCEEECCHHHHHHHHHHHHHHHHEEEHHHHCHHHHHHHHHHHHHHCCHHHH
MSHRSGETEDTTIADLAVAVGSGQIKTGAPARSERVAKYNQLLRIEEALGDAARYAGDLA
HHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FPRFALETR
CCCHHCCCC
>Mature Secondary Structure 
PIIEQVGAREILDSRGNPTVEVEIALTDGTFARAAVPSGASTGEHEAVELRDGGERYGG
CCHHHCCHHHHHHCCCCCEEEEEEEEECCCCHHHCCCCCCCCCCCCEEEECCCCCCCCC
KGVQKAVQAVLDEIGPAVIGLNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKA
HHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHCCCCEEEHHHHHHHHH
AADSAELPLFRYLGGPNAHILPVPMMNILNGGAHADTAVDIQEFMVAPIGAPSFAEALRW
HCCCCCCCHHHHCCCCCCEEECCCHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
GAEVYHSLKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLIGRAIESAGFKLGTDVALAL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
DAAATEFYSDGTGYKFEGSTRTAEQMAEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTAS
HHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHH
IGDRVQLVGDDVFVTNPERLEEGIEKGVANALLVKVNQIGTLTETLDAVALAHHSGYRTM
CCCEEEEECCCEEECCHHHHHHHHHHHHHHHHEEEHHHHCHHHHHHHHHHHHHHCCHHHH
MSHRSGETEDTTIADLAVAVGSGQIKTGAPARSERVAKYNQLLRIEEALGDAARYAGDLA
HHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FPRFALETR
CCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA