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The map label for this gene is ksgA

Identifier: 41407073

GI number: 41407073

Start: 1013028

End: 1013984

Strand: Direct

Name: ksgA

Synonym: MAP0975

Alternate gene names: 41407073

Gene position: 1013028-1013984 (Clockwise)

Preceding gene: 41407072

Following gene: 41407074

Centisome position: 20.97

GC content: 71.26

Gene sequence:

>957_bases
GTGGCCAGTGTGCAGCGGAAGAGCTGGTGCGCGCTGACCATCCGGCTCCTCGGGCGCACCGAGATCAGGCGGCTGGCCAA
AGAACTTGAATTTCGGCCACGGAAATCCCTCGGCCAGAACTTCGTGCACGACGCCAACACGGTGCGCCGGGTGGTGTCGA
CGTCCGGGGTGAGTCGCTCCGACCACGTCCTGGAGGTCGGTCCCGGGCTTGGCCCGCTCACGCTGGCGTTGCTGGACCGC
GGCGCCCACGTCACCGCCGTGGAGATCGATCCGGTGCTGGCCGAGCGGTTGCCGCACACCGTCGCCGAACACTCGCACAG
CGAAATCCAGCGCCTGACCGTGCTCAACCGCGACGTGCTGACGCTGCGCCGCGACGAGCTGGCCGAGCCGCCGACCGCGG
TGGTGGCCAATCTGCCCTACAACGTCGCGGTCCCGGCCCTGCTGCACCTGCTCGCCGAATTCCCGTCCATCCGGACGGTG
ACCGTCATGGTGCAGGCCGAGGTGGCCGAACGGCTGGCCGCCGAGCCGGGCGGCAAGGAGTACGGCGTGCCCAGCGTCAA
GGTCCGCTTCTTCGGCCGGGTCCGCCGGTGCGGCATGGTGTCGCCGACGGTGTTCTGGCCGATTCCCCGGGTGTATTCGG
GGCTGGTGCGCATCGACCGCTATCCGACCTCGCCGTGGCCCACCGACCCGGCCTTCCGCCGGCAGGTGTTCGAGTTGGTG
GACATCGCCTTCGGCCAGCGGCGCAAGACCTGCCGCAACGCGTTCGTCGACTGGGCCGGCTCGGGCAACGAGTCGGCGGA
TCGCCTGCTGGCCGCCAGCATCGACCCGGCGCGCCGCGGCGAGACGCTGTCCATCGACGACTTCGTCCGGCTGCTGCAGC
GGTCCGCCGATCGGGGCGGAACCGACCGCGAGGGAACCAGCCCGCCGACCGCCGGACAGGGCGCCCCGGCCCGCTGA

Upstream 100 bases:

>100_bases
GCAACGGCGGGTTGCGGTTCGCCCCGCGCGCCGACCTGGCCACCCGCGAAGAGCAGATCACCGTCGCCGAGGTGACCCGA
GAGCGCCAGGGTTGGGGTGC

Downstream 100 bases:

>100_bases
TCGCGGGACGCCCCGGGTCGCGATGCGTGTGCAAGGCGGCCGGCAGCGATAGTCTGCTGCGGTGGGTAACGATGTCTGAC
GGCAACACCGCCGCGGCTTG

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MASVQRKSWCALTIRLLGRTEIRRLAKELEFRPRKSLGQNFVHDANTVRRVVSTSGVSRSDHVLEVGPGLGPLTLALLDR
GAHVTAVEIDPVLAERLPHTVAEHSHSEIQRLTVLNRDVLTLRRDELAEPPTAVVANLPYNVAVPALLHLLAEFPSIRTV
TVMVQAEVAERLAAEPGGKEYGVPSVKVRFFGRVRRCGMVSPTVFWPIPRVYSGLVRIDRYPTSPWPTDPAFRRQVFELV
DIAFGQRRKTCRNAFVDWAGSGNESADRLLAASIDPARRGETLSIDDFVRLLQRSADRGGTDREGTSPPTAGQGAPAR

Sequences:

>Translated_318_residues
MASVQRKSWCALTIRLLGRTEIRRLAKELEFRPRKSLGQNFVHDANTVRRVVSTSGVSRSDHVLEVGPGLGPLTLALLDR
GAHVTAVEIDPVLAERLPHTVAEHSHSEIQRLTVLNRDVLTLRRDELAEPPTAVVANLPYNVAVPALLHLLAEFPSIRTV
TVMVQAEVAERLAAEPGGKEYGVPSVKVRFFGRVRRCGMVSPTVFWPIPRVYSGLVRIDRYPTSPWPTDPAFRRQVFELV
DIAFGQRRKTCRNAFVDWAGSGNESADRLLAASIDPARRGETLSIDDFVRLLQRSADRGGTDREGTSPPTAGQGAPAR
>Mature_317_residues
ASVQRKSWCALTIRLLGRTEIRRLAKELEFRPRKSLGQNFVHDANTVRRVVSTSGVSRSDHVLEVGPGLGPLTLALLDRG
AHVTAVEIDPVLAERLPHTVAEHSHSEIQRLTVLNRDVLTLRRDELAEPPTAVVANLPYNVAVPALLHLLAEFPSIRTVT
VMVQAEVAERLAAEPGGKEYGVPSVKVRFFGRVRRCGMVSPTVFWPIPRVYSGLVRIDRYPTSPWPTDPAFRRQVFELVD
IAFGQRRKTCRNAFVDWAGSGNESADRLLAASIDPARRGETLSIDDFVRLLQRSADRGGTDREGTSPPTAGQGAPAR

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=286, Percent_Identity=30.7692307692308, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI156415992, Length=302, Percent_Identity=31.1258278145695, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1786236, Length=270, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25146882, Length=221, Percent_Identity=34.3891402714932, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI25141369, Length=305, Percent_Identity=26.5573770491803, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324989, Length=191, Percent_Identity=30.3664921465969, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21358017, Length=283, Percent_Identity=30.3886925795053, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357273, Length=289, Percent_Identity=27.3356401384083, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 35100; Mature: 34968

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVQRKSWCALTIRLLGRTEIRRLAKELEFRPRKSLGQNFVHDANTVRRVVSTSGVSRS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
DHVLEVGPGLGPLTLALLDRGAHVTAVEIDPVLAERLPHTVAEHSHSEIQRLTVLNRDVL
CCEEEECCCCCHHHHHHHHCCCEEEEEECCHHHHHHCCHHHHHCCHHHHHHHHHHHHHHH
TLRRDELAEPPTAVVANLPYNVAVPALLHLLAEFPSIRTVTVMVQAEVAERLAAEPGGKE
HHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHCCCCCCC
YGVPSVKVRFFGRVRRCGMVSPTVFWPIPRVYSGLVRIDRYPTSPWPTDPAFRRQVFELV
CCCCCCHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
DIAFGQRRKTCRNAFVDWAGSGNESADRLLAASIDPARRGETLSIDDFVRLLQRSADRGG
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHCCCEECHHHHHHHHHHHHCCCC
TDREGTSPPTAGQGAPAR
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASVQRKSWCALTIRLLGRTEIRRLAKELEFRPRKSLGQNFVHDANTVRRVVSTSGVSRS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
DHVLEVGPGLGPLTLALLDRGAHVTAVEIDPVLAERLPHTVAEHSHSEIQRLTVLNRDVL
CCEEEECCCCCHHHHHHHHCCCEEEEEECCHHHHHHCCHHHHHCCHHHHHHHHHHHHHHH
TLRRDELAEPPTAVVANLPYNVAVPALLHLLAEFPSIRTVTVMVQAEVAERLAAEPGGKE
HHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHCCCCCCC
YGVPSVKVRFFGRVRRCGMVSPTVFWPIPRVYSGLVRIDRYPTSPWPTDPAFRRQVFELV
CCCCCCHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
DIAFGQRRKTCRNAFVDWAGSGNESADRLLAASIDPARRGETLSIDDFVRLLQRSADRGG
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHCCCEECHHHHHHHHHHHHCCCC
TDREGTSPPTAGQGAPAR
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA