| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is yqhE [C]
Identifier: 41407005
GI number: 41407005
Start: 937769
End: 938617
Strand: Direct
Name: yqhE [C]
Synonym: MAP0907
Alternate gene names: 41407005
Gene position: 937769-938617 (Clockwise)
Preceding gene: 41407004
Following gene: 41407013
Centisome position: 19.42
GC content: 65.72
Gene sequence:
>849_bases GTGAGCAAGGTTCCGACGATCGAACTCAACGACGGTGCGCGCATCCCGCAGCTCGGCTTCGGCGTGTATCAGATCAAGCC CGACGAGACTGCCGCGGCGGTGCGGGCGGCTCTGGATATCGGATACCGCCACATCGACACCGCCGAAATGTACGGCAACG AACGGGAAGTCGCTCAGGGTATTCGCGACGCCGGGCTGGATCGATCCGAGGTTTTCGTCACCAGCAAGCTCAACAACGGA TTTCACGAACCTGACGCCGCGCGCCGGGCATTCGACGCCACGCTGAACGCCTTGGGCTCCGACTACGTCGACCTGTTTCT GATCCACTGGCCGCTGCCCACGCTGTACGGCGGCGACTTCGTTTCCACCTGGCGGGTTTTGGAGGAGTTCGCCCGCGACG GCCGCGCCCGCAGCATCGGTGTGTCGAATTTCCAAGTCGCACACCTGGAGCGGCTCGCCGCCGAAACCGACACCGTGCCC GCCGTCAACCAGGTCGAGGTGCATCCCTACTTCACCAACGAGAAGGTCCGCGGCTACGCCCGCGAGCACGGCCTCGCGAT CGAGGCGTGGTCGCCCATCGCGCAGGGCGGCGTGCTCGGCGATGCGGTCATCAACCGCATCGCCGACGGTCTCGGCCGCA CCGCCGCGCAGGTGGTGCTGCGCTGGCACATCCAGCGCGGCGACATCGTCTTTCCCAAGACGGTCAACCCGGATCGGATG AAATCGAACTTCGAACTGTTCGACTTCGAGCTGGACGAGCGCGCGATGGAGGCGATCTCGGCGCTGGACCGCGGGGAATC CGGGCGACGCGGCCCCAACCCGGACACCTTCGACTACATACCGCGCTGA
Upstream 100 bases:
>100_bases ATTGGGAGCGGCCGTGGTGGGCGACTACCTGCGGTCCCGGCGGCGTCGATAGCGACACCGGTCGCGCGACTGAGTTTGAC TGTGAAGGAGGAAAACCCGG
Downstream 100 bases:
>100_bases CGGCGCAGCATCAAAAAGGCTGCGCGACAGGCCTTTTCGATGCTGCCAAAAGATGCGCTCCTAGGGCCGTGGCCGGCGCG CCTTGCGCCTGATGCCCACC
Product: hypothetical protein
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 282; Mature: 281
Protein sequence:
>282_residues MSKVPTIELNDGARIPQLGFGVYQIKPDETAAAVRAALDIGYRHIDTAEMYGNEREVAQGIRDAGLDRSEVFVTSKLNNG FHEPDAARRAFDATLNALGSDYVDLFLIHWPLPTLYGGDFVSTWRVLEEFARDGRARSIGVSNFQVAHLERLAAETDTVP AVNQVEVHPYFTNEKVRGYAREHGLAIEAWSPIAQGGVLGDAVINRIADGLGRTAAQVVLRWHIQRGDIVFPKTVNPDRM KSNFELFDFELDERAMEAISALDRGESGRRGPNPDTFDYIPR
Sequences:
>Translated_282_residues MSKVPTIELNDGARIPQLGFGVYQIKPDETAAAVRAALDIGYRHIDTAEMYGNEREVAQGIRDAGLDRSEVFVTSKLNNG FHEPDAARRAFDATLNALGSDYVDLFLIHWPLPTLYGGDFVSTWRVLEEFARDGRARSIGVSNFQVAHLERLAAETDTVP AVNQVEVHPYFTNEKVRGYAREHGLAIEAWSPIAQGGVLGDAVINRIADGLGRTAAQVVLRWHIQRGDIVFPKTVNPDRM KSNFELFDFELDERAMEAISALDRGESGRRGPNPDTFDYIPR >Mature_281_residues SKVPTIELNDGARIPQLGFGVYQIKPDETAAAVRAALDIGYRHIDTAEMYGNEREVAQGIRDAGLDRSEVFVTSKLNNGF HEPDAARRAFDATLNALGSDYVDLFLIHWPLPTLYGGDFVSTWRVLEEFARDGRARSIGVSNFQVAHLERLAAETDTVPA VNQVEVHPYFTNEKVRGYAREHGLAIEAWSPIAQGGVLGDAVINRIADGLGRTAAQVVLRWHIQRGDIVFPKTVNPDRMK SNFELFDFELDERAMEAISALDRGESGRRGPNPDTFDYIPR
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI223468663, Length=291, Percent_Identity=35.3951890034364, Blast_Score=189, Evalue=2e-48, Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=31.9587628865979, Blast_Score=186, Evalue=1e-47, Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=31.9587628865979, Blast_Score=186, Evalue=1e-47, Organism=Homo sapiens, GI5174695, Length=297, Percent_Identity=35.6902356902357, Blast_Score=186, Evalue=2e-47, Organism=Homo sapiens, GI4502049, Length=289, Percent_Identity=35.9861591695502, Blast_Score=179, Evalue=2e-45, Organism=Homo sapiens, GI24497583, Length=300, Percent_Identity=34.3333333333333, Blast_Score=179, Evalue=4e-45, Organism=Homo sapiens, GI310109920, Length=300, Percent_Identity=33.6666666666667, Blast_Score=177, Evalue=6e-45, Organism=Homo sapiens, GI5453543, Length=300, Percent_Identity=33.6666666666667, Blast_Score=177, Evalue=6e-45, Organism=Homo sapiens, GI45446745, Length=300, Percent_Identity=33.6666666666667, Blast_Score=176, Evalue=2e-44, Organism=Homo sapiens, GI4503285, Length=300, Percent_Identity=33.6666666666667, Blast_Score=176, Evalue=2e-44, Organism=Homo sapiens, GI310109922, Length=284, Percent_Identity=34.1549295774648, Blast_Score=173, Evalue=2e-43, Organism=Homo sapiens, GI93277124, Length=296, Percent_Identity=31.7567567567568, Blast_Score=171, Evalue=9e-43, Organism=Homo sapiens, GI24497585, Length=303, Percent_Identity=32.6732673267327, Blast_Score=169, Evalue=2e-42, Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=34.8920863309352, Blast_Score=167, Evalue=8e-42, Organism=Homo sapiens, GI291291012, Length=265, Percent_Identity=34.3396226415094, Blast_Score=165, Evalue=5e-41, Organism=Homo sapiens, GI300116271, Length=279, Percent_Identity=35.4838709677419, Blast_Score=160, Evalue=9e-40, Organism=Homo sapiens, GI310109926, Length=118, Percent_Identity=40.6779661016949, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI207028673, Length=118, Percent_Identity=40.6779661016949, Blast_Score=95, Evalue=5e-20, Organism=Homo sapiens, GI310109924, Length=152, Percent_Identity=32.2368421052632, Blast_Score=89, Evalue=5e-18, Organism=Escherichia coli, GI87082198, Length=279, Percent_Identity=41.9354838709677, Blast_Score=247, Evalue=7e-67, Organism=Escherichia coli, GI1786400, Length=253, Percent_Identity=37.9446640316205, Blast_Score=169, Evalue=1e-43, Organism=Escherichia coli, GI1788081, Length=288, Percent_Identity=29.1666666666667, Blast_Score=104, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17537075, Length=293, Percent_Identity=36.518771331058, Blast_Score=197, Evalue=6e-51, Organism=Caenorhabditis elegans, GI17537077, Length=292, Percent_Identity=35.958904109589, Blast_Score=195, Evalue=2e-50, Organism=Caenorhabditis elegans, GI17564128, Length=296, Percent_Identity=33.1081081081081, Blast_Score=180, Evalue=9e-46, Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=34.4322344322344, Blast_Score=173, Evalue=7e-44, Organism=Caenorhabditis elegans, GI17537079, Length=294, Percent_Identity=31.2925170068027, Blast_Score=165, Evalue=2e-41, Organism=Caenorhabditis elegans, GI71998625, Length=271, Percent_Identity=31.7343173431734, Blast_Score=162, Evalue=1e-40, Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=31.9852941176471, Blast_Score=158, Evalue=3e-39, Organism=Caenorhabditis elegans, GI17538386, Length=274, Percent_Identity=32.1167883211679, Blast_Score=158, Evalue=4e-39, Organism=Caenorhabditis elegans, GI17566692, Length=309, Percent_Identity=31.0679611650485, Blast_Score=155, Evalue=3e-38, Organism=Caenorhabditis elegans, GI17552492, Length=263, Percent_Identity=30.7984790874525, Blast_Score=150, Evalue=9e-37, Organism=Caenorhabditis elegans, GI17550248, Length=300, Percent_Identity=28.6666666666667, Blast_Score=138, Evalue=3e-33, Organism=Caenorhabditis elegans, GI17562292, Length=278, Percent_Identity=26.978417266187, Blast_Score=127, Evalue=7e-30, Organism=Saccharomyces cerevisiae, GI6324694, Length=298, Percent_Identity=37.5838926174497, Blast_Score=213, Evalue=2e-56, Organism=Saccharomyces cerevisiae, GI6320576, Length=294, Percent_Identity=36.734693877551, Blast_Score=199, Evalue=5e-52, Organism=Saccharomyces cerevisiae, GI6322556, Length=269, Percent_Identity=34.5724907063197, Blast_Score=167, Evalue=2e-42, Organism=Saccharomyces cerevisiae, GI6321896, Length=303, Percent_Identity=33.6633663366337, Blast_Score=166, Evalue=4e-42, Organism=Saccharomyces cerevisiae, GI6319625, Length=281, Percent_Identity=35.2313167259786, Blast_Score=166, Evalue=4e-42, Organism=Saccharomyces cerevisiae, GI6320079, Length=278, Percent_Identity=29.4964028776978, Blast_Score=133, Evalue=4e-32, Organism=Drosophila melanogaster, GI20129731, Length=290, Percent_Identity=37.9310344827586, Blast_Score=198, Evalue=3e-51, Organism=Drosophila melanogaster, GI24657054, Length=286, Percent_Identity=36.3636363636364, Blast_Score=194, Evalue=5e-50, Organism=Drosophila melanogaster, GI21356425, Length=294, Percent_Identity=34.0136054421769, Blast_Score=192, Evalue=3e-49, Organism=Drosophila melanogaster, GI24662789, Length=293, Percent_Identity=35.4948805460751, Blast_Score=188, Evalue=4e-48, Organism=Drosophila melanogaster, GI24663317, Length=295, Percent_Identity=34.2372881355932, Blast_Score=186, Evalue=2e-47, Organism=Drosophila melanogaster, GI24662781, Length=278, Percent_Identity=37.7697841726619, Blast_Score=185, Evalue=3e-47, Organism=Drosophila melanogaster, GI24662785, Length=280, Percent_Identity=37.8571428571429, Blast_Score=183, Evalue=9e-47, Organism=Drosophila melanogaster, GI45553081, Length=298, Percent_Identity=33.2214765100671, Blast_Score=176, Evalue=2e-44, Organism=Drosophila melanogaster, GI24644950, Length=303, Percent_Identity=31.3531353135314, Blast_Score=163, Evalue=1e-40, Organism=Drosophila melanogaster, GI221378297, Length=323, Percent_Identity=30.3405572755418, Blast_Score=156, Evalue=2e-38, Organism=Drosophila melanogaster, GI281366140, Length=259, Percent_Identity=31.6602316602317, Blast_Score=141, Evalue=4e-34,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 31368; Mature: 31237
Theoretical pI: Translated: 4.96; Mature: 4.96
Prosite motif: PS00062 ALDOKETO_REDUCTASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 1.4 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSKVPTIELNDGARIPQLGFGVYQIKPDETAAAVRAALDIGYRHIDTAEMYGNEREVAQG CCCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCHHCCHHHHHCCHHHHHHH IRDAGLDRSEVFVTSKLNNGFHEPDAARRAFDATLNALGSDYVDLFLIHWPLPTLYGGDF HHHHCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHEEEEEECCCCHHCCCHH VSTWRVLEEFARDGRARSIGVSNFQVAHLERLAAETDTVPAVNQVEVHPYFTNEKVRGYA HHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHH REHGLAIEAWSPIAQGGVLGDAVINRIADGLGRTAAQVVLRWHIQRGDIVFPKTVNPDRM HHCCEEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECCCCCHHHH KSNFELFDFELDERAMEAISALDRGESGRRGPNPDTFDYIPR CCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure SKVPTIELNDGARIPQLGFGVYQIKPDETAAAVRAALDIGYRHIDTAEMYGNEREVAQG CCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCHHCCHHHHHCCHHHHHHH IRDAGLDRSEVFVTSKLNNGFHEPDAARRAFDATLNALGSDYVDLFLIHWPLPTLYGGDF HHHHCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHEEEEEECCCCHHCCCHH VSTWRVLEEFARDGRARSIGVSNFQVAHLERLAAETDTVPAVNQVEVHPYFTNEKVRGYA HHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHH REHGLAIEAWSPIAQGGVLGDAVINRIADGLGRTAAQVVLRWHIQRGDIVFPKTVNPDRM HHCCEEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECCCCCHHHH KSNFELFDFELDERAMEAISALDRGESGRRGPNPDTFDYIPR CCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA