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The map label for this gene is uvrD

Identifier: 41406991

GI number: 41406991

Start: 919590

End: 921914

Strand: Direct

Name: uvrD

Synonym: MAP0893

Alternate gene names: 41406991

Gene position: 919590-921914 (Clockwise)

Preceding gene: 41406988

Following gene: 41406994

Centisome position: 19.04

GC content: 68.13

Gene sequence:

>2325_bases
ATGAGTGTGCACGTAACAGATGCCAAGCCGGTCTCCGAAGCCGAGCAATTGCTCGAGGGGCTCAATCCGCAACAGCGCCA
GGCCGTGGTGCACGAGGGTTCGCCGCTGCTGATCGTCGCCGGGGCGGGTTCGGGGAAGACGGCGGTGCTGACCCGCCGCG
TCGCCTACCTGATCGCGGCCCGCGGGGTCGGGGTGGGCCAGGTGCTGGCCATCACCTTCACCAACAAGGCCGCCGCCGAG
ATGCGGGAACGGGTGGTGCGGCTGGTGGGCAACCGGGCCCGCGCCATGTGGGTGTCCACCTTTCATTCGACCTGCGTGCG
CATCCTGCGCAACCAGGCGTCGCTGATCGAGGGCCTCAATTCCAACTTCTCGATCTACGACGCCGACGACTCGCGGCGGC
TGCTGCAGATGATCGGCCGCGACATGGGCCTGGACATCAAGCGCTACTCGCCGCGGCTGTTGGCCAACGCGATCTCCAAC
CTGAAGAACGAGCTGATCGACCCCGCCGCGGCGGTCGCCAACCTCACCGACGGTTCCGACGAGTTGTCCCGCACCGTGGC
AAGCGTCTACGGCGAATACCAGCGCCGGCTGCGGGCGGCCAACGCGCTGGACTTCGACGACCTGATCGGCGAGACGGTGG
CGGTGCTGCGGGCCTTCCCGCAGATCGCCCAGCACTACCGGCGGCGGTTCCGGCACGTGCTCGTCGACGAGTACCAGGAC
ACCAACCACGCGCAGTACGTGCTGGTGCGCGAGTTGGTGGGCACCGACACCGAGGACGGCGTTCCCCCCGGCGAGCTGTG
CGTGGTCGGCGACGCCGACCAGTCGATCTATGCCTTCCGCGGCGCCACCATCCGCAACATCGAGGACTTCGAACGCGACT
ACCCGGACGCGACAACCATTCTGCTGGAACAGAATTACCGCTCGACACAGAACATCCTGTCGGCGGCCAACTCGGTGATC
GCGCGTAACTCCGGTCGCCGCGACAAGCGGCTGTGGACCGACGCCGGCGCCGGCGAGCTGATCGTCGGCTACGTCGCCGA
CAACGAGCACGACGAGGCCCGCTTCGTCGCCGAGGAGATCGACGCGCTCGCGCAGAAGGGCGAGATCACCTACAACGACG
TCGCCGTCTTCTACCGCACCAACAACTCGTCGCGGTCCTTCGAGGAGGTGTTCATCCGCGCCGGGATCCCCTACAAAGTC
GTTGGGGGAGTGCGCTTTTACGAGCGCAAGGAGATCCGCGACATCATTGCCTACCTGCGGGTGCTGGACAACCCCGGCGA
CGCGGTGAGCATGCGGCGCATCCTCAACACCCCGCGCCGGGGGATCGGTGATCGGGCCGAGGCCTGCGTGGCGGTGTACG
CCGAGAACACCGGTGCCAGTTTCGCCGACGCGCTGGTGGCCGCGGCCGAAGGCAAAGTGCCGATGCTGAATTCGCGCGCG
GAGAAGGCGATCGCGGGTTTCGTCGAGTTGCTGGACGACCTGCGCGGCCGGCTGGACGACGATCTCGGCGACCTGGTCGA
GTCGGTGCTCGAACGCACCGGCTACCGCCGGGAGCTGGAATCGTCCACCGATCCCCAAGAGCTGGCGCGTCTGGACAACC
TCAACGAACTCGTCAGCGTCGCACACGAATTCAGCACCGACCGGGCGAACGCCGCCGCGCTGGACGAGTCGCTGGATGCC
GCGGACGACGAAGACGTGCCCGACACCGGTGTGCTGGCCGAGTTCTTGGAACGGGTCTCGCTGGTCTCCGACAGCGACGA
GATCCCCGAGGACGGCGCCGGGATGGTCACGCTGATGACCCTGCACACCGCGAAGGGCCTGGAGTTCCCGGTGGTGTTCG
TCACCGGCTGGGAGGACGGGATGTTCCCGCACATGCGGTCGCTGGACGATCCGGTCGAACTCTCCGAGGAGCGGCGGCTG
GCCTACGTGGGCATCACCCGGGCCCGGCAGCGGCTCTACCTGAGCCGGGCCATCGTCCGCTCGTCGTGGGGCCAGCCCAT
GCTCAACCCGGAATCTCGGTTCCTGCGGGAGATTCCGCAGGAACTGATCGAGTGGCGGCGCACCGCGCCGGCGCCGTCGT
TCAGCGCACCGGTCAGCGGCGCCGGCCGGTTCGGCACCCCGCGGGCGGCCCCGACCCGCGCCGCAATGAGCAAACGGCCG
CTGCTGGTGCTGGCGCCGGGCGACCGGGTGACGCACGACAAGTACGGGCTCGGCCGGGTCGAGGAGGTGTCCGGCGCCGG
CGAGTCGGCGATGTCACTGATCGACTTCGGCAGCTCCGGGCGGGTGAAGCTGATGCACAACCACGCCCCGATCAGCAAGC
TCTAA

Upstream 100 bases:

>100_bases
CCCGGCGGCCCGGTCGGCCCGGCGGCGGGCGGCCGGAACACTAACCTGGTTGGACGACTGGGCGCTGTGCGTCGGTGGGC
GGCGGTAAGTTTGAACTGAC

Downstream 100 bases:

>100_bases
CCGCGCCGAGCGTGCATTCAGTGCGAGAAAATCGCCCGCGAAATCTTCGCCGTCAGTGCGCATTCGGCGACGCTCAGGCG
TCCAGCCAGCGTTTGGCCTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 774; Mature: 773

Protein sequence:

>774_residues
MSVHVTDAKPVSEAEQLLEGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRVAYLIAARGVGVGQVLAITFTNKAAAE
MRERVVRLVGNRARAMWVSTFHSTCVRILRNQASLIEGLNSNFSIYDADDSRRLLQMIGRDMGLDIKRYSPRLLANAISN
LKNELIDPAAAVANLTDGSDELSRTVASVYGEYQRRLRAANALDFDDLIGETVAVLRAFPQIAQHYRRRFRHVLVDEYQD
TNHAQYVLVRELVGTDTEDGVPPGELCVVGDADQSIYAFRGATIRNIEDFERDYPDATTILLEQNYRSTQNILSAANSVI
ARNSGRRDKRLWTDAGAGELIVGYVADNEHDEARFVAEEIDALAQKGEITYNDVAVFYRTNNSSRSFEEVFIRAGIPYKV
VGGVRFYERKEIRDIIAYLRVLDNPGDAVSMRRILNTPRRGIGDRAEACVAVYAENTGASFADALVAAAEGKVPMLNSRA
EKAIAGFVELLDDLRGRLDDDLGDLVESVLERTGYRRELESSTDPQELARLDNLNELVSVAHEFSTDRANAAALDESLDA
ADDEDVPDTGVLAEFLERVSLVSDSDEIPEDGAGMVTLMTLHTAKGLEFPVVFVTGWEDGMFPHMRSLDDPVELSEERRL
AYVGITRARQRLYLSRAIVRSSWGQPMLNPESRFLREIPQELIEWRRTAPAPSFSAPVSGAGRFGTPRAAPTRAAMSKRP
LLVLAPGDRVTHDKYGLGRVEEVSGAGESAMSLIDFGSSGRVKLMHNHAPISKL

Sequences:

>Translated_774_residues
MSVHVTDAKPVSEAEQLLEGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRVAYLIAARGVGVGQVLAITFTNKAAAE
MRERVVRLVGNRARAMWVSTFHSTCVRILRNQASLIEGLNSNFSIYDADDSRRLLQMIGRDMGLDIKRYSPRLLANAISN
LKNELIDPAAAVANLTDGSDELSRTVASVYGEYQRRLRAANALDFDDLIGETVAVLRAFPQIAQHYRRRFRHVLVDEYQD
TNHAQYVLVRELVGTDTEDGVPPGELCVVGDADQSIYAFRGATIRNIEDFERDYPDATTILLEQNYRSTQNILSAANSVI
ARNSGRRDKRLWTDAGAGELIVGYVADNEHDEARFVAEEIDALAQKGEITYNDVAVFYRTNNSSRSFEEVFIRAGIPYKV
VGGVRFYERKEIRDIIAYLRVLDNPGDAVSMRRILNTPRRGIGDRAEACVAVYAENTGASFADALVAAAEGKVPMLNSRA
EKAIAGFVELLDDLRGRLDDDLGDLVESVLERTGYRRELESSTDPQELARLDNLNELVSVAHEFSTDRANAAALDESLDA
ADDEDVPDTGVLAEFLERVSLVSDSDEIPEDGAGMVTLMTLHTAKGLEFPVVFVTGWEDGMFPHMRSLDDPVELSEERRL
AYVGITRARQRLYLSRAIVRSSWGQPMLNPESRFLREIPQELIEWRRTAPAPSFSAPVSGAGRFGTPRAAPTRAAMSKRP
LLVLAPGDRVTHDKYGLGRVEEVSGAGESAMSLIDFGSSGRVKLMHNHAPISKL
>Mature_773_residues
SVHVTDAKPVSEAEQLLEGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRVAYLIAARGVGVGQVLAITFTNKAAAEM
RERVVRLVGNRARAMWVSTFHSTCVRILRNQASLIEGLNSNFSIYDADDSRRLLQMIGRDMGLDIKRYSPRLLANAISNL
KNELIDPAAAVANLTDGSDELSRTVASVYGEYQRRLRAANALDFDDLIGETVAVLRAFPQIAQHYRRRFRHVLVDEYQDT
NHAQYVLVRELVGTDTEDGVPPGELCVVGDADQSIYAFRGATIRNIEDFERDYPDATTILLEQNYRSTQNILSAANSVIA
RNSGRRDKRLWTDAGAGELIVGYVADNEHDEARFVAEEIDALAQKGEITYNDVAVFYRTNNSSRSFEEVFIRAGIPYKVV
GGVRFYERKEIRDIIAYLRVLDNPGDAVSMRRILNTPRRGIGDRAEACVAVYAENTGASFADALVAAAEGKVPMLNSRAE
KAIAGFVELLDDLRGRLDDDLGDLVESVLERTGYRRELESSTDPQELARLDNLNELVSVAHEFSTDRANAAALDESLDAA
DDEDVPDTGVLAEFLERVSLVSDSDEIPEDGAGMVTLMTLHTAKGLEFPVVFVTGWEDGMFPHMRSLDDPVELSEERRLA
YVGITRARQRLYLSRAIVRSSWGQPMLNPESRFLREIPQELIEWRRTAPAPSFSAPVSGAGRFGTPRAAPTRAAMSKRPL
LVLAPGDRVTHDKYGLGRVEEVSGAGESAMSLIDFGSSGRVKLMHNHAPISKL

Specific function: Has Both Atpase And Helicase Activities. Unwinds DNA Duplexes With 3' To 5' Polarity With Respect To The Bound Strand And Initiates Unwinding Most Effectively When A Single-Stranded Region Is Present. Involved In The Post-Incision Events Of Nucleotide Exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=745, Percent_Identity=39.7315436241611, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI48994965, Length=671, Percent_Identity=38.0029806259314, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1787196, Length=346, Percent_Identity=27.1676300578035, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322369, Length=764, Percent_Identity=29.0575916230367, Blast_Score=237, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6324477, Length=682, Percent_Identity=22.8739002932551, Blast_Score=117, Evalue=5e-27,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 85305; Mature: 85174

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVHVTDAKPVSEAEQLLEGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRVAYLIAA
CEEECCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
RGVGVGQVLAITFTNKAAAEMRERVVRLVGNRARAMWVSTFHSTCVRILRNQASLIEGLN
CCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SNFSIYDADDSRRLLQMIGRDMGLDIKRYSPRLLANAISNLKNELIDPAAAVANLTDGSD
CCCEEEECCHHHHHHHHHCHHCCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCHH
ELSRTVASVYGEYQRRLRAANALDFDDLIGETVAVLRAFPQIAQHYRRRFRHVLVDEYQD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TNHAQYVLVRELVGTDTEDGVPPGELCVVGDADQSIYAFRGATIRNIEDFERDYPDATTI
CCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHCCCCCEEE
LLEQNYRSTQNILSAANSVIARNSGRRDKRLWTDAGAGELIVGYVADNEHDEARFVAEEI
EEECCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHH
DALAQKGEITYNDVAVFYRTNNSSRSFEEVFIRAGIPYKVVGGVRFYERKEIRDIIAYLR
HHHHHCCCCEEEEEEEEEEECCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHH
VLDNPGDAVSMRRILNTPRRGIGDRAEACVAVYAENTGASFADALVAAAEGKVPMLNSRA
HHCCCCHHHHHHHHHCCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHCCCCCCCCCHHH
EKAIAGFVELLDDLRGRLDDDLGDLVESVLERTGYRRELESSTDPQELARLDNLNELVSV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHCHHHHHHH
AHEFSTDRANAAALDESLDAADDEDVPDTGVLAEFLERVSLVSDSDEIPEDGAGMVTLMT
HHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
LHTAKGLEFPVVFVTGWEDGMFPHMRSLDDPVELSEERRLAYVGITRARQRLYLSRAIVR
EHHCCCCCCCEEEEECCCCCCCCHHHCCCCCHHHHHCCEEEEEEHHHHHHHHHHHHHHHH
SSWGQPMLNPESRFLREIPQELIEWRRTAPAPSFSAPVSGAGRFGTPRAAPTRAAMSKRP
HCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCC
LLVLAPGDRVTHDKYGLGRVEEVSGAGESAMSLIDFGSSGRVKLMHNHAPISKL
EEEECCCCCCCCCCCCCCCHHHHCCCCHHHHHHHCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
SVHVTDAKPVSEAEQLLEGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRVAYLIAA
EEECCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
RGVGVGQVLAITFTNKAAAEMRERVVRLVGNRARAMWVSTFHSTCVRILRNQASLIEGLN
CCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SNFSIYDADDSRRLLQMIGRDMGLDIKRYSPRLLANAISNLKNELIDPAAAVANLTDGSD
CCCEEEECCHHHHHHHHHCHHCCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCHH
ELSRTVASVYGEYQRRLRAANALDFDDLIGETVAVLRAFPQIAQHYRRRFRHVLVDEYQD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TNHAQYVLVRELVGTDTEDGVPPGELCVVGDADQSIYAFRGATIRNIEDFERDYPDATTI
CCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHCCCCCEEE
LLEQNYRSTQNILSAANSVIARNSGRRDKRLWTDAGAGELIVGYVADNEHDEARFVAEEI
EEECCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHH
DALAQKGEITYNDVAVFYRTNNSSRSFEEVFIRAGIPYKVVGGVRFYERKEIRDIIAYLR
HHHHHCCCCEEEEEEEEEEECCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHH
VLDNPGDAVSMRRILNTPRRGIGDRAEACVAVYAENTGASFADALVAAAEGKVPMLNSRA
HHCCCCHHHHHHHHHCCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHCCCCCCCCCHHH
EKAIAGFVELLDDLRGRLDDDLGDLVESVLERTGYRRELESSTDPQELARLDNLNELVSV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHCHHHHHHH
AHEFSTDRANAAALDESLDAADDEDVPDTGVLAEFLERVSLVSDSDEIPEDGAGMVTLMT
HHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
LHTAKGLEFPVVFVTGWEDGMFPHMRSLDDPVELSEERRLAYVGITRARQRLYLSRAIVR
EHHCCCCCCCEEEEECCCCCCCCHHHCCCCCHHHHHCCEEEEEEHHHHHHHHHHHHHHHH
SSWGQPMLNPESRFLREIPQELIEWRRTAPAPSFSAPVSGAGRFGTPRAAPTRAAMSKRP
HCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCC
LLVLAPGDRVTHDKYGLGRVEEVSGAGESAMSLIDFGSSGRVKLMHNHAPISKL
EEEECCCCCCCCCCCCCCCHHHHCCCCHHHHHHHCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]