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The map label for this gene is fabG [C]

Identifier: 41406988

GI number: 41406988

Start: 916352

End: 917113

Strand: Direct

Name: fabG [C]

Synonym: MAP0890

Alternate gene names: 41406988

Gene position: 916352-917113 (Clockwise)

Preceding gene: 41406987

Following gene: 41406991

Centisome position: 18.97

GC content: 67.59

Gene sequence:

>762_bases
ATGCTGCCGGAGATGACTCGCCAGAAGATCCTCATCACCGGCGCCAGCTCGGGCCTGGGCGCCGGGATGGCGCGCGCGTT
CGCCGCCAAGGGCCGCGACCTCGCGCTGTGCGCGCGCCGCGCCGACCGGCTCGACGAGCTCAAAGCCGAACTGTCGCAAC
GGTATCCGGCAATCACGGTCGCGGTCGCCGCGCTGGACGTCAACGACCACGAGCAGGTGCCCAAGGTTTTCGCCGAACTC
AGCGACGAACTCGGCGGCATCGACCGCGTCATCGTCAACGCCGGCATCGGCAAGGGCGCCAAGCTGGGCTCCGGCAAGCT
GTGGGCCAACAAGGCGACCATCGAGACCAACCTGGTGTCCGCGCTGGTGCAGATCGAGACCGCGCTGGAGATGTTCCACA
AGAACGGGTCGGGCCACCTGGTGCTGATCTCGTCGGTACTCGGCAACAAGGGAGTGCCCGGCGTCAAGGCGGCGTACGCG
GCGAGCAAGGCCGGCCTGAGCTCGCTGGGTGAATCGTTGCGCGCCGAATACGCCAAGGGGCCGATCAAGGTTTCGGTGCT
CGAGCCCGGCTACATCGAGTCGGAGATGACGGCCAAATCCAACAGCACAATGTTGATGGTGGACAACGAAACCGGGGTCA
GGGCATTGGTCGCCGCCATGGAGCGGGAGCCCGGCCGCGCGGCGGTGCCGTGGTGGCCGTGGGCGCCGCTGGTGCAGTTG
ATGCGGGTGCTGCCGCCGCGGCTGACCAAGATGTTCGCCTGA

Upstream 100 bases:

>100_bases
GTATTGCCCGACGTGCCAGACCGGCGGCAAGATCCTGGCCGACCGGCGGATGTCGCGTTTGCTGAAGTAGCCGCCGGCCG
CGGACTTGACACCTGTCGAT

Downstream 100 bases:

>100_bases
GTCAGCTGGTGCGGCCGCGTTCGCTGCGGTAGCGGCGCACCAGGGCGTCGGTGGAGCTGTCCGACTGCGGCGCCGGCGAG
TTGTTTGCGGTGATCACCGG

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MLPEMTRQKILITGASSGLGAGMARAFAAKGRDLALCARRADRLDELKAELSQRYPAITVAVAALDVNDHEQVPKVFAEL
SDELGGIDRVIVNAGIGKGAKLGSGKLWANKATIETNLVSALVQIETALEMFHKNGSGHLVLISSVLGNKGVPGVKAAYA
ASKAGLSSLGESLRAEYAKGPIKVSVLEPGYIESEMTAKSNSTMLMVDNETGVRALVAAMEREPGRAAVPWWPWAPLVQL
MRVLPPRLTKMFA

Sequences:

>Translated_253_residues
MLPEMTRQKILITGASSGLGAGMARAFAAKGRDLALCARRADRLDELKAELSQRYPAITVAVAALDVNDHEQVPKVFAEL
SDELGGIDRVIVNAGIGKGAKLGSGKLWANKATIETNLVSALVQIETALEMFHKNGSGHLVLISSVLGNKGVPGVKAAYA
ASKAGLSSLGESLRAEYAKGPIKVSVLEPGYIESEMTAKSNSTMLMVDNETGVRALVAAMEREPGRAAVPWWPWAPLVQL
MRVLPPRLTKMFA
>Mature_253_residues
MLPEMTRQKILITGASSGLGAGMARAFAAKGRDLALCARRADRLDELKAELSQRYPAITVAVAALDVNDHEQVPKVFAEL
SDELGGIDRVIVNAGIGKGAKLGSGKLWANKATIETNLVSALVQIETALEMFHKNGSGHLVLISSVLGNKGVPGVKAAYA
ASKAGLSSLGESLRAEYAKGPIKVSVLEPGYIESEMTAKSNSTMLMVDNETGVRALVAAMEREPGRAAVPWWPWAPLVQL
MRVLPPRLTKMFA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=195, Percent_Identity=31.7948717948718, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI109715829, Length=195, Percent_Identity=31.2820512820513, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI157739938, Length=188, Percent_Identity=30.3191489361702, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40254992, Length=186, Percent_Identity=29.0322580645161, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI32455239, Length=203, Percent_Identity=29.5566502463054, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI5031765, Length=203, Percent_Identity=29.5566502463054, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7657478, Length=203, Percent_Identity=31.5270935960591, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI7706318, Length=203, Percent_Identity=29.5566502463054, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI210032110, Length=243, Percent_Identity=26.7489711934156, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI19743808, Length=209, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI40807363, Length=229, Percent_Identity=29.6943231441048, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI226371731, Length=196, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=187, Percent_Identity=33.6898395721925, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1787820, Length=186, Percent_Identity=29.0322580645161, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI87082100, Length=196, Percent_Identity=31.6326530612245, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786701, Length=204, Percent_Identity=28.921568627451, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789208, Length=237, Percent_Identity=27.4261603375527, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=242, Percent_Identity=26.8595041322314, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71997402, Length=193, Percent_Identity=27.4611398963731, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17570069, Length=187, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=255, Percent_Identity=28.2352941176471, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=260, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=220, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=198, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21358495, Length=190, Percent_Identity=34.2105263157895, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI116007236, Length=223, Percent_Identity=29.5964125560538, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI116007238, Length=183, Percent_Identity=32.2404371584699, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24663911, Length=199, Percent_Identity=30.1507537688442, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571387, Length=214, Percent_Identity=32.7102803738318, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24641388, Length=210, Percent_Identity=30.4761904761905, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641232, Length=199, Percent_Identity=29.6482412060301, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24648693, Length=196, Percent_Identity=31.6326530612245, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21355889, Length=196, Percent_Identity=31.6326530612245, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI116007234, Length=199, Percent_Identity=31.6582914572864, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644339, Length=195, Percent_Identity=31.2820512820513, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281364494, Length=198, Percent_Identity=28.7878787878788, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648944, Length=198, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116007232, Length=189, Percent_Identity=32.2751322751323, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21357041, Length=195, Percent_Identity=30.2564102564103, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26874; Mature: 26874

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPEMTRQKILITGASSGLGAGMARAFAAKGRDLALCARRADRLDELKAELSQRYPAITV
CCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AVAALDVNDHEQVPKVFAELSDELGGIDRVIVNAGIGKGAKLGSGKLWANKATIETNLVS
EEEEECCCCHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCCCCEEECCCHHHHHHHH
ALVQIETALEMFHKNGSGHLVLISSVLGNKGVPGVKAAYAASKAGLSSLGESLRAEYAKG
HHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PIKVSVLEPGYIESEMTAKSNSTMLMVDNETGVRALVAAMEREPGRAAVPWWPWAPLVQL
CEEEEEECCCCCCHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHH
MRVLPPRLTKMFA
HHHCCHHHHHHCC
>Mature Secondary Structure
MLPEMTRQKILITGASSGLGAGMARAFAAKGRDLALCARRADRLDELKAELSQRYPAITV
CCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AVAALDVNDHEQVPKVFAELSDELGGIDRVIVNAGIGKGAKLGSGKLWANKATIETNLVS
EEEEECCCCHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCCCCEEECCCHHHHHHHH
ALVQIETALEMFHKNGSGHLVLISSVLGNKGVPGVKAAYAASKAGLSSLGESLRAEYAKG
HHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PIKVSVLEPGYIESEMTAKSNSTMLMVDNETGVRALVAAMEREPGRAAVPWWPWAPLVQL
CEEEEEECCCCCCHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHH
MRVLPPRLTKMFA
HHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]