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The map label for this gene is moaE2

Identifier: 41406902

GI number: 41406902

Start: 824334

End: 824759

Strand: Direct

Name: moaE2

Synonym: MAP0804

Alternate gene names: 41406902

Gene position: 824334-824759 (Clockwise)

Preceding gene: 41406901

Following gene: 41406906

Centisome position: 17.07

GC content: 71.83

Gene sequence:

>426_bases
ATGACGCTCGTCGTGCGCGCCGCCGTGACCGAGCACCCGATCGTGCTGGCCCAGCACGAGGAACTGGTCGGCCATCAGTC
GGCCGGGGCGGTCGTCGGGTTCGTCGGGATGATCCGCGACCACGACGGCGGGCGGCGGGTGGTTCGGCTGGAGTACTCCG
CGCATCCGAGTGCCGGCGAGGTCATGGCCGAGGTGGTGGCCGAGGTGGCGGAGCGGTCCTGCGGGGTGCGGGCCGTCGCC
GCCAGCCATCGGATCGGTGTGCTCAGCATCGGCGAGGCGGCGCTGGTGGCCGCCGTGGCCGCCGACCACCGGCAGGCCGC
ATTCGACACCTGTGCACAGCTGGTGGACACCGTCAAGGCGCGATTGCCGGTGTGGAAGCACCAGTTCTTCGCCGACGGCA
CCGACGAATGGGTGGGCTCGGCCTGA

Upstream 100 bases:

>100_bases
ACCTGCCGGGTTCGCCGGGCGGGGTGCGCGACGGCCTGGGCGTGCTCGCCGGTGTGCTCGACCACGCCCTCGACCAGCTC
GCCGGTAAAGATCACCCGCG

Downstream 100 bases:

>100_bases
GACCTGGATGCGCCGTGCCCAACACGCCCCGACAGGAGGGTTTTCGGGGCGTGTGGGGAATCCGGTGGGGTTAGGGCGTC
AGGCGCTGGGTGCGGGCTGC

Product: MoaE2

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E 2; Molybdopterin-converting factor large subunit 2; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MTLVVRAAVTEHPIVLAQHEELVGHQSAGAVVGFVGMIRDHDGGRRVVRLEYSAHPSAGEVMAEVVAEVAERSCGVRAVA
ASHRIGVLSIGEAALVAAVAADHRQAAFDTCAQLVDTVKARLPVWKHQFFADGTDEWVGSA

Sequences:

>Translated_141_residues
MTLVVRAAVTEHPIVLAQHEELVGHQSAGAVVGFVGMIRDHDGGRRVVRLEYSAHPSAGEVMAEVVAEVAERSCGVRAVA
ASHRIGVLSIGEAALVAAVAADHRQAAFDTCAQLVDTVKARLPVWKHQFFADGTDEWVGSA
>Mature_140_residues
TLVVRAAVTEHPIVLAQHEELVGHQSAGAVVGFVGMIRDHDGGRRVVRLEYSAHPSAGEVMAEVVAEVAERSCGVRAVAA
SHRIGVLSIGEAALVAAVAADHRQAAFDTCAQLVDTVKARLPVWKHQFFADGTDEWVGSA

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=121, Percent_Identity=30.5785123966942, Blast_Score=80, Evalue=7e-16,
Organism=Escherichia coli, GI1787003, Length=129, Percent_Identity=34.1085271317829, Blast_Score=64, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17509279, Length=115, Percent_Identity=31.304347826087, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356259, Length=127, Percent_Identity=29.9212598425197, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 14901; Mature: 14770

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVVRAAVTEHPIVLAQHEELVGHQSAGAVVGFVGMIRDHDGGRRVVRLEYSAHPSAGE
CEEEEEECCCCCCEEEECCHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCHHH
VMAEVVAEVAERSCGVRAVAASHRIGVLSIGEAALVAAVAADHRQAAFDTCAQLVDTVKA
HHHHHHHHHHHHCCCEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLPVWKHQFFADGTDEWVGSA
HCCHHHHHHHCCCCHHCCCCC
>Mature Secondary Structure 
TLVVRAAVTEHPIVLAQHEELVGHQSAGAVVGFVGMIRDHDGGRRVVRLEYSAHPSAGE
EEEEEECCCCCCEEEECCHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCHHH
VMAEVVAEVAERSCGVRAVAASHRIGVLSIGEAALVAAVAADHRQAAFDTCAQLVDTVKA
HHHHHHHHHHHHCCCEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLPVWKHQFFADGTDEWVGSA
HCCHHHHHHHCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]