Click here to switch to the map view.

The map label for this gene is fadA_1

Identifier: 41406887

GI number: 41406887

Start: 809058

End: 810269

Strand: Direct

Name: fadA_1

Synonym: MAP0789

Alternate gene names: 41406887

Gene position: 809058-810269 (Clockwise)

Preceding gene: 41406885

Following gene: 41406888

Centisome position: 16.75

GC content: 68.65

Gene sequence:

>1212_bases
ATGTCCGAAGAAGCTTTTATCTACGAAGCCATCCGCACACCGCGGGGCAAGCAGAAGAACGGCTCGCTGACCGAGGTGAA
GCCGCTCAACCTGGTGGTAGGCCTGGTCGACGAGCTGCGCCGGCGCTACCCCGACCTGGACGAGAGCCTGATCAGCGACA
TGATCCTGGGTGTCGTGTCCCCGGTCGGCGACCAGGGTGGCGACATCGCCCGCACCGCGGTGCTGGCCGCCGGCCTGCCC
GAGACCACCGGCGGCGTGCAGCTCAACCGGTTCTGCGCCTCGGGCCTCGAGGCCGTCAACACCGCCGCCCAGAAGGTGCG
CTCCGGCTGGGACGACCTGGTGCTGGCCGGCGGTGTGGAGTCGATGAGCCGGGTCCCGATGGGCTCCGACGGCGGCGCCT
GGGCCACCGACCCGGAGACCAACTACCGGATCGGCTTCGTGCCGCAGGGCATCGGCGCCGATTTGATCGCCACCCTCGAG
GGCTTCTCCCGCGAGGACGTCGACGCCTACGCGCTGCGCAGCCAGCAGAAGGCCGCCGCGGCCTGGTCGGGCGGCTACTT
CGCCAAGTCGGTGGTGCCGGTGCGTGACCAGAACGGTCTGGTCATCCTCGACCACGACGAGCACATGCGGCCCGACACCA
CGATGGAGGGCCTGGCCAAGCTGAAGACCGCGTTCGACGGTGTCGGCGAGATGGGCGGCTTCGACGACGTGGCGCTGCAG
AAGTACCACTGGGTCGAGAAGATCAACCACGTCCACACCGGCGGCAACAGCTCGGGCATCGTCGACGGCGCCGCGCTGGT
GCTGGTCGGCAGCGAAAAGGCCGGCAAGTCGCAGGGGTTGACCCCGCGGGCCCGCATCGTGGCCACCGCGACCAGCGGCT
CGGACCCGGTCATCATGCTCACCGGCCCCACCCCGGCCACCCGCAAGGTGCTCGACCGGGCCGGCCTGACGATCGACGAC
ATCGATCTGTTCGAACTGAACGAGGCGTTCGCGTCGGTGGTGCTGAAGTTCCAGAAAGACCTCAACATTCCCGACGAGAA
GCTCAACGTCAACGGCGGCGCCATCGCGATGGGCCACCCGCTGGGCGCCACCGGCGCCATGATCACCGGCACCATGGTCG
ACGAGCTCGAGCGCCGCAACGCGCGTCGCGCCCTGATCACGCTGTGCATCGGCGGCGGCATGGGTGTCGCCACCATCATC
GAGAGGGTTTAA

Upstream 100 bases:

>100_bases
AACAGGTTGGACGGGGGCCCTGTTAGGGTGGGGCCGGAACCTTGTCTTGAAGACGGATTCGCACCCTATTCGCCAGAACA
GGCCAGAACAGGAAGTCGTC

Downstream 100 bases:

>100_bases
GACCATGGCAGAGAACACCATCAAGTGGGACAAGGACGCCGACGGCATTGTCACGCTGACGCTCGACGACCCGACCGGGT
CGGCCAACGTGATGAACGAG

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSEEAFIYEAIRTPRGKQKNGSLTEVKPLNLVVGLVDELRRRYPDLDESLISDMILGVVSPVGDQGGDIARTAVLAAGLP
ETTGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAWATDPETNYRIGFVPQGIGADLIATLE
GFSREDVDAYALRSQQKAAAAWSGGYFAKSVVPVRDQNGLVILDHDEHMRPDTTMEGLAKLKTAFDGVGEMGGFDDVALQ
KYHWVEKINHVHTGGNSSGIVDGAALVLVGSEKAGKSQGLTPRARIVATATSGSDPVIMLTGPTPATRKVLDRAGLTIDD
IDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRNARRALITLCIGGGMGVATII
ERV

Sequences:

>Translated_403_residues
MSEEAFIYEAIRTPRGKQKNGSLTEVKPLNLVVGLVDELRRRYPDLDESLISDMILGVVSPVGDQGGDIARTAVLAAGLP
ETTGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAWATDPETNYRIGFVPQGIGADLIATLE
GFSREDVDAYALRSQQKAAAAWSGGYFAKSVVPVRDQNGLVILDHDEHMRPDTTMEGLAKLKTAFDGVGEMGGFDDVALQ
KYHWVEKINHVHTGGNSSGIVDGAALVLVGSEKAGKSQGLTPRARIVATATSGSDPVIMLTGPTPATRKVLDRAGLTIDD
IDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRNARRALITLCIGGGMGVATII
ERV
>Mature_402_residues
SEEAFIYEAIRTPRGKQKNGSLTEVKPLNLVVGLVDELRRRYPDLDESLISDMILGVVSPVGDQGGDIARTAVLAAGLPE
TTGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAWATDPETNYRIGFVPQGIGADLIATLEG
FSREDVDAYALRSQQKAAAAWSGGYFAKSVVPVRDQNGLVILDHDEHMRPDTTMEGLAKLKTAFDGVGEMGGFDDVALQK
YHWVEKINHVHTGGNSSGIVDGAALVLVGSEKAGKSQGLTPRARIVATATSGSDPVIMLTGPTPATRKVLDRAGLTIDDI
DLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRNARRALITLCIGGGMGVATIIE
RV

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=368, Percent_Identity=37.5, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI4501853, Length=366, Percent_Identity=39.344262295082, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI148539872, Length=423, Percent_Identity=35.2245862884161, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4557237, Length=424, Percent_Identity=31.3679245283019, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI4504327, Length=383, Percent_Identity=30.5483028720627, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI194353979, Length=89, Percent_Identity=50.561797752809, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1787663, Length=421, Percent_Identity=44.8931116389549, Blast_Score=321, Evalue=5e-89,
Organism=Escherichia coli, GI48994986, Length=407, Percent_Identity=39.8034398034398, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI87082165, Length=421, Percent_Identity=38.479809976247, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI1788554, Length=421, Percent_Identity=37.7672209026128, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788683, Length=442, Percent_Identity=28.7330316742081, Blast_Score=131, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI133906874, Length=417, Percent_Identity=38.1294964028777, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17535921, Length=416, Percent_Identity=33.1730769230769, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI25147385, Length=417, Percent_Identity=30.6954436450839, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17551802, Length=417, Percent_Identity=28.2973621103118, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17535917, Length=146, Percent_Identity=32.8767123287671, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322031, Length=405, Percent_Identity=35.0617283950617, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6325229, Length=421, Percent_Identity=30.4038004750594, Blast_Score=152, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24655093, Length=421, Percent_Identity=37.5296912114014, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI17648125, Length=371, Percent_Identity=36.9272237196765, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24640423, Length=374, Percent_Identity=31.0160427807487, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17137578, Length=404, Percent_Identity=30.4455445544554, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42597; Mature: 42466

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEAFIYEAIRTPRGKQKNGSLTEVKPLNLVVGLVDELRRRYPDLDESLISDMILGVVS
CCCCHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
PVGDQGGDIARTAVLAAGLPETTGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVE
CCCCCCCCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHH
SMSRVPMGSDGGAWATDPETNYRIGFVPQGIGADLIATLEGFSREDVDAYALRSQQKAAA
HHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AWSGGYFAKSVVPVRDQNGLVILDHDEHMRPDTTMEGLAKLKTAFDGVGEMGGFDDVALQ
HCCCCCHHHEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCHHCCCCCCHHHHH
KYHWVEKINHVHTGGNSSGIVDGAALVLVGSEKAGKSQGLTPRARIVATATSGSDPVIML
HHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCEEEE
TGPTPATRKVLDRAGLTIDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHP
ECCCHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCEEEECCC
LGATGAMITGTMVDELERRNARRALITLCIGGGMGVATIIERV
CCCCCCEEEHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure 
SEEAFIYEAIRTPRGKQKNGSLTEVKPLNLVVGLVDELRRRYPDLDESLISDMILGVVS
CCCHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
PVGDQGGDIARTAVLAAGLPETTGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVE
CCCCCCCCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHH
SMSRVPMGSDGGAWATDPETNYRIGFVPQGIGADLIATLEGFSREDVDAYALRSQQKAAA
HHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AWSGGYFAKSVVPVRDQNGLVILDHDEHMRPDTTMEGLAKLKTAFDGVGEMGGFDDVALQ
HCCCCCHHHEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCHHCCCCCCHHHHH
KYHWVEKINHVHTGGNSSGIVDGAALVLVGSEKAGKSQGLTPRARIVATATSGSDPVIML
HHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCEEEE
TGPTPATRKVLDRAGLTIDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHP
ECCCHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCEEEECCC
LGATGAMITGTMVDELERRNARRALITLCIGGGMGVATIIERV
CCCCCCEEEHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]