Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 52842885

GI number: 52842885

Start: 3026515

End: 3027459

Strand: Reverse

Name: gyaR [H]

Synonym: lpg2679

Alternate gene names: 52842885

Gene position: 3027459-3026515 (Counterclockwise)

Preceding gene: 52842891

Following gene: 52842884

Centisome position: 89.1

GC content: 38.52

Gene sequence:

>945_bases
ATGAAGCCATTTGTTTACCTGACCAACCAATTTCTAGAGCCAATTATTCCCATGCTGATTCCTGATTGGAACATTATTCA
TGGTTGGAAAATGGCTTCACGAGTGGATCAATCCCGGGTTGTGGCTTTAGCCACAACGGTATGGGATCAGATTGACCATT
CGTTTTTAATGCAATTTCCTAACTTGAAAATTATTAGTCACCTGGGAATAGGAACGGACAATATTGATATTAATTTTTTA
AAGCAAAATCATATTATTCTGCATTCACAACCTAATGCAGGTGTTCATGACACAGCAGAACTTGCTATCGCTTTATTGTT
AACACTGTCGCGAAGGGTGATTCTAAATGATCGCTATACCCGAAATAATGAATGGGTTGAGAAAAAGCCCCGTTTTCTAG
GCAACCATTTATTGGGAAAGCAATTGGGCTTGGTTGGATTCGGTCAAATTGGTGAAAAGATAGCGCAATTTGCAGAGCCT
TTCGGGCTAAAAATTGCTTATACGGCCCGAAGTCAAAAAAATAGCCCTTACTTGTATTGTCCAACAGCCGCAAATTTAGC
ATCTATTAGTGATTTTTTAATCATTTGTTGTTCCGGCGGTATTGATACACAACATTTAATTAACAAACAGGTTTTAGATA
ATTTAGGGCCAGAGGGATATTTGATTAATGTTGCGCGAGGCAGTATAGTGGATCAAAACGCTCTGATTGATGCTTTGCAA
CGCCATACAATCGCTGGTGCCGCTTTGGACGTATACCAGTATGAACCGGAAGTTCCTTTCGCTTTAAGGCAACTTGATAA
CGTCGTCTTATCACCACATATGGGTAGCTCAACTAAAGAAAATTTAAACCAGATGTTTCAATTACAGGCAAAACATTTAA
ACCAATATTTAAATGAGTCTTTGTGGCAAAGGGAAAGCCATGTAACTCTTTTTGAAGAACAATAA

Upstream 100 bases:

>100_bases
CGCTCATTTTACCGCTTGATTTTATTTGCTTGTCAGAAAGATGAGAGAGAATATCATGGGCAACACACGGAATCTTTATT
CTGAAAAATAGGACATTTTA

Downstream 100 bases:

>100_bases
TTATTTTTTATCAAATATAAGGATATATTATGCCCAGTACTTACATTCTAAATACCAATGACAAGGCGAGAGAGCGTCTT
TCTCTGCAACATCAATTGTA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKPFVYLTNQFLEPIIPMLIPDWNIIHGWKMASRVDQSRVVALATTVWDQIDHSFLMQFPNLKIISHLGIGTDNIDINFL
KQNHIILHSQPNAGVHDTAELAIALLLTLSRRVILNDRYTRNNEWVEKKPRFLGNHLLGKQLGLVGFGQIGEKIAQFAEP
FGLKIAYTARSQKNSPYLYCPTAANLASISDFLIICCSGGIDTQHLINKQVLDNLGPEGYLINVARGSIVDQNALIDALQ
RHTIAGAALDVYQYEPEVPFALRQLDNVVLSPHMGSSTKENLNQMFQLQAKHLNQYLNESLWQRESHVTLFEEQ

Sequences:

>Translated_314_residues
MKPFVYLTNQFLEPIIPMLIPDWNIIHGWKMASRVDQSRVVALATTVWDQIDHSFLMQFPNLKIISHLGIGTDNIDINFL
KQNHIILHSQPNAGVHDTAELAIALLLTLSRRVILNDRYTRNNEWVEKKPRFLGNHLLGKQLGLVGFGQIGEKIAQFAEP
FGLKIAYTARSQKNSPYLYCPTAANLASISDFLIICCSGGIDTQHLINKQVLDNLGPEGYLINVARGSIVDQNALIDALQ
RHTIAGAALDVYQYEPEVPFALRQLDNVVLSPHMGSSTKENLNQMFQLQAKHLNQYLNESLWQRESHVTLFEEQ
>Mature_314_residues
MKPFVYLTNQFLEPIIPMLIPDWNIIHGWKMASRVDQSRVVALATTVWDQIDHSFLMQFPNLKIISHLGIGTDNIDINFL
KQNHIILHSQPNAGVHDTAELAIALLLTLSRRVILNDRYTRNNEWVEKKPRFLGNHLLGKQLGLVGFGQIGEKIAQFAEP
FGLKIAYTARSQKNSPYLYCPTAANLASISDFLIICCSGGIDTQHLINKQVLDNLGPEGYLINVARGSIVDQNALIDALQ
RHTIAGAALDVYQYEPEVPFALRQLDNVVLSPHMGSSTKENLNQMFQLQAKHLNQYLNESLWQRESHVTLFEEQ

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=256, Percent_Identity=33.984375, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI23308577, Length=231, Percent_Identity=31.6017316017316, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI145580578, Length=262, Percent_Identity=28.6259541984733, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4557499, Length=262, Percent_Identity=28.6259541984733, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=28.957528957529, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI61743967, Length=262, Percent_Identity=27.8625954198473, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4557497, Length=262, Percent_Identity=27.8625954198473, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI87082289, Length=241, Percent_Identity=32.7800829875519, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789279, Length=228, Percent_Identity=31.140350877193, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081824, Length=266, Percent_Identity=27.4436090225564, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787645, Length=253, Percent_Identity=24.901185770751, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=222, Percent_Identity=30.1801801801802, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=279, Percent_Identity=25.089605734767, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320925, Length=275, Percent_Identity=29.8181818181818, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=247, Percent_Identity=29.1497975708502, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=275, Percent_Identity=29.4545454545455, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6321253, Length=271, Percent_Identity=27.3062730627306, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28571528, Length=264, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI45552429, Length=239, Percent_Identity=33.0543933054393, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24585514, Length=239, Percent_Identity=33.0543933054393, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI28574282, Length=239, Percent_Identity=33.0543933054393, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI45551003, Length=242, Percent_Identity=32.6446280991736, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI28574284, Length=242, Percent_Identity=32.6446280991736, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI19921140, Length=227, Percent_Identity=29.0748898678414, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28574286, Length=243, Percent_Identity=31.6872427983539, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24646446, Length=282, Percent_Identity=29.0780141843972, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646448, Length=282, Percent_Identity=29.0780141843972, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646452, Length=282, Percent_Identity=29.0780141843972, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646450, Length=282, Percent_Identity=29.0780141843972, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI62472511, Length=277, Percent_Identity=28.158844765343, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585516, Length=238, Percent_Identity=27.7310924369748, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35489; Mature: 35489

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPFVYLTNQFLEPIIPMLIPDWNIIHGWKMASRVDQSRVVALATTVWDQIDHSFLMQFP
CCCEEEHHHHHHHHHHHHHCCCCCEEECHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHCC
NLKIISHLGIGTDNIDINFLKQNHIILHSQPNAGVHDTAELAIALLLTLSRRVILNDRYT
CEEEEHCCCCCCCCCEEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEECCCCC
RNNEWVEKKPRFLGNHLLGKQLGLVGFGQIGEKIAQFAEPFGLKIAYTARSQKNSPYLYC
CCCCHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEC
PTAANLASISDFLIICCSGGIDTQHLINKQVLDNLGPEGYLINVARGSIVDQNALIDALQ
CCCCCHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
RHTIAGAALDVYQYEPEVPFALRQLDNVVLSPHMGSSTKENLNQMFQLQAKHLNQYLNES
HHHHHHHEEEEEECCCCCCHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LWQRESHVTLFEEQ
HHCCCCCEEEEECC
>Mature Secondary Structure
MKPFVYLTNQFLEPIIPMLIPDWNIIHGWKMASRVDQSRVVALATTVWDQIDHSFLMQFP
CCCEEEHHHHHHHHHHHHHCCCCCEEECHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHCC
NLKIISHLGIGTDNIDINFLKQNHIILHSQPNAGVHDTAELAIALLLTLSRRVILNDRYT
CEEEEHCCCCCCCCCEEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEECCCCC
RNNEWVEKKPRFLGNHLLGKQLGLVGFGQIGEKIAQFAEPFGLKIAYTARSQKNSPYLYC
CCCCHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEC
PTAANLASISDFLIICCSGGIDTQHLINKQVLDNLGPEGYLINVARGSIVDQNALIDALQ
CCCCCHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
RHTIAGAALDVYQYEPEVPFALRQLDNVVLSPHMGSSTKENLNQMFQLQAKHLNQYLNES
HHHHHHHEEEEEECCCCCCHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LWQRESHVTLFEEQ
HHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA