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The map label for this gene is fmt

Identifier: 52842800

GI number: 52842800

Start: 2927359

End: 2928303

Strand: Reverse

Name: fmt

Synonym: lpg2594

Alternate gene names: 52842800

Gene position: 2928303-2927359 (Counterclockwise)

Preceding gene: 52842801

Following gene: 52842799

Centisome position: 86.18

GC content: 41.48

Gene sequence:

>945_bases
ATGAATGGTTTAACTGTCGTTTTTGCTGGAACTCCAGAATTTGGCTTACCCTGTCTGGATGCCTTAATTCAATCAAGGCA
TCATCTCAAGGCTGTTTATACTCAGCCCGACAGGCCGGCTGGCCGAGGCCGTAAATTACAGGAGTCTCCTGTAAAAGAAT
GGGCAATAAATCACCAGATACCAGTTTATCAACCGCTTAATTTTAAAAATCAAGAAGCTGTCGATGAACTTTCTGCCTTA
AAGCCCGATGTAATGGTCGTGATAGCCTATGGATTAATATTACCAAAAGCAGTGTTGGAAATTCCTCGTCTGGGTTGTAT
TAATGTGCATGCTTCTCTGTTACCGCGCTGGCGTGGCGCATCTCCAATACAACATGCCATTTTACATGGTGATGCTGAAT
CCGGAGTGACCATTATGCAAATGGATGTTGGATTGGATACAGGCCCTATGTTATGCAAGGCCGCCTGTCCTGTGACTTCC
TCGGATACCGCTGGTAGTTTGCATGATAAATTAGCAAAAATGTCAGTAAAACCATTATTGGATGTTTTGGAGGCTTTAGC
ATCCAATTCAGCACAATTTGAATTACAAAACAATGAATTAGCGACTTATGCTGGTAAAATTAATAAAGAAGAGGCACGAA
TTAACTGGCATCAGTCTGCAGTGGAAATAGATAGAAAAATTCGCGCATTTAATCCATGGCCTGTTGCCTATACGCTGGCT
GGGGAATTAATGCTCAGAATTCACCAGGCAAAAGCAACTGATATCATGAGTACCGAGATGCCGGGCATGATATTAAATAT
CGATAAAAATGGAATGTTGGTCGCTACCAGTGATAATGCATTGTTAGTGGAAAAGATTCAATTTCCCGGAGCAAAGATCA
TTTCAGTCAGGGATTGGTTAAATTCGGGTAAAACACAATTGCATACTGGTTTAATGTTGCAATGA

Upstream 100 bases:

>100_bases
ATATGAATGGCAAATTGTTTGTCGATATGTTGTCTCCATTGAAGAGAATGATGGCTCGCCGGAAATTAGATAAGTTCAAG
CGTTTACAAGCTCGTAAGCC

Downstream 100 bases:

>100_bases
AAGTAAATGACAGATTCAACGCCTTAAAAATTTTGACGGCCTTGATAGAAAGCAGAAAAAACCTGTCCTATTTGATGTCT
CCGCAAGAGATTTCTCCCAT

Product: methionyl tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MNGLTVVFAGTPEFGLPCLDALIQSRHHLKAVYTQPDRPAGRGRKLQESPVKEWAINHQIPVYQPLNFKNQEAVDELSAL
KPDVMVVIAYGLILPKAVLEIPRLGCINVHASLLPRWRGASPIQHAILHGDAESGVTIMQMDVGLDTGPMLCKAACPVTS
SDTAGSLHDKLAKMSVKPLLDVLEALASNSAQFELQNNELATYAGKINKEEARINWHQSAVEIDRKIRAFNPWPVAYTLA
GELMLRIHQAKATDIMSTEMPGMILNIDKNGMLVATSDNALLVEKIQFPGAKIISVRDWLNSGKTQLHTGLMLQ

Sequences:

>Translated_314_residues
MNGLTVVFAGTPEFGLPCLDALIQSRHHLKAVYTQPDRPAGRGRKLQESPVKEWAINHQIPVYQPLNFKNQEAVDELSAL
KPDVMVVIAYGLILPKAVLEIPRLGCINVHASLLPRWRGASPIQHAILHGDAESGVTIMQMDVGLDTGPMLCKAACPVTS
SDTAGSLHDKLAKMSVKPLLDVLEALASNSAQFELQNNELATYAGKINKEEARINWHQSAVEIDRKIRAFNPWPVAYTLA
GELMLRIHQAKATDIMSTEMPGMILNIDKNGMLVATSDNALLVEKIQFPGAKIISVRDWLNSGKTQLHTGLMLQ
>Mature_314_residues
MNGLTVVFAGTPEFGLPCLDALIQSRHHLKAVYTQPDRPAGRGRKLQESPVKEWAINHQIPVYQPLNFKNQEAVDELSAL
KPDVMVVIAYGLILPKAVLEIPRLGCINVHASLLPRWRGASPIQHAILHGDAESGVTIMQMDVGLDTGPMLCKAACPVTS
SDTAGSLHDKLAKMSVKPLLDVLEALASNSAQFELQNNELATYAGKINKEEARINWHQSAVEIDRKIRAFNPWPVAYTLA
GELMLRIHQAKATDIMSTEMPGMILNIDKNGMLVATSDNALLVEKIQFPGAKIISVRDWLNSGKTQLHTGLMLQ

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI238814322, Length=318, Percent_Identity=27.3584905660377, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI21614513, Length=322, Percent_Identity=28.5714285714286, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI164663775, Length=236, Percent_Identity=35.5932203389831, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1789683, Length=307, Percent_Identity=52.1172638436482, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1788589, Length=278, Percent_Identity=28.0575539568345, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI133930964, Length=304, Percent_Identity=25, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319458, Length=348, Percent_Identity=25.8620689655172, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550868, Length=309, Percent_Identity=28.4789644012945, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28571984, Length=228, Percent_Identity=30.2631578947368, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585660, Length=325, Percent_Identity=26.1538461538462, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 34415; Mature: 34415

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLTVVFAGTPEFGLPCLDALIQSRHHLKAVYTQPDRPAGRGRKLQESPVKEWAINHQI
CCCEEEEEECCCCCCCHHHHHHHHCCHHEEEEEECCCCCCCCCCCCCCCCHHHHHCCCCC
PVYQPLNFKNQEAVDELSALKPDVMVVIAYGLILPKAVLEIPRLGCINVHASLLPRWRGA
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCC
SPIQHAILHGDAESGVTIMQMDVGLDTGPMLCKAACPVTSSDTAGSLHDKLAKMSVKPLL
CHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
DVLEALASNSAQFELQNNELATYAGKINKEEARINWHQSAVEIDRKIRAFNPWPVAYTLA
HHHHHHHCCCEEEEECCCCEEEECCCCCCCHHHEEHHHHHHHHHHHHCCCCCCCCHHHHH
GELMLRIHQAKATDIMSTEMPGMILNIDKNGMLVATSDNALLVEKIQFPGAKIISVRDWL
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCEEEEEEECCCCCEEEEEHHHH
NSGKTQLHTGLMLQ
CCCCCEECCCCCCC
>Mature Secondary Structure
MNGLTVVFAGTPEFGLPCLDALIQSRHHLKAVYTQPDRPAGRGRKLQESPVKEWAINHQI
CCCEEEEEECCCCCCCHHHHHHHHCCHHEEEEEECCCCCCCCCCCCCCCCHHHHHCCCCC
PVYQPLNFKNQEAVDELSALKPDVMVVIAYGLILPKAVLEIPRLGCINVHASLLPRWRGA
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCC
SPIQHAILHGDAESGVTIMQMDVGLDTGPMLCKAACPVTSSDTAGSLHDKLAKMSVKPLL
CHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
DVLEALASNSAQFELQNNELATYAGKINKEEARINWHQSAVEIDRKIRAFNPWPVAYTLA
HHHHHHHCCCEEEEECCCCEEEECCCCCCCHHHEEHHHHHHHHHHHHCCCCCCCCHHHHH
GELMLRIHQAKATDIMSTEMPGMILNIDKNGMLVATSDNALLVEKIQFPGAKIISVRDWL
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCEEEEEEECCCCCEEEEEHHHH
NSGKTQLHTGLMLQ
CCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA