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The map label for this gene is algC [H]

Identifier: 52842694

GI number: 52842694

Start: 2800077

End: 2801465

Strand: Reverse

Name: algC [H]

Synonym: lpg2486

Alternate gene names: 52842694

Gene position: 2801465-2800077 (Counterclockwise)

Preceding gene: 52842695

Following gene: 52842691

Centisome position: 82.45

GC content: 40.82

Gene sequence:

>1389_bases
ATGACCTATCAACAAAAACAAATTCCCCGCTCTGTCTTTCGTGCCTATGACATTAGGGGGATTATCGGTAAAGAACTGGA
TGAGAATTCTTTTTATAACATTGGTTTAGCTATTGCACGTTATTTACAAAAATTAAATCGTCGACAAATATTTGTAGCTC
GTGATGGACGTCTGACCAGTCATGCATTGGCTACGGCCTTGAAAGAGGGTTTGCTAGACAGTGGGATAGATATCCTTGAT
CTTGGTGCTGTGGCGACACCTGTCATGTATTATGCTACCCATACGCAAGGGATTGATTCTGGATTGATGGTTACCGGAAG
TCATAATCCTGCTGATTATAATGGTATCAAGTTAGTATTGGCTGGAAAAACATTAATTCAAGATGAAATAGATACACTTT
ATGCTTTGCTGGGTGAAGTCAAACAGTCAGCTGTTCGTGGCACAGAAACGGCTTTTGATGTGATAGAAGGCTACATTCAG
CGTATCGTGAGCGATATTCAATTGAAGCGCCCTTTAAAAGTAGTTGTTGATTGTGGAAATGGTGTGGCGGGTCCAATTAT
TCCCAGGGCTATTTCAAAATTAGGCTGTGAAGTCATTCCCCTGTATTGTGAAGTGGATGGTCGATTTCCCAATCATCATC
CTGACCCTTCAATAGAAGCTAATTTAGTTGATTTAAAAGCGGCTGTGGCAAATCATCAAGCTGATATTGGTTTGGGCTTT
GATGGGGATGCTGACAGACTTGGCCTAGTGACAAATAAAGGCGAAGTGATTTGGCCTGATCGTTTAATGATGTTTTACTC
ACGAGAGATTTTAAGTCGTAATCCAGGTGCTACTGTTGTGTTTGATGTGAAGTGCTCCAGTCATTTGGAGAAAGAAATCC
AGGCAGCAGGCGGTGTTGCCAGAATGTGCCCCACTGGCCATTCAATTGTGAAAGCGGTGATGAAAAAAGAACAAGCCATC
TTGGCTGGCGAAATGAGCGGGCATCTGTTTTTTAAAGATCGCTGGTATGGATTTGACGATGCTTTATATAGCGCATGCCG
ATTGTTAGAGATTATCAGTTTTTCCCATTTGACTGTCAGTGAACAATTTGAGTTGATCCCTAATAGTGTCAATACACCTG
AAATAAAAATAGCGATTACTGATGAAGAAAAATTTGATTTTATTCAGCGTTTTAGTGAGCAGGCTGATTTCCCTGAAGGT
AGGATTTTGAATATTGATGGTTTGCGTGTTGAATTTCCAAATGGATGGGGATTGTTACGAGCATCAAACACAACTCCTTG
TCTGGTCGCACGTTTTGAGGCGACAGATAAAGATCATCTGGAGCAAATTCAATATTTGTTTAAGAAACAAATTCAGCGCT
TGGATTCTGAGTTGGATTTGCCATTTTAG

Upstream 100 bases:

>100_bases
AGTTTTTATCCCGGTTGTACAGGCTTCTTTTGAGGTGGTCAATGAATTTACAGAAAGCTCCAGAGGAGAAGGTGGTTTTG
GTAGTTCCGGGAGATATTAA

Downstream 100 bases:

>100_bases
TGTTTAAGAATATGAAAAATCCAATATAGAGTTATCCTTTTCAGAGTTTGCCAGATTTGGACAGAACTCACGAAAAAGCC
TAGATAAAAGTTTATTTTTT

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTYQQKQIPRSVFRAYDIRGIIGKELDENSFYNIGLAIARYLQKLNRRQIFVARDGRLTSHALATALKEGLLDSGIDILD
LGAVATPVMYYATHTQGIDSGLMVTGSHNPADYNGIKLVLAGKTLIQDEIDTLYALLGEVKQSAVRGTETAFDVIEGYIQ
RIVSDIQLKRPLKVVVDCGNGVAGPIIPRAISKLGCEVIPLYCEVDGRFPNHHPDPSIEANLVDLKAAVANHQADIGLGF
DGDADRLGLVTNKGEVIWPDRLMMFYSREILSRNPGATVVFDVKCSSHLEKEIQAAGGVARMCPTGHSIVKAVMKKEQAI
LAGEMSGHLFFKDRWYGFDDALYSACRLLEIISFSHLTVSEQFELIPNSVNTPEIKIAITDEEKFDFIQRFSEQADFPEG
RILNIDGLRVEFPNGWGLLRASNTTPCLVARFEATDKDHLEQIQYLFKKQIQRLDSELDLPF

Sequences:

>Translated_462_residues
MTYQQKQIPRSVFRAYDIRGIIGKELDENSFYNIGLAIARYLQKLNRRQIFVARDGRLTSHALATALKEGLLDSGIDILD
LGAVATPVMYYATHTQGIDSGLMVTGSHNPADYNGIKLVLAGKTLIQDEIDTLYALLGEVKQSAVRGTETAFDVIEGYIQ
RIVSDIQLKRPLKVVVDCGNGVAGPIIPRAISKLGCEVIPLYCEVDGRFPNHHPDPSIEANLVDLKAAVANHQADIGLGF
DGDADRLGLVTNKGEVIWPDRLMMFYSREILSRNPGATVVFDVKCSSHLEKEIQAAGGVARMCPTGHSIVKAVMKKEQAI
LAGEMSGHLFFKDRWYGFDDALYSACRLLEIISFSHLTVSEQFELIPNSVNTPEIKIAITDEEKFDFIQRFSEQADFPEG
RILNIDGLRVEFPNGWGLLRASNTTPCLVARFEATDKDHLEQIQYLFKKQIQRLDSELDLPF
>Mature_461_residues
TYQQKQIPRSVFRAYDIRGIIGKELDENSFYNIGLAIARYLQKLNRRQIFVARDGRLTSHALATALKEGLLDSGIDILDL
GAVATPVMYYATHTQGIDSGLMVTGSHNPADYNGIKLVLAGKTLIQDEIDTLYALLGEVKQSAVRGTETAFDVIEGYIQR
IVSDIQLKRPLKVVVDCGNGVAGPIIPRAISKLGCEVIPLYCEVDGRFPNHHPDPSIEANLVDLKAAVANHQADIGLGFD
GDADRLGLVTNKGEVIWPDRLMMFYSREILSRNPGATVVFDVKCSSHLEKEIQAAGGVARMCPTGHSIVKAVMKKEQAIL
AGEMSGHLFFKDRWYGFDDALYSACRLLEIISFSHLTVSEQFELIPNSVNTPEIKIAITDEEKFDFIQRFSEQADFPEGR
ILNIDGLRVEFPNGWGLLRASNTTPCLVARFEATDKDHLEQIQYLFKKQIQRLDSELDLPF

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=443, Percent_Identity=34.5372460496614, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1789566, Length=457, Percent_Identity=23.8512035010941, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 51390; Mature: 51258

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQQKQIPRSVFRAYDIRGIIGKELDENSFYNIGLAIARYLQKLNRRQIFVARDGRLTS
CCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHH
HALATALKEGLLDSGIDILDLGAVATPVMYYATHTQGIDSGLMVTGSHNPADYNGIKLVL
HHHHHHHHHHHHHCCCCEEEHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCCCCEEEEE
AGKTLIQDEIDTLYALLGEVKQSAVRGTETAFDVIEGYIQRIVSDIQLKRPLKVVVDCGN
ECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
GVAGPIIPRAISKLGCEVIPLYCEVDGRFPNHHPDPSIEANLVDLKAAVANHQADIGLGF
CCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCC
DGDADRLGLVTNKGEVIWPDRLMMFYSREILSRNPGATVVFDVKCSSHLEKEIQAAGGVA
CCCCCCEEEEECCCCEECHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCH
RMCPTGHSIVKAVMKKEQAILAGEMSGHLFFKDRWYGFDDALYSACRLLEIISFSHLTVS
HHCCCCHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEH
EQFELIPNSVNTPEIKIAITDEEKFDFIQRFSEQADFPEGRILNIDGLRVEFPNGWGLLR
HHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCCEEEE
ASNTTPCLVARFEATDKDHLEQIQYLFKKQIQRLDSELDLPF
ECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TYQQKQIPRSVFRAYDIRGIIGKELDENSFYNIGLAIARYLQKLNRRQIFVARDGRLTS
CCCHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHH
HALATALKEGLLDSGIDILDLGAVATPVMYYATHTQGIDSGLMVTGSHNPADYNGIKLVL
HHHHHHHHHHHHHCCCCEEEHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCCCCEEEEE
AGKTLIQDEIDTLYALLGEVKQSAVRGTETAFDVIEGYIQRIVSDIQLKRPLKVVVDCGN
ECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
GVAGPIIPRAISKLGCEVIPLYCEVDGRFPNHHPDPSIEANLVDLKAAVANHQADIGLGF
CCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCC
DGDADRLGLVTNKGEVIWPDRLMMFYSREILSRNPGATVVFDVKCSSHLEKEIQAAGGVA
CCCCCCEEEEECCCCEECHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCH
RMCPTGHSIVKAVMKKEQAILAGEMSGHLFFKDRWYGFDDALYSACRLLEIISFSHLTVS
HHCCCCHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEH
EQFELIPNSVNTPEIKIAITDEEKFDFIQRFSEQADFPEGRILNIDGLRVEFPNGWGLLR
HHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCCEEEE
ASNTTPCLVARFEATDKDHLEQIQYLFKKQIQRLDSELDLPF
ECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]