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The map label for this gene is dut

Identifier: 52842695

GI number: 52842695

Start: 2801466

End: 2801936

Strand: Reverse

Name: dut

Synonym: lpg2487

Alternate gene names: 52842695

Gene position: 2801936-2801466 (Counterclockwise)

Preceding gene: 52842696

Following gene: 52842694

Centisome position: 82.46

GC content: 42.25

Gene sequence:

>471_bases
TTGAGAATTATTATGCATCAAGTTATTCAGTTAAAAATTCTGGATTCAAGGATAGGAGATACCATTCCATTGCCTGCCTA
TGCCACTGATGGGTCCGCTGGTCTGGATTTAAGGGTCTGTATCTCGGAGCCTATGCAAGTAGCACCTCAGCAAACAGTAT
TGCTGCCCACCGGCATTGCTATTTACATTGCCGATCCAAAGCTGGCGGCAGTGATTTTGCCAAGATCAGGTTTAGGCCAC
AAAAATGGTATTGTTTTAGGAAACCTTGTAGGGCTGATTGACTCCGATTATCAAGGAGAATTAAAAATCTCTTGTTGGAA
CAGGAGCCAGGAACATTTTACTGTTAATCCTGGTGATAGAATTGCTCAATTAGTTTTTATCCCGGTTGTACAGGCTTCTT
TTGAGGTGGTCAATGAATTTACAGAAAGCTCCAGAGGAGAAGGTGGTTTTGGTAGTTCCGGGAGATATTAA

Upstream 100 bases:

>100_bases
ACAAACAAATAGAGCTGCCATTAACCCATAAAACACGCCTGGCAGGCCAAATTATTGCAATCCTTGCTGCAAGTCTGCAA
AATTAGGCGCAATAAAACGA

Downstream 100 bases:

>100_bases
ATGACCTATCAACAAAAACAAATTCCCCGCTCTGTCTTTCGTGCCTATGACATTAGGGGGATTATCGGTAAAGAACTGGA
TGAGAATTCTTTTTATAACA

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MRIIMHQVIQLKILDSRIGDTIPLPAYATDGSAGLDLRVCISEPMQVAPQQTVLLPTGIAIYIADPKLAAVILPRSGLGH
KNGIVLGNLVGLIDSDYQGELKISCWNRSQEHFTVNPGDRIAQLVFIPVVQASFEVVNEFTESSRGEGGFGSSGRY

Sequences:

>Translated_156_residues
MRIIMHQVIQLKILDSRIGDTIPLPAYATDGSAGLDLRVCISEPMQVAPQQTVLLPTGIAIYIADPKLAAVILPRSGLGH
KNGIVLGNLVGLIDSDYQGELKISCWNRSQEHFTVNPGDRIAQLVFIPVVQASFEVVNEFTESSRGEGGFGSSGRY
>Mature_156_residues
MRIIMHQVIQLKILDSRIGDTIPLPAYATDGSAGLDLRVCISEPMQVAPQQTVLLPTGIAIYIADPKLAAVILPRSGLGH
KNGIVLGNLVGLIDSDYQGELKISCWNRSQEHFTVNPGDRIAQLVFIPVVQASFEVVNEFTESSRGEGGFGSSGRY

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=147, Percent_Identity=32.6530612244898, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI4503423, Length=147, Percent_Identity=31.9727891156463, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI70906441, Length=149, Percent_Identity=30.8724832214765, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1790071, Length=147, Percent_Identity=66.6666666666667, Blast_Score=216, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI71988561, Length=153, Percent_Identity=34.640522875817, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319729, Length=84, Percent_Identity=50, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921126, Length=130, Percent_Identity=33.0769230769231, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24583610, Length=130, Percent_Identity=33.0769230769231, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16861; Mature: 16861

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIMHQVIQLKILDSRIGDTIPLPAYATDGSAGLDLRVCISEPMQVAPQQTVLLPTGIA
CEEHHHHHHHEEEECHHCCCCCCCCEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCEE
IYIADPKLAAVILPRSGLGHKNGIVLGNLVGLIDSDYQGELKISCWNRSQEHFTVNPGDR
EEEECCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCEEEECCHHH
IAQLVFIPVVQASFEVVNEFTESSRGEGGFGSSGRY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRIIMHQVIQLKILDSRIGDTIPLPAYATDGSAGLDLRVCISEPMQVAPQQTVLLPTGIA
CEEHHHHHHHEEEECHHCCCCCCCCEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCEE
IYIADPKLAAVILPRSGLGHKNGIVLGNLVGLIDSDYQGELKISCWNRSQEHFTVNPGDR
EEEECCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCEEEECCHHH
IAQLVFIPVVQASFEVVNEFTESSRGEGGFGSSGRY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA