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The map label for this gene is phr [H]

Identifier: 39997921

GI number: 39997921

Start: 3112696

End: 3114081

Strand: Reverse

Name: phr [H]

Synonym: GSU2829

Alternate gene names: 39997921

Gene position: 3114081-3112696 (Counterclockwise)

Preceding gene: 39997922

Following gene: 39997920

Centisome position: 81.65

GC content: 59.02

Gene sequence:

>1386_bases
ATGAACTGCGGACGGATTCGTTCCCTGCTTCAGGGGGGGGAGGCCACGGCCGGGCCGGTGATATACTGGATGAGCAGGGA
CCAGCGCGTTGCCGACAACTGGGCTTTAATCCACGCCCAGAAGCTCGCACTGGCCCGTAGCGCACCGCTTGGGGTGCTCT
TCTGTCTTGCCCCACGTTTTCTCGGCGCGACCGCACGCCAGTATCGGTTCATGCTCAAAGGGCTGGAGCAGGTTCGGGCC
GCGCTGAATCGGCTTGATATTCCCTTCTTTCTCGTGACCGGTGATCCCAAGGGGGCGGTCGCGGCCTTCACGAGGCGGCA
CAGGGTTTCGTATCTGGTTACCGATTTTGATCCGCTTCGTGTCAAACGGGAGTGGAAACGGCAGGTGGCAGGGGAGATAT
CAATCCCGTTCGACGAGGTGGATGCCCATAATATAGTCCCCTGCTGGATCACATCACAGCGTCAGGAGTGGGGGGCATAC
ACCATCCGCCCAAAGATACACCGGCTGCTTCCCGATTTCATGGAGCCGTTTCCGCCTCTGCAACGTCACCCGTTTCCGTG
GCAGGGAGCGCTGCCTTCAGACGCCGAGTGGCGTGAGACTTTTACGGGGATGACCTTGGACGAATCGGTGCCCGAGGTCA
GCTGGCTCGCGTCGGGAGAAGAGGCAGCGCAGGCCGCTTTGGCCAGATTTCTTGAAGACGGTCTGGCGGGCTACGCAACC
CGGCGCAATAATCCTGCAGTAATGGGACAGTCGGGATTATCCCCCTGGCTCCATTTCGGCCAGCTTTCCGCCCAGAGGGT
CGCGCAGGCAGCGTTTGCTGCCGCCGCGCCGATAGAATCGCGTGATGCCTTTCTTGAAGAATTGATCGTACGTCGGGAGC
TTGCCGACAATTTTTGCTATTACAACGATGCCTACGACCGCTTCGACGGTTTTCCCGAGTGGGCGCAAAGAACCCTCAAC
CGGCATCGGCACGATCCTCGCCCCCAGTGCTATGAGCATGACGTGCTGGAGCAGGGACAGACCCACGATTCTCTCTGGAA
TGCAGCACAACTGGAAATGGTACGCTGGGGCAGGATGCACGGCTACCTGAGAATGTACTGGGCAAAGAAACTGCTCGAGT
GGACCTCTTCGCCCGAAGATGCCCTCATGATTGCCATTCAACTCAACGACCGCTATCAGCTCGACGGCAGGGACCCCAAC
GGATACGCTGGCATTGCCTGGAGCATCGGCGGTGTCCATGATCGTCCCTGGGCAGAGAGACCCGTCTTTGGCACGATTCG
CTTCATGAGCCGCGACGGCTGCCGGAGAAAGTTCGATACAGATGCCTACGAACGCCGGGTGATTATTAGTCCTGCCACAT
GTGCGGGAATAGCTCTGTGTAAATAA

Upstream 100 bases:

>100_bases
CTTGAGCCGTGGAATGATACGCTCCGCTGAAAGGCGGTTGCATCGTCTCGGGGGAGCGATACAATAATGTTCCTGAACTT
CGACAGTCACTGGGGGGACC

Downstream 100 bases:

>100_bases
CGGCACGTACAAGCAAGTTATTGATGAACGTCCTGATTTCTGGTAAGAATATCCAGCCGGGACAGTCGGAATAACCAGGG
GCGCCCAAGGAGACTCCGGG

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MNCGRIRSLLQGGEATAGPVIYWMSRDQRVADNWALIHAQKLALARSAPLGVLFCLAPRFLGATARQYRFMLKGLEQVRA
ALNRLDIPFFLVTGDPKGAVAAFTRRHRVSYLVTDFDPLRVKREWKRQVAGEISIPFDEVDAHNIVPCWITSQRQEWGAY
TIRPKIHRLLPDFMEPFPPLQRHPFPWQGALPSDAEWRETFTGMTLDESVPEVSWLASGEEAAQAALARFLEDGLAGYAT
RRNNPAVMGQSGLSPWLHFGQLSAQRVAQAAFAAAAPIESRDAFLEELIVRRELADNFCYYNDAYDRFDGFPEWAQRTLN
RHRHDPRPQCYEHDVLEQGQTHDSLWNAAQLEMVRWGRMHGYLRMYWAKKLLEWTSSPEDALMIAIQLNDRYQLDGRDPN
GYAGIAWSIGGVHDRPWAERPVFGTIRFMSRDGCRRKFDTDAYERRVIISPATCAGIALCK

Sequences:

>Translated_461_residues
MNCGRIRSLLQGGEATAGPVIYWMSRDQRVADNWALIHAQKLALARSAPLGVLFCLAPRFLGATARQYRFMLKGLEQVRA
ALNRLDIPFFLVTGDPKGAVAAFTRRHRVSYLVTDFDPLRVKREWKRQVAGEISIPFDEVDAHNIVPCWITSQRQEWGAY
TIRPKIHRLLPDFMEPFPPLQRHPFPWQGALPSDAEWRETFTGMTLDESVPEVSWLASGEEAAQAALARFLEDGLAGYAT
RRNNPAVMGQSGLSPWLHFGQLSAQRVAQAAFAAAAPIESRDAFLEELIVRRELADNFCYYNDAYDRFDGFPEWAQRTLN
RHRHDPRPQCYEHDVLEQGQTHDSLWNAAQLEMVRWGRMHGYLRMYWAKKLLEWTSSPEDALMIAIQLNDRYQLDGRDPN
GYAGIAWSIGGVHDRPWAERPVFGTIRFMSRDGCRRKFDTDAYERRVIISPATCAGIALCK
>Mature_461_residues
MNCGRIRSLLQGGEATAGPVIYWMSRDQRVADNWALIHAQKLALARSAPLGVLFCLAPRFLGATARQYRFMLKGLEQVRA
ALNRLDIPFFLVTGDPKGAVAAFTRRHRVSYLVTDFDPLRVKREWKRQVAGEISIPFDEVDAHNIVPCWITSQRQEWGAY
TIRPKIHRLLPDFMEPFPPLQRHPFPWQGALPSDAEWRETFTGMTLDESVPEVSWLASGEEAAQAALARFLEDGLAGYAT
RRNNPAVMGQSGLSPWLHFGQLSAQRVAQAAFAAAAPIESRDAFLEELIVRRELADNFCYYNDAYDRFDGFPEWAQRTLN
RHRHDPRPQCYEHDVLEQGQTHDSLWNAAQLEMVRWGRMHGYLRMYWAKKLLEWTSSPEDALMIAIQLNDRYQLDGRDPN
GYAGIAWSIGGVHDRPWAERPVFGTIRFMSRDGCRRKFDTDAYERRVIISPATCAGIALCK

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586398, Length=436, Percent_Identity=49.5412844036697, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24586396, Length=436, Percent_Identity=49.5412844036697, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24586404, Length=152, Percent_Identity=60.5263157894737, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 52651; Mature: 52651

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS01083 DNA_PHOTOLYASES_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCGRIRSLLQGGEATAGPVIYWMSRDQRVADNWALIHAQKLALARSAPLGVLFCLAPRF
CCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
LGATARQYRFMLKGLEQVRAALNRLDIPFFLVTGDPKGAVAAFTRRHRVSYLVTDFDPLR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCEEEEEECCCHHH
VKREWKRQVAGEISIPFDEVDAHNIVPCWITSQRQEWGAYTIRPKIHRLLPDFMEPFPPL
HHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCHHCCCEEECHHHHHHHHHHHCCCCCC
QRHPFPWQGALPSDAEWRETFTGMTLDESVPEVSWLASGEEAAQAALARFLEDGLAGYAT
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
RRNNPAVMGQSGLSPWLHFGQLSAQRVAQAAFAAAAPIESRDAFLEELIVRRELADNFCY
CCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEE
YNDAYDRFDGFPEWAQRTLNRHRHDPRPQCYEHDVLEQGQTHDSLWNAAQLEMVRWGRMH
ECCCHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GYLRMYWAKKLLEWTSSPEDALMIAIQLNDRYQLDGRDPNGYAGIAWSIGGVHDRPWAER
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEECCCCCCCCEEEEEECCCCCCCCCCCC
PVFGTIRFMSRDGCRRKFDTDAYERRVIISPATCAGIALCK
CCEEEEEEHHCCCCCCCCCCHHHCCEEEECCCHHCCCEECC
>Mature Secondary Structure
MNCGRIRSLLQGGEATAGPVIYWMSRDQRVADNWALIHAQKLALARSAPLGVLFCLAPRF
CCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
LGATARQYRFMLKGLEQVRAALNRLDIPFFLVTGDPKGAVAAFTRRHRVSYLVTDFDPLR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCEEEEEECCCHHH
VKREWKRQVAGEISIPFDEVDAHNIVPCWITSQRQEWGAYTIRPKIHRLLPDFMEPFPPL
HHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCHHCCCEEECHHHHHHHHHHHCCCCCC
QRHPFPWQGALPSDAEWRETFTGMTLDESVPEVSWLASGEEAAQAALARFLEDGLAGYAT
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
RRNNPAVMGQSGLSPWLHFGQLSAQRVAQAAFAAAAPIESRDAFLEELIVRRELADNFCY
CCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEE
YNDAYDRFDGFPEWAQRTLNRHRHDPRPQCYEHDVLEQGQTHDSLWNAAQLEMVRWGRMH
ECCCHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GYLRMYWAKKLLEWTSSPEDALMIAIQLNDRYQLDGRDPNGYAGIAWSIGGVHDRPWAER
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEECCCCCCCCEEEEEECCCCCCCCCCCC
PVFGTIRFMSRDGCRRKFDTDAYERRVIISPATCAGIALCK
CCEEEEEEHHCCCCCCCCCCHHHCCEEEECCCHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7813451; 9371463 [H]