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The map label for this gene is zraS [C]

Identifier: 39997849

GI number: 39997849

Start: 3029367

End: 3031139

Strand: Reverse

Name: zraS [C]

Synonym: GSU2755

Alternate gene names: 39997849

Gene position: 3031139-3029367 (Counterclockwise)

Preceding gene: 39997851

Following gene: 39997847

Centisome position: 79.47

GC content: 67.91

Gene sequence:

>1773_bases
ATGGGCGGCCGCTTCGCATGCATGTCCTGCCGGTGGAAGATTCCGCCCGTCCCGTTGCCGGGGCGCGGCTACCGGTACCT
GGCCGTGCTGTTGACGGTGCTCGCGGCGCTGGTCCTTGTGGCCGTGGGAACAGCGTCGGCCGCCGACGCGCCCCGCGACC
GGCATCGCACCATCGTCGTGGGCGGCGATCGCGACTACCCCCCCTACGAGTTCATCGACCAGAACGGCAAGCCCGCCGGC
TACAACGTGGAACTGACCCGGGCCATCGCCGAGGTGATGGGGATGACGGTGGAGTTTCGCCTCGGCGCCTGGTCGGAGAT
GTTCTCCGCCCTCAAGAGCGGTCGGGTCGACGTGCTCCAAGGGATCTCGTGGTCCGAGAAGCGGGCCAGGCAGATCGATT
TCACCCCGCCTCACACCATTGTCTACCATGCCATCTTTGCCCGGCGCGATTCGCCCCCTGCCGCGGGACTTGAGGATCTG
AGGGGCAGGAAGGTGGCGCTCCACCGGGACGGGATCATGCACGAGTACCTGGCGGAGCGGGGCTACGGCAAGGACCTGGT
CCTGACCCCGACCCCGGCGGACGCCCTCCGGCTCCTGGCCGCGGGGGGGTGCGACTACGCGGTGGTGGCCATGGTTCCCG
GCATGTACATCATCCGGGAGAACCGGCTCACGAACCTGGTGCCCGTGGCCCGGAGCATCGCGGCCCAGCGTTACGGGTAT
GCAGTCCGCCAGGGGGATGCGGAGCTTCTGGCCCGCTTCAGCGAGGGGCTCGCCATCCTCAGGAAGACCGGCCAGTACGA
GGCGATCCGCGCCAAGTGGCTGGGGGTGCTGGAGCCCCAGCCGGTCCGCTGGCAGGAGATCGCCAAGTATGCGGCGGTGG
TGGTGATTCCCCTGCTCGTCATCCTCGGCGGCACGGTGCTCTGGAGCCATTCGCTCCGGCGGCAGGTGGCCCAGCGGACC
GAATCCCTTTCCCGGGCCCTGGAGGAGGTCCAGCTTAACCAGCAGCAGCTCCTGCAGGCCGACAAGATGGCTGCGCTGGG
CATCCTGGTTTCCGGCGTGGCCCACGAGATCAACAACCCCACCGGCCTCATCCTGCTGGACGTGCCGATCCTGCGCAAGA
TCTACAATGATGCGGCCCCCATCCTGGAGGAGCGCTACCGGACGGAGGGGGACTTCACCCTCGGCGGGCTCCGTTACTCA
CGGGTTCGTGAGGAGGTGCCGCGGCTTCTGGACGAGATGCAGGACGGGGCCAAGCGGATCAAGCGGATCGTTGAGGACCT
GAAGGACTTTGCCCGGCGCGACGACGTGGGCGGCAAGGAGCTGGTCGACCTCAACGGCGTGGCCCAGGCGGCGGTACGGC
TGGTGGATGCCTCGCTGCGCAAGGCCACGACCCGCTTCACTGCCCGCTATGAGCCCGACCTGCCGCGGGTGCTGGCAAAC
GTCCAGCGGATCGAGCAGGTGGTGGTGAACCTGGTCCTCAACGCCTGCCAGGCCCTGCCGGACCCGAGCCGGGGTATTGA
GCTGGAGACCTCTTTCGATCCGGCCGTTGGGTGTGTGAACCTGCGGGTGCGGGATGAGGGGAGCGGCATCGCGCCGGAAA
ACATCCCGCGCCTCACCGACCCCTTCTTCACCACCAAGCGGGAGAGCGGCGGCACCGGCCTGGGGCTCTCGGTATCCGCG
GGCATCATCAAGGAGCATGGGGGAGCCCTTTCCTTCGAGTCGGCTCTTGGCGAGGGGACCACGGTTACGCTTTCTCTGCC
GGTTATCGCCTGA

Upstream 100 bases:

>100_bases
GACGGCTCGTCTGGGTGTTATACTATAGTGACCCGTCCGATACAAGCGCCGGGATCGGTCCGTGCCCGCGCGACCGATTA
GCCGGAAAGGAGGCTCCGCC

Downstream 100 bases:

>100_bases
TTGTTGCGCTGACTGTGGCGATCGGGAGGCGGAGGGTTCGCTCAGAAAAGAGTCCAAGCGTCGCCGGTCGGGTTTCATGG
GGGCTGATCGGCCGTTTCCG

Product: substrate-binding protein/sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 589

Protein sequence:

>590_residues
MGGRFACMSCRWKIPPVPLPGRGYRYLAVLLTVLAALVLVAVGTASAADAPRDRHRTIVVGGDRDYPPYEFIDQNGKPAG
YNVELTRAIAEVMGMTVEFRLGAWSEMFSALKSGRVDVLQGISWSEKRARQIDFTPPHTIVYHAIFARRDSPPAAGLEDL
RGRKVALHRDGIMHEYLAERGYGKDLVLTPTPADALRLLAAGGCDYAVVAMVPGMYIIRENRLTNLVPVARSIAAQRYGY
AVRQGDAELLARFSEGLAILRKTGQYEAIRAKWLGVLEPQPVRWQEIAKYAAVVVIPLLVILGGTVLWSHSLRRQVAQRT
ESLSRALEEVQLNQQQLLQADKMAALGILVSGVAHEINNPTGLILLDVPILRKIYNDAAPILEERYRTEGDFTLGGLRYS
RVREEVPRLLDEMQDGAKRIKRIVEDLKDFARRDDVGGKELVDLNGVAQAAVRLVDASLRKATTRFTARYEPDLPRVLAN
VQRIEQVVVNLVLNACQALPDPSRGIELETSFDPAVGCVNLRVRDEGSGIAPENIPRLTDPFFTTKRESGGTGLGLSVSA
GIIKEHGGALSFESALGEGTTVTLSLPVIA

Sequences:

>Translated_590_residues
MGGRFACMSCRWKIPPVPLPGRGYRYLAVLLTVLAALVLVAVGTASAADAPRDRHRTIVVGGDRDYPPYEFIDQNGKPAG
YNVELTRAIAEVMGMTVEFRLGAWSEMFSALKSGRVDVLQGISWSEKRARQIDFTPPHTIVYHAIFARRDSPPAAGLEDL
RGRKVALHRDGIMHEYLAERGYGKDLVLTPTPADALRLLAAGGCDYAVVAMVPGMYIIRENRLTNLVPVARSIAAQRYGY
AVRQGDAELLARFSEGLAILRKTGQYEAIRAKWLGVLEPQPVRWQEIAKYAAVVVIPLLVILGGTVLWSHSLRRQVAQRT
ESLSRALEEVQLNQQQLLQADKMAALGILVSGVAHEINNPTGLILLDVPILRKIYNDAAPILEERYRTEGDFTLGGLRYS
RVREEVPRLLDEMQDGAKRIKRIVEDLKDFARRDDVGGKELVDLNGVAQAAVRLVDASLRKATTRFTARYEPDLPRVLAN
VQRIEQVVVNLVLNACQALPDPSRGIELETSFDPAVGCVNLRVRDEGSGIAPENIPRLTDPFFTTKRESGGTGLGLSVSA
GIIKEHGGALSFESALGEGTTVTLSLPVIA
>Mature_589_residues
GGRFACMSCRWKIPPVPLPGRGYRYLAVLLTVLAALVLVAVGTASAADAPRDRHRTIVVGGDRDYPPYEFIDQNGKPAGY
NVELTRAIAEVMGMTVEFRLGAWSEMFSALKSGRVDVLQGISWSEKRARQIDFTPPHTIVYHAIFARRDSPPAAGLEDLR
GRKVALHRDGIMHEYLAERGYGKDLVLTPTPADALRLLAAGGCDYAVVAMVPGMYIIRENRLTNLVPVARSIAAQRYGYA
VRQGDAELLARFSEGLAILRKTGQYEAIRAKWLGVLEPQPVRWQEIAKYAAVVVIPLLVILGGTVLWSHSLRRQVAQRTE
SLSRALEEVQLNQQQLLQADKMAALGILVSGVAHEINNPTGLILLDVPILRKIYNDAAPILEERYRTEGDFTLGGLRYSR
VREEVPRLLDEMQDGAKRIKRIVEDLKDFARRDDVGGKELVDLNGVAQAAVRLVDASLRKATTRFTARYEPDLPRVLANV
QRIEQVVVNLVLNACQALPDPSRGIELETSFDPAVGCVNLRVRDEGSGIAPENIPRLTDPFFTTKRESGGTGLGLSVSAG
IIKEHGGALSFESALGEGTTVTLSLPVIA

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=266, Percent_Identity=35.7142857142857, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788228, Length=252, Percent_Identity=25.7936507936508, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788549, Length=256, Percent_Identity=31.25, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787031, Length=255, Percent_Identity=29.8039215686275, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1787088, Length=254, Percent_Identity=26.7716535433071, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790300, Length=270, Percent_Identity=31.1111111111111, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788649, Length=254, Percent_Identity=24.8031496062992, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1787085, Length=250, Percent_Identity=24.4, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786600, Length=193, Percent_Identity=27.4611398963731, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI145693157, Length=203, Percent_Identity=27.0935960591133, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789149, Length=214, Percent_Identity=25.7009345794392, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64691; Mature: 64559

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGRFACMSCRWKIPPVPLPGRGYRYLAVLLTVLAALVLVAVGTASAADAPRDRHRTIVV
CCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
GGDRDYPPYEFIDQNGKPAGYNVELTRAIAEVMGMTVEFRLGAWSEMFSALKSGRVDVLQ
ECCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCHHHHH
GISWSEKRARQIDFTPPHTIVYHAIFARRDSPPAAGLEDLRGRKVALHRDGIMHEYLAER
CCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEECCCHHHHHHHHC
GYGKDLVLTPTPADALRLLAAGGCDYAVVAMVPGMYIIRENRLTNLVPVARSIAAQRYGY
CCCCCEEECCCCHHHHHHHHCCCCCEEHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCH
AVRQGDAELLARFSEGLAILRKTGQYEAIRAKWLGVLEPQPVRWQEIAKYAAVVVIPLLV
HHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ILGGTVLWSHSLRRQVAQRTESLSRALEEVQLNQQQLLQADKMAALGILVSGVAHEINNP
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
TGLILLDVPILRKIYNDAAPILEERYRTEGDFTLGGLRYSRVREEVPRLLDEMQDGAKRI
CEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
KRIVEDLKDFARRDDVGGKELVDLNGVAQAAVRLVDASLRKATTRFTARYEPDLPRVLAN
HHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VQRIEQVVVNLVLNACQALPDPSRGIELETSFDPAVGCVNLRVRDEGSGIAPENIPRLTD
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCC
PFFTTKRESGGTGLGLSVSAGIIKEHGGALSFESALGEGTTVTLSLPVIA
CCCCCCCCCCCCCCCCEECCCHHHHCCCCEEHHHHCCCCCEEEEEECCCC
>Mature Secondary Structure 
GGRFACMSCRWKIPPVPLPGRGYRYLAVLLTVLAALVLVAVGTASAADAPRDRHRTIVV
CCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
GGDRDYPPYEFIDQNGKPAGYNVELTRAIAEVMGMTVEFRLGAWSEMFSALKSGRVDVLQ
ECCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCHHHHH
GISWSEKRARQIDFTPPHTIVYHAIFARRDSPPAAGLEDLRGRKVALHRDGIMHEYLAER
CCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEECCCHHHHHHHHC
GYGKDLVLTPTPADALRLLAAGGCDYAVVAMVPGMYIIRENRLTNLVPVARSIAAQRYGY
CCCCCEEECCCCHHHHHHHHCCCCCEEHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCH
AVRQGDAELLARFSEGLAILRKTGQYEAIRAKWLGVLEPQPVRWQEIAKYAAVVVIPLLV
HHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ILGGTVLWSHSLRRQVAQRTESLSRALEEVQLNQQQLLQADKMAALGILVSGVAHEINNP
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
TGLILLDVPILRKIYNDAAPILEERYRTEGDFTLGGLRYSRVREEVPRLLDEMQDGAKRI
CEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
KRIVEDLKDFARRDDVGGKELVDLNGVAQAAVRLVDASLRKATTRFTARYEPDLPRVLAN
HHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VQRIEQVVVNLVLNACQALPDPSRGIELETSFDPAVGCVNLRVRDEGSGIAPENIPRLTD
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCC
PFFTTKRESGGTGLGLSVSAGIIKEHGGALSFESALGEGTTVTLSLPVIA
CCCCCCCCCCCCCCCCEECCCHHHHCCCCEEHHHHCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]