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The map label for this gene is moeA [H]

Identifier: 39997797

GI number: 39997797

Start: 2982149

End: 2983366

Strand: Direct

Name: moeA [H]

Synonym: GSU2703

Alternate gene names: 39997797

Gene position: 2982149-2983366 (Clockwise)

Preceding gene: 39997796

Following gene: 39997798

Centisome position: 78.19

GC content: 65.44

Gene sequence:

>1218_bases
GTGCCGTCTTTCACCGAAGCCCGCAGCATTATTCTCGATCGCGTAGCGCCGCTCGGCGTCGAGCGGGTGGGCATCCTGGA
GGCCGTCGGCCGGGTTCTTGCCGAGAACCTGATCGCCCCCTGGGAGATGCCCCTCTGCGACAACTCCGCCATGGACGGCT
TTGCCGTGCGCGCCGACGACTGTGGTGAGACTCCGGTATCCCTGAAGGTTACGGGCTATATCCCCGCCGGCGGCCGGCCC
GCCGGTCCGGTGGAGCCCGGCTGCGCCATCAGGATCATGACCGGCGCACCGGTCCCGTCCGGCTGCGACGCGGTGGTGCC
GGTGGAAGAAACCGAAGATGAAGGCGACGCGGTCCGGATCATGGCCACGGTCGCGCGTCGCCAGCACATCCGCTTCAAGG
GAGAAGATGTCGCCACGGGCGATATCGTCGTCCCCCGCGGCACCCTGCTCCAGCCCCCCGAAATCAGCATGCTCGCATCC
TTCGGCAAGGCACTGGTGCCGGTATTTCGCAAGGCCCGGGTCGCCATTCTGTCCACCGGCGACGAACTGGTCGAATTGGG
CGAGTCCCCCGCACCGGGTACGATCATCAACTCCAACGCCCTGTCCCTGGCAGCCGCGGTACGCCAGTGCGGCGCCGAAC
CAGTTATCATCGGCATCGCCCGCGACAACCGGGAAAGCCATCGCGAAAAGCTTGCCGAAGGGCTTAAAGCCGACGTTCTC
ATCACGTCGGCCGGCGTCTCGGCCGGCGACCGCGACCTGGTCCGCGATGTCCTGGCCGAACTGGGGGCTGAACAGCTCTT
CTGGAAGGTCGACATGAAACCCGGCGGCCCCACCGCTTTCAGCATGCATGGTCCGGTACCGGTCTTCTCCCTTCCCGGCA
ACCCGGTCTCCACCATGATCACCTTCGAGTTCTTCGTCCGTCCGGCGCTCCTGCGGATGATGGGACACAGCCGCGTGGTG
CGCCCCTTTGTTAAGGCCACTCTGCTGGAAGAGGCACGCAAGAAACCGGGCAAGGTAAACTTCCTCCGGGTACAGGCGAC
AGAACGGGACGGCCGTCTGGTGGCATCCACTGCCGGTGAGCAGCACACCGGCATTCTCAGGACCATGGTCAATGCCAACG
CTCTGGTGCTGCTTCCCCGGGAGGCCTCGGTCGTCCCGGCCGGAAGCGAGGTGGAGATGATGATCCTGCGGGACGACGTT
ACGATGCTGGAACGCTAA

Upstream 100 bases:

>100_bases
ATGCGGAGCGGCTGGGAGGAGATCGCATTCACCTGGTGGCGGGCGAACTGGCCAACCCACTTACGGGCGTCAAATTATCC
AGCAGCGAAGGAGACGAATT

Downstream 100 bases:

>100_bases
GGGAGATCGCGTATGTCCTTCAACCATTTTGACGACCAGGGACGGGCCATCATGGTGGACGTGAGCGGCAAGCAGCCGAC
CCTGCGCACCGCTACGGCCG

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPSFTEARSIILDRVAPLGVERVGILEAVGRVLAENLIAPWEMPLCDNSAMDGFAVRADDCGETPVSLKVTGYIPAGGRP
AGPVEPGCAIRIMTGAPVPSGCDAVVPVEETEDEGDAVRIMATVARRQHIRFKGEDVATGDIVVPRGTLLQPPEISMLAS
FGKALVPVFRKARVAILSTGDELVELGESPAPGTIINSNALSLAAAVRQCGAEPVIIGIARDNRESHREKLAEGLKADVL
ITSAGVSAGDRDLVRDVLAELGAEQLFWKVDMKPGGPTAFSMHGPVPVFSLPGNPVSTMITFEFFVRPALLRMMGHSRVV
RPFVKATLLEEARKKPGKVNFLRVQATERDGRLVASTAGEQHTGILRTMVNANALVLLPREASVVPAGSEVEMMILRDDV
TMLER

Sequences:

>Translated_405_residues
MPSFTEARSIILDRVAPLGVERVGILEAVGRVLAENLIAPWEMPLCDNSAMDGFAVRADDCGETPVSLKVTGYIPAGGRP
AGPVEPGCAIRIMTGAPVPSGCDAVVPVEETEDEGDAVRIMATVARRQHIRFKGEDVATGDIVVPRGTLLQPPEISMLAS
FGKALVPVFRKARVAILSTGDELVELGESPAPGTIINSNALSLAAAVRQCGAEPVIIGIARDNRESHREKLAEGLKADVL
ITSAGVSAGDRDLVRDVLAELGAEQLFWKVDMKPGGPTAFSMHGPVPVFSLPGNPVSTMITFEFFVRPALLRMMGHSRVV
RPFVKATLLEEARKKPGKVNFLRVQATERDGRLVASTAGEQHTGILRTMVNANALVLLPREASVVPAGSEVEMMILRDDV
TMLER
>Mature_404_residues
PSFTEARSIILDRVAPLGVERVGILEAVGRVLAENLIAPWEMPLCDNSAMDGFAVRADDCGETPVSLKVTGYIPAGGRPA
GPVEPGCAIRIMTGAPVPSGCDAVVPVEETEDEGDAVRIMATVARRQHIRFKGEDVATGDIVVPRGTLLQPPEISMLASF
GKALVPVFRKARVAILSTGDELVELGESPAPGTIINSNALSLAAAVRQCGAEPVIIGIARDNRESHREKLAEGLKADVLI
TSAGVSAGDRDLVRDVLAELGAEQLFWKVDMKPGGPTAFSMHGPVPVFSLPGNPVSTMITFEFFVRPALLRMMGHSRVVR
PFVKATLLEEARKKPGKVNFLRVQATERDGRLVASTAGEQHTGILRTMVNANALVLLPREASVVPAGSEVEMMILRDDVT
MLER

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=395, Percent_Identity=36.7088607594937, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI10880983, Length=395, Percent_Identity=36.7088607594937, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1787049, Length=384, Percent_Identity=40.3645833333333, Blast_Score=241, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI25147659, Length=394, Percent_Identity=30.9644670050761, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=339, Percent_Identity=26.5486725663717, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136978, Length=388, Percent_Identity=31.4432989690722, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24638841, Length=388, Percent_Identity=31.4432989690722, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43201; Mature: 43069

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFTEARSIILDRVAPLGVERVGILEAVGRVLAENLIAPWEMPLCDNSAMDGFAVRADD
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCC
CGETPVSLKVTGYIPAGGRPAGPVEPGCAIRIMTGAPVPSGCDAVVPVEETEDEGDAVRI
CCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCEEHH
MATVARRQHIRFKGEDVATGDIVVPRGTLLQPPEISMLASFGKALVPVFRKARVAILSTG
HHHHHHHHHCEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEECC
DELVELGESPAPGTIINSNALSLAAAVRQCGAEPVIIGIARDNRESHREKLAEGLKADVL
HHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCEEEE
ITSAGVSAGDRDLVRDVLAELGAEQLFWKVDMKPGGPTAFSMHGPVPVFSLPGNPVSTMI
EEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCEEECCCCEEEEECCCCCHHHHH
TFEFFVRPALLRMMGHSRVVRPFVKATLLEEARKKPGKVNFLRVQATERDGRLVASTAGE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEECCCC
QHTGILRTMVNANALVLLPREASVVPAGSEVEMMILRDDVTMLER
CHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEECCHHHHCC
>Mature Secondary Structure 
PSFTEARSIILDRVAPLGVERVGILEAVGRVLAENLIAPWEMPLCDNSAMDGFAVRADD
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCC
CGETPVSLKVTGYIPAGGRPAGPVEPGCAIRIMTGAPVPSGCDAVVPVEETEDEGDAVRI
CCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCEEHH
MATVARRQHIRFKGEDVATGDIVVPRGTLLQPPEISMLASFGKALVPVFRKARVAILSTG
HHHHHHHHHCEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEECC
DELVELGESPAPGTIINSNALSLAAAVRQCGAEPVIIGIARDNRESHREKLAEGLKADVL
HHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCEEEE
ITSAGVSAGDRDLVRDVLAELGAEQLFWKVDMKPGGPTAFSMHGPVPVFSLPGNPVSTMI
EEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCEEECCCCEEEEECCCCCHHHHH
TFEFFVRPALLRMMGHSRVVRPFVKATLLEEARKKPGKVNFLRVQATERDGRLVASTAGE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEECCCC
QHTGILRTMVNANALVLLPREASVVPAGSEVEMMILRDDVTMLER
CHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]