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The map label for this gene is prsA [H]

Identifier: 39997524

GI number: 39997524

Start: 2663855

End: 2664910

Strand: Direct

Name: prsA [H]

Synonym: GSU2429

Alternate gene names: 39997524

Gene position: 2663855-2664910 (Clockwise)

Preceding gene: 39997520

Following gene: 39997533

Centisome position: 69.84

GC content: 60.42

Gene sequence:

>1056_bases
ATGAACCTGACGAAGACACTGCGTGCGAACATCCTCTCCCTCGCTGCACTGGTTGCACTCTCCGGAGCGGCGATCGGGGC
GGAGGCGGCACCCGCCAAGAAGGAAGACAAAACCGACAAGCCTGCGGCGGCCCCGGCCAAGCAGGAAGAAAAGAACGTTG
CCCCCCTCGACCCGGCAGCGGTGGTGGTGAAGGTCAACGGCGTAGCCATAACCCGCGCCGAGGTTGACCGGGCAAAGAAA
GTCCTCATGTCCCAGAACCGGATGACCCAGCCCGTGACTCCCGATATCGCCCAGAAGGTGGAAGAGGCGGCGGTGAGCCA
GCTCATCGCCAAGGAACTCCTCTACCAGGCCGGCAGGAAACAGGAGATCAAGGATCTGGACAAGCAGATCCAGGAGCGGG
TAAGCCAGAGCAAGGCCCGCTTCCCCTCACAGGAAGAGTACCTGAAGACCCTCAAGAGCATGGACATGACCGAGAAGGAC
GTCGAGACCTTCGCCCGGGAAGACCTGGTCATCAACAATCTGATCGAAAAAGACGTCGTGGCCAAGACCACCGTGTCCGA
CGAAGAGGCCAAGAAGTTCTATAACGACAACATCGACAAGTTCAAGCGGGACGAGACGGTGAAGGCGAGCCACATCCTGA
TCAAGGTGGAGCCCAACGCTTCCGCCGACGACAAGAAGAAGGCCAAGGAAAAGGCCGAGGCGATCCTGAAGCAGGTGAAG
GGCGGCGCCGACTTCGCCGAGGTGGCCAAGAAGGAGTCCGGCTGTCCCAGCGCACCCCAGGGCGGCGATCTGGGCTTCTT
CGGCAAGGGCCAGATGGTTCCCCCGTTCGAGAAGGCCGCCTTCGCCATGAAGCCCGGCGAGGTGAGCGATGTGGTCGAGA
CCCAGTTCGGCTACCACATCATCAAGCTGACCGACAAGCGCCCCGCCGAGACCGTCAAGTTCGAGGAGACCAAGGACCGG
ATCGTTCAGTTCCTGAAGCAGCAGAAGGTTCAGGAAGGGATCAACGAGTACGTGGAGAACCTGAAGAAAGCTGCCAAGAT
CGAGATGGCCAAGTAG

Upstream 100 bases:

>100_bases
CGGCGCCGGGCGGCCCGGAACAACTTTTTTCGTTACACAAATACGCATATAGTGATAGTATTAAAACGCTTTGCACCCCA
CCAAAGGAGATTTGACTGCA

Downstream 100 bases:

>100_bases
CCCTCACCGGTTCACGGCTTGCGCAGCACGAAAAAAGGCCCGTCCACAGCGACGGGCCTTTTTTTATATCTGCACCCCGG
AACATCAGGACTTCGGTGCG

Product: peptidyl-prolyl cis-trans isomerase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNLTKTLRANILSLAALVALSGAAIGAEAAPAKKEDKTDKPAAAPAKQEEKNVAPLDPAAVVVKVNGVAITRAEVDRAKK
VLMSQNRMTQPVTPDIAQKVEEAAVSQLIAKELLYQAGRKQEIKDLDKQIQERVSQSKARFPSQEEYLKTLKSMDMTEKD
VETFAREDLVINNLIEKDVVAKTTVSDEEAKKFYNDNIDKFKRDETVKASHILIKVEPNASADDKKKAKEKAEAILKQVK
GGADFAEVAKKESGCPSAPQGGDLGFFGKGQMVPPFEKAAFAMKPGEVSDVVETQFGYHIIKLTDKRPAETVKFEETKDR
IVQFLKQQKVQEGINEYVENLKKAAKIEMAK

Sequences:

>Translated_351_residues
MNLTKTLRANILSLAALVALSGAAIGAEAAPAKKEDKTDKPAAAPAKQEEKNVAPLDPAAVVVKVNGVAITRAEVDRAKK
VLMSQNRMTQPVTPDIAQKVEEAAVSQLIAKELLYQAGRKQEIKDLDKQIQERVSQSKARFPSQEEYLKTLKSMDMTEKD
VETFAREDLVINNLIEKDVVAKTTVSDEEAKKFYNDNIDKFKRDETVKASHILIKVEPNASADDKKKAKEKAEAILKQVK
GGADFAEVAKKESGCPSAPQGGDLGFFGKGQMVPPFEKAAFAMKPGEVSDVVETQFGYHIIKLTDKRPAETVKFEETKDR
IVQFLKQQKVQEGINEYVENLKKAAKIEMAK
>Mature_351_residues
MNLTKTLRANILSLAALVALSGAAIGAEAAPAKKEDKTDKPAAAPAKQEEKNVAPLDPAAVVVKVNGVAITRAEVDRAKK
VLMSQNRMTQPVTPDIAQKVEEAAVSQLIAKELLYQAGRKQEIKDLDKQIQERVSQSKARFPSQEEYLKTLKSMDMTEKD
VETFAREDLVINNLIEKDVVAKTTVSDEEAKKFYNDNIDKFKRDETVKASHILIKVEPNASADDKKKAKEKAEAILKQVK
GGADFAEVAKKESGCPSAPQGGDLGFFGKGQMVPPFEKAAFAMKPGEVSDVVETQFGYHIIKLTDKRPAETVKFEETKDR
IVQFLKQQKVQEGINEYVENLKKAAKIEMAK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI5453898, Length=109, Percent_Identity=39.4495412844037, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1790211, Length=99, Percent_Identity=46.4646464646465, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786238, Length=216, Percent_Identity=24.537037037037, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786645, Length=146, Percent_Identity=29.4520547945205, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17537729, Length=116, Percent_Identity=37.0689655172414, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322478, Length=134, Percent_Identity=37.3134328358209, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17647355, Length=105, Percent_Identity=38.0952380952381, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 38671; Mature: 38671

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTKTLRANILSLAALVALSGAAIGAEAAPAKKEDKTDKPAAAPAKQEEKNVAPLDPAA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCE
VVVKVNGVAITRAEVDRAKKVLMSQNRMTQPVTPDIAQKVEEAAVSQLIAKELLYQAGRK
EEEEECCEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
QEIKDLDKQIQERVSQSKARFPSQEEYLKTLKSMDMTEKDVETFAREDLVINNLIEKDVV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AKTTVSDEEAKKFYNDNIDKFKRDETVKASHILIKVEPNASADDKKKAKEKAEAILKQVK
HHHCCCHHHHHHHHCCCHHHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
GGADFAEVAKKESGCPSAPQGGDLGFFGKGQMVPPFEKAAFAMKPGEVSDVVETQFGYHI
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHCEEE
IKLTDKRPAETVKFEETKDRIVQFLKQQKVQEGINEYVENLKKAAKIEMAK
EEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLTKTLRANILSLAALVALSGAAIGAEAAPAKKEDKTDKPAAAPAKQEEKNVAPLDPAA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCE
VVVKVNGVAITRAEVDRAKKVLMSQNRMTQPVTPDIAQKVEEAAVSQLIAKELLYQAGRK
EEEEECCEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
QEIKDLDKQIQERVSQSKARFPSQEEYLKTLKSMDMTEKDVETFAREDLVINNLIEKDVV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AKTTVSDEEAKKFYNDNIDKFKRDETVKASHILIKVEPNASADDKKKAKEKAEAILKQVK
HHHCCCHHHHHHHHCCCHHHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
GGADFAEVAKKESGCPSAPQGGDLGFFGKGQMVPPFEKAAFAMKPGEVSDVVETQFGYHI
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHCEEE
IKLTDKRPAETVKFEETKDRIVQFLKQQKVQEGINEYVENLKKAAKIEMAK
EEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]