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The map label for this gene is 39996942

Identifier: 39996942

GI number: 39996942

Start: 2011297

End: 2012724

Strand: Direct

Name: 39996942

Synonym: GSU1843

Alternate gene names: NA

Gene position: 2011297-2012724 (Clockwise)

Preceding gene: 39996936

Following gene: 39996946

Centisome position: 52.73

GC content: 64.22

Gene sequence:

>1428_bases
ATGCAGATCATCCATCACGGCGGCATATTCGGCGTCACCGGGTCCTGTCACGAGCTCGTCATCTCCGACAACGCCGCCAT
CCTCATTGATTGCGGCCTCCTCCAGGGGAACGACGGCGCCGGCGGCAAGAGATTTCCTTTTATCGACTTTCCGCTTGACC
GGGTCAAGGGGCTGGTGCTCACCCATGTCCACATCGATCACTGCGGACGTATCCCCCACTTGCTGGGAGCGGGGTTCCAG
GGGCCCATCTGGTGCAGTGAGGCATCCGCCCTGCTCCTGCCCCTGGTTCTTGAGGACGCCGTCAAGGTCGGCATCACCCG
TGACGAGCACCTCATCGCCCGCTTCCTCAATGCCGTGAAAAAACGGCTGGTCCCCCTCCCCTACGACAGGTGGCACCAGC
TGGGAAGCTGGGATGGTCGCTCCGCTTCGCTGCGTCTTCAGCAGGCGGGGCATATTCTGGGCTCGGCGTACGTGGAGGTG
TCGGTCAGTCCGGCGTCTCAGGCGGAGCAGACCGGCACCGTCAACGGGACAAGGGGCGATACGGTCGTTGTCTTCTCCGG
GGACCTGGGCGCGCCCTTCACCCCGTTGCTGCCCGACCCGAAACCGCCCGAACGGGCAGACATCCTGGTTCTCGAATCGA
CCTACGGCGACCGGCAGCACGAGGGACGCGAACAGCGCCGGGAGCGACTGTGCAGAGTCATCGTCCGGGCGCTCGAAAAT
CGCGGCGCCCTTCTGGTGCCGGCCTTCAGTATCGGCAGGACCCAGGAACTGCTCTACGAGATCGAGGATCTCATCAGCCG
GCACCGGACCGAGGAGGCGGCCGCCGGCCTGCCGTGGGACGACCTGGAAATCATCGTCGATTCGCCGCTGGCCCTCAGCG
TCACCCGGGTCTACGACCGGCTGCGCAGACTCTGGGACGAAGAAGCGCTCGAAACCGTTGCCCAGAACCGTCATCCCCTA
TCCTTCGAGCAGATGACCGTCATCGAGAGCCACGCCGATCATCGGGCCACGGTGGAGTATCTCCGCAAAACCGCCCGCCC
CTGCATCGTCATCGCTGCCGGCGGTATGTGCGCGGGCGGACGCATTGTCAATTACCTCAAGGCCCTGATGCCGGATCCGC
GCACCGATATCCTCTTTGTGGGCTATCAGGCCGCGGGAACTCCGGGGAGAGAGATTCTGGAAGCGGCTAAACAAAAATGG
GAAACCGGGGGCCGCCCCTCCATCGACCTGGACGGCGGCACCTACCCCCTGCGGGCGGCCGTCCACACCATCAGCGGCTA
TTCGGCCCATGCCGACCAGCGGGACCTTGTCGAATTCGTCGAAGGAATCACCGTCCCTCCGAAAACCATCAGGCTTGTGC
ACGGCGAAGAGGAGGCGCGGACGGCTCTGGCTGGAGTACTTGCGGAGAAGGGGTATCAGGTGGAGTAG

Upstream 100 bases:

>100_bases
TCGCCTTTCAGTCAACCGGAAATGCGCATATGCCCTTGACTTCTCCCCTGGCTTTTATTAACAAATTTACACACTACTTT
GTCAATTCCGGGGAGAACCG

Downstream 100 bases:

>100_bases
AAGCCGACCGGCGCGGGAGTGAGAGAGCGGAAACCACGCTCTCACTCCCGCGCCGGTCGTAGCAGGAATCAGTTGACCAT
TACCTGGTCGACGACCAACT

Product: metallo-beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MQIIHHGGIFGVTGSCHELVISDNAAILIDCGLLQGNDGAGGKRFPFIDFPLDRVKGLVLTHVHIDHCGRIPHLLGAGFQ
GPIWCSEASALLLPLVLEDAVKVGITRDEHLIARFLNAVKKRLVPLPYDRWHQLGSWDGRSASLRLQQAGHILGSAYVEV
SVSPASQAEQTGTVNGTRGDTVVVFSGDLGAPFTPLLPDPKPPERADILVLESTYGDRQHEGREQRRERLCRVIVRALEN
RGALLVPAFSIGRTQELLYEIEDLISRHRTEEAAAGLPWDDLEIIVDSPLALSVTRVYDRLRRLWDEEALETVAQNRHPL
SFEQMTVIESHADHRATVEYLRKTARPCIVIAAGGMCAGGRIVNYLKALMPDPRTDILFVGYQAAGTPGREILEAAKQKW
ETGGRPSIDLDGGTYPLRAAVHTISGYSAHADQRDLVEFVEGITVPPKTIRLVHGEEEARTALAGVLAEKGYQVE

Sequences:

>Translated_475_residues
MQIIHHGGIFGVTGSCHELVISDNAAILIDCGLLQGNDGAGGKRFPFIDFPLDRVKGLVLTHVHIDHCGRIPHLLGAGFQ
GPIWCSEASALLLPLVLEDAVKVGITRDEHLIARFLNAVKKRLVPLPYDRWHQLGSWDGRSASLRLQQAGHILGSAYVEV
SVSPASQAEQTGTVNGTRGDTVVVFSGDLGAPFTPLLPDPKPPERADILVLESTYGDRQHEGREQRRERLCRVIVRALEN
RGALLVPAFSIGRTQELLYEIEDLISRHRTEEAAAGLPWDDLEIIVDSPLALSVTRVYDRLRRLWDEEALETVAQNRHPL
SFEQMTVIESHADHRATVEYLRKTARPCIVIAAGGMCAGGRIVNYLKALMPDPRTDILFVGYQAAGTPGREILEAAKQKW
ETGGRPSIDLDGGTYPLRAAVHTISGYSAHADQRDLVEFVEGITVPPKTIRLVHGEEEARTALAGVLAEKGYQVE
>Mature_475_residues
MQIIHHGGIFGVTGSCHELVISDNAAILIDCGLLQGNDGAGGKRFPFIDFPLDRVKGLVLTHVHIDHCGRIPHLLGAGFQ
GPIWCSEASALLLPLVLEDAVKVGITRDEHLIARFLNAVKKRLVPLPYDRWHQLGSWDGRSASLRLQQAGHILGSAYVEV
SVSPASQAEQTGTVNGTRGDTVVVFSGDLGAPFTPLLPDPKPPERADILVLESTYGDRQHEGREQRRERLCRVIVRALEN
RGALLVPAFSIGRTQELLYEIEDLISRHRTEEAAAGLPWDDLEIIVDSPLALSVTRVYDRLRRLWDEEALETVAQNRHPL
SFEQMTVIESHADHRATVEYLRKTARPCIVIAAGGMCAGGRIVNYLKALMPDPRTDILFVGYQAAGTPGREILEAAKQKW
ETGGRPSIDLDGGTYPLRAAVHTISGYSAHADQRDLVEFVEGITVPPKTIRLVHGEEEARTALAGVLAEKGYQVE

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=450, Percent_Identity=26.2222222222222, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI33300633, Length=453, Percent_Identity=23.1788079470199, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32564696, Length=464, Percent_Identity=25.2155172413793, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32566029, Length=451, Percent_Identity=25.4988913525499, Blast_Score=132, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323307, Length=469, Percent_Identity=25.1599147121535, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24648013, Length=440, Percent_Identity=24.5454545454545, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21358523, Length=450, Percent_Identity=23.5555555555556, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 52097; Mature: 52097

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIIHHGGIFGVTGSCHELVISDNAAILIDCGLLQGNDGAGGKRFPFIDFPLDRVKGLVL
CEEEECCCEEECCCCCEEEEEECCCEEEEEEEEEECCCCCCCCCCCEECCCHHHHCCEEE
THVHIDHCGRIPHLLGAGFQGPIWCSEASALLLPLVLEDAVKVGITRDEHLIARFLNAVK
EEEEHHHCCCCHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KRLVPLPYDRWHQLGSWDGRSASLRLQQAGHILGSAYVEVSVSPASQAEQTGTVNGTRGD
HHCCCCCHHHHHHCCCCCCCCCEEEHHHHCHHHEEEEEEEEECCCHHHHHCCCCCCCCCC
TVVVFSGDLGAPFTPLLPDPKPPERADILVLESTYGDRQHEGREQRRERLCRVIVRALEN
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
RGALLVPAFSIGRTQELLYEIEDLISRHRTEEAAAGLPWDDLEIIVDSPLALSVTRVYDR
CCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEECCCHHHHHHHHHHH
LRRLWDEEALETVAQNRHPLSFEQMTVIESHADHRATVEYLRKTARPCIVIAAGGMCAGG
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCH
RIVNYLKALMPDPRTDILFVGYQAAGTPGREILEAAKQKWETGGRPSIDLDGGTYPLRAA
HHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHH
VHTISGYSAHADQRDLVEFVEGITVPPKTIRLVHGEEEARTALAGVLAEKGYQVE
HHHHCCCCCCCCHHHHHHHHHCCCCCCHHEEEEECCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQIIHHGGIFGVTGSCHELVISDNAAILIDCGLLQGNDGAGGKRFPFIDFPLDRVKGLVL
CEEEECCCEEECCCCCEEEEEECCCEEEEEEEEEECCCCCCCCCCCEECCCHHHHCCEEE
THVHIDHCGRIPHLLGAGFQGPIWCSEASALLLPLVLEDAVKVGITRDEHLIARFLNAVK
EEEEHHHCCCCHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KRLVPLPYDRWHQLGSWDGRSASLRLQQAGHILGSAYVEVSVSPASQAEQTGTVNGTRGD
HHCCCCCHHHHHHCCCCCCCCCEEEHHHHCHHHEEEEEEEEECCCHHHHHCCCCCCCCCC
TVVVFSGDLGAPFTPLLPDPKPPERADILVLESTYGDRQHEGREQRRERLCRVIVRALEN
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
RGALLVPAFSIGRTQELLYEIEDLISRHRTEEAAAGLPWDDLEIIVDSPLALSVTRVYDR
CCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEECCCHHHHHHHHHHH
LRRLWDEEALETVAQNRHPLSFEQMTVIESHADHRATVEYLRKTARPCIVIAAGGMCAGG
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCH
RIVNYLKALMPDPRTDILFVGYQAAGTPGREILEAAKQKWETGGRPSIDLDGGTYPLRAA
HHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHH
VHTISGYSAHADQRDLVEFVEGITVPPKTIRLVHGEEEARTALAGVLAEKGYQVE
HHHHCCCCCCCCHHHHHHHHHCCCCCCHHEEEEECCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA