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The map label for this gene is purM

Identifier: 39996857

GI number: 39996857

Start: 1920404

End: 1921450

Strand: Direct

Name: purM

Synonym: GSU1758

Alternate gene names: 39996857

Gene position: 1920404-1921450 (Clockwise)

Preceding gene: 39996852

Following gene: 39996858

Centisome position: 50.35

GC content: 59.31

Gene sequence:

>1047_bases
GTGACAAAGAGAGGTTTTACCTATAAGGACGCCGGTGTCGACATCGATGCCGGCAACACGTTTGTGGGGCTCATCAAACC
GTTCGTGAAAGCCACTTCCAGGCCCGAGGTCATCTCGGACATCGGCGGCTTCGGCGGGCTCTTTTCCCTGAACACCAACA
AGTACCGCAACCCCGTCCTGGTTTCGGGAACCGACGGCGTCGGCACCAAGCTCAAGATCGCCATGATGGCCGACCGGCAT
GATACCGTCGGCATCGACTTGGTGGCCATGTGCGTCAACGACATCATCGTCCAGGGTGCCGAGCCGCTCTTTTTCCTCGA
CTATTTCGCCACGGGCAAACTGGACCCCCAGCGGGGAGCTGCCGTGGTTAAAGGTATCTCGGAGGGATGCGTCCAGGCCG
GCTGTGCCCTTATCGGTGGCGAGACGGCGGAGATGCCCGGCTTCTATCAGCCTGGTGAATACGACCTTGCCGGGTTCACT
GTAGGCGTAGTCGAGCGCGACAACATCATCGACGGATCATCCATCACCGTGGGAAACCGTCTCGTGGGCATCGCCTCCAG
CGGCCTCCACAGTAACGGCTATTCGCTCGCCCGCAAGATTATCTTTGAATCCATGGGACTCGGCATAGACTCCATTCTGC
CAGGACTCGGCATGTCCGCGGCAGACGCCCTGCTTACCCCTACCAAAATCTACGTCAAGACCATTCTCAACCTGCTGAGG
GACTTCCACGTGAACGGCATCGCGCACATTACCGGCGGCGGCCTGCTGGAAAACGTCCCCCGCGTCTTGCCCAACGGCTG
CAAGGCTTTGGTGCATCTGGACAGCTGCCCGCTTCCGCCCCTCTTCTCCCTGCTTCAAGAGGCAGGATCCGTTGAGCGGG
ACGAAATGTACCGCACGTTCAACTGTGGAATCGGCATGGTGCTGGCAGTACCCGAAAACGAGGCCGACGAGATACTTATC
CGCCTTTCGGGACTTCAGGAGAAGGCCTTCATCATCGGCGAAATCGCCAAGTGCGAGCCCGGCGCCGAGATGGTCGAACT
CGTATAA

Upstream 100 bases:

>100_bases
TTGTAAACCCTTTTTTCAGGCCTCAAACCGCGCCAGATAGGGTTTGACATTTACCGGTTCATGCGATAAATTTTCACTTC
TTTTAACGGGAGGAAACGTA

Downstream 100 bases:

>100_bases
ACGGGACGTGGCACCATGGGAGCCCCTATGATTCAACCGCTTGCAGTTGGTGTTCTCGTTTCGGGCAATGGCTCGAATCT
CCAGGCGATCATCGACCGGA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTKRGFTYKDAGVDIDAGNTFVGLIKPFVKATSRPEVISDIGGFGGLFSLNTNKYRNPVLVSGTDGVGTKLKIAMMADRH
DTVGIDLVAMCVNDIIVQGAEPLFFLDYFATGKLDPQRGAAVVKGISEGCVQAGCALIGGETAEMPGFYQPGEYDLAGFT
VGVVERDNIIDGSSITVGNRLVGIASSGLHSNGYSLARKIIFESMGLGIDSILPGLGMSAADALLTPTKIYVKTILNLLR
DFHVNGIAHITGGGLLENVPRVLPNGCKALVHLDSCPLPPLFSLLQEAGSVERDEMYRTFNCGIGMVLAVPENEADEILI
RLSGLQEKAFIIGEIAKCEPGAEMVELV

Sequences:

>Translated_348_residues
MTKRGFTYKDAGVDIDAGNTFVGLIKPFVKATSRPEVISDIGGFGGLFSLNTNKYRNPVLVSGTDGVGTKLKIAMMADRH
DTVGIDLVAMCVNDIIVQGAEPLFFLDYFATGKLDPQRGAAVVKGISEGCVQAGCALIGGETAEMPGFYQPGEYDLAGFT
VGVVERDNIIDGSSITVGNRLVGIASSGLHSNGYSLARKIIFESMGLGIDSILPGLGMSAADALLTPTKIYVKTILNLLR
DFHVNGIAHITGGGLLENVPRVLPNGCKALVHLDSCPLPPLFSLLQEAGSVERDEMYRTFNCGIGMVLAVPENEADEILI
RLSGLQEKAFIIGEIAKCEPGAEMVELV
>Mature_347_residues
TKRGFTYKDAGVDIDAGNTFVGLIKPFVKATSRPEVISDIGGFGGLFSLNTNKYRNPVLVSGTDGVGTKLKIAMMADRHD
TVGIDLVAMCVNDIIVQGAEPLFFLDYFATGKLDPQRGAAVVKGISEGCVQAGCALIGGETAEMPGFYQPGEYDLAGFTV
GVVERDNIIDGSSITVGNRLVGIASSGLHSNGYSLARKIIFESMGLGIDSILPGLGMSAADALLTPTKIYVKTILNLLRD
FHVNGIAHITGGGLLENVPRVLPNGCKALVHLDSCPLPPLFSLLQEAGSVERDEMYRTFNCGIGMVLAVPENEADEILIR
LSGLQEKAFIIGEIAKCEPGAEMVELV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=347, Percent_Identity=53.8904899135447, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI209869995, Length=347, Percent_Identity=53.8904899135447, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI209869993, Length=347, Percent_Identity=53.8904899135447, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1788845, Length=344, Percent_Identity=57.5581395348837, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17567511, Length=349, Percent_Identity=43.8395415472779, Blast_Score=248, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6321203, Length=342, Percent_Identity=50, Blast_Score=312, Evalue=5e-86,
Organism=Drosophila melanogaster, GI24582400, Length=295, Percent_Identity=43.728813559322, Blast_Score=238, Evalue=4e-63,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_GEOSL (Q74CB6)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952808.1
- HSSP:   P08178
- ProteinModelPortal:   Q74CB6
- SMR:   Q74CB6
- GeneID:   2687407
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1758
- NMPDR:   fig|243231.1.peg.1746
- TIGR:   GSU1758
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- BioCyc:   GSUL243231:GSU_1758-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36841; Mature: 36710

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRGFTYKDAGVDIDAGNTFVGLIKPFVKATSRPEVISDIGGFGGLFSLNTNKYRNPVL
CCCCCCEECCCCEEECCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEECCCCCCCCEE
VSGTDGVGTKLKIAMMADRHDTVGIDLVAMCVNDIIVQGAEPLFFLDYFATGKLDPQRGA
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHH
AVVKGISEGCVQAGCALIGGETAEMPGFYQPGEYDLAGFTVGVVERDNIIDGSSITVGNR
HHHHHHHHHHHHHCHHEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEECCE
LVGIASSGLHSNGYSLARKIIFESMGLGIDSILPGLGMSAADALLTPTKIYVKTILNLLR
EEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHH
DFHVNGIAHITGGGLLENVPRVLPNGCKALVHLDSCPLPPLFSLLQEAGSVERDEMYRTF
HHCCCCEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHC
NCGIGMVLAVPENEADEILIRLSGLQEKAFIIGEIAKCEPGAEMVELV
CCCCEEEEEECCCCCCEEEEEECCCCCCHHEEEHHHCCCCCHHHHHCC
>Mature Secondary Structure 
TKRGFTYKDAGVDIDAGNTFVGLIKPFVKATSRPEVISDIGGFGGLFSLNTNKYRNPVL
CCCCCEECCCCEEECCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEECCCCCCCCEE
VSGTDGVGTKLKIAMMADRHDTVGIDLVAMCVNDIIVQGAEPLFFLDYFATGKLDPQRGA
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHH
AVVKGISEGCVQAGCALIGGETAEMPGFYQPGEYDLAGFTVGVVERDNIIDGSSITVGNR
HHHHHHHHHHHHHCHHEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEECCE
LVGIASSGLHSNGYSLARKIIFESMGLGIDSILPGLGMSAADALLTPTKIYVKTILNLLR
EEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHH
DFHVNGIAHITGGGLLENVPRVLPNGCKALVHLDSCPLPPLFSLLQEAGSVERDEMYRTF
HHCCCCEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHC
NCGIGMVLAVPENEADEILIRLSGLQEKAFIIGEIAKCEPGAEMVELV
CCCCEEEEEECCCCCCEEEEEECCCCCCHHEEEHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA