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The map label for this gene is czcD [H]

Identifier: 39995595

GI number: 39995595

Start: 517626

End: 518621

Strand: Reverse

Name: czcD [H]

Synonym: GSU0487

Alternate gene names: 39995595

Gene position: 518621-517626 (Counterclockwise)

Preceding gene: 39995599

Following gene: 39995594

Centisome position: 13.6

GC content: 61.75

Gene sequence:

>996_bases
ATGCACGCAGACTCTCATCTGGACAGAAGCATTACCGGACGGCTGAAATATGCCATCGCCCTGACTGCGCTGACCCTCGT
GGCGGAAATTGTCGGCGGCATCTGGACCAACTCGCTCGCGCTCCTGTCGGACGCGGCCCATGTGTTTCTCGATCTCTTCG
CCCTGGTGCTCTCGCTGGCCGCCATCAAGCTCGCGTCATACCCCGCCAGCGACACCAAAACTTTCGGCTGGCACCGGGCG
GAGGTCTTTGCCTCGTTCATCAACGGCGCCACGGTCTTTCTCATGGCACTGGGCATCTTTTACGAGGCGGTGGGACGGCT
GATGAACCCCGAAGCGGTGAAGAGCCTGCCGATGCTGCTCATCGCCACTCTGGGTCTGGTGATGAATCTCATTTCGGCCA
CGGCCCTCCATGGGCACTCCCACGACGATCTTAACGTCCGCAGCGCCTTCCTCCACGTTGTTGGCGACGCGGCGGCATCA
GTGGGAGTCATCGTCGGCGGGCTCATCATGTACTTCACCGGTTGGTACGTCTTGGACGCCCTCATCTCCATCGGCATCGG
CTGCGTCATCTTCGCAGGCTCGTGGCGGGTATTGCGGGAGGCGGCCCACATTCTCCTGGAAGGAGTACCCCGGGGAATGA
GCACGCAGCAGGTGGCCAACGAGATGGCAGGCGTGGAAGGGGTCAATGCCGTTCATCAGATGAACATCTGGACCATCTGC
TCCCATATCCTGGCGCTGTCCGCCCACGTGGACGTAAAACCCGAGTACAAGGGACAGCAAGCCGAGGTTCTACGACAGAT
CGAACAACTGCTCTTTGAGCGTTACCACATCACCCACACGACCCTCCAGGCCGAGTGCACCCGCTGCGTCGACGGGCCGG
TCATCAAGGACCTCCGGCACCGACCGCGCCACGGCCAGAGCCATGACGACCATCACCACGCCCATGCGCACTGCACCCAC
GGCCCCCACGGACATCATCACGGGCATTCACACTAG

Upstream 100 bases:

>100_bases
AGCGTAGACGGGCTCTTTACCATTGACCGGCCAGTCGGCGCTTTGATACACTTCGCCGACAAGCGACCCGCACAAGCGGT
GCCCCCCCGGGAGACCTCTG

Downstream 100 bases:

>100_bases
CAGGCCGGAGGCGCAATCGCAATGCTCCCCTACACACTGATTCAGGAAGCCGACGACCGACTCAGGAAGCGGGTTCGTCG
CACCGAGCTCATCCACTCCC

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MHADSHLDRSITGRLKYAIALTALTLVAEIVGGIWTNSLALLSDAAHVFLDLFALVLSLAAIKLASYPASDTKTFGWHRA
EVFASFINGATVFLMALGIFYEAVGRLMNPEAVKSLPMLLIATLGLVMNLISATALHGHSHDDLNVRSAFLHVVGDAAAS
VGVIVGGLIMYFTGWYVLDALISIGIGCVIFAGSWRVLREAAHILLEGVPRGMSTQQVANEMAGVEGVNAVHQMNIWTIC
SHILALSAHVDVKPEYKGQQAEVLRQIEQLLFERYHITHTTLQAECTRCVDGPVIKDLRHRPRHGQSHDDHHHAHAHCTH
GPHGHHHGHSH

Sequences:

>Translated_331_residues
MHADSHLDRSITGRLKYAIALTALTLVAEIVGGIWTNSLALLSDAAHVFLDLFALVLSLAAIKLASYPASDTKTFGWHRA
EVFASFINGATVFLMALGIFYEAVGRLMNPEAVKSLPMLLIATLGLVMNLISATALHGHSHDDLNVRSAFLHVVGDAAAS
VGVIVGGLIMYFTGWYVLDALISIGIGCVIFAGSWRVLREAAHILLEGVPRGMSTQQVANEMAGVEGVNAVHQMNIWTIC
SHILALSAHVDVKPEYKGQQAEVLRQIEQLLFERYHITHTTLQAECTRCVDGPVIKDLRHRPRHGQSHDDHHHAHAHCTH
GPHGHHHGHSH
>Mature_331_residues
MHADSHLDRSITGRLKYAIALTALTLVAEIVGGIWTNSLALLSDAAHVFLDLFALVLSLAAIKLASYPASDTKTFGWHRA
EVFASFINGATVFLMALGIFYEAVGRLMNPEAVKSLPMLLIATLGLVMNLISATALHGHSHDDLNVRSAFLHVVGDAAAS
VGVIVGGLIMYFTGWYVLDALISIGIGCVIFAGSWRVLREAAHILLEGVPRGMSTQQVANEMAGVEGVNAVHQMNIWTIC
SHILALSAHVDVKPEYKGQQAEVLRQIEQLLFERYHITHTTLQAECTRCVDGPVIKDLRHRPRHGQSHDDHHHAHAHCTH
GPHGHHHGHSH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=314, Percent_Identity=30.5732484076433, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI289803013, Length=294, Percent_Identity=30.6122448979592, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI289803009, Length=294, Percent_Identity=30.6122448979592, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI289803007, Length=294, Percent_Identity=30.6122448979592, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI289803003, Length=294, Percent_Identity=30.6122448979592, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI64762489, Length=294, Percent_Identity=30.6122448979592, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI21359890, Length=308, Percent_Identity=29.2207792207792, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI21361112, Length=314, Percent_Identity=29.2993630573248, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI20070323, Length=320, Percent_Identity=25.9375, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI222080086, Length=318, Percent_Identity=26.1006289308176, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI40255009, Length=318, Percent_Identity=26.1006289308176, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI14210520, Length=234, Percent_Identity=27.7777777777778, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI52351208, Length=122, Percent_Identity=37.7049180327869, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI52352803, Length=130, Percent_Identity=36.9230769230769, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786966, Length=278, Percent_Identity=35.2517985611511, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI193210990, Length=321, Percent_Identity=29.9065420560748, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17555796, Length=306, Percent_Identity=29.4117647058824, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17555794, Length=308, Percent_Identity=28.8961038961039, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI32564488, Length=282, Percent_Identity=29.7872340425532, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17550442, Length=123, Percent_Identity=31.7073170731707, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17550440, Length=123, Percent_Identity=31.7073170731707, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323899, Length=177, Percent_Identity=33.8983050847458, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=217, Percent_Identity=27.1889400921659, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320411, Length=187, Percent_Identity=34.2245989304813, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583858, Length=354, Percent_Identity=27.683615819209, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24656728, Length=334, Percent_Identity=29.0419161676647, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24656724, Length=334, Percent_Identity=29.0419161676647, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24656720, Length=334, Percent_Identity=29.0419161676647, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24656715, Length=334, Percent_Identity=29.0419161676647, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21357035, Length=334, Percent_Identity=29.0419161676647, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24584409, Length=161, Percent_Identity=29.1925465838509, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574430, Length=161, Percent_Identity=29.1925465838509, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24645863, Length=109, Percent_Identity=38.5321100917431, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585900, Length=152, Percent_Identity=30.2631578947368, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585898, Length=152, Percent_Identity=30.2631578947368, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585896, Length=152, Percent_Identity=30.2631578947368, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921672, Length=152, Percent_Identity=30.2631578947368, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36052; Mature: 36052

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHADSHLDRSITGRLKYAIALTALTLVAEIVGGIWTNSLALLSDAAHVFLDLFALVLSLA
CCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIKLASYPASDTKTFGWHRAEVFASFINGATVFLMALGIFYEAVGRLMNPEAVKSLPMLL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IATLGLVMNLISATALHGHSHDDLNVRSAFLHVVGDAAASVGVIVGGLIMYFTGWYVLDA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISIGIGCVIFAGSWRVLREAAHILLEGVPRGMSTQQVANEMAGVEGVNAVHQMNIWTIC
HHHHCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
SHILALSAHVDVKPEYKGQQAEVLRQIEQLLFERYHITHTTLQAECTRCVDGPVIKDLRH
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
RPRHGQSHDDHHHAHAHCTHGPHGHHHGHSH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHADSHLDRSITGRLKYAIALTALTLVAEIVGGIWTNSLALLSDAAHVFLDLFALVLSLA
CCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIKLASYPASDTKTFGWHRAEVFASFINGATVFLMALGIFYEAVGRLMNPEAVKSLPMLL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IATLGLVMNLISATALHGHSHDDLNVRSAFLHVVGDAAASVGVIVGGLIMYFTGWYVLDA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISIGIGCVIFAGSWRVLREAAHILLEGVPRGMSTQQVANEMAGVEGVNAVHQMNIWTIC
HHHHCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
SHILALSAHVDVKPEYKGQQAEVLRQIEQLLFERYHITHTTLQAECTRCVDGPVIKDLRH
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
RPRHGQSHDDHHHAHAHCTHGPHGHHHGHSH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]