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The map label for this gene is ilvA [H]

Identifier: 39995594

GI number: 39995594

Start: 516396

End: 517604

Strand: Reverse

Name: ilvA [H]

Synonym: GSU0486

Alternate gene names: 39995594

Gene position: 517604-516396 (Counterclockwise)

Preceding gene: 39995595

Following gene: 39995583

Centisome position: 13.57

GC content: 62.2

Gene sequence:

>1209_bases
ATGCTCCCCTACACACTGATTCAGGAAGCCGACGACCGACTCAGGAAGCGGGTTCGTCGCACCGAGCTCATCCACTCCCA
TCACTTCAGCGAGAAACTGGGAATCCCGATCTATTTCAAGTGCGAGAACCTCCAGCGCACCGGTGCGTTCAAGATCCGAG
GCGCCCTGAACTTCATGACGTCGCAGCCGCGGGAGGCACTGGCAAAGGGTGTCATTACCGCTTCTGCCGGTAACCATGCC
CAAGGAGTCGCGTTCTCGGCCGACCTGCTGGGAGTGCCGTCCACGGTGTTCATGCCGGAAAGCACGCCGCCGCAGAAGGT
CTTTGCCACCCGTGACTACGGCGCCGAGGTGGTACTCACCGGCCGCAACTTCGACGAGGCATACGCTGCAGCGGTCCAGG
CGCAGGAGGAACGGGGCGCCCTCTTCGTCCACCCCTTTGACGACCCGCTCGTGATGGCCGGGCAAGGCACCATCGGCCTG
GAAGTTCTCCAGGAGCTTCCCGATGTAGCCAATATCCTCGTCCCCATCGGCGGCGGCGGTCTCATCGCGGGCATCGCCAC
GGCCATCAGAGAAACCCACCCCCACGTGCGGATCATCGGCGTTGAAACAGCGGCGGCCCCATCCGCCCACTATTCGCTGC
AAAAGGGGAAGATCGTCCAGGTCCCCGTGACGGTCACCCTTGCCGACGGCATCGCGGTCAAGAAGCCAGGGGTGAACACC
TTTCCCATCATCAGGGACTTGGTGGACGAGGTGGTCTTGGTGGAAGAAGAGGAGATCGCCCTTGCCATCGTGGCGCTGCT
GGAGCGAACCAAGCTCTTGGTCGAGGGGGCCGGGGCCGTTCCGTTGGCCGCGCTTCTCAACCGGCGGGTGACTGATCTTT
CGGGAAAAACGGTCTGCGTGCTGTCGGGCGGGAATATCGACGTGAAGACCATCTCAGTAGTGGTGGAACGGGGTCTGGTG
GCTGCCGGGCGCTACCTGAAGCTGAAGGTGGAGCTGGACGATCTCCCCGGTGCCCTGGCGCGACTTGCGACGGAAATTGC
CGAGGCTAAAGCCAACATCTCCATCATCACCCATGACCGGCGCTCGAAATCGCTCCCCATCGGCAAGACCGAGGTCCTCA
TCGAGCTGGAGACCCGGGGGTTCGAGCACATTCAGGAGGTTATCTCTCACCTGCAGGGGGTGGGGTATCTGGTGGATGTG
CTGAAATAA

Upstream 100 bases:

>100_bases
GAGCCATGACGACCATCACCACGCCCATGCGCACTGCACCCACGGCCCCCACGGACATCATCACGGGCATTCACACTAGC
AGGCCGGAGGCGCAATCGCA

Downstream 100 bases:

>100_bases
GGCCGGAAACGAATTCCGCCGTAAGTGGTGCCACGGTGCCGGCCCCGGCCAGCCCCGGACGCCACAGATCGGCGATGCTA
TCCACATCATACCAGACAGG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MLPYTLIQEADDRLRKRVRRTELIHSHHFSEKLGIPIYFKCENLQRTGAFKIRGALNFMTSQPREALAKGVITASAGNHA
QGVAFSADLLGVPSTVFMPESTPPQKVFATRDYGAEVVLTGRNFDEAYAAAVQAQEERGALFVHPFDDPLVMAGQGTIGL
EVLQELPDVANILVPIGGGGLIAGIATAIRETHPHVRIIGVETAAAPSAHYSLQKGKIVQVPVTVTLADGIAVKKPGVNT
FPIIRDLVDEVVLVEEEEIALAIVALLERTKLLVEGAGAVPLAALLNRRVTDLSGKTVCVLSGGNIDVKTISVVVERGLV
AAGRYLKLKVELDDLPGALARLATEIAEAKANISIITHDRRSKSLPIGKTEVLIELETRGFEHIQEVISHLQGVGYLVDV
LK

Sequences:

>Translated_402_residues
MLPYTLIQEADDRLRKRVRRTELIHSHHFSEKLGIPIYFKCENLQRTGAFKIRGALNFMTSQPREALAKGVITASAGNHA
QGVAFSADLLGVPSTVFMPESTPPQKVFATRDYGAEVVLTGRNFDEAYAAAVQAQEERGALFVHPFDDPLVMAGQGTIGL
EVLQELPDVANILVPIGGGGLIAGIATAIRETHPHVRIIGVETAAAPSAHYSLQKGKIVQVPVTVTLADGIAVKKPGVNT
FPIIRDLVDEVVLVEEEEIALAIVALLERTKLLVEGAGAVPLAALLNRRVTDLSGKTVCVLSGGNIDVKTISVVVERGLV
AAGRYLKLKVELDDLPGALARLATEIAEAKANISIITHDRRSKSLPIGKTEVLIELETRGFEHIQEVISHLQGVGYLVDV
LK
>Mature_402_residues
MLPYTLIQEADDRLRKRVRRTELIHSHHFSEKLGIPIYFKCENLQRTGAFKIRGALNFMTSQPREALAKGVITASAGNHA
QGVAFSADLLGVPSTVFMPESTPPQKVFATRDYGAEVVLTGRNFDEAYAAAVQAQEERGALFVHPFDDPLVMAGQGTIGL
EVLQELPDVANILVPIGGGGLIAGIATAIRETHPHVRIIGVETAAAPSAHYSLQKGKIVQVPVTVTLADGIAVKKPGVNT
FPIIRDLVDEVVLVEEEEIALAIVALLERTKLLVEGAGAVPLAALLNRRVTDLSGKTVCVLSGGNIDVKTISVVVERGLV
AAGRYLKLKVELDDLPGALARLATEIAEAKANISIITHDRRSKSLPIGKTEVLIELETRGFEHIQEVISHLQGVGYLVDV
LK

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=311, Percent_Identity=38.9067524115756, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI19923959, Length=306, Percent_Identity=31.3725490196078, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI33469958, Length=313, Percent_Identity=29.7124600638978, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1789505, Length=308, Percent_Identity=48.3766233766234, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1790207, Length=380, Percent_Identity=35, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1789235, Length=208, Percent_Identity=24.0384615384615, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=394, Percent_Identity=41.3705583756345, Blast_Score=257, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI17537387, Length=397, Percent_Identity=36.272040302267, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17508781, Length=309, Percent_Identity=28.8025889967638, Blast_Score=140, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6320930, Length=323, Percent_Identity=39.0092879256966, Blast_Score=209, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6322631, Length=313, Percent_Identity=39.6166134185303, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6319788, Length=284, Percent_Identity=25.3521126760563, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21355833, Length=380, Percent_Identity=40.2631578947368, Blast_Score=217, Evalue=9e-57,
Organism=Drosophila melanogaster, GI24645328, Length=296, Percent_Identity=40.2027027027027, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43199; Mature: 43199

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPYTLIQEADDRLRKRVRRTELIHSHHFSEKLGIPIYFKCENLQRTGAFKIRGALNFMT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEECCCCCCCCEEEEEEHHHHC
SQPREALAKGVITASAGNHAQGVAFSADLLGVPSTVFMPESTPPQKVFATRDYGAEVVLT
CCHHHHHHCCEEEECCCCCCCCEEEEHHHCCCCCEEECCCCCCCHHEEEECCCCCEEEEE
GRNFDEAYAAAVQAQEERGALFVHPFDDPLVMAGQGTIGLEVLQELPDVANILVPIGGGG
CCCCHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCHHHHHHHHCCCCEEEEEECCCCH
LIAGIATAIRETHPHVRIIGVETAAAPSAHYSLQKGKIVQVPVTVTLADGIAVKKPGVNT
HHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCEEEEEEEEEEECCEEEECCCCCH
FPIIRDLVDEVVLVEEEEIALAIVALLERTKLLVEGAGAVPLAALLNRRVTDLSGKTVCV
HHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHCCHHCCCCCCEEEE
LSGGNIDVKTISVVVERGLVAAGRYLKLKVELDDLPGALARLATEIAEAKANISIITHDR
EECCCEEHHHHHHHHHCCCEECCCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECC
RSKSLPIGKTEVLIELETRGFEHIQEVISHLQGVGYLVDVLK
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MLPYTLIQEADDRLRKRVRRTELIHSHHFSEKLGIPIYFKCENLQRTGAFKIRGALNFMT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEECCCCCCCCEEEEEEHHHHC
SQPREALAKGVITASAGNHAQGVAFSADLLGVPSTVFMPESTPPQKVFATRDYGAEVVLT
CCHHHHHHCCEEEECCCCCCCCEEEEHHHCCCCCEEECCCCCCCHHEEEECCCCCEEEEE
GRNFDEAYAAAVQAQEERGALFVHPFDDPLVMAGQGTIGLEVLQELPDVANILVPIGGGG
CCCCHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCHHHHHHHHCCCCEEEEEECCCCH
LIAGIATAIRETHPHVRIIGVETAAAPSAHYSLQKGKIVQVPVTVTLADGIAVKKPGVNT
HHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCEEEEEEEEEEECCEEEECCCCCH
FPIIRDLVDEVVLVEEEEIALAIVALLERTKLLVEGAGAVPLAALLNRRVTDLSGKTVCV
HHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHCCHHCCCCCCEEEE
LSGGNIDVKTISVVVERGLVAAGRYLKLKVELDDLPGALARLATEIAEAKANISIITHDR
EECCCEEHHHHHHHHHCCCEECCCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECC
RSKSLPIGKTEVLIELETRGFEHIQEVISHLQGVGYLVDVLK
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA