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The map label for this gene is zraS [H]

Identifier: 39995579

GI number: 39995579

Start: 500664

End: 501923

Strand: Reverse

Name: zraS [H]

Synonym: GSU0471

Alternate gene names: 39995579

Gene position: 501923-500664 (Counterclockwise)

Preceding gene: 39995583

Following gene: 39995578

Centisome position: 13.16

GC content: 64.29

Gene sequence:

>1260_bases
ATGGATTCGACAACAATCCTACGTATGCGCGGCAATATCGTTTCCCTCATCGCCCTTGCGGCCGGAGTCATCCTGTCACT
GCTTCTCGGCTGGTTCGCCGTGGGAAACTACCGGAGCGCACGCCCCATTGCCGAAGGGAACCTCCGGGGGCTTGCCCTTT
CACTCACGTCGGCGCTGGAATCGATTGCGGCACGCGACTCGTCCCTGGCTTCACTGGCCGCCTTTCGCGCCCGGGACATC
GCCTATATCTCGGTCATCGACCGCAACGGCACCATCGTCTTTCACTCCAATGCCGACCTGATCGGATCGCGGGTGACGGA
TCAACGGTACGTGACGGTTCTCGGCGGACGGGGCTTGGCGGAAAACCGCATCAGACTCGGCACGGGCGAAGAGGTGTACG
AATATCATGCCCCCCTCCACCTCCCCGGCCGAACCCTGGCCCTGCGCCTGGCACTTCACCCCTGGCGAGCCGATGCGGTG
ATCCACCGGGCCAGGGTAGGCATGGTCGTGCTGTTTTCGCTGCTGGCGGCGGCCTGGACGATGGGGGTGCTCCTCTATCG
CTACGCCCGCCGGGCCCAGGAGCACCGGCTCGAAATGGTCCGACGGGAGCGGCTTGCGCAACTGGGAGAAATGGGGGCGG
TGCTTGCCCACGAGGTGCGCAACCCCCTGTCCGGGATCAAGGGCTACGCCCAACTGCTCATGGAACGGAGCAACGACGAT
GAAAACCGGGAGTTCTCCGCACTGATCGTCACCGAGGCAATCCGGCTCGAATCGCTCGTCAGCGACCTTCTTGCCTACGC
CCGGCCGGAGCCCGGGCCAGAAGGGCCGCTCCAGGTAAACGCGGTGATTGACCATGTGCTGGCACTGGTGGACCCCGAAG
CGCGGGCCGCCGGCGTCACCATTGCGGCATCCCTTGCCGAAGGATTGGCCACAAGAGGAAATGAAGCGCGGTTGGAGCAA
CTCATTCTCAATCTGGCAAAGAACGGCATTCAGGCCATGCCGGACGGGGGAACGCTCACCGTTGTCACCCGGCGCGAAGG
TAAAACGGTCGAGATCAGTGTGGCAGACCACGGCCACGGCATCGCCCCCCACGACCGGGAGCGGATATTCACCCCGTTCT
TCACCACAAAGGCCCGGGGCAGCGGCCTGGGGCTCGCCGTCTGCCGCAAGATAGCCGAAGCCCATGGGGGGAGCATCAGC
GTGGCGGATAATCCCGGCGGCGGCACCGTTTTTCGGGTAACACTCCCCCTTCACCGATGA

Upstream 100 bases:

>100_bases
CCTTCTTCCAGCATACCTCCGAAACCGTTCGGGGCAAGACATCATATCCGTTTGCACGGACAGCCGGCAATGCTATAGTA
CATTCAAATAAACAGATTAA

Downstream 100 bases:

>100_bases
GAGGCATACTACACACATGACGACACGCATACTCATAGCCGAAGATGACAGCACCTTCCGGGGATTTCTCAGGACAGTCC
TCAAGGGAGAGGGATACGAC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MDSTTILRMRGNIVSLIALAAGVILSLLLGWFAVGNYRSARPIAEGNLRGLALSLTSALESIAARDSSLASLAAFRARDI
AYISVIDRNGTIVFHSNADLIGSRVTDQRYVTVLGGRGLAENRIRLGTGEEVYEYHAPLHLPGRTLALRLALHPWRADAV
IHRARVGMVVLFSLLAAAWTMGVLLYRYARRAQEHRLEMVRRERLAQLGEMGAVLAHEVRNPLSGIKGYAQLLMERSNDD
ENREFSALIVTEAIRLESLVSDLLAYARPEPGPEGPLQVNAVIDHVLALVDPEARAAGVTIAASLAEGLATRGNEARLEQ
LILNLAKNGIQAMPDGGTLTVVTRREGKTVEISVADHGHGIAPHDRERIFTPFFTTKARGSGLGLAVCRKIAEAHGGSIS
VADNPGGGTVFRVTLPLHR

Sequences:

>Translated_419_residues
MDSTTILRMRGNIVSLIALAAGVILSLLLGWFAVGNYRSARPIAEGNLRGLALSLTSALESIAARDSSLASLAAFRARDI
AYISVIDRNGTIVFHSNADLIGSRVTDQRYVTVLGGRGLAENRIRLGTGEEVYEYHAPLHLPGRTLALRLALHPWRADAV
IHRARVGMVVLFSLLAAAWTMGVLLYRYARRAQEHRLEMVRRERLAQLGEMGAVLAHEVRNPLSGIKGYAQLLMERSNDD
ENREFSALIVTEAIRLESLVSDLLAYARPEPGPEGPLQVNAVIDHVLALVDPEARAAGVTIAASLAEGLATRGNEARLEQ
LILNLAKNGIQAMPDGGTLTVVTRREGKTVEISVADHGHGIAPHDRERIFTPFFTTKARGSGLGLAVCRKIAEAHGGSIS
VADNPGGGTVFRVTLPLHR
>Mature_419_residues
MDSTTILRMRGNIVSLIALAAGVILSLLLGWFAVGNYRSARPIAEGNLRGLALSLTSALESIAARDSSLASLAAFRARDI
AYISVIDRNGTIVFHSNADLIGSRVTDQRYVTVLGGRGLAENRIRLGTGEEVYEYHAPLHLPGRTLALRLALHPWRADAV
IHRARVGMVVLFSLLAAAWTMGVLLYRYARRAQEHRLEMVRRERLAQLGEMGAVLAHEVRNPLSGIKGYAQLLMERSNDD
ENREFSALIVTEAIRLESLVSDLLAYARPEPGPEGPLQVNAVIDHVLALVDPEARAAGVTIAASLAEGLATRGNEARLEQ
LILNLAKNGIQAMPDGGTLTVVTRREGKTVEISVADHGHGIAPHDRERIFTPFFTTKARGSGLGLAVCRKIAEAHGGSIS
VADNPGGGTVFRVTLPLHR

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=371, Percent_Identity=33.4231805929919, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1788549, Length=282, Percent_Identity=33.6879432624113, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1790300, Length=264, Percent_Identity=30.6818181818182, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=31.4893617021277, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081816, Length=235, Percent_Identity=29.3617021276596, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI145693157, Length=221, Percent_Identity=31.6742081447964, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790346, Length=215, Percent_Identity=31.6279069767442, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788393, Length=221, Percent_Identity=29.4117647058824, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=26.4840182648402, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=216, Percent_Identity=30.0925925925926, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=27.6018099547511, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=212, Percent_Identity=29.7169811320755, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786783, Length=239, Percent_Identity=27.1966527196653, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=223, Percent_Identity=22.8699551569507, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=214, Percent_Identity=24.7663551401869, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=218, Percent_Identity=29.8165137614679, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45229; Mature: 45229

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSTTILRMRGNIVSLIALAAGVILSLLLGWFAVGNYRSARPIAEGNLRGLALSLTSALE
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
SIAARDSSLASLAAFRARDIAYISVIDRNGTIVFHSNADLIGSRVTDQRYVTVLGGRGLA
HHHHCCHHHHHHHHHHHCCEEEEEEEECCCEEEEECCCCHHCCCCCCCEEEEEECCCCCC
ENRIRLGTGEEVYEYHAPLHLPGRTLALRLALHPWRADAVIHRARVGMVVLFSLLAAAWT
CCCEECCCCHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
MGVLLYRYARRAQEHRLEMVRRERLAQLGEMGAVLAHEVRNPLSGIKGYAQLLMERSNDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCC
ENREFSALIVTEAIRLESLVSDLLAYARPEPGPEGPLQVNAVIDHVLALVDPEARAAGVT
CCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCCCHHCCHH
IAASLAEGLATRGNEARLEQLILNLAKNGIQAMPDGGTLTVVTRREGKTVEISVADHGHG
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCCEEEEEEECCCCEEEEEEECCCCC
IAPHDRERIFTPFFTTKARGSGLGLAVCRKIAEAHGGSISVADNPGGGTVFRVTLPLHR
CCCCCCCCEECCEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCC
>Mature Secondary Structure
MDSTTILRMRGNIVSLIALAAGVILSLLLGWFAVGNYRSARPIAEGNLRGLALSLTSALE
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
SIAARDSSLASLAAFRARDIAYISVIDRNGTIVFHSNADLIGSRVTDQRYVTVLGGRGLA
HHHHCCHHHHHHHHHHHCCEEEEEEEECCCEEEEECCCCHHCCCCCCCEEEEEECCCCCC
ENRIRLGTGEEVYEYHAPLHLPGRTLALRLALHPWRADAVIHRARVGMVVLFSLLAAAWT
CCCEECCCCHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
MGVLLYRYARRAQEHRLEMVRRERLAQLGEMGAVLAHEVRNPLSGIKGYAQLLMERSNDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCC
ENREFSALIVTEAIRLESLVSDLLAYARPEPGPEGPLQVNAVIDHVLALVDPEARAAGVT
CCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCCCHHCCHH
IAASLAEGLATRGNEARLEQLILNLAKNGIQAMPDGGTLTVVTRREGKTVEISVADHGHG
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCCEEEEEEECCCCEEEEEEECCCCC
IAPHDRERIFTPFFTTKARGSGLGLAVCRKIAEAHGGSISVADNPGGGTVFRVTLPLHR
CCCCCCCCEECCEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]