Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 39995578

GI number: 39995578

Start: 499286

End: 500647

Strand: Reverse

Name: atoC [H]

Synonym: GSU0470

Alternate gene names: 39995578

Gene position: 500647-499286 (Counterclockwise)

Preceding gene: 39995579

Following gene: 39995577

Centisome position: 13.13

GC content: 63.58

Gene sequence:

>1362_bases
ATGACGACACGCATACTCATAGCCGAAGATGACAGCACCTTCCGGGGATTTCTCAGGACAGTCCTCAAGGGAGAGGGATA
CGACATCAGGGAGGCCGCTGACGGAGAAGAAGCCCTGGCCCTGCTGCGCCGCGAATCCTTCGACTTGGTCCTCTCTGACC
TGAGGATGCCCGGCATCGGAGGACTGGAACTTCTCCGGGCGAGCCGTGATGATGACTATCCGCCTGCATTCGTCATTCTC
ACGGCATTCGGAACCATCGAAGAAGCAGTGGCCGCGGTGAAAGAGGGGGCGGCTGATTTCCTCACCAAGCCCCTGAAGGA
CCCGGACACCCTGCGAGTTCTCGTAGGACGGGTCCTGTCCGGAAAGAGCCGTGAGCGGGAATACCTGGCCCTCAAGGAAA
CCGAAGCGGCGGGACTCCCGCCGGAGGATCTCATCTTCGCCGGCGAGGCCATGGCCCCGGTACGGCGACTCGTGGGAGAG
GTCGCCCCCACCGGCACCACCGTTCTGGTAAGCGGGGAAAGCGGCACCGGCAAGGAGCTCATCGCCCGGGCCGTGCATCT
CCTGTCACCCCGACACGGTGCCGGCTTCGTGGCGGTAAACTGTGCGGCAATCCCCGAAACCCTGCTCGAAAGCGAGCTGT
TCGGCCACGAGCGGGGAGCCTTCACCGGCGCGGTCCAGGCCCGGCGGGGGAAATTCGAACTGGCCCAGGGGGGAACTCTC
TTCCTTGACGAAATCGGGGAGCTCTCTCTCCCCCTTCAGGCGAAGCTCCTGCGGGTCCTCCAGGAGCGGGCCTTCGAGCG
GGTGGGAGGAAACCGGGAAATTCGGGCGGACGTGCGGGTAGTGGCTGCCACCAACCGGGATCTGGTCGTTGAAATCCGCG
AACGGCGCTTCAGGGAAGACCTTTTCTATCGCCTGAACGTGTTCCCCGTCGCGCTTCCCCCCCTACGGGAGCGCCGCGAC
GCCCTGCCACACCTGGTGAACTGGTTCATCCGTCGATTTTCGGGAGTAACCGGCAAAAAAATCCGGGGGATCGAACCCGA
TGCTATGGCGGCCCTCAAGCGCTACCCCTGGCCCGGCAACATCCGCGAACTCCAGAACGTCATTGAACGAGGAGTAATCC
TCGCCCGGCACGCCCTGACCCTGGACGATCTCCCTGAGACCTTCAGGGCACCTCTTCCTGCCGGGCAGGACGGGGAAGGA
GTTCTCAAGGGGCTGGAGCGGGAAGCAATCCTGGCCGCCCTCAAAAGCTGCGGCAACAACCGGCGCCTGACCGCCGAAAA
GCTTGGCATCTCCCGGCGTACCCTCCAGTACCGCCTTCGGGAGTATGGGTTGGTGGGGGATGATCGGGACGGTGCAAATT
AG

Upstream 100 bases:

>100_bases
GAAGCCCATGGGGGGAGCATCAGCGTGGCGGATAATCCCGGCGGCGGCACCGTTTTTCGGGTAACACTCCCCCTTCACCG
ATGAGAGGCATACTACACAC

Downstream 100 bases:

>100_bases
TCGTGAACATGTGCAATTTCTGCACTGAAATAACTGTGAAACATTTCGTCGCTACAAAAAATTACAAGCCATTTCAGCAT
GATACACCAGACACCAACCC

Product: sigma-54 dependent response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTTRILIAEDDSTFRGFLRTVLKGEGYDIREAADGEEALALLRRESFDLVLSDLRMPGIGGLELLRASRDDDYPPAFVIL
TAFGTIEEAVAAVKEGAADFLTKPLKDPDTLRVLVGRVLSGKSREREYLALKETEAAGLPPEDLIFAGEAMAPVRRLVGE
VAPTGTTVLVSGESGTGKELIARAVHLLSPRHGAGFVAVNCAAIPETLLESELFGHERGAFTGAVQARRGKFELAQGGTL
FLDEIGELSLPLQAKLLRVLQERAFERVGGNREIRADVRVVAATNRDLVVEIRERRFREDLFYRLNVFPVALPPLRERRD
ALPHLVNWFIRRFSGVTGKKIRGIEPDAMAALKRYPWPGNIRELQNVIERGVILARHALTLDDLPETFRAPLPAGQDGEG
VLKGLEREAILAALKSCGNNRRLTAEKLGISRRTLQYRLREYGLVGDDRDGAN

Sequences:

>Translated_453_residues
MTTRILIAEDDSTFRGFLRTVLKGEGYDIREAADGEEALALLRRESFDLVLSDLRMPGIGGLELLRASRDDDYPPAFVIL
TAFGTIEEAVAAVKEGAADFLTKPLKDPDTLRVLVGRVLSGKSREREYLALKETEAAGLPPEDLIFAGEAMAPVRRLVGE
VAPTGTTVLVSGESGTGKELIARAVHLLSPRHGAGFVAVNCAAIPETLLESELFGHERGAFTGAVQARRGKFELAQGGTL
FLDEIGELSLPLQAKLLRVLQERAFERVGGNREIRADVRVVAATNRDLVVEIRERRFREDLFYRLNVFPVALPPLRERRD
ALPHLVNWFIRRFSGVTGKKIRGIEPDAMAALKRYPWPGNIRELQNVIERGVILARHALTLDDLPETFRAPLPAGQDGEG
VLKGLEREAILAALKSCGNNRRLTAEKLGISRRTLQYRLREYGLVGDDRDGAN
>Mature_452_residues
TTRILIAEDDSTFRGFLRTVLKGEGYDIREAADGEEALALLRRESFDLVLSDLRMPGIGGLELLRASRDDDYPPAFVILT
AFGTIEEAVAAVKEGAADFLTKPLKDPDTLRVLVGRVLSGKSREREYLALKETEAAGLPPEDLIFAGEAMAPVRRLVGEV
APTGTTVLVSGESGTGKELIARAVHLLSPRHGAGFVAVNCAAIPETLLESELFGHERGAFTGAVQARRGKFELAQGGTLF
LDEIGELSLPLQAKLLRVLQERAFERVGGNREIRADVRVVAATNRDLVVEIRERRFREDLFYRLNVFPVALPPLRERRDA
LPHLVNWFIRRFSGVTGKKIRGIEPDAMAALKRYPWPGNIRELQNVIERGVILARHALTLDDLPETFRAPLPAGQDGEGV
LKGLEREAILAALKSCGNNRRLTAEKLGISRRTLQYRLREYGLVGDDRDGAN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=453, Percent_Identity=44.5916114790287, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1790437, Length=438, Percent_Identity=43.6073059360731, Blast_Score=342, Evalue=4e-95,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=39.1025641025641, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1788905, Length=389, Percent_Identity=42.4164524421594, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI87082117, Length=255, Percent_Identity=54.1176470588235, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1789087, Length=312, Percent_Identity=48.0769230769231, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI1789233, Length=364, Percent_Identity=39.5604395604396, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87082152, Length=333, Percent_Identity=43.2432432432432, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1787583, Length=350, Percent_Identity=39.1428571428571, Blast_Score=211, Evalue=9e-56,
Organism=Escherichia coli, GI1786524, Length=316, Percent_Identity=42.0886075949367, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI87081872, Length=322, Percent_Identity=39.7515527950311, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI87081858, Length=302, Percent_Identity=33.7748344370861, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789828, Length=224, Percent_Identity=38.3928571428571, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789809, Length=122, Percent_Identity=32.7868852459016, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790863, Length=119, Percent_Identity=34.453781512605, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787487, Length=113, Percent_Identity=38.0530973451327, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788191, Length=105, Percent_Identity=37.1428571428571, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787375, Length=103, Percent_Identity=31.0679611650485, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49940; Mature: 49809

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRILIAEDDSTFRGFLRTVLKGEGYDIREAADGEEALALLRRESFDLVLSDLRMPGIG
CCEEEEEECCCHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GLELLRASRDDDYPPAFVILTAFGTIEEAVAAVKEGAADFLTKPLKDPDTLRVLVGRVLS
HHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHC
GKSREREYLALKETEAAGLPPEDLIFAGEAMAPVRRLVGEVAPTGTTVLVSGESGTGKEL
CCCCCCHHEEEECCCCCCCCHHHHEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
IARAVHLLSPRHGAGFVAVNCAAIPETLLESELFGHERGAFTGAVQARRGKFELAQGGTL
HHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEECCCCEE
FLDEIGELSLPLQAKLLRVLQERAFERVGGNREIRADVRVVAATNRDLVVEIRERRFRED
EECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHH
LFYRLNVFPVALPPLRERRDALPHLVNWFIRRFSGVTGKKIRGIEPDAMAALKRYPWPGN
HHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCC
IRELQNVIERGVILARHALTLDDLPETFRAPLPAGQDGEGVLKGLEREAILAALKSCGNN
HHHHHHHHHHHHHHHHHHCCHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
RRLTAEKLGISRRTLQYRLREYGLVGDDRDGAN
CCEEHHHHCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TTRILIAEDDSTFRGFLRTVLKGEGYDIREAADGEEALALLRRESFDLVLSDLRMPGIG
CEEEEEECCCHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GLELLRASRDDDYPPAFVILTAFGTIEEAVAAVKEGAADFLTKPLKDPDTLRVLVGRVLS
HHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHC
GKSREREYLALKETEAAGLPPEDLIFAGEAMAPVRRLVGEVAPTGTTVLVSGESGTGKEL
CCCCCCHHEEEECCCCCCCCHHHHEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
IARAVHLLSPRHGAGFVAVNCAAIPETLLESELFGHERGAFTGAVQARRGKFELAQGGTL
HHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEECCCCEE
FLDEIGELSLPLQAKLLRVLQERAFERVGGNREIRADVRVVAATNRDLVVEIRERRFRED
EECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHH
LFYRLNVFPVALPPLRERRDALPHLVNWFIRRFSGVTGKKIRGIEPDAMAALKRYPWPGN
HHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCC
IRELQNVIERGVILARHALTLDDLPETFRAPLPAGQDGEGVLKGLEREAILAALKSCGNN
HHHHHHHHHHHHHHHHHHCCHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
RRLTAEKLGISRRTLQYRLREYGLVGDDRDGAN
CCEEHHHHCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]