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The map label for this gene is fabF-1 [H]

Identifier: 39995568

GI number: 39995568

Start: 490614

End: 491819

Strand: Reverse

Name: fabF-1 [H]

Synonym: GSU0460

Alternate gene names: 39995568

Gene position: 491819-490614 (Counterclockwise)

Preceding gene: 39995569

Following gene: 39995567

Centisome position: 12.89

GC content: 67.33

Gene sequence:

>1206_bases
ATGGACAAAACCCGCATCGCCATAACCGGTCTCGGCATCTTCTGCGCGGCCGGCAAAGACCTGGCATCCTTCACCGACGC
CCTGCTGCACGGACGCTGCGGCATCGGTCCGGTGGATCTTTTCGACGTCTCTCCCTTCCCTTCCCACATCGGAGCCCAGG
TGCGCGACTACTCCCCCCTGGACTACTTTGACCGGGCCGACGCCCGGCGGCTTTCCCGCACCGACCAGTTCGCCGCCGTT
GCAGCCGCGGAGGCCCTCGGCATGAGCGGCGCAAGGGAACACTACGACCCCTTTACCGTGGGGATCTGCGTGGGGGCCGG
TGCATCGGGGATGATCCACGGCGAGGCCTGGCTCCGTGACCGTCTTGCGGGCGGGAAGGGAAGGCCGGGCGACCTGCGTT
GCATCCTGCCGGACCGGACCACCACCGCCCTGGCGGAGCGCTTCGGCCTCTGGGGCTACCAGGGAAGCATCACTACCGCC
TGCTCCTCGTCGGCCACGGCTATCGGCTGGGGTGCCGACCTCATCGCCACAGGTCAGCTCGACGCCTGCCTCTGCGGCGG
AAGCGACACGCTCTCCATCCTCACCTATGCCGGATTCAACTCTCTGCGGGTCGTCGATCCCGAGCCCTGCTCCCCCTTCA
GCCTGGGCCGCCAGGGAATATCCCTCGGCGAAGGGGCGGCCTTCGTGGTCCTGGAACGGGAGGAGACGGCACGCAGCAGG
GGCGCTCGCATCTACGGCCGCGTTCTGGGCTATGCCTTGGCCGGCGAGGCCCATCACATGACCGCACCGGAGCCATCCGG
ATCGGAAGCGGCCCGGGTAATGCGGGCCGCCCTCGACAATGCAGGGGTTTCTGCCGGCGAAATCGGCTGGGTTAACGCCC
ACGGCACCGGCACTCCCCTCAACGACGTGGTGGAAAGCAAGGCCATGAAACTCGTGTTCGGCGCTGACGTGCAGCACGTC
CCCCTGGTCTCCACCAAGGGGATGACCGGCCACTGCCTGGGCGCCGCCGGCTCCATCGAAATCGTCGCCACCGTAACGGC
CCTGGGGGCAGGGATTATCCCCCGGACCCTCAACTTCCGGGGGAGCGATCCGGAGTGCGACCTGGACTACTGCCACGACG
GCCCACGGGAGAGCTCGGCAACCGTCGCCCTCTCCAATTCCTTTGCCTTTGGCGGCAACGTTACCTCGGTGGTGATCGGA
CGATGA

Upstream 100 bases:

>100_bases
TTCTTTGCCTTCGCCGGACCGTCCGGCTACAATATCACCATATGGCAGTTATCCACTAAAGAGCCTTGCCCGGCACTTCG
AGCCGTTCGAACGAATCACG

Downstream 100 bases:

>100_bases
GCATCCCGTCAATGGACATAGCCGTCACCGGCCTCGCCGCCATCTCCGCCGCCGGGGTGGGAATCGAACCGTTGCGGGAA
ACGGTGGCACAGCGTCAATG

Product: 3-oxoacyl-ACP synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MDKTRIAITGLGIFCAAGKDLASFTDALLHGRCGIGPVDLFDVSPFPSHIGAQVRDYSPLDYFDRADARRLSRTDQFAAV
AAAEALGMSGAREHYDPFTVGICVGAGASGMIHGEAWLRDRLAGGKGRPGDLRCILPDRTTTALAERFGLWGYQGSITTA
CSSSATAIGWGADLIATGQLDACLCGGSDTLSILTYAGFNSLRVVDPEPCSPFSLGRQGISLGEGAAFVVLEREETARSR
GARIYGRVLGYALAGEAHHMTAPEPSGSEAARVMRAALDNAGVSAGEIGWVNAHGTGTPLNDVVESKAMKLVFGADVQHV
PLVSTKGMTGHCLGAAGSIEIVATVTALGAGIIPRTLNFRGSDPECDLDYCHDGPRESSATVALSNSFAFGGNVTSVVIG
R

Sequences:

>Translated_401_residues
MDKTRIAITGLGIFCAAGKDLASFTDALLHGRCGIGPVDLFDVSPFPSHIGAQVRDYSPLDYFDRADARRLSRTDQFAAV
AAAEALGMSGAREHYDPFTVGICVGAGASGMIHGEAWLRDRLAGGKGRPGDLRCILPDRTTTALAERFGLWGYQGSITTA
CSSSATAIGWGADLIATGQLDACLCGGSDTLSILTYAGFNSLRVVDPEPCSPFSLGRQGISLGEGAAFVVLEREETARSR
GARIYGRVLGYALAGEAHHMTAPEPSGSEAARVMRAALDNAGVSAGEIGWVNAHGTGTPLNDVVESKAMKLVFGADVQHV
PLVSTKGMTGHCLGAAGSIEIVATVTALGAGIIPRTLNFRGSDPECDLDYCHDGPRESSATVALSNSFAFGGNVTSVVIG
R
>Mature_401_residues
MDKTRIAITGLGIFCAAGKDLASFTDALLHGRCGIGPVDLFDVSPFPSHIGAQVRDYSPLDYFDRADARRLSRTDQFAAV
AAAEALGMSGAREHYDPFTVGICVGAGASGMIHGEAWLRDRLAGGKGRPGDLRCILPDRTTTALAERFGLWGYQGSITTA
CSSSATAIGWGADLIATGQLDACLCGGSDTLSILTYAGFNSLRVVDPEPCSPFSLGRQGISLGEGAAFVVLEREETARSR
GARIYGRVLGYALAGEAHHMTAPEPSGSEAARVMRAALDNAGVSAGEIGWVNAHGTGTPLNDVVESKAMKLVFGADVQHV
PLVSTKGMTGHCLGAAGSIEIVATVTALGAGIIPRTLNFRGSDPECDLDYCHDGPRESSATVALSNSFAFGGNVTSVVIG
R

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=414, Percent_Identity=35.7487922705314, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI223972627, Length=244, Percent_Identity=34.8360655737705, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI41872631, Length=306, Percent_Identity=28.4313725490196, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=34.9514563106796, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1788663, Length=417, Percent_Identity=31.1750599520384, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=29.7820823244552, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71983535, Length=256, Percent_Identity=33.203125, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI212642053, Length=309, Percent_Identity=27.1844660194175, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17550940, Length=275, Percent_Identity=28.7272727272727, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=437, Percent_Identity=29.2906178489703, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=33.0952380952381, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI221330659, Length=293, Percent_Identity=26.962457337884, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19920632, Length=293, Percent_Identity=26.962457337884, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24581345, Length=254, Percent_Identity=26.7716535433071, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 41596; Mature: 41596

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTRIAITGLGIFCAAGKDLASFTDALLHGRCGIGPVDLFDVSPFPSHIGAQVRDYSPL
CCCCEEEEEECEEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHCCCCCCCCCC
DYFDRADARRLSRTDQFAAVAAAEALGMSGAREHYDPFTVGICVGAGASGMIHGEAWLRD
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEEEEEECCCCCCEEECHHHHHH
RLAGGKGRPGDLRCILPDRTTTALAERFGLWGYQGSITTACSSSATAIGWGADLIATGQL
HHCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCEEECCCCCCCEEECCCCEEECCCC
DACLCGGSDTLSILTYAGFNSLRVVDPEPCSPFSLGRQGISLGEGAAFVVLEREETARSR
CEEEECCCCCEEEEEECCCCEEEEECCCCCCHHHHCCCCCCCCCCEEEEEEECHHHHHHC
GARIYGRVLGYALAGEAHHMTAPEPSGSEAARVMRAALDNAGVSAGEIGWVNAHGTGTPL
CCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCH
NDVVESKAMKLVFGADVQHVPLVSTKGMTGHCLGAAGSIEIVATVTALGAGIIPRTLNFR
HHHHHHHHEEEEECCCCCCCCEEECCCCCCEEECCCCCEEEEEEEHHHCCCCCCCEECCC
GSDPECDLDYCHDGPRESSATVALSNSFAFGGNVTSVVIGR
CCCCCCCCHHCCCCCCCCCCEEEEECCEEECCCEEEEEEEC
>Mature Secondary Structure
MDKTRIAITGLGIFCAAGKDLASFTDALLHGRCGIGPVDLFDVSPFPSHIGAQVRDYSPL
CCCCEEEEEECEEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHCCCCCCCCCC
DYFDRADARRLSRTDQFAAVAAAEALGMSGAREHYDPFTVGICVGAGASGMIHGEAWLRD
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEEEEEECCCCCCEEECHHHHHH
RLAGGKGRPGDLRCILPDRTTTALAERFGLWGYQGSITTACSSSATAIGWGADLIATGQL
HHCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCEEECCCCCCCEEECCCCEEECCCC
DACLCGGSDTLSILTYAGFNSLRVVDPEPCSPFSLGRQGISLGEGAAFVVLEREETARSR
CEEEECCCCCEEEEEECCCCEEEEECCCCCCHHHHCCCCCCCCCCEEEEEEECHHHHHHC
GARIYGRVLGYALAGEAHHMTAPEPSGSEAARVMRAALDNAGVSAGEIGWVNAHGTGTPL
CCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCH
NDVVESKAMKLVFGADVQHVPLVSTKGMTGHCLGAAGSIEIVATVTALGAGIIPRTLNFR
HHHHHHHHEEEEECCCCCCCCEEECCCCCCEEECCCCCEEEEEEEHHHCCCCCCCEECCC
GSDPECDLDYCHDGPRESSATVALSNSFAFGGNVTSVVIGR
CCCCCCCCHHCCCCCCCCCCEEEEECCEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]