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The map label for this gene is hisC

Identifier: 38234140

GI number: 38234140

Start: 1591822

End: 1592922

Strand: Reverse

Name: hisC

Synonym: DIP1565

Alternate gene names: 38234140

Gene position: 1592922-1591822 (Counterclockwise)

Preceding gene: 38234141

Following gene: 38234139

Centisome position: 64.01

GC content: 48.68

Gene sequence:

>1101_bases
ATGAAAGATCTAACGCTGAATGATCTTCCTATTCGGGAAGAACTACGAGGCCAATCCGCTTATGGTGCACCACAACTTGA
CGTTGATGTTCGCCTCAATACAAATGAAAATCCCTACCCGCCCTCTGAAGCGCTCGTCGAAGAACTCGCCCGAGTCGTCG
CTGAGCAAGCGAGTAACCTGAACCGTTATCCCGAGCGCGACGCTGTAGAACTTCGTACCGAGCTTGCTCGATACATTACA
AAGTGTACTGGCGTACCAGTGACCTATGAGCAATTGTGGGCTGCCAATGGTTCAAACGAAGTCTTGCAACAATTGTTACA
AGCATTCGGCGGTCCCGGTCGAACTGTTTTGGGGTTCCAGCCAAGTTATTCAATGCACCCTATTTTGGCGCAAGGAACTC
AAACTACATTTATTAACTGCCCCCGCGATAAGGAGTTTCGCATCGATGTAGATGCAGCACTGGCGGCGATTACTACTCAT
CAGCCCAATATCGTCTTTGTGACTACCCCGAATAATCCCACAGGTGATGTGACCTCGCTAGATACGATCAAAAAGATCCT
AGATGTCGCGCCGGGAATCGTCATCGTGGATGAGGCGTATGCAGAATTTTCGGAACAGCCTAGTGCTATTTCCTTGCTGG
AAAACTATCCCACCAAGTTGGTTGTTTCTCGAACAATGAGTAAAGCCTTCGATTTTGCTGGTGGTCGATTAGGGTATTTT
GTCGCTCATAAGGCATTCATCGATGCCGTGATGCTCGTTCGACTTCCTTATCACCTCTCGCAGTTATCGCAGGCAGCGGC
CATTGTAGCGTTGCGGCATAGCGAAGAAACTTTAGCCACTGTGGCAAAACTCGTAGCGGAACGAAAGCGAGTCCAGCAAG
GTTTGCTCGAACTCGGATTTGAAATTGTGCCTAGCGAATCTAATTTCTTATTCTTTGGGCATTTTGAAGATCAGCACGCT
GCGTGGCAGGCATTTCTCGATCGTAAAGTACTTATCCGCGATGTGTCTGTTTCTGGTTATCTTCGTGCCACGGTCGGGTT
GCCGGAAGAAAACGATGCTTTCCTCAACGCTGCTAGAGAGGTAGCCCAACAATTCCTGTAA

Upstream 100 bases:

>100_bases
CCGAGGACCTTCCTGCACACGGCGAAGCAATTCGTACGCGCTTTGAAAATCTTGGCAACTAGGTCTCACTGAAAAAATAC
GGAAAGAATGCAGTAAACTC

Downstream 100 bases:

>100_bases
TCGCATAAAAGTGGGGCTTACCTTTTATGCAGTACAAACACTTTAGACTCTAAAACGCAGAAAGCATGGTGACCTTTAAT
TATGGCAACCCAACCTCGAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKDLTLNDLPIREELRGQSAYGAPQLDVDVRLNTNENPYPPSEALVEELARVVAEQASNLNRYPERDAVELRTELARYIT
KCTGVPVTYEQLWAANGSNEVLQQLLQAFGGPGRTVLGFQPSYSMHPILAQGTQTTFINCPRDKEFRIDVDAALAAITTH
QPNIVFVTTPNNPTGDVTSLDTIKKILDVAPGIVIVDEAYAEFSEQPSAISLLENYPTKLVVSRTMSKAFDFAGGRLGYF
VAHKAFIDAVMLVRLPYHLSQLSQAAAIVALRHSEETLATVAKLVAERKRVQQGLLELGFEIVPSESNFLFFGHFEDQHA
AWQAFLDRKVLIRDVSVSGYLRATVGLPEENDAFLNAAREVAQQFL

Sequences:

>Translated_366_residues
MKDLTLNDLPIREELRGQSAYGAPQLDVDVRLNTNENPYPPSEALVEELARVVAEQASNLNRYPERDAVELRTELARYIT
KCTGVPVTYEQLWAANGSNEVLQQLLQAFGGPGRTVLGFQPSYSMHPILAQGTQTTFINCPRDKEFRIDVDAALAAITTH
QPNIVFVTTPNNPTGDVTSLDTIKKILDVAPGIVIVDEAYAEFSEQPSAISLLENYPTKLVVSRTMSKAFDFAGGRLGYF
VAHKAFIDAVMLVRLPYHLSQLSQAAAIVALRHSEETLATVAKLVAERKRVQQGLLELGFEIVPSESNFLFFGHFEDQHA
AWQAFLDRKVLIRDVSVSGYLRATVGLPEENDAFLNAAREVAQQFL
>Mature_366_residues
MKDLTLNDLPIREELRGQSAYGAPQLDVDVRLNTNENPYPPSEALVEELARVVAEQASNLNRYPERDAVELRTELARYIT
KCTGVPVTYEQLWAANGSNEVLQQLLQAFGGPGRTVLGFQPSYSMHPILAQGTQTTFINCPRDKEFRIDVDAALAAITTH
QPNIVFVTTPNNPTGDVTSLDTIKKILDVAPGIVIVDEAYAEFSEQPSAISLLENYPTKLVVSRTMSKAFDFAGGRLGYF
VAHKAFIDAVMLVRLPYHLSQLSQAAAIVALRHSEETLATVAKLVAERKRVQQGLLELGFEIVPSESNFLFFGHFEDQHA
AWQAFLDRKVLIRDVSVSGYLRATVGLPEENDAFLNAAREVAQQFL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=379, Percent_Identity=30.3430079155673, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1788722, Length=323, Percent_Identity=23.8390092879257, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=359, Percent_Identity=28.6908077994429, Blast_Score=129, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_CORDI (P60999)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939907.1
- ProteinModelPortal:   P60999
- SMR:   P60999
- GeneID:   2650754
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1565
- NMPDR:   fig|257309.1.peg.1498
- HOGENOM:   HBG646350
- OMA:   CELYANQ
- PhylomeDB:   P60999
- ProtClustDB:   PRK03317
- BioCyc:   CDIP257309:DIP1565-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40532; Mature: 40532

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLTLNDLPIREELRGQSAYGAPQLDVDVRLNTNENPYPPSEALVEELARVVAEQASNL
CCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCC
NRYPERDAVELRTELARYITKCTGVPVTYEQLWAANGSNEVLQQLLQAFGGPGRTVLGFQ
CCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEC
PSYSMHPILAQGTQTTFINCPRDKEFRIDVDAALAAITTHQPNIVFVTTPNNPTGDVTSL
CCCCCCCCEECCCCEEEEECCCCCCEEEEHHHHHHHHEECCCCEEEEECCCCCCCCCCHH
DTIKKILDVAPGIVIVDEAYAEFSEQPSAISLLENYPTKLVVSRTMSKAFDFAGGRLGYF
HHHHHHHHHCCCEEEEEHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHH
VAHKAFIDAVMLVRLPYHLSQLSQAAAIVALRHSEETLATVAKLVAERKRVQQGLLELGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
EIVPSESNFLFFGHFEDQHAAWQAFLDRKVLIRDVSVSGYLRATVGLPEENDAFLNAARE
EEECCCCCEEEEECCCCHHHHHHHHHCCHHEEEECCCCCEEEEEECCCCCCHHHHHHHHH
VAQQFL
HHHHCC
>Mature Secondary Structure
MKDLTLNDLPIREELRGQSAYGAPQLDVDVRLNTNENPYPPSEALVEELARVVAEQASNL
CCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCC
NRYPERDAVELRTELARYITKCTGVPVTYEQLWAANGSNEVLQQLLQAFGGPGRTVLGFQ
CCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEC
PSYSMHPILAQGTQTTFINCPRDKEFRIDVDAALAAITTHQPNIVFVTTPNNPTGDVTSL
CCCCCCCCEECCCCEEEEECCCCCCEEEEHHHHHHHHEECCCCEEEEECCCCCCCCCCHH
DTIKKILDVAPGIVIVDEAYAEFSEQPSAISLLENYPTKLVVSRTMSKAFDFAGGRLGYF
HHHHHHHHHCCCEEEEEHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHH
VAHKAFIDAVMLVRLPYHLSQLSQAAAIVALRHSEETLATVAKLVAERKRVQQGLLELGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
EIVPSESNFLFFGHFEDQHAAWQAFLDRKVLIRDVSVSGYLRATVGLPEENDAFLNAARE
EEECCCCCEEEEECCCCHHHHHHHHHCCHHEEEECCCCCEEEEEECCCCCCHHHHHHHHH
VAQQFL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910