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The map label for this gene is hisD

Identifier: 38234141

GI number: 38234141

Start: 1592961

End: 1594310

Strand: Reverse

Name: hisD

Synonym: DIP1566

Alternate gene names: 38234141

Gene position: 1594310-1592961 (Counterclockwise)

Preceding gene: 38234145

Following gene: 38234140

Centisome position: 64.06

GC content: 51.93

Gene sequence:

>1350_bases
TTGAGGAAACGTAAAATTATGTTGAATGTGATTGATCTTCGCGGACACGTTCCCACCACAAGTGAGCTGCGTAGAACATT
GCCACGAGGCGGAACGGATATTAATTCGGTATTACCGATCGTCGAGCCAGTGGTTACCGACGTTAAGAATAGAGGTGCTG
CTGCCGCACTTGATTATGGAGAAAAATTCGATCACGTTCGCCCAACATCAATTCGAGTGCCGCAAGATGTCATCGATCAG
GCACTGGACAGCTTGGACCCCAATGTCATTGAGGCACTGAAAGAATCGATCGCCCGAGTGCGTGCAGTTCACTCTGAGCA
GCTTCCAGCCCAACACACCACTTCCTTTGGTGAAGGCGCAACAATTACAGAGAAGTTCATACCAGTATCTCGCGTTGGCC
TCTACGCTCCTGGTGGAAATGCTGTGTATCCCTCCAGCGTTATTATGAACGTTGTCCCCGCTCAAGAAGCGGGAGTGGAA
TCATTAGTTGTGGCTTCTCCTCCACAAAAAGATCACGGTGGATGGCCTCACCCCACTATTTTGGCCGCCGCTAAGCTTTT
GGGAGTAACTGAGGTTTGGGCTATGGGCGGTGCTCAAGCAGTGGCATTGTTGGCTTATGGCGATGATACCCAGCAAAATA
GTGCTGAAGTCTTAGAACCGGTCGATATGATTACTGGCCCTGGCAATATCTTTGTCACCGCTGCCAAGCGTTTGGTGCGC
GGGGTGGTGGGCATCGACTCTGAGGCTGGTCCAACAGAAATCGCTATCGTTGCCGACGCGCAGGCGAACCCAGTCTGGAT
CGCCTATGATCTCATCAGCCAAGCTGAACATGATGTTCTTGCTGCTTCGGTCCTTATCACGGACTCCGAAGAGTTGGCAC
AGCGCGTTAATGAGGAAGTCGCTGCCCGCTACAGTGTCACTCGCAACGCAGATCGCGTATCTGAGGCTCTCAAAGGCCAG
CAATCAGGCATCGTGCTTGTCGACGATCTCCCGACCGCCGTTATAGTGGCAGACGCATACGCTGCGGAACACTTGGAAAT
TCACACAGCAGAGTCCCACAAGGTGGCAGAACAAATTCGAAACGCTGGTGCAATATTTGTTGGCGGATATTCTCCGGTAC
CGCTAGGGGATTACTCAGCGGGTTCGAACCACGTACTGCCAACCTCTGGAAGCGCTCGTTATAGCTCCGGACTTTCTACG
CATACCTTCCTCAAGCCAGTCAACGTTATTTACTACGATGAGGTGGCACTGAAAGAAATTTCCGACACCGTGATCACCTT
GGCTGATGCCGAGGACCTTCCTGCACACGGCGAAGCAATTCGTACGCGCTTTGAAAATCTTGGCAACTAG

Upstream 100 bases:

>100_bases
GACGGGGGTGCTCCATACGCCTTGTTGTGGAGATAGCTGCATATAATGTGTGCTTTAGGCCCATCGTAGGCAGTGTTTTT
ACGGAAAACATCGAAAAATA

Downstream 100 bases:

>100_bases
GTCTCACTGAAAAAATACGGAAAGAATGCAGTAAACTCATGAAAGATCTAACGCTGAATGATCTTCCTATTCGGGAAGAA
CTACGAGGCCAATCCGCTTA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MRKRKIMLNVIDLRGHVPTTSELRRTLPRGGTDINSVLPIVEPVVTDVKNRGAAAALDYGEKFDHVRPTSIRVPQDVIDQ
ALDSLDPNVIEALKESIARVRAVHSEQLPAQHTTSFGEGATITEKFIPVSRVGLYAPGGNAVYPSSVIMNVVPAQEAGVE
SLVVASPPQKDHGGWPHPTILAAAKLLGVTEVWAMGGAQAVALLAYGDDTQQNSAEVLEPVDMITGPGNIFVTAAKRLVR
GVVGIDSEAGPTEIAIVADAQANPVWIAYDLISQAEHDVLAASVLITDSEELAQRVNEEVAARYSVTRNADRVSEALKGQ
QSGIVLVDDLPTAVIVADAYAAEHLEIHTAESHKVAEQIRNAGAIFVGGYSPVPLGDYSAGSNHVLPTSGSARYSSGLST
HTFLKPVNVIYYDEVALKEISDTVITLADAEDLPAHGEAIRTRFENLGN

Sequences:

>Translated_449_residues
MRKRKIMLNVIDLRGHVPTTSELRRTLPRGGTDINSVLPIVEPVVTDVKNRGAAAALDYGEKFDHVRPTSIRVPQDVIDQ
ALDSLDPNVIEALKESIARVRAVHSEQLPAQHTTSFGEGATITEKFIPVSRVGLYAPGGNAVYPSSVIMNVVPAQEAGVE
SLVVASPPQKDHGGWPHPTILAAAKLLGVTEVWAMGGAQAVALLAYGDDTQQNSAEVLEPVDMITGPGNIFVTAAKRLVR
GVVGIDSEAGPTEIAIVADAQANPVWIAYDLISQAEHDVLAASVLITDSEELAQRVNEEVAARYSVTRNADRVSEALKGQ
QSGIVLVDDLPTAVIVADAYAAEHLEIHTAESHKVAEQIRNAGAIFVGGYSPVPLGDYSAGSNHVLPTSGSARYSSGLST
HTFLKPVNVIYYDEVALKEISDTVITLADAEDLPAHGEAIRTRFENLGN
>Mature_449_residues
MRKRKIMLNVIDLRGHVPTTSELRRTLPRGGTDINSVLPIVEPVVTDVKNRGAAAALDYGEKFDHVRPTSIRVPQDVIDQ
ALDSLDPNVIEALKESIARVRAVHSEQLPAQHTTSFGEGATITEKFIPVSRVGLYAPGGNAVYPSSVIMNVVPAQEAGVE
SLVVASPPQKDHGGWPHPTILAAAKLLGVTEVWAMGGAQAVALLAYGDDTQQNSAEVLEPVDMITGPGNIFVTAAKRLVR
GVVGIDSEAGPTEIAIVADAQANPVWIAYDLISQAEHDVLAASVLITDSEELAQRVNEEVAARYSVTRNADRVSEALKGQ
QSGIVLVDDLPTAVIVADAYAAEHLEIHTAESHKVAEQIRNAGAIFVGGYSPVPLGDYSAGSNHVLPTSGSARYSSGLST
HTFLKPVNVIYYDEVALKEISDTVITLADAEDLPAHGEAIRTRFENLGN

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=434, Percent_Identity=34.7926267281106, Blast_Score=224, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6319819, Length=450, Percent_Identity=35.1111111111111, Blast_Score=252, Evalue=8e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_CORDI (P60858)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939908.1
- ProteinModelPortal:   P60858
- SMR:   P60858
- GeneID:   2650755
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1566
- NMPDR:   fig|257309.1.peg.1499
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- PhylomeDB:   P60858
- ProtClustDB:   PRK00877
- BioCyc:   CDIP257309:DIP1566-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47762; Mature: 47762

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 343-343 ACT_SITE 344-344 BINDING 135-135 BINDING 199-199 BINDING 229-229 BINDING 252-252 BINDING 274-274 BINDING 277-277 BINDING 344-344 BINDING 377-377 BINDING 431-431 BINDING 436-436

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKRKIMLNVIDLRGHVPTTSELRRTLPRGGTDINSVLPIVEPVVTDVKNRGAAAALDYG
CCCCEEEEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
EKFDHVRPTSIRVPQDVIDQALDSLDPNVIEALKESIARVRAVHSEQLPAQHTTSFGEGA
HHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
TITEKFIPVSRVGLYAPGGNAVYPSSVIMNVVPAQEAGVESLVVASPPQKDHGGWPHPTI
CHHHHCCCHHHCEEECCCCCCCCCHHHHHEECCCHHCCCCEEEEECCCCCCCCCCCCHHH
LAAAKLLGVTEVWAMGGAQAVALLAYGDDTQQNSAEVLEPVDMITGPGNIFVTAAKRLVR
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHH
GVVGIDSEAGPTEIAIVADAQANPVWIAYDLISQAEHDVLAASVLITDSEELAQRVNEEV
HHHCCCCCCCCCEEEEEECCCCCCEEEEHHHHHCCHHHHEEEEEEEECHHHHHHHHHHHH
AARYSVTRNADRVSEALKGQQSGIVLVDDLPTAVIVADAYAAEHLEIHTAESHKVAEQIR
HHHHHHHCCHHHHHHHHCCCCCCEEEEECCCCEEEEECHHHHCCEEEECCHHHHHHHHHH
NAGAIFVGGYSPVPLGDYSAGSNHVLPTSGSARYSSGLSTHTFLKPVNVIYYDEVALKEI
CCCEEEECCCCCCCCCCCCCCCCCEECCCCCCHHCCCCCHHHHHCCCEEEEECHHHHHHH
SDTVITLADAEDLPAHGEAIRTRFENLGN
CCCEEEEECCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRKRKIMLNVIDLRGHVPTTSELRRTLPRGGTDINSVLPIVEPVVTDVKNRGAAAALDYG
CCCCEEEEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
EKFDHVRPTSIRVPQDVIDQALDSLDPNVIEALKESIARVRAVHSEQLPAQHTTSFGEGA
HHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
TITEKFIPVSRVGLYAPGGNAVYPSSVIMNVVPAQEAGVESLVVASPPQKDHGGWPHPTI
CHHHHCCCHHHCEEECCCCCCCCCHHHHHEECCCHHCCCCEEEEECCCCCCCCCCCCHHH
LAAAKLLGVTEVWAMGGAQAVALLAYGDDTQQNSAEVLEPVDMITGPGNIFVTAAKRLVR
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHH
GVVGIDSEAGPTEIAIVADAQANPVWIAYDLISQAEHDVLAASVLITDSEELAQRVNEEV
HHHCCCCCCCCCEEEEEECCCCCCEEEEHHHHHCCHHHHEEEEEEEECHHHHHHHHHHHH
AARYSVTRNADRVSEALKGQQSGIVLVDDLPTAVIVADAYAAEHLEIHTAESHKVAEQIR
HHHHHHHCCHHHHHHHHCCCCCCEEEEECCCCEEEEECHHHHCCEEEECCHHHHHHHHHH
NAGAIFVGGYSPVPLGDYSAGSNHVLPTSGSARYSSGLSTHTFLKPVNVIYYDEVALKEI
CCCEEEECCCCCCCCCCCCCCCCCEECCCCCCHHCCCCCHHHHHCCCEEEEECHHHHHHH
SDTVITLADAEDLPAHGEAIRTRFENLGN
CCCEEEEECCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910