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The map label for this gene is hisA

Identifier: 38234135

GI number: 38234135

Start: 1587808

End: 1588536

Strand: Reverse

Name: hisA

Synonym: DIP1560

Alternate gene names: 38234135

Gene position: 1588536-1587808 (Counterclockwise)

Preceding gene: 38234136

Following gene: 38234134

Centisome position: 63.83

GC content: 52.26

Gene sequence:

>729_bases
ATGACTTTCACACTTCTCCCCGCCGTCGATGTTGTCGATGGTCAGGCAGTTCGTTTGGATCAAGGTGAAGCCGGAACCGA
AAAGTCGTACGGTTCCCCAATTGCGGCTGCACTGAAATGGCAGGAACAAGGGGCATCGTGGCTACATTTCGTGGATTTAG
ATGCAGCTTTCAACCGTGGATCGAATCATGAGCTGATGGCGGAAGTTGTGAAAAACCTAGATATTAACGTTGAGCTAACC
GGCGGCATTCGTGATGACGCATCGCTTAAGCGAGCACTTGCTACCGGTGCGCGTCGTGTCAACATCGGAACTGCCGCCTT
GGAAAAACCAGAGTGGATCGAGAAAGTTCTAGGCGAATACGGGGATGCCATCGCTGTCGATATAGCAGTGCGAAATATCG
ATGGCCAGTGGCGTACTCGTGGCAATGGCTGGGTCTCTGATGGTGGAGATCTTTGGGAGGTACTCGAGCGCCTTGATAGC
CAAGGATGCACACGATTTGTGGTCACCGATGTATCTAAGGATGGGACGCTAAGCGGTCCAAATATCGATTTGCTTCGCGA
CGTTTCCGCGGCAACCGATGCCAAGGTTGTAGCCTCTGGTGGTATCTCTACCTTGGAGGATGTGCTGGAGCTTGCGCGAT
ATGAAGACGAAGGTATTGATTCTGCCATTATTGGCAAAGCGCTGTATGAAGGCCGTTTTACCCTTAAGGAGGCGCTCGCC
GCGCTATGA

Upstream 100 bases:

>100_bases
TAAAACCCGCAATGCGGGACAGCTCGAGGATTCGGTGGGGTAGGGCTTCAACCCCGCTAGGGTGAGCCTTGTTGCGGATA
AGCGTCTACACTATTGCTTT

Downstream 100 bases:

>100_bases
CCGATGTTCGGGACCTTTATCATATTGCAGAGGCAATACTCGATGATGCCGAGCGTCTATTCATTCAGGGCATAGGTTCA
GCTCCTACAACGTTTAAAAA

Product: phosphoribosyl isomerase A

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTFTLLPAVDVVDGQAVRLDQGEAGTEKSYGSPIAAALKWQEQGASWLHFVDLDAAFNRGSNHELMAEVVKNLDINVELT
GGIRDDASLKRALATGARRVNIGTAALEKPEWIEKVLGEYGDAIAVDIAVRNIDGQWRTRGNGWVSDGGDLWEVLERLDS
QGCTRFVVTDVSKDGTLSGPNIDLLRDVSAATDAKVVASGGISTLEDVLELARYEDEGIDSAIIGKALYEGRFTLKEALA
AL

Sequences:

>Translated_242_residues
MTFTLLPAVDVVDGQAVRLDQGEAGTEKSYGSPIAAALKWQEQGASWLHFVDLDAAFNRGSNHELMAEVVKNLDINVELT
GGIRDDASLKRALATGARRVNIGTAALEKPEWIEKVLGEYGDAIAVDIAVRNIDGQWRTRGNGWVSDGGDLWEVLERLDS
QGCTRFVVTDVSKDGTLSGPNIDLLRDVSAATDAKVVASGGISTLEDVLELARYEDEGIDSAIIGKALYEGRFTLKEALA
AL
>Mature_241_residues
TFTLLPAVDVVDGQAVRLDQGEAGTEKSYGSPIAAALKWQEQGASWLHFVDLDAAFNRGSNHELMAEVVKNLDINVELTG
GIRDDASLKRALATGARRVNIGTAALEKPEWIEKVLGEYGDAIAVDIAVRNIDGQWRTRGNGWVSDGGDLWEVLERLDSQ
GCTRFVVTDVSKDGTLSGPNIDLLRDVSAATDAKVVASGGISTLEDVLELARYEDEGIDSAIIGKALYEGRFTLKEALAA
L

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=32.5102880658436, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1788336, Length=251, Percent_Identity=25.4980079681275, Blast_Score=70, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_CORDI (P60580)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939902.1
- ProteinModelPortal:   P60580
- SMR:   P60580
- GeneID:   2650749
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1560
- NMPDR:   fig|257309.1.peg.1493
- HOGENOM:   HBG541613
- OMA:   CARYVVT
- PhylomeDB:   P60580
- ProtClustDB:   PRK14024
- BioCyc:   CDIP257309:DIP1560-MONOMER
- BRENDA:   5.3.1.16
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR010188
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01919

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25987; Mature: 25856

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: ACT_SITE 10-10

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFTLLPAVDVVDGQAVRLDQGEAGTEKSYGSPIAAALKWQEQGASWLHFVDLDAAFNRG
CEEEECCCEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECHHHHCCC
SNHELMAEVVKNLDINVELTGGIRDDASLKRALATGARRVNIGTAALEKPEWIEKVLGEY
CCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCEEEECCHHHCCCHHHHHHHHHHC
GDAIAVDIAVRNIDGQWRTRGNGWVSDGGDLWEVLERLDSQGCTRFVVTDVSKDGTLSGP
CCEEEEEEEEEECCCCEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
NIDLLRDVSAATDAKVVASGGISTLEDVLELARYEDEGIDSAIIGKALYEGRFTLKEALA
CHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHH
AL
CC
>Mature Secondary Structure 
TFTLLPAVDVVDGQAVRLDQGEAGTEKSYGSPIAAALKWQEQGASWLHFVDLDAAFNRG
EEEECCCEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECHHHHCCC
SNHELMAEVVKNLDINVELTGGIRDDASLKRALATGARRVNIGTAALEKPEWIEKVLGEY
CCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCEEEECCHHHCCCHHHHHHHHHHC
GDAIAVDIAVRNIDGQWRTRGNGWVSDGGDLWEVLERLDSQGCTRFVVTDVSKDGTLSGP
CCEEEEEEEEEECCCCEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
NIDLLRDVSAATDAKVVASGGISTLEDVLELARYEDEGIDSAIIGKALYEGRFTLKEALA
CHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHH
AL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910